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Topic Review
Carotenoid Colorants from Plants and Microalgae
The substitution of synthetic food dyes with natural colorants continues to be assiduously pursued. The current list of natural carotenoid colorants consists of plant-derived annatto (bixin and norbixin), paprika (capsanthin and capsorubin), saffron (crocin), tomato and gac fruit lycopene, marigold lutein, and red palm oil (α- and β-carotene), along with microalgal Dunaliella β-carotene and Haematococcus astaxanthin and fungal Blakeslea trispora β-carotene and lycopene. Potential microalgal sources are being sought, especially in relation to lutein, for which commercial plant sources are lacking.
  • 1.4K
  • 15 Nov 2023
Topic Review
Immunological Synapse and Primary Cilium
The primary cilium is a small microtubule-based organelle that extends from the apical surface of most eukaryotic cells into the extracellular space for sensing and transducing a wide range of cues. Defects in cilia growth and function are associated with a group of human inherited multisystemic diseases, known as ciliopathies. In recent years a rising number of ciliary proteins have been described at extraciliary sites, both in ciliated and non-ciliated cells, and have been implicated in cilium-independent functions and different cellular processes. Hematopoietic cells, including T lymphocytes, do not form primary cilia. However, non-ciliated T cells co-opt the ciliogenesis machinery for the assembly and function of the immunological synapse, a well-organized structure formed by immune cells – multiple types of T cells, mast cells, NK cells, B cells, neutrophils, macrophages, and dendritic cells – allowing for antigen recognition and signaling, information exchange and polarized release of molecules into the synaptic cleft. The identification of many, unexpected similarities between the primary cilium and the T cell immunological synapse at the structural, functional and molecular levels have highlighted the homology between these structures, even though they show disparate morphologies. 
  • 1.4K
  • 11 Apr 2022
Topic Review
Polymer-Based Sensors
Due to the wide application of wearable electronic devices in daily life, research into flexible electronics has become very attractive. Various polymer-based sensors have emerged with great sensing performance and excellent extensibility. It is well known that different structural designs each confer their own unique, great impacts on the properties of materials. For polymer-based pressure/strain sensors, different structural designs determine different response-sensing mechanisms, thus showing their unique advantages and characteristics. 
  • 1.4K
  • 23 Feb 2023
Topic Review
Probabilistic Decline Curve Analysis Approaches
The decline curve analysis (DCA) technique is the simplest, fastest, least computationally demanding, and least data-required reservoir forecasting method. Assuming that the decline rate of the initial production data will continue in the future, the estimated ultimate recovery (EUR) can be determined at the end of the well/reservoir lifetime based on the declining mode. Many empirical DCA models have been developed to match different types of reservoirs as the decline rate varies from one well/reservoir to another. In addition to the uncertainties related to each DCA model’s performance, structure, and reliability, any of them can be used to estimate one deterministic value of the EUR, which, therefore, might be misleading with a bias of over- and/or under-estimation. To reduce the uncertainties related to the DCA, the EUR could be assumed to be within a certain range, with different levels of confidence. Probabilistic decline curve analysis (pDCA) is the method used to generate these confidence intervals (CIs), and many pDCA approaches have been introduced to reduce the uncertainties that come with the deterministic DCA.
  • 1.4K
  • 12 Jun 2023
Topic Review
Pictor
Pictor, a relatively faint constellation in the southern celestial hemisphere, is named after the easel used by artists to hold their canvases. It is located between the star Canopus and the Large Magellanic Cloud.
  • 1.4K
  • 15 Mar 2024
Topic Review
Natural Antioxidants for Reducing Lipid Rancidity
Natural antioxidants have been widely used in food preservation due to their unique properties that offer many advantages over synthetic molecules. Unlike synthetic agents, natural options derived from plants, fruits, and spices have been proven to be safe and effective in reducing lipid rancidity. These antioxidants possess a combination of beneficial compounds that act synergistically to delay oxidative processes, improving the shelf life and quality of food products. Additionally, natural antioxidants are typically recognized as safe by regulatory agencies and are favored by consumers who prefer natural food additives. By incorporating natural antioxidants, the food industry can not only improve food quality and safety, but also appeal to the growing demand for natural and organic food products.
  • 1.4K
  • 17 Apr 2023
Topic Review
Metabolic Syndrome
Metabolic syndrome is a cluster of metabolic risk factors, characterized by abdominal obesity, dyslipidemia, low levels of HDL-c, hypertension, and insulin resistance. Lifestyle modifications, especially dietary habits, are the main therapeutic strategy for the treatment and management of metabolic syndrome, but the most effective dietary pattern for its management has not been established. Specific dietary modifications, such as improving the quality of the foods or changing macronutrient distribution, showed beneficial effects on metabolic syndrome conditions and individual parameters. On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean DASH diet intervention as the new paradigm for metabolic syndrome prevention and treatment. The nutritional distribution and quality of these healthy diets allows health professionals to provide easy-to-follow dietary advice without the need for restricted diets. Nonetheless, energy-restricted dietary patterns and improvements in physical activity are crucial to improve the metabolic disturbances observed in metabolic syndrome patients.
  • 1.4K
  • 21 Oct 2020
Topic Review
Quantitative Epigenetics
Epigenetic modifications modulate gene expression without any change in genomic DNA sequences that affects multiple aspects of plant growth and development 
  • 1.4K
  • 10 Dec 2020
Topic Review
Printed Electrochemical Biosensors
Printing technologies represent powerful tools to combine simpler and more customizable fabrication of electrochemical biosensors with high resolution, miniaturization and integration with more complex microfluidic and electronics systems. Considering this framework, this review provides an overview of the opportunities offered by printed electrochemical biosensors in terms of transducing principles, metrological characteristics and enlargement of the application field, as well as of the main metrological challenges related.
  • 1.4K
  • 14 Dec 2020
Topic Review
Developmental Coordination Disorder
As described in the American Psychiatric Association’s (Washington, DC, USA) latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the child with Developmental Coordination Disorder （DCD) has motor coordination below expectations for his or her chronologic age and therefore may have been described as “clumsy” and may have had delays in early motor milestones, such as walking and crawling. Difficulties with coordination of either gross or fine motor movements, or both, could interfere with academic achievement or activities of daily living. Coordination difficulties do not relate to a medical condition or disease (e.g., cerebral palsy, muscular dystrophy, visual impairment, or intellectual disability).
  • 1.4K
  • 06 May 2021
Topic Review Video
Transgenerational-Epigenetic Inheritance and Immune System
Epigenetic modifications cause heritable changes in gene expression which are not due to alterations in underlying DNA sequence. Inside the eukaryotic nucleus, there is condense packing of DNA around histone proteins to constitute chromatin structure. Epigenetic modifications are caused by factors that alter chromatin structure. Some epigenetic factors are enzymes that regulate DNA methylation and histone modifications, non-coding RNA, and prions. An offspring inherits parental epigenetic modifications but most of them are deleted and reset during early developmental stages. Some epigenetic modifications are retained and persist across multiple generations. If any epigenetic modification is the result of a stimulus or immune response in one generation, such that the modification continues to be inherited in subsequent generations which are not subjected to the stimulus; and the inheritance continues beyond the 3rd generation in the female germline and 2nd generation in male, then the phenomenon is called transgenerational epigenetic inheritance (TGEI). This entry is focused on a review which discusses some examples of TGEI that are reported in association with  immune system development and disorders.
  • 1.4K
  • 22 May 2021
Topic Review
Water Hammer Modelling
Water Hammer is a physical phenomenon that occurs due to sudden stopping of flow in a pipeline system which causes a sudden large pressure rise mimicking the hammering effect. It is considered one of the worst nightmare for hydraulic engineers due to its potential of causing widespread damage to property and lives. Therefore, numerical estimation of water hammer pressure is crucial for the design, operation, and risk analysis of pipeline systems. Generally, the traditional Method of Characteristics (MOC) is preferred by modellers worldwide due to its simplicity and usability. However, due to high shock generation during large water hammer event in pipeline, Finite Volume Method (FVM) has a clear advantage because of its desirable attribute of conserving mass, momentum compared to traditional MOC Schemes. Further, modelling of the water hammer phenomenon for dynamic characteristics within a turbine is impossible using the classical 1D MOC or 1D FVM schemes, and such applications require more extensive 3D grids and turbulence models. Several commercial pieces of software for turbulence modelling available today can be effectively used for this type of study. Some well-known and well-applied turbulence models currently in use are FLUENT and CFX (https://www.ansys.com(accessed on 1 June 2021)).
  • 1.4K
  • 24 Jun 2021
Topic Review
Carsharing
As of 2019, carsharing was offered in over 50 countries, and over 200 carsharing providers were operating in over 3000 cities. Approximately 2.5 million carsharing users were registered in Germany in 2019. These users are given access to vehicles on an “as-needed” basis, which underlies a pay per use and/or membership-based pricing model.
  • 1.4K
  • 13 Jul 2021
Topic Review
External Human–Machine Interface of AVs
In future urban traffic, it is more likely that automated vehicles (AVs) will operate not in separated traffic spaces but in so-called mixed traffic environments where different types of traffic participants interact. Therefore, AVs must be able to communicate with other traffic participants, e.g., pedestrians as vulnerable road users (VRUs), to solve ambiguous traffic situations. Taking current traffic communication patterns into account, a combination of implicit communication via the driving behavior (e.g., deceleration, position in lane) and explicit communication via an external Human–Machine Interface (eHMI) seems to be a promising approach. The eHMI consists of an external interface connected to the vehicle, which can transmit explicit signals enabling interaction between AVs and other TPs.
  • 1.4K
  • 15 Aug 2021
Topic Review
English as a Foreign Language
In English as a Foreign Language (EFL) learning, in addition to the knowledge of the language, students should be provided with the features of pragmalinguistics and socio pragmatics in order to enable them to communicate effectively in English, as they need to communicate in a social context.
  • 1.4K
  • 16 Jan 2024
Topic Review
Deep eutectic solvents in pharmaceutical synthesis
DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). DES have been utilized in organic synthesis as green media thanks to the high potential to replace the classical solvents. In fact, since the DES are characterized by a network of hydrogen bonds, they have the possibility to dissolve solutes that can form hydrogen bonds and stabilize transition states. Furthermore, during the purification procedures, the addition of water to a DES (very soluble in water) causes the precipitation of organic products, facilitating the workup and avoiding the use of solvents for the extraction. 
  • 1.4K
  • 04 Nov 2021
Topic Review
Sustainable Tourism Issues in European Countries
Sustainable economic growth can be achieved through tourism by protecting the environment, maintaining natural resources, creating employment, improving cultural diversity, and recognizing cultural heritage values. The concept of tourism sustainability is gradually growing globally and becoming a dominant aspect in modern business, as companies need to meet stakeholders’ demands regarding environmental management. Sustainable tourism incorporates environmental, social, economic, and cultural issues into operations. The demand for green tourism, ethical consumption, protection of natural resources, and living close to nature is expected to increase. In particular, the latter gains more and more popularity due to the stress caused by the global pandemic and also because values have been re-evaluated at every level of society.
  • 1.4K
  • 06 Apr 2022
Topic Review
Targeting the Neural Circuits for Treating Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by cognitive and behavioral symptoms. These AD-related manifestations result from the alteration of neural circuitry by aggregated forms of amyloid-β (Aβ) and hyperphosphorylated tau, which are neurotoxic. From a neuroscience perspective, identifying neural circuits that integrate various inputs and outputs to determine behaviors can provide insight into the principles of behavior. Therefore, it is crucial to understand the alterations in the neural circuits associated with AD-related behavioral and psychological symptoms. Interestingly, it is well known that the alteration of neural circuitry is prominent in the brains of patients with AD. 
  • 1.4K
  • 28 Apr 2022
Topic Review
Machine Learning Model in HSI-AD
In the field of remote sensing, hyperspectral image (HSI) is a ground image collected by advanced sensor technology and imaging system mounted on satellites or other aircraft. Anomaly detection (AD) is a very important sub-branch in machine learning and has important applications in computer vision, data mining, and natural language processing (NLP). HSI-AD refers to the identification of pixels whose spectral characteristics in an image are significantly different from adjacent or global background pixels.
  • 1.4K
  • 05 May 2022
Topic Review Video Peer Reviewed
The Human Passion for Music
Music is a universal feature of human societies, which suggests that an evolutionary perspective should help people understand the appreciation. The reward (pleasure) system of the brain offers a suitable framework. The primary evolutionary advantage is probably related to the importance of language; features of sound, such as purity, harmony, complexity, and rhythmicity, are useful for facilitating oral communication. One would expect evolution to associate rewards with these qualities in order to stimulate the development of brain regions involved in interpreting and producing relevant sounds. There are additional adaptive aspects of music, such as relaxation, social coherence, and sexual selection. Music can be regarded as a superstimulus that accentuates and exploits rewards associated with hearing. As such, music is not necessarily adaptive in a biological sense, but serves the purpose of improving quality of life. 
  • 1.4K
  • 09 Jun 2022
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