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Topic Review
Laser-Induced Breakdown Spectroscopy for Food Quality Evaluation
Laser-induced Breakdown Spectroscopy (LIBS) is becoming an increasingly popular analytical technique for characterizing and identifying various products; its multi-element analysis, fast response, remote sensing, and sample preparation is minimal or nonexistent, and low running costs can significantly accelerate the analysis of foods with medicinal properties (FMPs). 
  • 1.4K
  • 28 Jul 2022
Topic Review
Proteolysis-targeting Chimeras for Drug Targeted Protein Research
Proteolysis-targeting chimera (PROTAC) is a heterobifunctional molecule. Typically, PROTAC consists of two terminals which are the ligand of the protein of interest (POI) and the specific ligand of E3 ubiquitin ligase, respectively, via a suitable linker. PROTAC degradation of the target protein is performed through the ubiquitin–proteasome system (UPS).
  • 1.4K
  • 26 Sep 2022
Topic Review
Philosophical Reflections in the Naisadhacarita
Philosophical Reflections in the Naisadhacarita is the doctoral (Ph.D.) thesis of Harekrishna Meher done in Banaras Hindu University in 1981. It discusses philosophical ideas as reflected in the Sanskrit Mahakavya ‘Naisadhacaritam’ authored by the distinguished poet Sriharsa (12th century). This book (ISBN:9788185094212), first published in 1989 by Punthi Pustak Calcutta, is circulated worldwide. Naisadhacarita Mahakavya of poet Sriharsa enjoys a prominent position among the five great epics of Sanskrit literature. Also known as ‘Naishadha’ or ‘Naishadhiya’, this epic contains twenty-two cantos completed with 2827 verses. Its main theme is the story of love between Nala, the King of Nisadha country and Damayanti, the Princess of Vidarbha. The story of Nala and Damayanti is found in the Mahabharata of Vyasa and Kathasaritsagara of Somadeva. The episode of the epic has been taken from the Mahabharata. Poet Sriharsa has remodelled the story and has added the sentiment of love to it. 
  • 1.4K
  • 10 Oct 2022
Topic Review
Aluminium(I)
In chemistry, aluminium(I) refers to monovalent aluminium (+1 oxidation state) in both ionic and covalent bonds. Along with aluminium(II), it is an extremely unstable form of aluminium. While late Group 3 elements such as thallium and indium prefer the +1 oxidation state, aluminium(I) is rare. Unlike late Group XIII elements, aluminium does not experience the inert pair effect, a phenomenon where valence s electrons are poorly shielded from nuclear charge due to the presence of filled d and f orbitals. As such, aluminium (III) ([math]\ce{ Al^3+ }[/math]) is the much more common oxidation state for aluminium. Aluminium(I) compounds are both prone to disproportionation and difficult to prepare. At standard conditions, they readily oxidize to the aluminium(III) form.
  • 1.4K
  • 14 Nov 2022
Topic Review
Post-Harvest Insect Management Practices in Ethiopia
Ethiopian subsistence farmers traditionally store their grain harvests, leaving them open to storage pests and fungi that can cause contamination of major staple crops. Applying the most effective strategy requires a precise understanding of the insect species, infestation rates, storage losses, and storage conditions in the various types of farmers’ grain stores.
  • 1.4K
  • 28 Nov 2022
Topic Review
Jasmonic Acid in Plant Response to Necrotrophic Fungi
Jasmonic acid (JA) and its derivatives, all named jasmonates, are the simplest phytohormones which regulate multifarious plant physiological processes including development, growth and defense responses to various abiotic and biotic stress factors. Moreover, jasmonate plays an important mediator’s role during plant interactions with necrotrophic oomycetes and fungi in the process of activation defense responses.
  • 1.4K
  • 05 May 2023
Topic Review
Properties and Acne Treatment of Tea Tree Oil
Tea tree oil is an essential oil extracted from Melaleuca alternifolia (Maiden & Betch) Cheel with known antibacterial, anti-inflammatory, and antioxidant properties and widely used in cosmetic products to treat acne vulgaris. 
  • 1.4K
  • 06 Jul 2023
Topic Review
Phosphorus Dendrimers for the Synthesis of Metal Nanoparticles
Nanoparticles are defined as matter that has at least one dimension between 1 and 100 nm, and that generally has different properties from its bulk. Phosphorus dendrimers are hyperbranched macromolecules synthesized step-by-step, bearing a phosphorus atom at each branching point. Such type of dendrimers are suitable for the synthesis of diverse types of metal nanoparticles from organometallic precursors.
  • 1.4K
  • 21 Aug 2023
Topic Review
The Application of Potassium Diformate in Aquaculture
Potassium diformate (KDF) is an organic acid salt. It is a dimer formed through hydrogen bonding between one molecule of formic acid and one molecule of potassium formate. The chemical formula of KDF is HCOOH·HCOOK, with a molecular weight of 130.14. It is a white or slightly yellow crystalline powder with no discernible pungent odor. KDF dissolves in water and exhibits a pronounced hygroscopic nature. Its aqueous solution is acidic and remains stable under acidic conditions, while it decomposes into formate and formic acid under neutral or slightly alkaline conditions. Compared with formic acid, KDF overcomes the irritability, corrosiveness, and instability of formic acid. Therefore, KDF is a more suitable additive in feed, providing a safer and more stable solution in maintaining the balance of microbial communities in aquatic animals.
  • 1.4K
  • 07 Mar 2024
Topic Review
STAC3 Disorder
STAC3 disorder (formerly known as Native American myopathy) is a condition that primarily affects skeletal muscles, which are muscles that the body uses for movement.
  • 1.4K
  • 24 Dec 2020
Topic Review
Application of Amphibian Skin and Skin Secretion
Amphibians have been consumed as an alternative protein source all around the world due to their delicacy. The skin of edible amphibians, particularly frogs and giant salamanders, always goes to waste without further utilization. However, these wastes can be utilized to extract protein and bioactive peptides (BPs). Various BPs have been extracted and reported for numerous biological activities such as antioxidant, antimicrobial, anticancer, antidiabetic, etc. The main BPs identified were brevinins, bombesins, dermaseptins, esculentins, magainin, temporins, tigerinins, and salamandrins. 
  • 1.4K
  • 24 Mar 2023
Topic Review
PFAS in the Environment
The current article reviews the state of art of the perfluoroalkyl and polyfluoroalkyl substances (PFASs) compounds and provides an overview of PFASs occurrence in the environment, wildlife, and humans. This study reviews the issues concerning PFASs exposure and potential risks generated with a focus on PFAS occurrence and transformation in various media, discusses their physicochemical characterization and treatment technologies, before discussing the potential human exposure routes. The various toxicological impacts to human health are also discussed. The article pays particular attention to the complexity and challenging issue of regulating PFAS compounds due to the arising uncertainty and lack of epidemiological evidence encountered. The variation in PFAS regulatory values across the globe can be easily addressed due to the influence of multiple scientific, technical, and social factors. The varied toxicology and the insufficient definition of PFAS exposure rate are among the main factors contributing to this discrepancy. The lack of proven standard approaches for examining PFAS in surface water, groundwater, wastewater, or solids adds more technical complexity. Although it is agreed that PFASs pose potential health risks in various media, the link between the extent of PFAS exposure and the significance of PFAS risk remain among the evolving research areas. There is a growing need to address the correlation between the frequency and the likelihood of human exposure to PFAS and the possible health risks encountered.  The current entry highlighted the significance of the future research required to fill in the knowledge gap in PFAS toxicology and to better understand this through real field data and long-term monitoring programs.
  • 1.4K
  • 19 Aug 2021
Topic Review
Building the Circular Supply Chain
The circular supply chain involves return processes and the manufacturer intends to capture additional value in the supply chain. In this paper, value chains have been mapped to visualize the links and interactions between the different stages and actors to understand the complexities of these systems and to make informed decisions. It can be concluded that to develop a new relationship capacity will allow for reaching more frequent, closer relationships with more actors. These relationships will be developed within an adapted organizational and logistical framework that is framed in new business model archetypes. However, dimensions related to the business environment such as sectoral, legislative, and fiscal frameworks must be incorporated.
  • 1.4K
  • 11 Apr 2021
Topic Review
Experimental Autoimmune Uveitis
Reactive oxygen species (ROS) are produced by host phagocytes and play an important role in antimicrobial actions against various pathogens. Autoimmune uveitis causes blindness and severe visual impairment in humans at all ages worldwide. However, the role of ROS in autoimmune uveitis remains unclear. We used ROS-deficient (Ncf1-/-) mice to investigate the role of ROS in experimental autoimmune uveitis (EAU). Besides, we also used the antioxidant N-acetylcysteine treatment to evaluate the effect of suppression of ROS on EAU in mice. The EAU disease scores of Ncf1-/- mice were significantly lower than those of wild-type mice. EAU induction increased the levels of cytokines (IL-1α, IL-1β, IL-4, IL-6, IL-12, IL-17, and TNF-α) and chemokines (MCP-1) in the retinas of wild-type mice but not in those of Ncf1-/- mice. EAU induction enhanced the level of NF-κB activity in wild-type mice. However, the level of NF-κB activity in Ncf1-/- mice with EAU induction was low. Treatment with the antioxidant N-acetylcysteine also decreased the severity of EAU in mice with reduced levels of oxidative stress, inflammatory mediators, and NF-κB activation in the retina. We successfully revealed a novel role of ROS in the pathogenesis of EAU and suggest a potential antioxidant role for the treatment of autoimmune uveitis in the future.
  • 1.4K
  • 30 Oct 2020
Topic Review
Optical Detection of Pathogenic Bacteria
The optical detection of pathogenic bacteria is a growing area of ongoing research for clinically-focused applications. Different modalities, like vibrational spectroscopy, fluorescence, scattering- and polarization-based systems, have the potential to provide information about the biomolecular and morphological characteristics of a species for sample identification and differentiation. Additionally, growth pattern recognition, single-cell versus biofilm formations, cell motility and viability, cell mutation, and antibiotic resistance status can be studied with various optical modalities, providing great potential for rapid characterization of disease-causing pathogens.
  • 1.4K
  • 03 Dec 2020
Topic Review
Airway Inflammation
The effects of airway inflammation on airway smooth muscle (ASM) are mediated by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα).
  • 1.4K
  • 12 Jan 2021
Topic Review
Olive Tree
Extra-virgin olive oil (EVOO) contains many bioactive compounds with multiple biological activities that make it one of the most important functional foods. Both the constituents of the lipid fraction and that of the unsaponifiable fraction show a clear action in reducing oxidative stress by acting on various body components, at concentrations established by the European Food Safety Authority’s claims. In addition to the main product obtained by the mechanical pressing of the fruit, i.e., the EVOO, the residual by-products of the process also contain significant amounts of antioxidant molecules, thus potentially making the Olea europea L. an excellent example of the circular economy. In fact, the olive mill wastewaters, the leaves, the pomace, and the pits discharged from the EVOO production process are partially recycled in the nutraceutical and cosmeceutical fields also because of their antioxidant effect.
  • 1.4K
  • 25 Mar 2021
Topic Review
Synthesis of N,N'-Chelate Organoboron Derivatives
N,N′-chelate organoboron compounds have been successfully applied in bioimaging, organic light-emitting diodes (OLEDs), functional polymer, photocatalyst, electroluminescent (EL) devices, and other science and technology areas. However, the concise and efficient synthetic methods become more and more significant for material science, biomedical research, or other practical science.
  • 1.4K
  • 31 Mar 2021
Topic Review
BIM, GPP for CDW Management
Information Modelling and Management (IMM) methods for Most Economically Advantageous Tender (MEAT) can promote the adoption of environmentally sustainable practices. Despite the wide regulatory framework and existing drivers, Construction and Demolition Waste (CDW) trend is still upward. The literature review regarding IMM and CDW management implementation during the design phases is mainly focused on studies and applications from the designer and contractor’s points of view, although few studies focused on Green Public Procurement (GPP) and CDW management integration from the Public Client’s point of view. This research aims at investigating the integration and efficiency of MEAT and IMM to promote the application of sustainable strategies focused on waste reduction and resource valorization. The study investigates the Public Client’s role in promoting sustainable practices, introducing digital material inventory and BIM during the design phases, and including environmental award criteria in the call for tender documents. A Design Build (DB) procurement model is considered in the case study of a brownfield renovation and the construction of a new school in northern Italy. The methodology provided the Public Client with a replicable method to evaluate the environmental impact of the bids, allowing for proper selective demolition planning, CDW decrease, and organization while promoting their integration in companies’ expertise and procedures.
  • 1.4K
  • 06 Sep 2021
Topic Review
Cell-Scaffold Constructs for Bone Regeneration Therapy
Bone tissue engineering (BTE) is a process of combining live osteoblast progenitors with a biocompatible scaffold to produce a biological substitute that can integrate into host bone tissue and recover its function. Mesenchymal stem cells (MSCs) are the most researched post-natal stem cells because they have self-renewal properties and a multi-differentiation capacity that can give rise to various cell lineages, including osteoblasts. BTE technology utilizes a combination of MSCs and biodegradable scaffold material, which provides a suitable environment for functional bone recovery and has been developed as a therapeutic approach to bone regeneration.
  • 1.4K
  • 28 Oct 2021
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