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Topic Review
Metallurgy/Weldability of High-Strength Cold-Resistant and Cryogenic Steels
Thermomechanical Controlled Processing (TMCP), the initial microstructure and mechanical properties of rolled products made of high-strength steels, have a significant influence on the properties and reliability of welded structures for low temperature and cryogenic service.
  • 1.4K
  • 13 Dec 2021
Topic Review
Peanut (Arachis hypogaea L.) under Multiple Abiotic Stress
The frequency and severity of extreme climatic conditions such as drought, salinity, cold, and heat are increasing due to climate change. Moreover, in the field, plants are affected by multiple abiotic stresses simultaneously or sequentially. Peanut metabolomics identified 160 metabolites, including amino acids, sugars, sugar alcohols, organic acids, fatty acids, sugar acids, and other organic compounds. Pathway enrichment analysis revealed that abiotic stresses significantly affected amino acid, amino sugar, and sugar metabolism. 
  • 1.4K
  • 23 Mar 2022
Topic Review
Telomere in Aging and Cancer
The history of telomere was initially closely related to the concept of senescence. They were conceived as the internal biological clock limiting the proliferation potential of eukaryotic cells (Hayflick limit). Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment.
  • 1.4K
  • 27 Apr 2022
Topic Review
Prediction of Penalties or Compensation Payments in Companies
Corporate misconduct is a huge and widespread problem in the economy. Many companies make mistakes that result in them having to pay penalties or compensation to other businesses. Some of these cases are so serious that they take a toll on a company’s financial condition. Several algorithms were to create and evaluate which can predict whether a company will have to pay a penalty and to discover what financial indicators may signal it.
  • 1.4K
  • 27 Jun 2022
Topic Review
Active Compounds from Antrodia cinnamomea
Antrodia cinnamomea is a precious and popular edible and medicinal mushroom. It has attracted increasing attention due to its various and excellent bioactivities, such as hepatoprotection, hypoglycemic, antioxidant, antitumor, anticancer, anti-inflammatory, immunomodulation, and gut microbiota regulation properties. To elucidate its bioactivities and develop novel functional foods or medicines, numerous studies have focused on the isolation and identification of the bioactive compounds of A. cinnamomea. 
  • 1.4K
  • 11 Oct 2022
Topic Review
Roadrunner (Supercomputer)
Roadrunner was a supercomputer built by IBM for the Los Alamos National Laboratory in New Mexico, USA. The US$100-million Roadrunner was designed for a peak performance of 1.7 petaflops. It achieved 1.026 petaflops on May 25, 2008, to become the world's first TOP500 LINPACK sustained 1.0 petaflops system. In November 2008, it reached a top performance of 1.456 petaFLOPS, retaining its top spot in the TOP500 list. It was also the fourth-most energy-efficient supercomputer in the world on the Supermicro Green500 list, with an operational rate of 444.94 megaflops per watt of power used. The hybrid Roadrunner design was then reused for several other energy efficient supercomputers. Roadrunner was decommissioned by Los Alamos on March 31, 2013. In its place, Los Alamos commissioned a supercomputer called Cielo, which was installed in 2010. Cielo was smaller and more energy efficient than Roadrunner, and cost $54 million.
  • 1.4K
  • 19 Oct 2022
Topic Review
Stoned (Computer Virus)
Stoned is a boot sector computer virus created in 1987. It is one of the first viruses and is thought to have been written by a student in Wellington, New Zealand. By 1989 it had spread widely in New Zealand and Australia, and variants became very common worldwide in the early 1990s. A computer infected with the original version had a one in eight probability that the screen would declare: "Your PC is now Stoned!", a phrase found in infected boot sectors of infected floppy disks and master boot records of infected hard disks, along with the phrase "Legalise Marijuana". Later variants produced a range of other messages.
  • 1.4K
  • 03 Nov 2022
Biography
Valeri Kubasov
Valeri Nikolayevich Kubasov (Russian: Вале́рий Никола́евич Куба́сов; 7 January 1935 – 19 February 2014) was a Soviet/Russia n cosmonaut who flew on two missions in the Soyuz programme as a flight engineer: Soyuz 6 and Soyuz 19 (the Apollo–Soyuz mission), and commanded Soyuz 36 in the Intercosmos programme. On 21 July 1975, the Soyuz 7K-TM module used for ASTP lande
  • 1.4K
  • 30 Nov 2022
Topic Review
Climate, Urbanization and Environmental Pollution in West Africa
The need to elucidate the urbanization–climate–pollution nexus in West Africa arose from the several reported, but disjointed cases of climate extremes and environmental degradation in the sub-region. Since colonization and subsequent independence of nations in the West African region, several urban cities began to spring up and gradually grow. Urbanization was essentially characterized by population growth without complementary infrastructural development, weak coping strategies against climate extremes, numerous economic challenges, and high risk of environmental pollution. Initiative for urban renewal, urban greening and smart city development was low, and preparedness against future impact of extreme climate events and climate change is uncertain.
  • 1.4K
  • 12 Dec 2022
Biography
David E. Pergrin
Colonel David E. Pergrin (26 July 1917 – 7 April 2012) was commanding officer of the 291st Engineer Combat Battalion of the United States Army during World War II. Before the war he earned an engineering degree at Pennsylvania State University, graduating in 1940. While at Penn State he participated in the ROTC program. In addition, Pergrin played on the university's football team, was elected
  • 1.4K
  • 29 Dec 2022
Topic Review
Targeted Cytokine Delivery for Cancer Treatment
Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly limit clinical applications. Due to their high specificity and affinity, tumor-specific monoclonal antibodies or their antigen-binding fragments are capable of delivering fused cytokines to tumors and, therefore, of decreasing the number and severity of side effects, as well as of enhancing the therapeutic index. Targeted cytokine-mediated activation of the immune cells may trigger massive cytokine production at the disease site, making the local environmental conditions more favorable for local immune system cell functioning.
  • 1.4K
  • 10 Feb 2023
Topic Review
Tuning between Nuclear Organization and Functionality in Health
The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements, including chromatin organization, nuclear envelope associated proteome and transport, nuclear–cytoskeletal contacts, and the mechano-regulatory signaling cascades. The size and morphology of the nucleus could impose a significant impact on nuclear mechanics, chromatin organization, gene expression, cell functionality and disease development. The maintenance of nuclear organization during genetic or physical perturbation is crucial for the viability and lifespan of the cell. Abnormal nuclear envelope morphologies, such as invagination and blebbing, have functional implications in several human disorders, including cancer, accelerated aging, thyroid disorders, and different types of neuro-muscular diseases. 
  • 1.4K
  • 07 Mar 2023
Topic Review
Potential Bioactive Components in Fruits and Vegetable Wastes
The food production industry generates millions of tonnes of waste every day, making it a major contributor to global waste production. Given the growing public concern about this issue, there has been a focus on utilizing the waste generated from popular fruits and vegetables, which contain high-added-value compounds. By efficiently using food waste from the fruit and vegetable industries, we can promote sustainable consumption and production practices that align with the United Nations' Sustainable Development Goals (SDGs).
  • 1.4K
  • 14 Apr 2023
Topic Review
Antimicrobial Resistance as Serious Threat for Public Health
Antibiotics are among the most important discoveries of the 20th century, having saved millions of lives from infectious diseases. Microbes have developed acquired antimicrobial resistance (AMR) to many drugs due to high selection pressure from increasing use and misuse of antibiotics over the years. The transmission and acquisition of AMR occur primarily via a human–human interface both within and outside of healthcare facilities. A huge number of interdependent factors related to healthcare and agriculture govern the development of AMR through various drug-resistance mechanisms. The emergence and spread of AMR from the unrestricted use of antimicrobials in livestock feed has been a major contributing factor. The prevalence of antimicrobial-resistant bacteria has attained an incongruous level worldwide and threatens global public health as a silent pandemic, necessitating urgent intervention. 
  • 1.4K
  • 31 Jul 2023
Topic Review
The Role of Uric Acid in Human Health
Uric acid is the final product of purine metabolism and is converted to allantoin in most mammals via the uricase enzyme. The accumulation of loss of function mutations in the uricase gene rendered hominoids (apes and humans) to have higher urate concentrations compared to other mammals. The loss of human uricase activity may have allowed humans to survive environmental stressors, evolution bottlenecks, and life-threatening pathogens. While high urate levels may contribute to developing gout and cardiometabolic disorders such as hypertension and insulin resistance, low urate levels may increase the risk for neurodegenerative diseases. The double-edged sword effect of uric acid has resurrected a growing interest in urate’s antioxidant role and the uricase enzyme’s role in modulating the risk of obesity. 
  • 1.4K
  • 13 Oct 2023
Topic Review
Generative AI on Cultural Translation in Jewelry Design
The current proliferation of artificial intelligence (AI) is prominently shaping the design industry. Generative AI, such as text-to-image and image-to-image models, has gained widespread use, notably for its efficiency and quality improvements. Leveraging AI image generators has shifted the designer’s focus from technical tasks to strategic decisions related to visual appeal, cognitive engagement, and emotional resonance. Furthermore, the challenges inherent in human–AI collaboration have been revealed, stemming from communication difficulties and the risk of fixating on specific details to stylistic constraints.
  • 1.4K
  • 28 Dec 2023
Topic Review
Hunting Deeply Hidden Software Vulnerabilities
Fuzz testing is a simple automated software testing approach that discovers software vulnerabilities at a high level of performance by using randomly generated seeds. However, it is restrained by coverage and thus, there are chances of finding bugs entrenched in the deep execution paths of the program. To eliminate these limitations in mutational fuzzers, patching-based fuzzers and hybrid fuzzers have been proposed as groundbreaking advancements which combine two software testing approaches. Despite those methods having demonstrated high performance across different benchmarks such as DARPA CGC programs, they still present deficiencies in their ability to analyze deeper code branches and in bypassing the roadblocks checks (magic bytes, checksums) in real-world programs. In this research, we design DeepDiver, a novel transformational hybrid fuzzing tool that explores deeply hidden software vulnerabilities. Our approach tackles limitations exhibited by existing hybrid fuzzing frameworks, by negating roadblock checks (RC) in the program. By negating the RCs, the hybrid fuzzer can explore new execution paths to trigger bugs that are hidden in the abysmal depths of the binary. We combine AFL++ and concolic execution engine and leveraged the trace analyzer approach to construct the tree for each input to detect RCs. To demonstrate the efficiency of DeepDiver, we tested it with the LAVA-M dataset and eight large real-world programs. Overall, DeepDiver outperformed existing software testing tools, including the patching-based fuzzer and state-of-the-art hybrid fuzzing techniques. On average, DeepDiver discovered vulnerabilities 32.2% and 41.6% faster than QSYM and AFLFast respectively, and it accomplished in-depth code coverage.
  • 1.4K
  • 30 Oct 2020
Topic Review
Avian Influenza Virus in Bangladesh
Highly pathogenic H5N1 and low pathogenic H9N2 avian influenza viruses are circulating in Bangladesh since 2007 causing serious economic losses to the country. Multiple virus introductions of different clades of HPAIV H5N1, reassorted genotypes, and on-going diversification of LPAIV H9N2 create a highly volatile virological environment which potentially implicates increased virulence, adaptation to new host species, and subsequent zoonotic transmission.
  • 1.4K
  • 22 Jul 2020
Topic Review
Ion Exchange Membranes by NMR
An ion-exchange membrane lets pass certain ions while blocking other ions or neutral molecules. Nuclear Magnetic Resonance (NMR) spectroscopy is a technique for determining the content, purity, and molecular structure of a sample. NMR methods provide the unique possibility of acquiring detailed information on the state of molecules and ions, the local molecular and ionic mobility, and the diffusion on the spatial scale from several tenths of nanometer to several millimeters.
  • 1.4K
  • 18 Jun 2021
Topic Review
Integration of CVD Graphene on Silicon Wafers
The exceptional electronic, optical and mechanical properties of graphene can lead to revolutionary new devices. Since the transfer process of graphene from a dedicated growth substrate to another substrate is prone to induce defects and contamination and can increase costs, there is a large interest in methods for growing graphene directly on silicon wafers. It has become clear that chemical vapor deposition (CVD) is the most promising process to guarantee large-area high-quality graphene.
  • 1.4K
  • 27 Jun 2022
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