Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Opioid-Induced Constipation in Cancer Patients
Opioid-induced constipation (OIC) is a disabling symptom which 60–90 percent of cancer patients with chronic opioid use experience. Peripherally acting μ-opioid receptor antagonists (PAMORAs) are a class of medications aiming to reverse opioids’ adverse effects on the gut by interacting with opioid receptors in the gastrointestinal tract without significantly crossing the blood–brain barrier, and therefore they are not affecting the analgesic opioid effects in the central nervous system.
  • 114
  • 22 Mar 2024
Topic Review
Flavonoids as CYP3A4 Inhibitors In Vitro
CYP enzymes are a group of heme-containing enzymes that play important roles in the metabolism of many drugs and other xenobiotics. They are located in the endoplasmic reticulum of cells throughout the body, but they are most abundant in the liver.
  • 112
  • 22 Mar 2024
Topic Review
Chemical and Biological Properties of Xanthohumol
Xanthohumol (Xn), a prenylated chalcone found in Hop (Humulus lupulus L.), has been shown to have potent anti-aging, diabetes, inflammation, microbial infection, and cancer properties. 
  • 190
  • 22 Mar 2024
Topic Review
Isoprene-Derived Signaling Molecules in Plant System
Isoprene, a lipophilic and unstable compound with the chemical formula C5H8, is transported to plant chloroplasts via the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway, which relies on photosynthesis. Although only about 20% of terrestrial plants can synthesize isoprene, those that emit it are more adaptable to oxidative and thermal stresses. Plants use volatile organic compounds (VOCs) to communicate with other living things. Isoprene, monoterpenes and sesquiterpenes make up the largest class of volatile organic compounds (VOCs) emitted by plants terpenes. In plant–plant interactions, mono- and sesquiterpenes are well-known communication molecules. On the other hand, isoprene, the smallest and most often released terpene, is instead given a role in fighting abiotic stressors. 
  • 187
  • 22 Mar 2024
Topic Review
-Omics Approaches in Studies of Polystyrene MNP Toxicity
The investigation of the toxicity mechanism of micro- and nanoplastics (MNPs) is a topic of major concern for the scientific community. The use of transcriptomics, proteomics, and metabolomics has suggested that the main pathways affected by polystyrene (PS) MNPs are related to energy metabolism, oxidative stress, immune response, and the nervous system, both in fishes and aquatic invertebrates. 
  • 329
  • 22 Mar 2024
Topic Review
Climate Change-Related Disaster Risk Mitigation
Instead of addressing the disaster’s underlying risk, the traditional disaster insurance strategy largely focuses on providing financial security for asset recovery after a disaster. This constraint becomes especially concerning as the threat of climate-related disasters grows since it may result in rising long-term damage expenditures.
  • 173
  • 22 Mar 2024
Topic Review
Temperatures and Light Effect on Dormancy
Dormancy is defined as the sum of processes that create a situation wherein embryonic tissues are unable to grow, even under environmental conditions that generally favor growth and development. The effects of temperature to break dormancy, from work done on peach, can be summarized as follows: Effective temperatures are between −2 °C and 13 °C, and the most effective being 4–8 °C with reduced efficiency at higher and lower temperatures. Moderate temperatures between 13 °C and 16 °C that will not break dormancy alone, when occurring in a daily cycle after previous chilling, enhance the effect of chilling. On the other hand, temperatures higher than 18 °C in a daily cycle will nullify former chilling. This negative effect of high temperatures increases the longer the duration and the higher the temperature. However, when cycles are longer than a day, the chilling effect is final and cannot be nullified by high temperatures. Apart from the effects of temperature on dormancy, light effects on dormancy in peach trials had also been detected Clearly, the dormant vegetative buds perceive light signals and react to light during dormancy and bud breaks. On the other hand, flower buds in peach were found to be non-responsive to light. Dormancy in vegetative buds is induced by short days. During endodormancy, the limitation of light and even total darkness enhance bud breaks in spring, compared to buds receiving natural light. But darkness in spring will prevent vegetative bud break even following sufficient chilling during winter.  So, there is an analogy between chilling and darkness.
  • 148
  • 22 Mar 2024
Topic Review
RBPs Associated with Cardiomyopathies
Cardiomyopathies are structural and functional abnormalities of the myocardium and represent a heterogenous group of cardiac disorders, including dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM), and arrhythmogenic cardiomyopathy (ACM). RNA-binding proteins (RBPs) are major regulators of gene expression at the post-transcriptional level and contribute to generating protein abundance and diversity within a cell.
  • 203
  • 22 Mar 2024
Topic Review
Data Gathering and Disease Detection in Healthcare WSN
Wireless sensor networks (WSNs) consist of a multitude of distributed devices, equipped with sensors, to monitor physical or environmental conditions. These devices, also known as nodes, collaboratively pass their data through the network to a main location or sink where the data can be observed and analyzed. WSNs have emerged as a promising technology in healthcare, enabling continuous patient monitoring and early disease detection. 
  • 150
  • 22 Mar 2024
Topic Review
Treatment of Cisplatin/Platinum-Ineligible Metastatic Urothelial Carcinoma
Metastatic urothelial cancer (mUC) is an aggressive malignancy with limited treatment options. Cisplatin-based chemotherapy has been the standard of care in metastatic urothelial cancer (mUC). However, many patients with comorbidities cannot receive cisplatin or its alternative, carboplatin. ‘Cisplatin-ineligible’ and ‘platinum-ineligible’ patients lacked effective therapy options. However, the combination of enfortumab vedotin (EV), an antibody–drug conjugate targeting Nectin-4, with pembrolizumab (P), an antibody targeting the programmed death-1 (PD-1) immune checkpoint, is changing the status quo of frontline mUC treatment, with potential synergy seen in the EV-103 and EV-302 clinical trials.
  • 230
  • 22 Mar 2024
  • Page
  • of
  • 5488
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Video Production Service
Feedback