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Topic Review
Neural Circuitry Plasticity in SDH during Pain Pathogenesis
Pathological pain emerges from nociceptive system dysfunction, resulting in heightened pain circuit activity. Various forms of circuitry plasticity, such as central sensitization, synaptic plasticity, homeostatic plasticity, and excitation/inhibition balance, contribute to the malfunction of neural circuits during pain pathogenesis. A new form of plasticity in the spinal dorsal horn (SDH), named neural circuit polarization (NCP), was discovered in pain models induced by HIV-1 gp120 and chronic morphine administration. NCP manifests as an increase in excitatory postsynaptic currents (EPSCs) in excitatory neurons and a decrease in EPSCs in inhibitory neurons, presumably facilitating hyperactivation of pain circuits. The expression of NCP is associated with astrogliosis. Ablation of reactive astrocytes or suppression of astrogliosis blocks NCP and, concomitantly, the development of gp120- or morphine-induced pain.
  • 209
  • 06 Mar 2024
Topic Review
Liquid Biopsy in Type 2 Diabetes
As the burden of type 2 diabetes (T2D) continues to escalate globally, there is a growing need for novel, less-invasive biomarkers capable of early diabetes detection and monitoring of disease progression. Liquid biopsy, recognized for its minimally invasive nature, is increasingly being applied beyond oncology, and nevertheless shows its potential when the collection of the tissue biopsy is not possible. This diagnostic approach involves utilizing liquid biopsy markers such as cell-free nucleic acids, extracellular vesicles, and diverse metabolites for the molecular diagnosis of T2D and its related complications.
  • 102
  • 06 Mar 2024
Topic Review
Control Technology of Offshore Wind Power Systems
As global energy crises and climate change intensify, offshore wind energy, as a renewable energy source, is given more attention globally. The wind power generation system is fundamental in harnessing offshore wind energy, where the control and design significantly influence the power production performance and the production cost.
  • 210
  • 06 Mar 2024
Topic Review
Low-Dose Alcohol Consumption on Chronic Liver Disease
Although alcohol is one of the most important etiologic agents in the development of chronic liver disease worldwide, also recognized as a promoter of carcinogenesis, several studies have shown a beneficial effect of moderate consumption in terms of reduced cardiovascular morbidity and mortality. Whether this benefit is also present in patients with liver disease due to other causes (viral, metabolic, and others) is still debated. Although there is no clear evidence emerging from guidelines and scientific literature, total abstention from drinking is usually prescribed in clinical practice.
  • 124
  • 06 Mar 2024
Topic Review
Heat Stress Tolerance in Cowpea
Heat stress is often described as a condition of high temperatures that are sufficient to cause permanent damage to plant processes, including shortening the time for photosynthetic contribution to seed production. Heat stress on most plants can impact functions through the direct effects of high tissue temperature or the indirect consequences of the high evaporative demand accompanying hot weather. Understanding the impact of heat stress is crucial for plant breeding because it relates to key adaptive, biochemical, morphological, physiological, and reproductive processes. Despite its ability to thrive in high-temperature environments, cowpea productivity can be hampered by heat stress, particularly when night air temperatures exceed 17 °C. The crop’s germplasm pool potentially possesses significant genetic variability that can be harnessed to breed for heat-tolerant varieties. 
  • 160
  • 06 Mar 2024
Topic Review
Fluorescence Imaging with Chemical Sensors in Marine Research
Fluorescence imaging in combination with optical chemical sensors has become a powerful analytical tool that enables the visualization and quantification of chemical species within a sample or on sample surfaces. By the use of fluorescent sensor parameters which exhibit no intrinsic color or fluorescence, e.g., oxygen, pH, CO2, and H2O2, various metal cations or temperature can be imaged. Imaging methods by the means of optical sensors are applied in diverse scientific areas such as medical research and diagnostics, aerodynamics, environmental analysis, or marine research.
  • 133
  • 06 Mar 2024
Topic Review
Ohio’s 5G and Broadband Workforce
Advancements in fifth generation (5G) technology and broadband communications create novel opportunities in numerous sectors, especially with regard to workforce development. As modern society further shifts to become that of an ‘information society’, 5G and broadband investment, development, and use have been shown to increase income, employment, and business expansion, especially in rural areas.
  • 152
  • 06 Mar 2024
Topic Review
Predatory and Defensive Strategies in Cone Snails
Cone snails are specialized carnivorous marine mollusks that can be found in coral reef areas, from shallow intertidal to deeper waters, and spread across the tropical Indian, Pacific, and Atlantic Oceans. They are classified as gastropods within the Conidae family, which feature hollow radular teeth and venom glands. They use a complex venom mixture to paralyze and hunt fish, mollusks, and worms.
  • 107
  • 06 Mar 2024
Topic Review
Pathogenetic Mechanism in Giant Cell Arteritis
Giant cell arteritis (GCA) is an autoimmune disease affecting large vessels in patients over 50 years old. It is an exemplary model of a classic inflammatory disorder with IL-6 playing the leading role.
  • 122
  • 06 Mar 2024
Topic Review
Role of Propolis in Modifying Aging Hallmarks
Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases.
  • 137
  • 06 Mar 2024
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