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Topic Review
Gene Therapy for Patients with Hemophilia A
The standard of care for hemophilia A has been intravenous administration of exogenous factor VIII (FVIII), either as prophylaxis or episodically. Gene therapy is a treatment strategy used to repair or provide a functional copy of a gene that is either absent or expressed as a non-functional protein. Treating a genetic disease with gene therapy requires that the transgene (or its protein product) be delivered to the physiologically relevant target tissue or tissues, be stably expressed, and not interfere with the functional integrity of the cells in these tissues. The ultimate goal of gene therapy for patients with hemophilia A is the production of a treatment that is given as a one-time infusion and that allows adequate long-term expression of the deficient FVIII, with the maintenance of steady-state plasma FVIII concentrations. This would minimize (or ideally eliminate) bleeding episodes and thereby decrease the patient and societal burden of the disease.
  • 1.5K
  • 29 Nov 2022
Topic Review
Application of Mixed Potential Theory to Leaching
Leaching is a central unit operation in the hydrometallurgical processing of minerals, which often occurs by means of electrochemical reactions. Application of mixed potential theory to explain the kinetics of oxidative and reductive leaching processes is a useful concept in explaining observed results. Native metals, selected oxides, and most base metal sulfides are electron-conducting phases. For these minerals, leaching may take place by normal corrosion, passivation or galvanic couple mechanisms, which provide individual electrode kinetics enabling the calculation of mixed potentials and overall reaction kinetics. 
  • 1.5K
  • 08 Jul 2022
Topic Review
Nanotechnology Application
The application of nanotechnology, molecular biotechnologies, and nano-sciences for medical purposes has been termed nanomedicine, a promising growing area of medical research. The aim of this paper is to provide an overview of and discuss nanotechnology applications in the early epochs of life, from transplacental transfer to neonatal/pediatric conditions. Diagnostic and therapeutic applications, mainly related to the respiratory tract, the neurosensory system, and infections, are explored and discussed. Preclinical studies show promising results for a variety of conditions, including for the treatment of pregnancy complications and fetal, neonatal, and pediatric diseases. However, given the complexity of the functions and interactions between the placenta and the fetus, and the complex and incompletely understood determinants of tissue growth and differentiation during early life, there is a need for much more data to confirm the safety and efficacy of nanotechnology in this field.
  • 1.5K
  • 13 Feb 2021
Topic Review
HBSL
Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL) is a condition that affects the brain and spinal cord (central nervous system). In particular, the condition affects nerves in specific regions (called tracts) within the spinal cord and the brainstem, which is the part of the brain that connects to the spinal cord. HBSL is a form of leukodystrophy, which is a group of conditions that involve abnormalities of the nervous system's white matter. The white matter consists of nerve fibers covered by a fatty substance, called myelin, that insulates the fibers and promotes the rapid transmission of nerve impulses. In HBSL, the nervous system has a reduced ability to form myelin (hypomyelination).
  • 1.5K
  • 04 Jan 2021
Topic Review
P63 and p73 Protein Interactions
Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and differentiated cells. Investigations of p63 and p73 protein–protein interactions reveal distinct  functions underlying the aforementioned distribution. The p73 and p63 cooperate in the genome stability surveillance in proliferating cells; p73 specific interactors contribute to the transcriptional repression, anaphase promoting complex and spindle assembly checkpoint, whereas p63 specific interactors play roles in the regulation of mRNA processing and splicing in both proliferating and differentiated cells suggesting diversification of the RNA and DNA specific functions within the p53 family.
  • 1.5K
  • 07 Jan 2021
Topic Review
Bone Fragility
Bone material strength is determined by several factors, such as bone mass, matrix composition, mineralization, architecture and shape. From a clinical perspective, bone fragility is classified as primary (i.e., genetic and rare) or secondary (i.e., acquired and common) osteoporosis
  • 1.5K
  • 02 Feb 2021
Topic Review
Laser Wakefield Electron Acceleration
Laser wakefield electron acceleration (LWFA) is an emerging technology for the next generation of electron accelerators. As intense laser technology has rapidly developed, LWFA has overcome its limitations and has proven its possibilities to facilitate compact high-energy electron beams.
  • 1.5K
  • 30 Jun 2021
Topic Review
Welfare of Italian Heavy Pigs
Italian heavy pigs are characterized by much higher body weights and age at slaughter (approximately 160–170 kg, and over 9 months of age) than the majority of pigs reared in Europe. This results in peculiar behavioral and rearing-related needs compared to smaller pigs. However, there is a limited body of research dealing with the welfare of this productive category, and several aspects have not been investigated yet. In particular, the lack of knowledge on space requirements, injuries, and positive welfare (included human–animal relationships) are crucial aspects that should be explored in order to define a baseline to set up measures for the improvement of the production system. It is hoped that this content will help to promote knowledge and specific policies aimed at enhancing the ethical attributes of this renowned production, thus improving animal welfare, meeting consumers’ expectations, and increasing the value of its marketing chain.
  • 1.5K
  • 05 Jul 2021
Topic Review
Nanomaterials in Cell-Based Drug Delivery Systems
The combination of nanomaterials with cell-based drug delivery systems has shown tremendous advantages in cancer treatment.
  • 1.5K
  • 29 Mar 2022
Topic Review
Immunological Mechanisms of Vaccine-Induced Protection against SARS-CoV-2 Infections
SARS-CoV-2 is attached to host cells via binding to the viral spike (S) proteins and its cellular receptors angiotensin-converting enzyme 2 (ACE2). Consequently, the S protein is primed with serine proteases TMPRSS2 and TMPRSS4, which facilitate the fusion of viral and cellular membranes result in the entry of viral RNA into the host cell. The long-term protective immunity is provided by the vaccine antigen (or pathogen)-specific immune effectors and the activation of immune memory cells that can be efficiently and rapidly reactivated upon pathogen exposure.
  • 1.5K
  • 29 Nov 2021
Topic Review
Vertical Barriers for Land Contamination Containment
Soil pollution is one of the major threats to the environment and jeopardizes the provision of key soil ecosystem services. Vertical barriers, including slurry trench walls and walls constructed with soil mix technology, have been employed for decades to control groundwater flow and subsurface contaminant transport.
  • 1.5K
  • 30 Jan 2022
Topic Review
Heat Therapy
Heat therapy, also called thermotherapy, is the use of heat in therapy, such as for pain relief and health. It can take the form of a hot cloth, hot water bottle, ultrasound, heating pad, hydrocollator packs, whirlpool baths, cordless FIR heat therapy wraps, and others. It can be beneficial to those with arthritis and stiff muscles and injuries to the deep tissue of the skin. Heat may be an effective self-care treatment for conditions like rheumatoid arthritis. Heat therapy is most commonly used for rehabilitation purposes. The therapeutic effects of heat include increasing the extensibility of collagen tissues; decreasing joint stiffness; reducing pain; relieving muscle spasms; reducing inflammation, edema, and aids in the post acute phase of healing; and increasing blood flow. The increased blood flow to the affected area provides proteins, nutrients, and oxygen for better healing.
  • 1.5K
  • 31 Oct 2022
Topic Review
Doubting Thomas
A doubting Thomas is a skeptic who refuses to believe without direct personal experience — a reference to the Gospel of John's depiction of the Apostle Thomas, who, in John's account, refused to believe the resurrected Jesus had appeared to the ten other apostles until he could see and feel Jesus' crucifixion wounds. In art, the episode (formally called the Incredulity of Thomas) has been frequently depicted since at least the 15th century, with its depiction reflecting a range of theological interpretations.
  • 1.5K
  • 31 Oct 2022
Topic Review
Medication Related Osteonecrosis of the Jaw (MRONJ)
Medication-related osteonecrosis of the jaw (MON, MRONJ) is progressive death of the jawbone in a person exposed to a medications known to increase the risk of disease, in the absence of a previous radiation treatment. It may lead to surgical complication in the form of impaired wound healing following oral and maxillofacial surgery, periodontal surgery, or endodontic therapy. Particular medications can result in MRONJ, a serious but uncommon side effect in certain individuals. Such medications are frequently used to treat diseases that cause bone resorption such as osteoporosis, or to treat cancer. The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs. This condition was previously known as bisphosphonate-related osteonecrosis of the jaw (BON or BRONJ) because osteonecrosis of the jaws correlating with bisphosphate treatment was frequently encountered, with its first incident occurring in 2003. Osteonecrotic complications associated with denosumab, another antiresorptive drug from a different drug category, were soon determined to be related to this condition. Newer medications such as anti-angiogenic drugs have been potentially implicated causing a very similar condition and consensus shifted to refer to the related conditions as MRONJ; however, this has not been definitively demonstrated. There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not a viable preventive strategy on a general-population basis because the medications are beneficial in the treatment and prevention of osteoporosis (including prevention of bony fractures) and treatment of bone cancers. Current recommendations are for a 2 month drug holiday prior to dental surgery for those who are at risk (intravenous drug therapy, greater than 4 years of by-mouth drug therapy, other factors that increase risk such as steroid therapy). It usually develops after dental treatments involving exposure of bone or trauma, or may arise spontaneously. Patients who develop MRONJ may experience prolonged healing, pain, swelling, infection, exposed bone, after dental procedures, though some patients may have no signs/symptoms.
  • 1.5K
  • 17 Nov 2022
Topic Review
Serendipita indica as a Growth Promoter
Serendipita indica has been found to be a prime beneficial microorganism that improved the growth and development of various plant species under normal and stress conditions. 
  • 1.5K
  • 27 Dec 2022
Topic Review
Use of Deep Learning for Video Classification
Deep learning models, specifically convolutional neural networks (CNNs), are well known for understanding images. An artificial neural network (ANN) is an algorithm based on interconnected nodes to recognize the relationships in a set of data. Algorithms based on ANNs have shown a great success in modeling both the lineßar and the non-linear relationships in the underlying data. Due to the huge success rate of these algorithms, they are extensively being used for different real-time applications.
  • 1.5K
  • 15 May 2023
Topic Review
Energy Consumption Problems in Autonomous Systems
Autonomous systems are a rapidly developing research field that may revolutionize many industries and applications in transportation, manufacturing, healthcare, and agriculture. They offer the potential to boost effectiveness, to lower expenses, and to enhance safety. Autonomous systems incorporate sensors, software, and artificial intelligence algorithms to perceive their environment, make decisions, and take actions. However, one of the main challenges autonomous systems face is energy consumption. These systems require significant energy to power their sensors, processors, and other components. This is especially true for autonomous systems designed for mobility autonomous systems, such as autonomous vehicles (AVs) and unmanned aerial vehicles (UAVs).
  • 1.5K
  • 21 Dec 2023
Topic Review
Digitalization and Supply Chain Performance
Supply chain digitization (SCD) is a driving force, integrating digital technologies like big data, cloud computing, blockchain, Internet of Things (IoT), and artificial intelligence into supply chain activities. SCD focuses on “data-driven decision-making”, creating operational processes enriched by digital technologies.
  • 1.5K
  • 17 Jan 2024
Topic Review
Intestinal Permeability
The intestinal epithelial barrier consists of multiple elements that contribute to its function as a physical, chemical, and immunological defense. While the mucus layer, intestinal epithelium, and the underlying immune cells in the lamina propria comprise a major component of the defense response, intestinal epithelial permeability is regulated by tight junctions.
  • 1.5K
  • 03 Sep 2021
Topic Review
Progesterone as an Anti-Inflammatory Drug
The specific regulation of inflammatory processes by steroid hormones has been actively studied, especially by progesterone (P4) and progestins. The mechanisms of the anti-inflammatory and immunomodulatory P4 action are not fully clear. The anti-inflammatory effects of P4 can be defined as nonspecific, associated with the inhibition of NF-κB and COX, as well as the inhibition of prostaglandin synthesis, or as specific, associated with the regulation of T-cell activation, the regulation of the production of pro- and anti-inflammatory cytokines, and the phenomenon of immune tolerance. The specific anti-inflammatory effects of P4 and its derivatives (progestins) can also include the inhibition of proliferative signaling pathways and the antagonistic action against estrogen receptor beta-mediated signaling as a proinflammatory and mitogenic factor. The anti-inflammatory action of P4 is accomplished through the participation of progesterone receptor (PR) chaperones HSP90, as well as immunophilins FKBP51 and FKBP52, which are the validated targets of clinically approved immunosuppressive drugs. The immunomodulatory and anti-inflammatory effects of HSP90 inhibitors, tacrolimus and cyclosporine, are manifested, among other factors, due to their participation in the formation of an active ligand–receptor complex of P4 and their interaction with its constituent immunophilins. Pharmacological agents such as HSP90 inhibitors can restore the lost anti-inflammatory effect of glucocorticoids and P4 in chronic inflammatory and autoimmune diseases. By regulating the activity of FKBP51 and FKBP52, it is possible to increase or decrease hormonal signaling, as well as restore it during the development of hormone resistance. The combined action of immunophilin suppressors with steroid hormones may be a promising strategy in the treatment of chronic inflammatory and autoimmune diseases, including endometriosis, stress-related disorders, rheumatoid arthritis, and miscarriages. Presumably, the hormone receptor- and immunophilin-targeted drugs may act synergistically, allowing for a lower dose of each.
  • 1.5K
  • 26 Sep 2022
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