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Topic Review
Nox4
The NADPH oxidase Nox4 is a hydrogen peroxide (H2O2)-producing enzyme, with the highest expression in the kidney. As the kidney is involved in volume and blood pressure control through sodium handling, we set out to determine the impact of a low sodium diet on these parameters in WT and Nox4-/- mice. Nox4 expression in the murine kidney was restricted to the proximal tubule. Nevertheless, low-sodium-induced weight loss and sodium sparing function was similar in WT and Nox4-/- mice, disputing an important function of renal Nox4 in sodium handling. In contrast, a low sodium diet resulted in a reduction in systolic blood pressure in Nox4-/- as compared to WT mice. This was associated with a selectively lower pressure to heart-rate ratio, as well as heart to body weight ratio. In general, a low sodium diet leads to activation of sympathetic tone and the renin angiotensin system, which subsequently increases peripheral resistance. Our observations suggest that the control by this system is attenuated in Nox4-/- mice, resulting in lower blood pressure in response to low sodium.
  • 1.5K
  • 24 Aug 2021
Topic Review
Techniques for Antifungal Combinations
The general approach of studying antifungal combinations is (i) to choose an experimental technique, (ii) to obtain raw numerical data, (iii) to analyze these data either graphically or numerically; (iv) to interpret the results, and (v) to conclude on the mode of interaction: synergy, indifference (no interaction), or antagonism.
  • 1.5K
  • 25 Mar 2021
Topic Review
Hepatic Enzyme Profile in Horses
For diagnostic purposes, liver enzymes are usually classified into hepatocellular and cholestatic. These two groups of equine liver-specific enzymes include sorbitol dehydrogenase (SDH), glutamate dehydrogenase (GLDH), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP). SDH and GLDH mostly reflect hepatocellular injury and cholestasis, while GGT expresses high values in biliary necrosis or hyperplasia. Likewise, AST, LDH, and ALP also reflect hepatocellular and biliary disease, but these enzymes are not liver specific. From the clinical point of view of the course of liver or biliary disease, AST and ALP are indicative of chronic disease, whereas SDH, GGT, and GLDH indicate an acute course.
  • 1.5K
  • 15 Apr 2022
Topic Review
People with Aphasia
People with Aphasia (PWA) are individuals who experience difficulties in one or more aspects of communication, such as the ability to speak, understand, read and write, due to acquired brain damage (e.g.stroke, dementia, brain tumour, traumatic brain injury).  
  • 1.5K
  • 27 Oct 2020
Topic Review
Ketone Bodies as Epigenetic Modifiers
 Ketogenesis and ketolysis are the main regulatory metabolic pathways of ketone bodies (KBs). These pathways are active during conditions like adherence to ketogenic diet or starvation, where carbohydrates availability is reduced, or fatty acid levels are increased. Epigenetic changes are influenced by KBs, and in particular βOHB, which regulates cellular processes through epigenetic mechanisms, and therefore serves as a strong epigenetic modifiers and exerts its anti-inflammatory effect providing potential targeted therapy in asthma.   
  • 1.5K
  • 30 Jan 2021
Topic Review
Catalytic Cathodes for Na-CO2 Batteries
Na-CO2 batteries with high energy density are drawing tremendous attention because of their advantages of combining cost-effective energy conversion and storage with CO2 clean recycle and utilization. Nevertheless, their commercial applications are impeded by unsatisfactory electrochemical performance including large overpotentials, poor rate capability, fast capacity deterioration, and inferior durability, which mainly results from the inefficient electrocatalysts of cathode materials. 
  • 1.5K
  • 23 Jun 2021
Topic Review
Vaccinium Species: Composition and Activity
The genus Vaccinium L. (Ericaceae) includes more than 450 species, which grow mainly in cooler areas of the northern hemisphere. Vaccinium species have been used in the traditional medicine of different cultures and the berries are widely consumed as food. Indeed, Vaccinium supplements-based herbal medicine and functional food, mainly from V. myrtillus and V. macrocarpon, are used in Europe and North America. Biological studies support traditional uses since for many of Vaccinium components important biological functions have been described, including antioxidant, antitumor, anti-inflammatory, antidiabetic, and endothelium protective activities. Vaccinium components, such as polyphenols, anthocyanins, and flavonoids, are widely recognized as modulators of cellular pathways involved in pathological conditions, thus indicating that Vaccinium may be an important source of bioactive molecules. 
  • 1.5K
  • 14 Jul 2021
Topic Review
Irrigation-Water and Cotton
A decrease in water resources, as well as changing environmental conditions, calls for efficient irrigation-water management in cotton-production systems. Cotton (Gossypium sp.) is an important cash crop in many countries, and it is used more than any other fiber in the world. 
  • 1.5K
  • 06 Feb 2022
Topic Review
Nuclear Envelope Integrity in Health and Disease
The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE morphology is characterized by a wide range of diversity and abnormality such as invagination and blebbing, and it is a diagnostic factor for pathologies such as cancer.
  • 1.5K
  • 15 Feb 2022
Topic Review
Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis
Connective Tissue Growth Factor, also known as the cellular communication network 2 (CCN2), is a TGF-β-target gene and a member of the CCN family of secreted proteins that regulate matricellular protein. Matricellular proteins are expressed at higher levels during physiological and pathological processes, with distinct functions that bind to multiple receptors, other growth factors, and proteases, modulating their activity and mediating cross-talk between the ECM and cells. Idiopathic Pulmonary Fibrosis is a chronic, devastating, irreversible lung disease, characterized by injury-induced alveolar epithelial cell stress, progressive pathogenic myofibroblast differentiation, and imbalanced macrophage polarization, resulting in ECM deposition. 
  • 1.5K
  • 04 Jul 2022
Topic Review
Mechanical Strength and Durability of Dune Sand
According to the authors’ best information, the majority of research focuses on other waste materials, such as recycling industrial waste (glass, silica fume, marble and waste foundry sand), etc. However, some researchers suggest dune sand as an alternative material for concrete production, but knowledge is still scarce. Therefore, a comprehensive overview is required on dune sand to evaluate its current progress as well as its effects on the strength and durability properties of concrete. 
  • 1.5K
  • 26 Sep 2022
Topic Review
Sugarcane Genome Editing via CRISPR/Cas9 for Sustainable Production
Sugarcane crop constitutes one of the most vital sources of sugar and bioenergy globally; however, higher level of polyploidy makes its genome editing an intricate task. Recently, genome editing has become easier with CRISPR/Cas9 system that uses Cas9 to target sequence-specific regions and introduce double-strand breaks into the target region. This technique has been successfully employed to develop new varieties of sugarcane having desired phenotypic and physiological traits. Several genes can be fused with the CRISPR/Cas9 system leading to successful metabolic engineering and biological improvement for ensuring sustainable enhancement in sugarcane production. This simple RNA-guided genome editing technique has become a revolutionary tool and innovative application in biology that might be effectively employed for inducing specified genomic modifications in plant tissues.
  • 1.5K
  • 18 Oct 2022
Topic Review
Death of Lazarus Averbuch
Lazarus Averbuch (1889–1908) was a Russian-born Jewish immigrant to Chicago who was shot and killed by Chicago Chief of Police George Shippy on March 2, 1908. The incident occurred during an era of public fear of foreign-born anarchists in the United States, following their involvement with the Haymarket affair in 1886. The exact circumstances of the shooting remain contested, but Averbuch's death has inspired speculation, ideological arguments, and works of fiction.
  • 1.5K
  • 24 Nov 2022
Topic Review
Probe for Single-Molecule Fluorescence Microscopy
Probe choice in single-molecule microscopy requires deeper evaluations than those adopted for less sensitive fluorescence microscopy studies. Fluorophore characteristics can alter or hide subtle phenomena observable at the single-molecule level, wasting the potential of the sophisticated instrumentation and algorithms developed for this kind of advanced applications. The three typical groups of fluorophores are fluorescent proteins, organic dyes and quantum dots; here their advantages, drawbacks and use in single-molecule microscopy are discussed. Some requirements are common to all applications, such as high brightness and photostability, specific and efficient labeling, controlled stoichiometry, no perturbation on the system. Other requirements depend on the specific type of single-molecule technique; some of them are here described with their specific requirements for probe choice.
  • 1.5K
  • 13 Feb 2023
Topic Review
Pharmacological Wound Healing Evidence of Iberian Lamiaceae
The traditional use of the family Lamiaceae has been highlighted in several ethnobotanical assays carried out within the Iberian Peninsula. Usually, Lamiaceae species are rich essential oil-bearing plants with a great diversity of phenolic compounds, polyphenols, iridoids, diterpenoids, triterpenoids, saponins and, in some restricted cases, pyridine and pyrrolidine alkaloids.
  • 1.5K
  • 01 Mar 2023
Topic Review
Ecosystem Service Trade-Offs/Synergies of Karst Desertification Control
Ecosystem services, as the term of a scientific period, began in 1970 with the publication of the UN University’s report on “Human Impact on the Global Environment”. Since then, Costanza has proposed that ecosystem services are benefits derived directly or indirectly by human beings from the ecosystem, which are used to maintain the natural environmental conditions and utilities on which human beings depend for survival and development. Trade-offs, as a fundamental concept, first appeared in economics and were defined as opportunity costs. Where resources are scarce, an individual or group must give up a certain amount of additional scarce resources to obtain more of the scarce resources. Karst desertification refers to the land degradation phenomenon caused by the disturbance and destruction of unreasonable human social and economic activities under the fragile karst environment in the subtropical zone, which is manifested by soil erosion, gradual rock exposure, land productivity degradation, and a desert-like landscape on the surface. The results of management over the years show that forests, as the main provider of ecosystem services, have the functions of water conservation, soil and water conservation, carbon sequestration, and climate change mitigation. In particular, they play an irreplaceable role in managing karst desertification.
  • 1.5K
  • 13 Mar 2023
Topic Review
Genomic and Udder Evaluation for Dairy Cattle Selection
Genomic and phenotypic selection criteria have been crucial in dairy cattle. Udder health and milk production are important factors affecting productivity in dairy cattle. Furthermore, genomic and phenotypic selection are essential tools for increasing milk supply for human consumption, decreasing the use of antimicrobial products, improving animal health and welfare, and developing efficient dairy cattle production systems. 
  • 1.5K
  • 19 May 2023
Topic Review
ESG Transparency and Firm Valuation in Palm Oil
Environmental, social, and governance (ESG) integration is an increasingly popular and innovative investing strategy that requires companies to be transparent about their ESG practices to facilitate investors’ decisions. In the palm oil sector, companies are addressing ESG risks by adopting and disclosing ESG efforts to improve access to financing. 
  • 1.5K
  • 28 Nov 2023
Topic Review
The Melanocortin System in Inflammatory Bowel Diseases
The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory processes. In the latter context, the system has assumed importance in conditions of chronic digestive inflammation, such as inflammatory bowel diseases (IBD), in which numerous experiences have been accumulated in mouse models of colitis.
  • 1.5K
  • 28 Sep 2023
Topic Review
Heat Stress Responses in Maize
High temperatures causing heat stress disturb cellular homeostasis and impede growth and development in plants. Extensive agricultural losses are attributed to heat stress, often in combination with other stresses. Plants have evolved a variety of responses to heat stress to minimize damage and to protect themselves from further stress. A narrow temperature window separates growth from heat stress, and the range of temperatures conferring optimal growth often overlap with those producing heat stress. Heat stress induces a cytoplasmic heat stress response (HSR) in which heat shock transcription factors (HSFs) activate a constellation of genes encoding heat shock proteins (HSPs).
  • 1.5K
  • 06 Mar 2021
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