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Topic Review
Pervasive Developmental Disorder Not Otherwise Specified
A pervasive developmental disorder not otherwise specified (Including atypical autism) (PDD-NOS) is one of the four autistic disorders (AD) in the DSM-5 and also was one of the five disorders classified as a pervasive developmental disorder (PDD) in the DSM-IV According to the DSM-4, PDD-NOS is a diagnosis that is used for "severe or pervasive impairment in the development of reciprocal social interaction and/or verbal and nonverbal communication skills, or when stereotyped behavior, interests, and/or activities are present, but the criteria are not met for a specific PDD" or for several other disorders. PDD-NOS includes atypical autism, because the criteria for autistic disorder are not met, for instance because of late age of onset, atypical symptomatology, or subthreshold symptomatology, or all of these. Even though PDD-NOS is considered milder than typical autism, this is not always true. While some characteristics may be milder, others may be more severe.
  • 1.5K
  • 12 Dec 2022
Topic Review
Multiple Myeloma Pathogenesis and The Existing Therapies
Multiple myeloma (MM) is a mature B-cell neoplasm that is characterized by uncontrolled growth of plasma cells (PCs) in bone marrow (BM) which leads to excessive secretion of antibodies. The progression of MM is a multistep process that starts with an asymptomatic premalignant condition known as monoclonal gammopathy of undetermined significance (MGUS), in which BM produces abnormal PCs and secretes M protein instead of normal antibodies.
  • 1.5K
  • 17 Mar 2023
Topic Review
The PINK1/Parkin Pathway
The process by which dysfunctional mitochondria are selectively targeted for lysosome-mediated degradation otherwise known as mitophagy, requires the serine/threonine kinase PINK1 and the E3 ubiquitin ligase Parkin to occur. In the last decade the PINK1/Parkin pathway received great attention due to its importance in many physiological and pathological processes. Understanding the mechanisms by which mitochondria are selectively recognized and targeted for degradation is thus fundamental to understand and to develop therapies for many devastating diseases. Here the mechanisms at the basis of the PINK1/Parkin-mediated degradation of dysfunctional mitochondria are described.
  • 1.5K
  • 27 Oct 2020
Topic Review
Sensitive Clay Slope
Sensitive clays are known for producing retrogressive landslides, also called spread or flowslides. The key characteristics associated with the occurrence of these landslides on a sensitive clay slope must be assessed, and the potential retrogressive distance must be evaluated. Common risk analysis methods include empirical methods for estimating the distance of potential retrogression, analytical limit equilibrium methods, numerical modelling methods using the strength reduction technique, and the integration of a progressive failure mechanism into numerical methods. Methods developed for zoning purposes in Norway and Quebec provide conservative results in most cases, even if they don’t cover the worst cases scenario. A flowslide can be partially analysed using analytical limit equilibrium methods and numerical methods having strength reduction factor tools. Numerical modelling of progressive failure mechanisms using numerical methods can define the critical parameters of spread-type landslides, such as critical unloading and the retrogression distance of the failure. Continuous improvements to the large-deformation numerical modeling approach allow its application to all types of sensitive clay landslides.
  • 1.5K
  • 20 Aug 2020
Topic Review
Bioluminescence Imaging
Bioluminescence imaging (BLI) is based on the catalytic activity of luciferase enzymes, which oxidize the substrate called luciferin to generate an excited-state molecule that emits bioluminescence.
  • 1.5K
  • 12 Oct 2020
Topic Review
Iron Assimilation
Iron is a key transition metal required by most microorganisms and is prominently utilised in the transfer of electrons during metabolic reactions. The acquisition of iron is essential and becomes a crucial pathogenic event for opportunistic fungi. Iron is not readily available in the natural environment as it exists in its insoluble ferric form, i.e., in oxides and hydroxides. During infection, the host iron is bound to proteins such as transferrin, ferritin, and haemoglobin. As such, access to iron is one of the major hurdles that fungal pathogens must overcome in an immunocompromised host. Thus, these opportunistic fungi utilise three major iron acquisition systems to overcome this limiting factor for growth and proliferation. (Draft for definition)
  • 1.5K
  • 09 Dec 2020
Topic Review
Topologies for CMOS CP Circuits
CP design topologies have been analyzed with different design and process schemes in the last decades . 
  • 1.5K
  • 08 Apr 2021
Topic Review
High-Anthocyanin Purple Rice
Purple rice is recognized as a source of natural anthocyanin compounds among health-conscious consumers who employ rice as their staple food. Anthocyanin is one of the major antioxidant compounds that protect against the reactive oxygen species (ROS) that cause cellular damage in plants and animals, including humans.
  • 1.5K
  • 30 Sep 2021
Topic Review
PARP in DNA Damage Repair
Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They attach mono- or poly-ADP-ribose to targets using NAD+ as a substrate. Poly-ADP-ribosylation (PARylation) is central to the important functions of PARP enzymes in the DNA damage response and nucleosome remodelling. Activation of PARP happens through DNA binding via zinc fingers and/or the WGR domain. Modulation of their activity using PARP inhibitors occupying the NAD+ binding site has proven successful in cancer therapies. For decades, studies set out to elucidate their full-length molecular structure and activation mechanism. 
  • 1.5K
  • 02 Sep 2021
Topic Review
Fracture-Healing Process
Fracture-healing is a complex multi-stage process that usually progresses flawlessly, resulting in restoration of bone architecture and function. Regrettably, however, a considerable number of fractures fail to heal, resulting in delayed unions or non-unions. This may significantly impact several aspects of a patient’s life.
  • 1.5K
  • 27 Sep 2021
Topic Review
Powdery Mildew Resistance Loci in Vines
Grapevine (Vitis vinifera) is one of the main fruit crops worldwide, with near of 7.3 million hectares planted in 2020, but along with its economic relevance, it has been associated with diverse pathogens that affect grapevine yield, fruit, and wine quality, of which powdery mildew is the most important disease prior to harvest. Its causal agent is the biotrophic fungus Erysiphe necator, which generates a decrease in cluster weight, delays fruit ripening, and reduces photosynthetic and transpiration rates. In addition, powdery mildew induces metabolic reprogramming in its host, affecting primary metabolism. Most commercial grapevine cultivars are highly susceptible to powdery mildew; consequently, large quantities of fungicide are applied during the productive season. These pesticide applications have been associated with high exposure to it, and pesticides are associated with health problems, negative environmental impacts, and high costs for farmers. In parallel, consumers are demanding more sustainable practices during food production. Therefore, new grapevine cultivars with genetic resistance to powdery mildew are needed for sustainable viticulture, while maintaining yield, fruit, and wine quality. Two main gene families confer resistance to powdery mildew in the Vitaceae, Run (Resistance to Uncinula necator) and Ren (Resistance to Erysiphe necator), and the resistance they confer is associated with the presence of each locus since there are still no genes that alone can produce a powerful genetic resistance. Because the resistance mediated by the plant immune response is highly complex and considers the evolution and adaptation of the pathogen in parallel to that of the plant.
  • 1.5K
  • 22 Jun 2022
Topic Review
Ankle Problems
Ankle problems are very common symptoms which include pain or any discomfort happened in the ankles. Mild ankle pain often could be healed by home treatments though it takes certain time to cure. Specialized physicians are needed when severe ankle pain happens, especially it is kind of injury.
  • 1.5K
  • 01 Nov 2022
Topic Review
Clip (Command)
The clipboard is a buffer that some operating systems provide for short-term storage and transfer within and between application programs. The clipboard is usually temporary and unnamed, and its contents reside in the computer's RAM. The clipboard provides an application programming interface by which programs can specify cut, copy and paste operations. It is left to the program to define methods for the user to command these operations, which may include keybindings and menu selections. When an element is copied or cut, the clipboard must store enough information to enable a sensible result no matter where the element is pasted. Application programs may extend the clipboard functions that the operating system provides. A clipboard manager may give the user additional control over the clipboard. Specific clipboard semantics vary among operating systems, can also vary between versions of the same system, and can sometimes be changed by programs and by user preferences. Windows, Linux and macOS support a single clipboard transaction.
  • 1.5K
  • 01 Nov 2022
Topic Review
Neo-Confederate
Neo-Confederates are groups and individuals who portray the Confederate States of America and its actions during the American Civil War in a positive light. Some neo-Confederate organizations such as the League of the South continue to advocate the secession of the former Confederate States.
  • 1.5K
  • 17 Nov 2022
Topic Review
Gel Ball Shooter
Gel blasters, also known as gel guns, gel shooters, gel markers, hydro markers, hydro blasters, water bead blasters or gelsoft, are toy guns similar in design to airsoft guns, but the projectiles they shoot are 6–8 mm (0.24–0.31 in) superabsorbent polymer water beads (most commonly sodium polyacrylate, colloquially called water beads, hydrogel balls, gel balls, water bullets or simply gels), which are often sold commercially as moisture retainers for gardening and pot/vase floriculture. Gel blasters are often played in CQB-style shooting skirmishes similar to paintball by squads or local clubs of enthusiasts often referred to as "gelballers", but follows an airsoft-like honor-based gameplay umpiring system. MilSim games involving players wearing camouflage and dump pouches are very popular, while "SpeedGel" players are more casual with team jerseys and often wear paintball masks. In addition to safety gear such as eye protections, the sport is heavily regulated on the field and players must adhere to safety rules.
  • 1.5K
  • 02 Dec 2022
Topic Review
Plant-Based Diets effects on Skin Diseases
A plant-based diet refers to a way of eating that primarily focuses on consuming foods derived from plants. This includes a wide variety of vegetables, fruits, beans, lentils, legumes, nuts, seeds, fungi, and whole grains. Animal products and processed foods are limited or avoided in this dietary approach. Plant-based diets have been found to have benefits for various conditions and diseases and specific plant-based functional foods can play a role in supporting skin health. One of the targets of this dietary pattern is the gut microbiota, the community of microorganisms residing in our digestive system. Improving the health of the gut microbiota may contribute to some of the positive effects observed on overall health, including the skin. By adopting a plant-based diet, individuals can provide their bodies with a rich array of nutrients, antioxidants, and fiber that are abundant in plant foods. These components can support overall health and may have a positive impact on the condition of the skin. However, it's important to note that individual results may vary, and maintaining a balanced diet, as well as considering other factors like skincare routines and overall lifestyle, is essential for optimal skin health.
  • 1.5K
  • 10 Jul 2023
Topic Review
TOR–Auxin Connection Upstream Root-Hair Growth
Plant growth and productivity are orchestrated by a network of signaling cascades involved in balancing responses to perceived environmental changes with resource availability. Vascular plants are divided into the shoot, an aboveground organ where sugar is synthesized, and the underground located root. Continuous growth requires the generation of energy in the form of carbohydrates in the leaves upon photosynthesis and uptake of nutrients and water through root hairs. Root hair outgrowth depends on the overall condition of the plant and its energy level must be high enough to maintain root growth. TARGET OF RAPAMYCIN (TOR)-mediated signaling cascades serve as a hub to evaluate which resources are needed to respond to external stimuli and which are available to maintain proper plant growth. Root hair formation further requires appropriate distribution of the phytohormone auxin, which primes root hair cell fate and triggers root hair elongation. While TOR activity partially depends on auxin signaling, auxin distribution to the root tip and the redistribution towards the root hair zone are, on the other hand, dependent on TOR activity. Together, both signaling cascades are interwoven to orchestrate proper root hair outgrowth to ensure efficient plant nutrition. 
  • 1.5K
  • 02 Feb 2021
Topic Review
Lyotropic Liquid Crystalline Nanostructures as Drug Delivery Systems
Lyotropic liquid crystals (LLC) result from the self-assembly process of amphiphilic molecules, such as lipids, into water, being organized in different mesophases. The non-lamellar formed mesophases, such as bicontinuous cubic (forming cubosomes) and inverse hexagonal (forming hexosomes), attract great scientific interest in the field of pharmaceutical nanotechnology. Non-lamellar LLC nanosystems can be utilized as drug delivery nanosystems, as well as for protein, peptide, and nucleic acid delivery. They exhibit major advantages, including stimuli-responsive properties for the “on demand” drug release and the ability for controlled release, by manipulating their internal conformation properties and their administration by different routes. Moreover, non-lamellar LLC nanosystems exhibit unique adjuvant properties to activate the immune system, being ideal for the development of novel vaccines. 
  • 1.5K
  • 29 Jun 2022
Topic Review
Human iPSCs into Cardiomyocytes
Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized the complex scientific field of disease modeling and personalized therapy. Cardiac differentiation of human iPSCs into cardiomyocytes (hiPSC-CMs) has been used in a wide range of healthy and disease models by deriving CMs from different somatic cells. Unfortunately, hiPSC-CMs have to be improved because existing protocols are not completely able to obtain mature CMs recapitulating physiological properties of human adult cardiac cells. Therefore, improvements and advances able to standardize differentiation conditions are needed. Lately, evidences of an epigenetic memory retained by the somatic cells used for deriving hiPSC-CMs has led to evaluation of different somatic sources in order to obtain more mature hiPSC-derived CMs.
  • 1.5K
  • 23 Oct 2020
Topic Review
OmniSCV
OmniSCV is a tool for generating datasets of omnidirectional images with semantic and depth information. 
  • 1.5K
  • 30 Oct 2020
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