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Topic Review
Wireless Sensor Networks for Healthcare
Wireless sensor networks for healthcare refers to the networks that help to monitor the physical conditions. This entry details the Real-Time Centralized Activity Recognition and Real-Time Distributed Activity Recognition.
  • 1.5K
  • 27 Apr 2021
Topic Review
Obesity and Ovarian Function
Obesity is a prevalent disease worldwide, usually associated with infertility. Studies in obese infertile females show the occurrence of systemic hyperestrogenemia, hyperinsulinemia, and associated ovarian dysfunction through premature follicular atresia and anovulation. Indeed, the ovaries of obese mothers have been shown to accumulate lipids, high levels of reactive oxygen species, and inflammatory mediators. Furthermore, obesity has been shown to hamper not only oocyte maturation and quality but also embryo development, with reported long term effects and direct causality between obesity in the mother and prevalence of cardiovascular disease or cancer in the offspring.  
  • 1.5K
  • 19 May 2021
Topic Review
Triazole-Modified Nucleic Acids
Locked nucleic acids (LNAs) are widely used in RNA therapeutics as LNA-modified antisense oligonucleotides. From the structural point of view, LNA is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2′-oxygen and the 4′-carbon. This conformational restriction causes an increased binding affinity to complementary DNA and RNA sequences, but the susceptibility to RNase H should be optimized for individual applications.
  • 1.5K
  • 17 Jun 2021
Topic Review
The Roles of Mitochondrial to Chronic Kidney Disease
Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species (ROS) generation, and cell differentiation and death. Mitochondrial dysfunction has been recognized as a contributor in many diseases. The kidney is an organ enriched in mitochondria and with high energy demand in the human body. Recent studies have been focusing on how mitochondrial dysfunction contributes to the pathogenesis of different forms of kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD). AKI has been linked to an increased risk of developing CKD. AKI and CKD have a broad clinical syndrome and a substantial impact on morbidity and mortality, encompassing various etiologies and representing important challenges for global public health. Renal mitochondrial disorders are a common feature of diverse forms of AKI and CKD, which result from defects in mitochondrial structure, dynamics, and biogenesis as well as crosstalk of mitochondria with other organelles. Persistent dysregulation of mitochondrial homeostasis in AKI and CKD affects diverse cellular pathways, leading to an increase in renal microvascular loss, oxidative stress, apoptosis, and eventually renal failure. It is important to understand the cellular and molecular events that govern mitochondria functions and pathophysiology in AKI and CKD, which should facilitate the development of novel therapeutic strategies. This review provides an overview of the molecular insights of the mitochondria and the specific pathogenic mechanisms of mitochondrial dysfunction in the progression of AKI, CKD, and AKI to CKD transition. We also discuss the possible beneficial effects of mitochondrial-targeted therapeutic agents for the treatment of mitochondrial dysfunction-mediated AKI and CKD, which may translate into therapeutic options to ameliorate renal injury and delay the progression of these kidney diseases.
  • 1.5K
  • 01 Nov 2021
Topic Review
Targeting TIGIT
TIGIT is a negative regulator of immune response known to bind to PVR ligands with greater affinity and outcompete the costimulatory receptors, CD226 and CD96, expressed on T cells, thereby inhibiting the activation, proliferation, and differentiation of T cells (). Further, TIGIT engagement ensures the survival of inhibited T cells by activating cell survival pathways. TIGIT activation on NK cells was shown to inhibit cytotoxic granule polarization and IFN-γ production and decrease NK cell cytotoxicity. In addition, TIGIT interaction on Tregs skews the cytokine balance, suppresses Th1 or Th17 phenotype, and induces Th2 phenotype.
  • 1.5K
  • 29 Mar 2022
Topic Review
Education for Environmental Citizenship
Environmental citizenship and environmental education are a particularly special field for the symbolic and practical clashes of competing ideas, interests, and organizations. Smederevac-Lalic et al. explain that formal, informal, and non-formal education are mediators of other types of knowledge and that the perceptions and interests of participants in the three organizational forms also express different intentions and aspirations.
  • 1.5K
  • 14 Dec 2021
Topic Review
Role of Immunoproteasome Subunits in Cancer
Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Specialized proteasome complexes called immunoproteasomes process viral, bacterial, and tumor antigens for presentation on MHC class I molecules, which can induce CD8 T cells to mount effective immune responses. Immunoproteasomes are distinguished by three subunits that alter the catalytic activity of the proteasome and are inducible by inflammatory stimuli such as interferon-γ (IFN-γ). This inducible activity places them in central roles in cancer, autoimmunity, and inflammation. 
  • 1.5K
  • 29 Mar 2022
Topic Review
Anti-Depressant Properties of Crocin Molecules in Saffron
Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this research. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits N-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome.
  • 1.5K
  • 01 Apr 2022
Topic Review
Hybrid Material-Based Chemiresistive Sensors
Development of hybrid materials, especially inorganic–organic materials, coordination polymers, conducting polymers, carbon materials, and many more, has produced breakthroughs in diverse applications. Various advance materials have been reported in the literature using metal organic frameworks (MOFs), which compensate for the limitations of sensors. 
  • 1.5K
  • 28 Nov 2022
Topic Review
Lung Sound Waveforms
Lung auscultation has long been used as a valuable medical tool to assess respiratory health and has gotten a lot of attention in recent years, notably following the coronavirus epidemic. Lung auscultation is used to assess a patient’s respiratory role. Modern technological progress has guided the growth of computer-based respiratory speech investigation, a valuable tool for detecting lung abnormalities and diseases. Several recent studies have reviewed this important area, but none are specific to lung sound-based analysis with deep-learning architectures from one side and the provided information was not sufficient for a good understanding of these techniques. 
  • 1.5K
  • 24 May 2023
Topic Review
Hungarian Agriculture and Livestock Sector
Livestock farming in developed countries faces adverse environmental impacts, including greenhouse gas emissions and pollution. Moreover, economic and social issues have emerged, such as farm concentration and the aging of farmers. Consequently, the decline of small farms and household animal husbandry substantially impacted rural communities, posing challenges for rural development.
  • 1.5K
  • 19 Jun 2023
Topic Review
The Potential of Home Hydroponics
The global food system is facing significant challenges that make it unsustainable and environmentally harmful. These challenges not only threaten food security but also have severe negative impacts on the environment. In this context, hydroponics emerges as a sustainable, plant-based food production technique that can be employed as a solution in urban areas. It can be implemented in domestic microproduction systems, serving as a complementary alternative to conventional food production methods.
  • 1.5K
  • 01 Feb 2024
Topic Review
Graphene-Metal Oxide Semiconductor Nanocomposite
Graphene is one of the most favorite materials for materials science research owing to its distinctive chemical and physical properties, such as superior conductivity, extremely larger specific surface area, and good mechanical/chemical stability with the flexible monolayer structure. Graphene is considered as a supreme matrix and electron arbitrator of semiconductor nanoparticles for environmental pollution remediation.
  • 1.5K
  • 07 Dec 2020
Topic Review
Abstractive vs. Extractive Summarization
Due to the huge and continuously growing size of the textual corpora existing on the Internet, important information may go unnoticed or become lost. At the same time, the task of summarizing these resources by human experts is tedious and time consuming. This necessitates the automation of the task. Natural language processing (NLP) is a multidisciplinary research field, merging aspects and approaches from computer science, artificial intelligence and linguistics; it deals with the development of processes that semantically and efficiently analyze vast amounts of textual data. Text summarization (TS) is a fundamental NLP subtask, which has been defined as the process of the automatic creation of a concise and fluent summary that captures the main ideas and topics of one or multiple documents.
  • 1.5K
  • 07 Jul 2023
Topic Review
Obesity and Respiratory Infections
Obesity has become a major metabolic disorder due to a combination of genetic, nutritional, and environmental factors. Energy balance in the body is sustained by regulating food intake and energy expenditure. Excessive calorie consumption and/or inadequate energy expenditure result in the accumulation of excess body fat, which eventually leads to an obese phenotype. Obesity has long been linked to increased susceptibility and severity of infectious diseases of the respiratory tract. Studies have shown that Body Mass Index (BMI) is linked to worse outcomes and increased severity of respiratory tract infections, such as non-allergic rhinitis and influenza-like illness. During the 2009 H1N1 pandemic and the ongoing SARS-CoV-2 (COVID-19) pandemic, obesity also became a significant risk factor for severe illness and higher mortality.
  • 1.5K
  • 27 Feb 2023
Topic Review
WOX Gene Family
WUSCHEL-related homeobox (WOX) transcription factors (TFs) are well known for their role in plant development but are rarely studied in citrus. CsRAP2.12 and CsHB22 bind to the CsWUS promoter and regulate its activity. CsCYCD3 protein involved in cell proliferation interact with CsWUS protein 
  • 1.5K
  • 17 May 2021
Topic Review
Supercritical CO2
Supercritical CO2 (scCO2) is an alternative promising solvent that has been actively used in recent decades to simplify many processes of polymer synthesis, modification, decomposition, etc.
  • 1.5K
  • 15 Nov 2022
Topic Review
Waste Treatment and Disposal in the European Union
Disposal via landfill has historically been the dominant method of municipal waste treatment and disposal in the European Union (EU). The EU’s Waste Framework Directive of 1975 (Council Directive 75/442/EEC) introduced the waste hierarchy into European waste policy for the first time, emphasising the importance of waste minimisation. Implementation of the waste hierarchy was optional to member states; but there was an expectation that it would be included within national waste management legislation. The waste hierarchy is a guiding principle that gives top priority to preventing waste; when waste is created, it gives priority to direct re-use, recycling, recovery methods, such as energy recovery, and last of all disposal (Council Directive 2008/98/EC).
  • 1.5K
  • 27 Jul 2022
Topic Review
Head-On Soccer
Head-On Soccer[lower-alpha 1] is a soccer video game originally developed and published by U.S. Gold for the Sega Genesis in 1995. Featuring an arcade-style approach to soccer compared to other titles that were released at the time, Head-On Soccer allows players to have the choice of playing across any of the game modes available against with either CPU-controlled opponents or other players with the team of their choosing. Initially launched for the Genesis, it was then released on the Super Nintendo Entertainment System a few months after the original version and was later ported to the Atari Jaguar in December of the same year under the name Fever Pitch Soccer, which was the title of the game on PAL territories. Head-On Soccer received generally positive reception from critics since its release on the Sega Genesis, with praise towards the graphics, sound, gameplay and the ability to upgrade the various abilities of the team players upon winning matches. The Super NES version also received positive reception, with praise to the improved graphics and sound from the Genesis original while the Jaguar version, though criticized for not taking advantage of the hardware and its similarity with the 16-bit versions, was generally well-received and considered by some reviewers as one of the better titles for the system. Critics, however, compared the game with both the FIFA series from Electronic Arts and the original International Superstar Soccer from Konami.
  • 1.5K
  • 29 Sep 2022
Topic Review
Catalytic Applications of Single-Atom Catalysts
Heterogeneous catalysis is an important research hotspot in the global field. Due to its economic and energy-saving features, it is widely used in the transformation of various energy resources (e.g., petroleum, coal, natural gas, and solar energy) in nature, the synthesis of numerous industrial chemicals, the purification of vehicle exhaust, and so on. It is estimated that catalysts are used in the production processes of about 80% of artificial chemicals at some stages, and about 35% of the world’s gross domestic product (GDP) is accounted for by catalytic processes. In the field of catalysis, exploring the efficient, stable, and economical catalyst formulations has promoted the rapid development of nanomaterials synthesis methods. Traditional heterogeneous catalysts are metal nanoparticles (NPs) dispersed on supports. Among them, noble metals are the most efficient catalysts. 
  • 1.5K
  • 04 Nov 2022
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