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Biography
Mohammad Tolba
Mohammad Tolba is an Egyptian Salafi activist and entrepreneur. He was one of the protestors in the Tahrir Square during the Egyptian Revolution of 2011. In the same year, he founded "Salafyo Costa," or "Costa Salafis" an activist group that embraces cultural diversity and pluralism and strives for social justice. Tolba and other founders of the group named themselves after their meeting place:[
  • 1.5K
  • 05 Dec 2022
Topic Review
Physical Methods for Biodegradable Polymers
Biodegradable polymers are materials that can decompose through the action of various environmental microorganisms, such as bacteria and fungi, to form water and carbon dioxide. The biodegradability characteristics have led to a growing demand for the accurate and precise determination of the degraded polymer composition. With the advancements in analytical product development, various analytical methods are available and touted as practical and preferable methods of bioanalytical techniques, which enable the understanding of the complex composition of biopolymers such as polyhydroxyalkanoates and poly(lactic acid).
  • 1.5K
  • 14 Dec 2022
Topic Review
The SARS-CoV-2 Nucleocapsid Protein
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world is still expanding. Thus, there is an urgent need to better understand this novel virus and find a way to control its spread. Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance. Based on the evolutionary conservation of the N protein in coronavirus, we reviewed the currently available knowledge regarding the SARS-CoV-2 N protein in terms of structure, biological functions, and clinical application as a drug target or vaccine candidate.
  • 1.5K
  • 30 Jun 2021
Topic Review
Antioxidants and Human Oocyte Mitochondrial
Mitochondria produce adenosine triphosphate (ATP) while also generating high amounts of reactive oxygen species (ROS) derived from oxygen metabolism. ROS are small but highly reactive molecules that can be detrimental if unregulated. While normally functioning mitochondria produce molecules that counteract ROS production, an imbalance between the amount of ROS produced in the mitochondria and the capacity of the cell to counteract them leads to oxidative stress and ultimately to mitochondrial dysfunction. This dysfunction impairs cellular functions through reduced ATP output and/or increased oxidative stress. Mitochondrial dysfunction may also lead to poor oocyte quality and embryo development, ultimately affecting pregnancy outcomes. Improving mitochondrial function through antioxidant supplementation may enhance reproductive performance. Recent studies suggest that antioxidants may treat infertility by restoring mitochondrial function and promoting mitochondrial biogenesis. Antioxidant properties of coenzyme-Q10, resveratrol, melatonin and several vitamins have been evaluated in the human oocyte, although their direct action on mitochondrial function has yet to be elucidated.
  • 1.5K
  • 10 Jan 2021
Topic Review
Green Food Development in China
China feeds approximately 22% of the global population with only 7% of the global arable land because of its surprising success in intensive agriculture. This outstanding achievement is partially overshadowed by agriculture-related large-scale environmental pollution across the nation. To ensure nutrition security and environmental sustainability, China proposed the Green Food Strategy in the 1990s and set up a specialized management agency, the China Green Food Development Center, with a monitoring network for policy and standard creation, brand authorization, and product inspection.
  • 1.5K
  • 24 Dec 2020
Topic Review
HSAN IE
Hereditary sensory and autonomic neuropathy type IE (HSAN IE) is a disorder that affects the nervous system. It is characterized by three main features: hearing loss, a decline of intellectual function (dementia), and a worsening loss of sensation in the feet and legs (peripheral neuropathy).
  • 1.5K
  • 04 Jan 2021
Topic Review
Diagnostic Network Optimization
Diagnostics services are an essential component of healthcare systems, advancing universal health coverage and ensuring global health security, but are often unavailable or under-resourced in low- and middle-income (LMIC) countries. Typically, diagnostics are delivered at various tiers of the laboratory network based on population needs, and resource and infrastructure constraints. A diagnostic network additionally incorporates screening and includes point-of-care testing that may occur outside of a laboratory in the community and clinic settings; it also emphasizes the importance of supportive network elements, including specimen referral systems, as being critical for the functioning of the diagnostic network. To date, design and planning of diagnostic networks in LMICs has largely been driven by infectious diseases such as TB and HIV, relying on manual methods and expert consensus, with a limited application of data analytics. Recently, there have been efforts to improve diagnostic network planning, including diagnostic network optimization (DNO). The DNO process involves the collection, mapping, and spatial analysis of baseline data; selection and development of scenarios to model and optimize; and lastly, implementing changes and measuring impact.
  • 1.5K
  • 18 Mar 2021
Topic Review
Bionanotechnology in Food Packaging
Bionanotechnology, as a tool for incorporation of biological molecules into nanoartifacts, is gaining more and more importance in the field of food packaging. It offers an advanced expectation of food packaging that can ensure longer shelf life of products and safer packaging with improved food quality and traceability. 
  • 1.5K
  • 19 Feb 2021
Topic Review
Ibrexafungerp (formerly SCY-078 or MK-3118)
Ibrexafungerp (formerly SCY-078 or MK-3118) is a first-in-class triterpenoid antifungal or “fungerp” that inhibits biosynthesis of β-(1,3)-D-glucan in the fungal cell wall, a mechanism of action similar to that of echinocandins. Distinguishing characteristics of ibrexafungerp include oral bioavailability, a favourable safety profile, few drug-drug interactions, good tissue penetration, increased activity at low pH and activity against multi-drug resistant isolates including C. auris and C. glabrata. In vitro data has demonstrated broad and potent activity against Candida and Aspergillus species. Importantly, ibrexafungerp also has potent activity against azole-resistant isolates, including biofilm-forming Candida spp., and echinocandin-resistant isolates. It also has activity against the asci form of Pneumocystis spp., and other pathogenic fungi including some non-Candida yeasts and non-Aspergillus moulds. In vivo data have shown IBX to be effective for treatment of candidiasis and aspergillosis. Ibrexafungerp is effective for the treatment of acute vulvovaginal candidiasis in completed phase 3 clinical trials.
  • 1.5K
  • 19 Mar 2021
Topic Review
Organic Photodetectors
Organic photodetectors (OPDs) have gained increasing interest as they offer cost-effective fabrication methods using solution processes and a tunable spectral response range, making them particularly attractive for large area image sensors on lightweight flexible substrates. Carrier blocking layers engineering is very important to the high performance of OPDs that can select a certain charge carriers (holes or electrons) to be collected and suppress another carrier. Carrier blocking layers of OPDs play a critical role in reducing dark current, boosting their efficiency and long-time stability.
  • 1.5K
  • 26 Jul 2021
Topic Review
Congenital Adrenal Hyperplasia in Japan
Congenital adrenal hyperplasia (CAH) is an inherited disorder caused by the absence or severely impaired activity of steroidogenic enzymes involved in cortisol biosynthesis. More than 90% of cases result from 21-hydroxylase deficiency (21OHD). To prevent life-threatening adrenal crisis and to help perform appropriate sex assignments for affected female patients, newborn screening (NBS) programs for the classical form of CAH have been introduced in numerous countries.
  • 1.5K
  • 30 Aug 2021
Topic Review
Cerebral Ischemia
Cerebral ischemia represents the third cause of death and the first cause of disability in adults. This process results from decreasing cerebral blood flow levels as a result of the occlusion of a major cerebral artery. This restriction in blood supply generates low levels of oxygen and glucose, which leads to a decrease in the energy metabolism of the cell, producing inflammation, and finally, neurological deterioration. Currently, blood restoration of flow is the only effective approach as a therapy in terms of ischemic stroke. However, a significant number of patients still have a poor prognosis, probably owing to the increase in the generation of reactive oxygen species (ROS) during the reperfusion of damaged tissue. Oxidative stress and inflammation can be avoided by modulating mitochondrial function and have been identified as potential targets for the treatment of cerebral ischemia. In recent years, the beneficial actions of flavonoids and polyphenols against cerebrovascular diseases have been extensively investigated. The use of resveratrol (RSV) has been shown to markedly decrease brain damage caused by ischemia in numerous studies. According to in vitro and in vivo experiments, there is growing evidence that RSV is involved in several pathways, including cAMP/AMPK/SIRT1 regulation, JAK/ERK/STAT signaling pathway modulation, TLR4 signal transduction regulation, gut/brain axis modulation, GLUT3 up-regulation inhibition, neuronal autophagy activation, and de novo SUR1 expression inhibition.
  • 1.5K
  • 09 Sep 2021
Topic Review
Disordered Proteins and Dynamic Interactions
Intrinsically disordered proteins (IDPs) or regions (IDRs), compared to the well-structural proteins, do not have stable tertiary structures under physiological conditions, and even remain dynamic in specific complexes and functional assemblies. It is now recognized that they are highly prevalent and play important roles in biology and human diseases due to the presence of many representative conformational states and potential dynamic interactions, which requires computer simulations for describing disordered protein ensembles and dynamic interactions involved in biological functions, diseases, and therapeutics.
  • 1.5K
  • 27 Oct 2021
Topic Review
The Role of Urban Green Infrastructure
The urban green infrastructure (UGI) is “an interconnected network of urban green spaces, including multiple types of natural or man-made systems, ranging from large-scale water or terrestrial ecosystems to small-scale pocket parks or green components, such as green walls in cities”. It provides ecosystems services that are highly important for human well-being in cities.
  • 1.5K
  • 28 Feb 2022
Topic Review
Voting-Based Leader-Election Scheme in Lead-Follow UAV Swarm
The recent advances in unmanned aerial vehicles (UAVs) enormously improve their utility and expand their application scope. The UAV and swarm implementation further prevail in Smart City practices with the aid of edge computing and urban Internet of Things. The lead–follow formation in UAV swarm is an important organization means and has been adopted in diverse exercises, for its efficiency and ease of control. The reliability of centralization makes the entire swarm system in risk of collapse and instability, if a fatal fault incident happens in the leader. Researchers propose a voting-based leader election scheme inspired by the Raft method in distributed computation consensus to build a mechanism helping the distributed swarm recover from possible failures.
  • 1.5K
  • 15 Aug 2022
Topic Review
Overview of Human Biofluids
An overview of the physiological role of the principal body fluids in human health is discussed, with an emphasis on key aspects of the structure and functions of macrocirculation and microcirculation. The lymph and the lymphatic system are described in detail, as well as blood flow in the respiratory system, the digestive system, the brain, and the eye. The urinary system, the fluids within the gastrointestinal tract, cerebrospinal fluid, serous body fluids, synovial fluid, and other relevant human fluids are also concisely discussed. 
  • 1.5K
  • 23 Sep 2022
Topic Review
Bio-Based Materials for Chronic Diabetic Wounds
Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and higher healthcare costs. There are several factors that can complicate the healing process of wounds, including inadequate conditions for cell migration, proliferation, and angiogenesis, microbial infections, and prolonged inflammatory responses.
  • 1.5K
  • 30 Mar 2023
Topic Review
Antioxidant Activity of Coumarins
Ubiquitously present in plant life, coumarins have multiple applications—in everyday life, in organic synthesis, in medicine and many others. They are well known for their broad spectrum of physiological effects. The specific structure of the coumarin scaffold involves a conjugated system with excellent charge and electron transport properties. The antioxidant activity of natural coumarins has been a subject of intense study for at least two decades. Significant research into the antioxidant behavior of natural/semi-synthetic coumarins and their complexes has been carried out and published in scientific literature.
  • 1.5K
  • 11 May 2023
Topic Review
Corrosion Stiction in Automotive Braking Systems
The rotor–brake pad assembly for application in automotive braking systems is a complex multimaterial system subjected to several aggressive environments, including rain, snow, and chlorides during winter driving. Corrosion issues involving the rotor–brake pad assembly, in particular for cast-iron rotors, can negatively affect the performance, safety, and reliability of the braking system. Under highly oxidative conditions, electrochemical processes occurring at the gray cast-iron rotor surface can generate corrosion products (iron oxides) that can penetrate the brake pad material through the intrinsic porosity of the friction material employed for the production of the brake pad. The corrosion of gray cast iron discs can lead to a strong adhesion of the brake pad at the pad/disc interface that can impair the reliability and performance of the braking system.
  • 1.5K
  • 30 May 2023
Topic Review
Treatment Drugs for Silicosis
Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public health problem. Cumulative studies are focusing on elucidating the pathogenesis of silicosis in order to identify preventive or therapeutic antifibrotic agents. However, the existing research on the mechanism of silica-dust-induced pulmonary fibrosis is only the tip of the iceberg and lags far behind clinical needs. Idiopathic pulmonary fibrosis (IPF), as a pulmonary fibrosis disease, also has the same problem.
  • 1.5K
  • 15 Jun 2023
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