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Topic Review
Vitamin D: Cost-Effectively Overcoming Infections and Chronic Diseases
The prevalence of chronic diseases increases with age, especially in those with co-morbidities. The two most common denominators are the high prevalence of vitamin D deficiency and low concentrations of angiotensin-converting enzyme receptor-2 (ACE2). Whether vitamin D deficiency initiates or aggravates chronic diseases is unclear: the likelihood is both. Hypovitaminosis D negatively affects all body systems, especially the musculoskeletal and immune systems. Many chronic conditions and infections can be minimized using the right dose of vitamin D supplements administered at the right frequency (daily or once weekly) or direct sun exposure to one-third of the skin between 10:30 AM and 1:30 PM, in summer like sunlight, for 20 to 60 minutes depending on the skin tone. It is advisable to wear sunglasses and a brimmed hat to protect one’s eyes and face. Maintaining the population serum 25(OH)D concentration above 40 ng/mL (i.e., sufficiency) ensures a better immune system, minimizing symptomatic diseases and reducing infections and chronic diseases. The best clinical outcome and longevity are expected from maintaining the serum 25-hydroxyvitamin D concentrations between 50 and 80 ng/mL.
  • 1.5K
  • 04 Sep 2023
Topic Review
IoT-Based Visualisation Platforms for Tracking Household Carbon Footprints
Carbon dioxide (CO2) and other greenhouse gases are the main causes of global climate change. This phenomenon impacts natural and human systems around the world through the rising global average surface temperature, extreme weather, changes in precipitation patterns, rising sea levels, and ocean acidification. However, this concept is alien to most people in developing countries. They are also unaware of the connection between energy efficiency and climate change. This dearth of knowledge makes them opt for highly inefficient appliances. Internet of Things (IoT)-based visualisation platforms for tracking household carbon footprints (CFs) have been seen as a good concept for combating this global phenomenon; however, there are potential challenges and ethical restrictions that must be addressed when implementing platforms for tracking household CFs. 
  • 1.5K
  • 30 Oct 2023
Topic Review
Plant Xyloglucan Xyloglucosyl Transferases
Plant xyloglucan xyloglucosyl transferases or xyloglucan endo-transglycosylases (XET; EC 2.4.1.207) catalogued in the glycoside hydrolase family 16 constitute cell wall-modifying enzymes that play a fundamental role in the cell wall expansion and re-modelling. Over the past thirty years, it has been established that XET enzymes catalyse homo-transglycosylation reactions with xyloglucan (XG)-derived substrates and hetero-transglycosylation reactions with neutral and charged donor and acceptor substrates other than XG-derived. This broad specificity in XET isoforms is credited to a high degree of structural and catalytic plasticity that has evolved ubiquitously in algal, moss, fern, basic Angiosperm, monocot, and eudicot enzymes. These XET isoforms constitute gene families that are differentially expressed in tissues in time- and space-dependent manners during plant growth and development, and in response to biotic and abiotic stresses.
  • 1.5K
  • 03 Dec 2020
Topic Review
Selenomethionine
Selenium is an essential trace element. Although this chalcogen forms a wide variety of compounds, there are surprisingly few small-molecule organic selenium compounds (OSeCs) in biology. Besides its more prominent relative selenocysteine (SeCys), the amino acid selenomethionine (SeMet) is one example. SeMet is synthesized in plants and some fungi and, via nutrition, finds its way into mammalian cells. In contrast to its sulfur analog methionine (Met), SeMet is extraordinarily redox active under physiological conditions and via its catalytic selenide (RSeR’)/selenoxide (RSe(O)R’) couple provides protection against reactive oxygen species (ROS) and other possibly harmful oxidants. In contrast to SeCys, which is incorporated via an eloquent ribosomal mechanism, SeMet can enter such biomolecules by simply replacing proteinogenic Met. Interestingly, eukaryotes, such as yeast and mammals, also metabolize SeMet to a small family of reactive selenium species (RSeS). Together, SeMet, proteins containing SeMet and metabolites of SeMet form a powerful triad of redox-active metabolites with a plethora of biological implications. In any case, SeMet and its family of natural RSeS provide plenty of opportunities for studies in the fields of nutrition, aging, health and redox biology. 
  • 1.5K
  • 23 Jun 2021
Topic Review
Tea Resists Carcinogenesis
Tea remains one of the most prevalent beverages consumed due in part to its physiological properties. The active compounds in tea, including tea polyphenols, tea polysaccharides, L-theanine, tea pigments, caffeine and other minor composition, can directly or indirectly reduce oncogenesis and cancerometastasis. Interestingly, the different types of tea (such as unfermented green tea, partially fermented oolong tea, and fully fermented black tea or pu-erh tea) have the different anti-cancer property.
  • 1.5K
  • 13 Oct 2021
Topic Review
Railway Transportation Sector
A wide analysis is presented, detecting which are the main measures adopted for improving the efficiency, related to the power systems for supplying trains and to the train traffic control, with a focus on the storage system integration.
  • 1.5K
  • 28 Oct 2020
Topic Review
Interferon Lambda
Interferons (IFN) are crucial for the innate immune response. Slightly more than two decades ago, a new type of IFN was discovered: the lambda IFN (type III IFN). Like other IFN, the type III IFN display antiviral activity against a wide variety of infections, they induce expression of antiviral, interferon-stimulated genes (MX1, OAS, IFITM1), and they have immuno-modulatory activities that shape adaptive immune responses. Unlike other IFN, the type III IFN signal through distinct receptors is limited to a few cell types, primarily mucosal epithelial cells. Type III IFN elicit fewer inflammatory responses than the Type I IFN and are gaining interest as antiviral treatments.
  • 1.5K
  • 08 Feb 2021
Topic Review
Microneedle Array Technology in Nanomedicine
Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but also can impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents.
  • 1.5K
  • 26 Jan 2021
Topic Review
MRNA Encoded Antibodies
The field of mRNA has made significant progress in the last ten years and has emerged as a highly attractive means of encoding and producing any protein of interest in vivo. Through the natural role of mRNA as a transient carrier of genetic information for translation into proteins, in vivo expression of mRNA-encoded antibodies offer many advantages over recombinantly produced antibodies.
  • 1.5K
  • 22 Mar 2021
Topic Review
NRF2 Signaling Pathway in Cancer
Nuclear factor-erythroid 2-related factor 2 (NRF2) and its major negative modulator Kelch-like ECH-associated protein 1 (KEAP1) are main players of the cellular defense mechanisms against internal and external cell stressors.
  • 1.5K
  • 26 May 2021
Topic Review
Aerosols Deposition and Marine Biota
Atmospheric aerosol deposition (wet and dry) is an important source of macro and micronutrients (N, P, C, Si, and Fe) to the oceans. Most of the mass flux of air particles is made of fine mineral particles emitted from arid or semi-arid areas (e.g., deserts) and transported over long distances until deposition to the oceans. However, this atmospheric deposition is affected by anthropogenic activities, which heavily impacts the content and composition of aerosol constituents, contributing to the presence of potentially toxic elements (e.g., Cu). Under this scenario, the deposition of natural and anthropogenic aerosols will impact the biogeochemical cycles of nutrients and toxic elements in the ocean, also affecting (positively or negatively) primary productivity and, ultimately, the marine biota. 
  • 1.5K
  • 08 Jun 2021
Topic Review
V-HOE Based Solar Concentrators
The fundamental advantages of volume holographic optical elements are very appealing for lightweight and cheap solar concentrators applications and can become a valuable asset that can be integrated into solar panels. 
  • 1.5K
  • 10 Jun 2021
Topic Review
Lime Mortar
Lime is an ancient construction material that has been utilized throughout the world in various forms, providing stable construction methods in usable conditions. Lime mortar is well known for its low carbon footprint in production and carbon absorption throughout its lifespan as a hardened material. The significant benefits of lime mortar were analyzed and reviewed for further research. Ancient lime constructions need proper maintenance for aesthetic and structural strengthening to preserve this cultural architecture of national pride. Hence, the characterization of ancient mortars is mandatory for renovation work. 
  • 1.5K
  • 10 Jun 2022
Topic Review
Corporate Social Responsibility in Corporate Strategies of SDGs
The Sustainable Development Goals (SDGs) are a unique collective agreement of the modern time, which was concluded between government, society, and business at a global scale and which ensures outstanding progress in sustainable development. Society is the direct beneficiary of the SDGs, but bears the lowest expenditures for their implementation and, thus, supports them. The government protects society’s interests, and implementation of the SDGs is among its main responsibilities. Participation of business in the achievement of the SDGs is complex and contradictory, deserving special attention. It is no coincidence that the necessity for the integration of the SDGs into corporate strategies is a part of the agenda in the Decade of Action.
  • 1.5K
  • 22 Jun 2022
Topic Review
Atmospheric Models
Static atmospheric models describe how the ideal gas properties (namely: pressure, temperature, density, and molecular weight) of an atmosphere change, primarily as a function of altitude. The World Meteorological Organization defines a standard atmosphere as "a hypothetical vertical distribution of atmospheric temperature, pressure and density which, by international agreement, is roughly representative of year-round, midlatitude conditions. Typical usages are as a basis for pressure altimeter calibrations, aircraft performance calculations, aircraft and rocket design, ballistic tables, and meteorological diagrams." For example, the U.S. Standard Atmosphere derives the values for air temperature, pressure, and mass density, as a function of altitude above sea level. Other static atmospheric models may have other outputs, or depend on inputs besides altitude.
  • 1.5K
  • 08 Oct 2022
Topic Review
Diaspora
Diaspora is a free personal web server that implements a distributed social networking service. Installations of the software form nodes (termed "pods") which make up the distributed Diaspora social network. The project was founded by Dan Grippi, Maxwell Salzberg, Raphael Sofaer and Ilya Zhitomirskiy, students at New York University's Courant Institute of Mathematical Sciences. The group received crowdfunding in excess of $200,000 via Kickstarter. A consumer alpha version was released on 23 November 2010. Konrad Lawson, blogging for the Chronicle of Higher Education, suggested Diaspora in July 2011 as an alternative to corporately produced software.
  • 1.5K
  • 09 Nov 2022
Topic Review
Social Network Analysis (Criminology)
Social network analysis in criminology views social relationships in terms of network theory, consisting of nodes (representing individual actors within the network) and ties (which represent relationships between the individuals, such as offender movement, co-offenders, crime groups, etc.) These networks are often depicted in a social network diagram, where nodes are represented as points and ties are represented as lines.
  • 1.5K
  • 21 Nov 2022
Topic Review
The Amazing Bulk
The Amazing Bulk is a 2012 American direct-to-video superhero film directed by Lewis Schoenbrun. Considered to be a mockbuster of the Marvel Studios film The Incredible Hulk, as well as other media featuring the Hulk character, the film's settings and visuals are almost entirely all reused stock imagery, graphics, and video purchased from various websites.
  • 1.5K
  • 25 Nov 2022
Topic Review
The Social Determinants of Health
The five main areas of social determinants of health (SDOH) are economic stability, healthcare access and quality, education access and quality, social and community context, and the neighborhood and built environment. Each of these domains can be further detailed by specific factors that may go on to affect a patient’s quality of life and health.
  • 1.5K
  • 29 Jan 2023
Topic Review
Orodispersible Films
Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery.
  • 1.5K
  • 28 Dec 2023
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