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Topic Review
S3 ViRGE
The S3 Virtual Reality Graphics Engine (ViRGE) graphics chipset was one of the first 2D/3D accelerators designed for the mass market. Introduced in 1995 by then graphics powerhouse S3, Inc., the ViRGE was S3's first foray into 3D-graphics. The S3/Virge was the successor to the successful Trio64V+. ViRGE/325 was pin compatible with the Trio64 chip, retaining the DRAM-framebuffer interface (up to 4MB), and clocking both the core and memory up to 80 MHz. In Windows, Virge was benchmarked as the fastest DRAM-based accelerator of the era. The VRAM-based version, ViRGE/VX, was actually slower in lower resolutions, but had a faster RAMDAC to support high-resolution modes not available on the 325.
  • 1.5K
  • 25 Nov 2022
Topic Review
Pharmacological Chaperones for Mucopolysaccharidoses
It has been proposed that t pharmacological chaperones (PCs), can restore the folding, trafficking, and biological activity of mutated enzymes. PCs have the advantages of wide tissue distribution, potential oral administration, lower production cost, and fewer issues of immunogenicity than enzyme replacement therapy. In this paper, we will review the advances in the identification and characterization of PCs for the MPS.
  • 1.5K
  • 30 Oct 2020
Topic Review
Ischemic Stroke
"The term stroke is defined as ”…a neurological deficit attributed to an acute focal injury of the central nervous system (CNS) by a vascular cause, including cerebral infarction, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH)…”, thus comprising an intraluminal obstructive/ischemic and/or wall tear and a lesion mechanism.
  • 1.5K
  • 29 Oct 2020
Topic Review
Methods for Bioaerosol Characterization
Bioaerosol characterization represents a major challenge for the risk assessment and management of exposed people. One of the most important bioaerosol sources is the organic waste collection and treatment. This work analyzed and discussed the literature with the purpose of investigating the main techniques used nowadays for bioaerosol monitoring during organic waste treatment. The discussion includes an overview on the most effcient sampling, DNA extraction, and analysis methods, including both the cultural and the bio-molecular approach. Generally, an exhaustive biological risk assessment is not applied due to the organic waste heterogeneity, treatment complexity, and unknown aerosolized emission rate. However, the application of bio-molecular methods allows a better bioaerosol characterization, and it is desirable to be associated with standardized cultural methods. Risk assessment for organic waste workers generally includes the evaluation of the potential exposition to pathogens and opportunistic pathogens or to other microorganisms as biomarkers. In most cases, Saccharopolyspora rectivirgula, Legionella spp., Aspergillus spp., and Mycobacterium spp. are included. Future perspectives are focused on identifying common composting biomarkers, on investigating the causality process between chronic bioaerosol exposure and disease onset, and finally, on defining common exposure limits.
  • 1.5K
  • 20 Jul 2020
Topic Review
HEV infectivity in water samples
Hepatitis E virus (HEV) is a non-enveloped single-stranded positive-sense RNA virus, belonging to the Hepeviridae family, resistant to environmental conditions, and transmitted by the consumption of contaminated water. This virus is responsible for both sporadic and epidemic outbreaks, leading to thousands of infections per year in several countries, and is thus considered an emerging disease in Europe and Asia. This study refers to a survey in Portugal during 2019, targeting the detection and eventual quantification of enteric viruses in surface and drinking water sources. Samples positive for HEV RNA were recurrently found by reverse transcription quantitative PCR (RT-qPCR), in both matrices. The infectivity of these samples was evaluated in cultured Vero E6 cells and RNA from putative viruses produced in cell cultures was subjected to RT-qPCR targeting HEV genomic RNA. Our results evidenced the existence of samples positive either for HEV RNA (77.8% in surface water and 66.7% in drinking water) or for infectious HEV (23.0% in surface water and 27.7% in drinking water). These results highlight the need of effective virological control of water for human consumption and activities.
  • 1.5K
  • 26 Oct 2020
Topic Review
Photovoltaic Systems (PVSs)
In a grid-connected photovoltaic system (PVS) synchronization and islanding detection techniques have to operate in coordination. Abnormal conditions can arise on the utility grid which require a prompt response from the PVS, hence the information provided by the synchronization system are fundamental for the grid voltage monitoring. The islanding detection techniques are based also on the information provided by the synchronization techniques and some islanding detection techniques require additional synchronization systems. Besides, after an islanding event, the PVS reconnection procedure has to be managed with two synchronization systems. For all these reasons synchronization and islanding detection issues have been analyzed together. 
  • 1.5K
  • 13 Jul 2020
Topic Review
Canine Heat-Related Illness
Heat-related illness - more commonly known as "heat stroke" - is a potentially fatal disorder that can affect both man and animals. The condition has two main causes: exertional and environmental heat. Exertional heat-related illness occurs either when a dog is active in a hot environment, or associated with strenuous and typically prolonged activity in any temperature. Environmental heat-related illness occurs when the ambient temperature and humidity increase beyond the dog's cooling limits, cases of environmental heat-related illness typically occur during heatwave events.  
  • 1.5K
  • 17 Aug 2020
Topic Review
Silica Pervaporation Membranes
Solvents are very critical not only to produce lifesaving drugs, but also to manufacture many household products. Hence, they are widely used in the pharmaceutical industry, petroleum refineries, paints and coatings, adhesives, printing inks, industrial cleaning and research essential to the fields of medicine and disease diagnosis. Conventional technologies such as distillation which are used to recover those solvents, are energy-intensive, inefficient and suffer from high operating and maintenance costs. Pervaporation based membrane separation overcomes these challenges and in conjunction with the utilization of inorganic membranes derived from non-toxic, sufficiently abundant and hence expendable, silica, allows for high operating temperatures and enhanced chemical and structural integrity, raw material abundance and easy disposability. However, silica membranes possess some disadvantages, such as an inadequacy in the complete understanding of the governing mechanism as well as compromised structural integrity towards dilute aqueous organic mixtures.  Membrane-based separation is predicted to dominate the industry in the coming decades, as the process is being understood at a deeper level, leading to the fabrication of tailored membranes for niche applications. The current review aims to compile and present the extensive and often dispersive scientific investigations to the reader and highlight the current scenario as well as the limitations suffered by this mature field. In addition, viable alternative to the conventional methodologies, as well as other rival materials in existence to achieve membrane-based pervaporation are highlighted.
  • 1.5K
  • 13 Aug 2020
Topic Review
Brain–Gut–Microbiome Axis
Beginning with the concept of the brain–gut axis, the importance of the interaction between the brain and the gastrointestinal tract has been extended to the microbiome with increasing clinical applications. With the recent development of various techniques for microbiome analysis, the number of relevant preclinical and clinical studies on animals and human subjects has rapidly increased. Various psychotic symptoms a ect the intestinal microbiome through the hypothalamus–pituitary–adrenal gland axis. Conversely, the intestinal microbiome regulates the gastrointestinal tract environment and affects psychological factors by means of the microorganisms or their metabolites, either acting directly on the brain or through the synthesis of various neurotransmitters.
  • 1.5K
  • 26 Oct 2020
Topic Review
SARS-CoV-2 Spike Protein and PAH
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the current pandemic of coronavirus disease 2019 (COVID-19), and COVID-19 vaccines focus on its spike protein. However, in addition to facilitating the membrane fusion and viral entry, the SARS-CoV-2 spike protein promotes cell growth signaling in human lung vascular cells, and patients who have died of COVID-19 have thickened pulmonary vascular walls, linking the spike protein to a fatal disease, pulmonary arterial hypertension (PAH). 
  • 1.5K
  • 22 Jan 2021
Topic Review
Metamaterials for Device Applications
Metamaterials are the major type of artificially engineered materials which exhibit naturally unobtainable properties according to how their microarchitectures are engineered. Owing to their unique and controllable effective properties, including electric permittivity and magnetic permeability, the metamaterials play a vital role in the development of meta-devices.
  • 1.5K
  • 12 May 2021
Topic Review
Ataxia Telangiectasia Mutated
ATM is among of the most critical initiators and coordinators of the DNA-damage response. ATM canonical and non-canonical signaling pathways involve hundreds of downstream targets that control many important cellular processes such as DNA damage repair, apoptosis, cell cycle arrest, metabolism, proliferation, oxidative sensing, among others. Of note, ATM is often considered a major tumor suppressor because of its ability to induce apoptosis and cell cycle arrest. However, in some advanced stage tumor cells, ATM signaling is increased and confers remarkable advantages for cancer cell survival, resistance to radiation and chemotherapy, biosynthesis, proliferation, and metastasis. 
  • 1.5K
  • 02 Jun 2021
Topic Review
Sensor and Actuator Fault Diagnosis
Sensors and actuators are key components in the robot system, but their working environment is very complex, with electromagnetic interference, vibration, etc., which will affect the output of the sensors and then the actuators. Moreover, the variable load on manipulators is also a challenge for system state feedback or estimation. All of the above factors make the faults diagnosis of robot system sensors and actuators an urgent task. The DCNN is used to deal with sensor and actuator faults of robot joints, such as gain error, offset error, and malfunction for both sensors and actuators, and different fault types are diagnosed using the trained neural network.
  • 1.5K
  • 29 Jun 2021
Topic Review
Control, Biocontrol and IPM Perspectives of Varroa Destructor
Varroa destructor is a parasitic organism feeding and living among honeybees. It transmits viruses like the Deformed Wing Virus which can lead to the decline and death of the colony. Many treatments have been developed over the years like formamidine amitraz, pyrethroid tau-fluvalinate, organophosphate coumaphos or even acids like formic and oxalic to control the spread of the mite. However, none of this solution provides long-term sustainability for honeybees and no resistance from V. destructor. Therefore, the development of alternative tools remains open.
  • 1.5K
  • 26 Oct 2021
Topic Review
Role of Hydrogen Sulfide
Hydrogen sulfide (H2S) is a gasotransmitter able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H2S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H2S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines.
  • 1.5K
  • 11 Feb 2022
Topic Review
Digital Technologies Increase Consumer Acceptance of Circular Clothes
Experimentation with, and the implementation of, circular business models (CBMs) has gained rapid traction within the textiles and fashion industry over the last five years. Substitution of virgin materials with bioderived alternatives, extending the lifecycle of garments through resale, and rental services and the recycling or upcycling of garments are some of the strategies being used to reduce the 1.2 billion tonnes of greenhouse gas emissions and 92 million tonnes of waste associated with the sector in 2017. However, whilst CBMs demonstrate environmental and economic benefits, low consumer acceptance is considered by business professionals and policymakers to be one of the main barriers to the transition towards a circular economy. Digitisation is widely acknowledged as a catalyst for innovation in many sectors and digital technologies are driving new ways to exchange and share goods and services, enabling companies to match the supply, and demand for, otherwise underused assets and products. Online platforms, in particular, have played a crucial role in driving the growth of used goods and resale in other consumer goods markets, such as consumer technology. 
  • 1.5K
  • 30 May 2022
Topic Review
Retail Loss Prevention
Retail loss prevention is a set of practices employed by retail companies to preserve profit. Profit preservation is any business activity specifically designed to reduce preventable losses. A preventable loss is any business cost caused by deliberate or inadvertent human actions, colloquially known as "shrinkage". Deliberate human actions that cause loss to a retail company can be theft, fraud, vandalism, waste, abuse, or misconduct. Inadvertent human actions attributable to loss are poorly executed business processes, where employees fail to follow existing policies or procedures – or cases in which business policies and procedures are lacking. Loss prevention is mainly found within the retail sector but also can be found within other business environments. Since retail loss prevention is geared towards the elimination of preventable loss and the bulk of preventable loss in retail is caused by deliberate human activity, traditional approaches to retail loss prevention have been through visible security measures matched with technology such as CCTV and electronic sensor barriers. Most companies take this traditional approach by either having their own in-house loss prevention team or using external security agencies. Charles A. Sennewald and John H. Christman state, "Four elements are necessary for a successful loss prevention plan: 1) Total support from top management, 2) A positive employee attitude, 3) Maximum use of all available resources, 4) A system which establishes both responsibility and accountability for loss prevention through evaluations that are consistent and progressive."
  • 1.5K
  • 31 Oct 2022
Topic Review
Hyperuricemia and the Kidneys
Uric acid is the end-product of purine metabolism in humans and apes, unlike other mammals which have uricase. This genetic evolution has led humans to exhibit plasma uric acid levels that are 3–10 times higher than those of other mammals. The association of hyperuricemia with increased cardiovascular risk may partly be explained by the activation of the renin-angiotensin system (RAS). When mild hyperuricemia was induced in rats by providing oxonic acid in the diet, blood pressure was elevated, and juxtaglomerular renin expression increased. Plasma renin activity and plasma aldosterone concentration were also elevated in rats with hyperuricemia, but these associations were unclear in adults with essential hypertension. Intrarenal RAS activity may be affected by hyperuricemia in humans.
  • 1.5K
  • 30 Nov 2022
Topic Review
Freshet
thumb|An example of usage of the term "freshet" is shown in the text on a historic marker at Durgin Bridge near Sandwich, New Hampshire. The term freshet is most commonly used to describe a spring thaw resulting from snow and ice melt in rivers located in upper North America. A spring freshet can sometimes last several weeks on large river systems, resulting in significant inundation of flood plains as the snowpack melts in the river's watershed. Freshets can occur with differing strength and duration depending upon the depth of the snowpack and the local average rates of warming temperatures. Deeper snowpacks which melt quickly can result in more severe flooding. Late spring melts allow for faster flooding; this is because the relatively longer days and higher solar angle allow for average melting temperatures to be reached quickly, causing snow to melt rapidly. Snowpacks at higher altitudes and in mountainous areas remain cold and tend to melt over a longer period of time and thus do not contribute to major flooding. Serious flooding from southern freshets are more often related to rain storms of large tropical weather systems rolling in from the South Atlantic or Gulf of Mexico, to add their powerful heating capacity to lesser snow packs. Tropically induced rainfall influenced quick melts can also affect snow cover to latitudes as far north as southern Canada, so long as the generally colder air mass is not blocking northward movement of low pressure systems. In the eastern part of the continent, annual freshets occur from the Canada Taiga ranging along both sides of the Great Lakes then down through the heavily forested Appalachian mountain chain and St. Lawrence valley from Northern Maine and New Brunswick into barrier ranges in North Carolina and Tennessee . In the western part of the continent, freshets occur throughout the generally much higher elevations of the various west coast mountain ranges that extend southward down from Alaska even into the northern parts of Arizona and New Mexico.
  • 1.5K
  • 30 Nov 2022
Topic Review
Solar Thermal Systems
The use of solar thermal systems (STSs) has reached a significant edge. The increasing research on developing an alternative power supply for limiting fossil fuel usage and climate change are the driving forces of STSs. STSs’ applications, including PV/T or “photovoltaic/thermal” systems, zero-energy buildings, greenhouse solar thermal applications, solar thermal for pumping water, solar thermal refrigerators, solar chimneys, water desalination, and solar collectors, along with the benefits and challenges of these applications.
  • 1.5K
  • 28 Dec 2022
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