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Topic Review
Pathological Angiogenesis
Pathological angiogenesis, which is mainly induced through vascular endothelial growth factors (VEGF) and their receptors, is involved in many of these vision-impairing ocular disorders, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), and corneal neovascularization. 
  • 1.6K
  • 23 Feb 2021
Topic Review
Microglia in Neurogenesis
Certain pools of microglia are determinant cells in different phases of the generation of new neurons. This sheds light on how cells cooperate in order to fine tune brain organization.
  • 1.6K
  • 01 Jun 2021
Topic Review
Microbial Biostimulants
A microbial plant biostimulant, according to the Reg.UE 2019/1009, consists of a microorganism or a consortium of microorganisms able to stimulate plant nutrition processes independently of the product’s nutrient content with the sole aim of improving one or more of the following characteristics of the plant or the plant rhizosphere: (a) nutrient use efficiency; (b) tolerance to abiotic stress; (c) quality traits; (d) availability of confined nutrients in soil or rhizosphere. The allowed microorganisms are listed in the CMC-7 (Component Material Categories, number 7), which includes four different genera: Azotobacter spp., Mycorrhizal fungi, Rhizobium spp., and Azospirillum spp.
  • 1.6K
  • 22 Sep 2021
Topic Review
Leaves of Diospyros kaki (Persimmon)
Diospyros kaki (persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon leaves to identify the biologically active compounds. The antioxidative effect of the ethyl acetate layer from the ethanol extract of the persimmon leaves was demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and online high-performance liquid chromatography-2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (HPLC-ABTS) analysis. 
  • 1.6K
  • 11 Nov 2021
Topic Review
Camelina (Camelina sativa (L.) Crantz)
Camelina (Camelina sativa (L.) Crantz) is a protein and oilseed crop belonging to the family Brassicaceae.
  • 1.6K
  • 18 Feb 2022
Topic Review
Metal Complexes of the Porphyrin-Functionalized Polybenzoxazine
Porphyrin is a molecular material with many potential applications. New porphyrin-functionalized benzoxazine (Por-BZ) in high purity and yield was synthesized in this study based on 1H and 13C NMR and FTIR spectroscopic analyses through the reduction of Schiff base formed from tetrakis(4-aminophenyl)porphyrin (TAPP) and salicylaldehyde and the subsequent reaction with CH2O. Thermal properties of the product formed through ring-opening polymerization (ROP) of Por-BZ were measured using DSC, TGA and FTIR spectroscopy. Because of the rigid structure of the porphyrin moiety appended to the benzoxazine unit, the temperature required for ROP (314 °C) was higher than the typical Pa-type benzoxazine monomer (ca. 260 °C); furthermore, poly(Por-BZ) possessed a high thermal decomposition temperature (Td10 = 478 °C) and char yield (66 wt%) after thermal polymerization at 240 °C. An investigation of the thermal and luminescence properties of metal–porphyrin complexes revealed that the insertion of Ni and Zn ions decreased the thermal ROP temperatures of the Por-BZ/Ni and Por-BZ/Zn complexes significantly, to 241 and 231 °C, respectively. The metal ions acted as the effective promoter and catalyst for the thermal polymerization of the Por-BZ monomer, and also improved the thermal stabilities after thermal polymerization. 
  • 1.6K
  • 24 Feb 2022
Topic Review
Biofilm Prevention and Therapy: Alternatives to Standard Antibiotics
In order to combat the global health crisis of escalating antibacterial resistance, guidelines on responsible antimicrobial stewardship are urgently required. Yet, currently there is no international consensus. Tackling discrepancies that may arise when implementing novel antibiotics is critical to their longevity of use. A wide range of antibiotics previously heavily used is no longer effective due to elevated minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) doses for treatment. Thus, there is a pressing need to develop effective way to prevent biofilm from forming as well as to carefully apply alternative therapies to standard antibiotic treatments.
  • 1.6K
  • 11 May 2022
Topic Review
Chlorophyllide
Chlorophyllide a and Chlorophyllide b are the biosynthetic precursors of chlorophyll a and chlorophyll b respectively. Their propionic acid groups are converted to phytyl esters by the enzyme chlorophyll synthase in the final step of the pathway. Thus the main interest in these chemical compounds has been in the study of chlorophyll biosynthesis in plants, algae and cyanobacteria. Chlorophyllide a is also an intermediate in the biosynthesis of bacteriochlorophylls.
  • 1.6K
  • 11 Oct 2022
Topic Review
DAVINCI+
DAVINCI+ (Deep Atmosphere Venus Investigation of Noble gases, Chemistry, and Imaging, Plus) is a planned mission for an orbiter and atmospheric probe to the planet Venus. Together with the VERITAS mission, which will also study Venus, it was selected by NASA on 2 June 2021 to be part of their Discovery Program. DAVINCI+ will send both an orbiter and a descent probe to Venus. The orbiter will image Venus in multiple wavelengths from above, while the descent probe will study the chemical composition of Venus' atmosphere and take photographs during descent. The DAVINCI+ probe will travel through the Venusian atmosphere, sampling the atmosphere, and returning measurements down to the surface. These measurements are important to understanding the origin of the atmosphere, how it has evolved, and how and why it is different from the atmosphere of Earth and Mars. The measurements taken by DAVINCI+ will investigate the possible history of water on Venus and the chemical processes at work in the unexplored lower atmosphere. Before it reaches the surface, the DAVINCI+ probe will capture high resolution images of the planet's ridged terrain ("tesserae"), returning the first images of the planet's surface since Soviet Venera 13 lander in 1981. It will also collect data for studying the planet's origin, and its tectonic and weathering history.
  • 1.6K
  • 17 Oct 2022
Topic Review
WRKY Transcription Factor
The WRKY transcription factor family (pronounced ‘worky’) is a class of DNA-binding proteins. WRKY transcription factors are primarily specific to plants and algae (Viridiplantae); although, individual WRKY proteins do appear in the human protozoan parasite Giardia lamblia and slime mold Dictyostelium discoideum. These transcription factors recognize a (T/A)TGAC(T/A) cis-regulatory element, also known as a W-box, in the promoters of target genes. WRKY transcription factors play a major role in plant defense to abiotic and biotic stresses, but also contribute to plant development and secondary metabolism. These roles are governed by an ever increasingly complex network of interactions with other DNA-binding and non-DNA-binding proteins.
  • 1.6K
  • 28 Oct 2022
Topic Review
Audio-Based Hazard Detection for Construction Safety
Safety-critical sounds at job sites play an essential role in construction safety, but hearing capability is often declined due to the use of hearing protection and the complicated nature of construction noise. Thus, preserving or augmenting the auditory situational awareness of construction workers has become a critical need. 
  • 1.6K
  • 06 Dec 2022
Biography
Alexander Dewdney
Alexander Keewatin Dewdney (born August 5, 1941) is a Canadian mathematician, computer scientist, author, filmmaker, and conspiracy theorist. Dewdney is the son of Canadian artist and author Selwyn Dewdney, and brother of poet Christopher Dewdney. He was born in London, Ontario. In his student days, Dewdney made a number of influential experimental films, including Malanga, on the poet Gerald
  • 1.6K
  • 12 Dec 2022
Topic Review
Plant-Derived Metal Nanoparticles
Plant-derived metal nanoparticles (PDMNPs) have gained considerable interest because of their tremendous and remarkable potential as therapeutic agents as well as development of less expensive, safer, and easier biomedical equipment. PDMNPs are synthesized from metal salts or oxides by using plant extracts because plants have diversified bioactive compounds that can act as reducing and stabilizing agents at the time of nanoparticle synthesis. Besides, PDMNPs take advantages over the nanoparticles synthesized by other methods because of their low cost, environmental friendliness, and sustainability. 
  • 1.6K
  • 23 Mar 2023
Topic Review
Stomatognathic Diseases in Neurological Disorders
Patients affected by neurological disorders can develop stomatognathic diseases (SD) related to decreased bite force and quality of mastication, bruxism, severe clicking and other temporomandibular disorders (TMD), which deeply affect patients’ swallowing, masticatory and phonation functions and, therefore, their quality of life. 
  • 1.6K
  • 23 May 2023
Topic Review
Oxidative Stress Markers
Reactive oxygen species (ROS) have deleterious effects on cell components (protein-derived enzymes, lipid-rich membranes, nucleic acids, and carbohydrates), causing functional and structural alterations. Depending on the molecular targets of ROS action, oxidative stress (OS) markers show a wide variety. Therefore, they can be divided into four main classes: markers of lipid peroxidation, DNA oxidative damage, protein oxidation, and carbohydrate oxidation. The antioxidant molecules also represent an important source of biomarkers to evaluate OS.
  • 1.6K
  • 05 Sep 2023
Topic Review
Neutrophil
Neutrophils represent about 50–70% of all white blood cells in the human circulation and are widely recognized as the first line of defense in infectious disease. However, neutrophils also have a clear modulatory role in human diseases such as cancer, respiratory disease, and autoimmunity. Infections and/or any inflammatory signals trigger a rapid influx of neutrophils from the peripheral blood to the inflammatory site, where they can utilize a broad variety of effector functions to.  Neutrophils are well known phagocytic cells, engulfing microorganisms or in case of bigger targets, such as cancer cells, taking “bites” of the membrane in a process called ‘trogocytosis’. Moreover, neutrophils are armed with granules that are loaded with proteases and inflammatory mediators  that are released upon activation. In addition, during a so called ‘oxidative burst’ neutrophils release high levels of  reactive oxygen species (ROS), which can trigger cell death of the target cell. Finally, neutrophils can entrap foreign materials in so called ‘neutrophil extracellular traps’ (NETs), which are mainly composed of neutrophil DNA and Granular contents. The effector functions of neutrophils can be triggered by antibodies that activate  neutrophils by binding to Fc-receptors (FcRs), leading to antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although neutrophils are mainly involved in innate immunity, neutrophils contribute to adaptive immune responses. 
  • 1.6K
  • 05 Jan 2021
Topic Review
EV-Based Vaccines
Extracellular vesicles (EVs) are secreted from almost all human cells and mediate intercellular communication by transferring heterogeneous molecules (i.e., DNA, RNAs, proteins, and lipids). In this way, EVs participate in various biological processes, including immune responses. Viruses can hijack EV biogenesis systems for their dissemination, while EVs from infected cells can transfer viral proteins to uninfected cells and to immune cells in order to mask the infection or to trigger a response. Several studies have highlighted the role of native or engineered EVs in the induction of B cell and CD8(+) T cell reactions against viral proteins, strongly suggesting these antigen-presenting EVs as a novel strategy for vaccine design, including the emerging COVID-19. EV-based vaccines overcome some limitations of conventional vaccines and introduce novel unique characteristics useful in vaccine design, including higher bio-safety and efficiency as antigen-presenting systems and as adjuvants.
  • 1.6K
  • 02 Feb 2021
Topic Review
Babesia spp. Identification
Babesiosis is considered one of the main vector-borne diseases caused by intraerythrocytic parasites, just behind malaria disease whose etiological agent is transmitted by mosquitoes.
  • 1.6K
  • 24 Feb 2021
Topic Review
Bartonella henselae in a Biofilm
Bartonella henselae (B. henselae) is a gram-negative bacterium that causes cat scratch disease, bacteremia, and endocarditis, as well as other clinical presentations. B. henselae has been shown to form a biofilm in vitro that likely plays a role in the establishment and persistence of the bacterium in the host.
  • 1.6K
  • 28 Apr 2021
Topic Review
Proteases and Mucus
Proteases are enzymes that catalyse the hydrolysis of peptide bonds within proteins, facilitating their cleavage; this hydrolysis can either activate, inactivate, or modulate the activity of the target protein.
  • 1.6K
  • 04 Jun 2021
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