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Topic Review
Phytochemicals in Prostate Cancer
Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. 
  • 1.6K
  • 14 Sep 2021
Topic Review
Decellularized Colorectal Cancer Matrices as Bioactive Scaffolds
More than a physical structure providing support to tissues, the extracellular matrix (ECM) is a complex and dynamic network of macromolecules that modulates the behavior of both cancer cells and associated stromal cells of the tumor microenvironment (TME). Over the last few years, several efforts have been made to develop new models that accurately mimic the interconnections within the TME and specifically the biomechanical and biomolecular complexity of the tumor ECM. Particularly in colorectal cancer, the ECM is highly remodeled and disorganized and constitutes a key component that affects cancer hallmarks, such as cell differentiation, proliferation, angiogenesis, invasion and metastasis. Therefore, several scaffolds produced from natural and/or synthetic polymers and ceramics have been used in 3D biomimetic strategies for colorectal cancer research. Nevertheless, decellularized ECM from colorectal tumors is a unique model that offers the maintenance of native ECM architecture and molecular composition.
  • 1.6K
  • 18 Jan 2022
Topic Review Peer Reviewed
The Applications of Microphysiological Systems in Biomedicine: Impact on Urologic and Orthopaedic Research
Microphysiological systems (MPSs) are in vitro models that can incorporate dynamic stimuli such as flow, pressure and contraction in cell culture, enabling the formation of cellular architectures and retrieving physiological function often absent in conventional 2D-cell culture. MPS applications saw a substantial growth in recent years, drawing attention from industry as a strategy to optimize pre-clinical drug-development purposes, as well as from biomedical research, to fill a gap between in vivo and in vitro models. Several MPS platforms are now available and are employed in the development of bone and kidney complex systems for urologic and orthopaedic research. These advances have enabled, for example, the in vitro modelling of bone regeneration and renal drug secretion, and have dramatic potential to improve research into both orthopaedic and urology cancers. 
  • 1.6K
  • 16 Jun 2022
Topic Review
Animal Models and Helicobacter pylori Infection
Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. 
  • 1.6K
  • 14 Jul 2022
Topic Review
Microfluidic Device in Anti-Cancer Drug Screening
Having its root lying in microelectronics, microfluidics seems to hold great potential to explore people's limited knowledge in the field of oncology. It offers numerous advantages such as a low sample volume, minimal cost, parallelization, and portability and has been advanced in the field of molecular biology and chemical synthesis. The platform has been proved to be valuable in cancer research, especially for diagnostics and prognosis purposes and has been successfully employed in recent years. Organ-on-a-chip, a biomimetic microfluidic platform, simulating the complexity of a human organ, has emerged as a breakthrough in cancer research as it provides a dynamic platform to simulate tumor growth and progression in a chip.
  • 1.6K
  • 15 Jul 2022
Topic Review
Methods for Quality Assessment of Citrus Fruit
Citrus spp. are spread mainly in the Mediterranean basin and represent the largest fruit source for human consumption. Postharvest losses, mainly due to diseases and metabolic disorders of fruits, can cause severe wastage, reaching 30 to 50% of the total production. Preserving quality and extending shelf life are essential objectives for postharvest technological innovation, determined by the proper handling, treatment, storage and transport of harvested produce. Moreover, the application of novel sustainable strategies is critical for the reduction of synthetic fungicide residues on fruit surfaces and the impact on the environment caused by waste disposal of fungicides. In modern citrus packinghouses, advanced systems for sorting and measuring the external and internal quality of large amounts of citrus fruits rely on automated and reliable inspection systems based on computer vision techniques, equipped with electronic sorting devices capable of examining fruit images at a very high speed and measuring external properties, such as colour, size and the presence of damage or defects.
  • 1.6K
  • 20 Jul 2022
Topic Review
Reggiane Re.2000
The Reggiane Re 2000 Falco I was an Italian all metal, low-wing monoplane developed and manufactured by aircraft company Reggiane. The type was used extensively by the Regia Aeronautica (Italian Air Force) and the Swedish Air Force during the first part of the Second World War. The Re 2000 was developed by a team headed by aircraft designers Roberto Longhi and Antonio Alessio to be a lightly-built and highly maneuverable interceptor/fighter aircraft. The emergent design, which had been designated as the Re 2000 Falco I, was equipped with a Curtiss-Wright-style retractable undercarriage, bore substantial similarities to the American-built Seversky P-35. On 24 May 1939, the prototype performed its maiden flight. Flight testing of the prototype revealed it to be able to outfight several significant combat aircraft of the time, including even the more modern Macchi C 200 and the German Messerschmitt Bf 109E fighters. During the run up to and following the outbreak of the Second World War, the aircraft was ordered by several nations, including the Hungarian, Swedish, United Kingdom and Italian governments. Upon entering squadron service, the Re 2000 soon proved to be a technically advanced aircraft, being well balanced and extremely aerodynamic during flight, but was not without its faults. Although the aircraft was potentially superior to Italian contemporary fighters (Fiat G 50 and Macchi C 200), the Re 2000 was not considered to be satisfactory by Italian military authorities. Consequently, the manufacturer built the type for export and almost all of the first production served with the Swedish Air Force and Hungarian Air Force , rather than in the Regia Aeronautica. The Re.2000 served as the starting point for several derivatives, including the MÁVAG Héja, Reggiane Re.2001, Re.2002, Re.2003, Re.2004, Re.2005, Re.2006 and Re.2007 combat aircraft.
  • 1.6K
  • 23 Nov 2022
Topic Review
Influence of 3D Printing Parameters on FFF Prints
The advancement in 3D printing techniques has raised the hope to use additively manufactured parts as final products in various industries. Due to the layer-by-layer nature of AM parts, they are highly susceptible to failure when they are subjected to fatigue loading. This entry provides a detailed account of the influence of 3D printing parameters on the fatigue properties of parts manufactured by fused filament fabrication (FFF). Existing standards for fatigue testing of polymers and their limitation for 3D-printed parts are discussed. In addition, the cyclic behaviour of polymers is reviewed, and the impact of 3D printing parameters on the mechanical behaviour of FFF parts under tensile, compressive, flexural, and bending fatigue is investigated according to the published results in the literature. Finally, a summary of the works undertaken and suggestions for future research are provided. The influence of 3D printing parameters on the fatigue performance of prints can be different from that seen in the case of static loading and strongly depends on the fatigue loading type. While cross-over infill patterns, higher infill density, and higher layer height favour achieving higher fatigue strength in all loading types, raster orientation is best to be aligned parallel to the tensile loads and perpendicular to the compressive, flexural, and bending forces. In the case of tensile and flexural loading, Y build orientation yields the best result. Finally, print velocity was found to be less significant compared to other parameters, implying that it can be set at high values for faster printing.
  • 1.6K
  • 10 Feb 2023
Topic Review
Polyphenols in Diet and Their Biological Significance
Polyphenols are vital phytonutrients of plant origin that can be incorporated as functional ingredients in foods to offer an effective natural therapy against obesity. There have been efforts to discover alternative obesity treatments from dietary polyphenols.
  • 1.6K
  • 15 Feb 2023
Topic Review
Antioxidant Potential of Glutathione and Crosstalk with Phytohormones
Glutathione (GSH) is an abundant tripeptide that can enhance plant tolerance to biotic and abiotic stress. Its main role is to counter free radicals and detoxify reactive oxygen species (ROS) generated in cells under unfavorable conditions. Moreover, along with other second messengers (such as ROS, calcium, nitric oxide, cyclic nucleotides, etc.), GSH also acts as a cellular signal involved in stress signal pathways in plants, directly or along with the glutaredoxin and thioredoxin systems.
  • 1.6K
  • 07 Apr 2023
Topic Review
Climate Change and Reproductive Biocomplexity in Fishes
The continuing and rapid climate change will have an adverse effect on reproduction by jeopardising successful breeding and survival of fishes impacting on the viability of sustainability in both aquaculture systems and the ocean. 
  • 1.6K
  • 20 Apr 2023
Topic Review
Fruit and Vegetable Harvesting Robots
Intelligent agriculture imposes higher requirements on the recognition and localization of fruit and vegetable picking robots. Due to its unique visual information and relatively low hardware cost, machine vision is widely applied in the recognition and localization of fruit and vegetable picking robots.  Visual sensors are used to acquire image information and the three-dimensional positioning of targets. Machine vision algorithms are used for target recognition. Common algorithms include image segmentation, object detection, and three-dimensional reconstruction. Image segmentation algorithms can segment target objects in complex scenes, object detection algorithms can timely detect target objects and other interferences in images, while three-dimensional reconstruction algorithms can convert the two-dimensional image information obtained by the camera into three-dimensional spatial information of the target.
  • 1.6K
  • 26 Sep 2023
Topic Review
Multiple Familial Trichoepithelioma
Multiple familial trichoepithelioma is a condition involving multiple skin tumors that develop from structures associated with the skin (skin appendages), such as hair follicles and sweat glands. People with multiple familial trichoepithelioma typically develop large numbers of smooth, round tumors called trichoepitheliomas, which arise from hair follicles. Trichoepitheliomas are generally noncancerous (benign) but occasionally develop into a type of skin cancer called basal cell carcinoma.
  • 1.6K
  • 23 Dec 2020
Topic Review
Sustainability-Sport-Physical Activity
The present study is a synthesizing analysis of international literature on correlations between sustainability, sport, and physical activity. The study of sustainability is considered essential in modern research; its multidisciplinary approach relies on sports science and sports economics as well. There are several aspects of sustainability that are closely associated with health and health preservation; the beneficial effect of exercise on health is also widely known. For the analysis of this complex matter, our current study relied on secondary sources, and besides exploring specialist literature, it also illustrates and analyzes related statistical data. Our results highlight the correlations between living environment and physical activity, the importance of increasing individual commitment towards sustainability and using green spaces for exercising, as well as questions on social and environmental development in relation to physical activity. The study revealed the existence of highly complex links between physical environment, physical activities, and sustainability. The results section of our study provides a brief summary on the possible ways of making people physically active. Increasing physical activity is of paramount importance for achieving the objectives formulated in relation to sustainability.
  • 1.6K
  • 19 Feb 2021
Topic Review
Zebrafish Models of Neuroblastoma
For nearly a decade, researchers in the field of pediatric oncology have been using zebrafish as a model for understanding the contributions of genetic alternations to the pathogenesis of neuroblastoma (NB), and exploring the molecular and cellular mechanisms that underlie neuroblastoma initiation and metastasis.
  • 1.6K
  • 18 Mar 2021
Topic Review
Honeybee Microbiota
Numerous honeybee (Apis mellifera) products, such as honey, propolis, and bee venom, are used in traditional medicine to prevent illness and promote healing. Therefore, this insect has a huge impact on humans’ way of life and the environment. While the population of A. mellifera is large, there is concern that widespread commercialization of beekeeping, combined with environmental pollution and the action of bee pathogens, has caused significant problems for the health of honeybee populations. One of the strategies to preserve the welfare of honeybees is to better understand and protect their natural microbiota. 
  • 1.6K
  • 05 Sep 2021
Topic Review
Forest Biomass
Forest biomass is a sustainable source of renewable energy and a valuable alternative to finite fossil fuels. However, its overharvesting may lead to soil nutrient depletion and threaten future stand productivity, as well as affect the habitat for biodiversity.
  • 1.6K
  • 16 Jan 2022
Topic Review
Enzymatic Metabolism of Flavonoids
Gastrointestinal (GI) cancer is a prevalent global health disease with a massive burden on health care providers. Internal and external factors such as obesity, smoking, diet (red meat), low socioeconomic status and infection with Helicobacter pylori are the critical risk factors of GI cancers. Flavonoids are natural phenolic compounds found abundantly in fruits and vegetables. Upon ingestion, 90% of flavonoids consumed require further enzymatic metabolism by the gut microbiome to enhance their bioavailability and absorption. Several epidemiological studies reported that consumption of flavonoids and their enzymatic conversion by gut microbes is strongly associated with the reduced risk of GI cancer development. This review summarizes the current knowledge on the enzymatic conversion of flavonoids by the human gut microbiome. It also addresses the underlying anti-GI cancer effects on metabolic pathways such as apoptosis and cellular proliferation. Overall, metabolites produced from flavonoid’s enzymatic conversion illustrate anti-GI cancer effects, but the mechanisms of action need further clarification.
  • 1.6K
  • 09 Aug 2021
Topic Review
Probiotics and Oral Candidiasis
Oral candidiasis (OC) is an increasing health problem due to the introduction of new drugs, population aging, and increasing prevalence of chronic illness.  The intake of probiotics can have a beneficial effect on OC and that the effects could vary according to the patients’ characteristics.
  • 1.6K
  • 24 Aug 2021
Topic Review
Changing Food Consumption Patterns and Land Requirements
The food consumed and the household size determine the land requirement for food. Continued population growth without improved living standards and adequate food production output per hectare will further exacerbate food insecurity and land shortage in Nigeria.
  • 1.6K
  • 19 Jan 2022
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