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Topic Review
Olive Oil Wastewater Management
Olive oil production processes usually generate large amounts of high load polluted wastewater known as Olive Mill Wastewater (OMW), locally known as “Zibar”. Most of these olive oil-producing processes are found in the Mediterranean countries, where olive trees are planted to produce both olives and olive oil.
  • 1.6K
  • 02 Jun 2022
Topic Review
ML-Based Detection Approaches of Coal Workers’ Pneumoconiosis
Computer-aided diagnostic (CAD) systems can assist radiologists in detecting coal workers’ pneumoconiosis (CWP) in their chest X-rays. Early diagnosis of the CWP can significantly improve workers’ survival rate.  The feature extraction and detection approaches of computer-based analysis in CWP using chest X-ray radiographs (CXR) can be summarised into three categories: classical methods including computer and international labor organization (ILO) classification-based detection; traditional machine learning methods; and CNN methods.
  • 1.6K
  • 10 Jul 2024
Topic Review
Digital Mathematics Textbooks
Digital mathematics textbooks differ from traditional printed textbooks in, among other things, their dynamic structural elements, representing a potential that traditional textbooks cannot fulfil. Notably, dynamic structural elements, i.e., multimodal representations of mathematics, could be of particular importance for learning, which is why the scientific interest in digital mathematics textbooks has increased and many digital textbooks have been developed.
  • 1.6K
  • 17 Jun 2022
Topic Review
Industry 4.0 and Lean Six Sigma Integration
In recent years, Industry 4.0 (I4.0) has been a recurrent theme in the literature on Lean Six Sigma (LSS), given the synergies that can arise from their combination. However, several factors can affect the integration of I4.0 and LSS in practice. This article presents a systematic literature review of the barriers to integration and the critical success factors (i.e., enablers) involved in this process.
  • 1.6K
  • 28 Nov 2022
Topic Review
MiRNA-Encoded Peptide Discovery and Functions
microRNAs (MiRNAs) are small endogenous single-stranded RNAs (20 to 22 nucleotides) that are involved in post-transcriptional gene silencing in eukaryotes. They allow the downregulation of target genes by specifically triggering the degradation of their messenger RNAs (mRNAs) or by inhibiting their translation. Most plant species have several hundred annotated miRNA genes. miRNA primary transcripts were recently shown to contain functional short Open Reading Frames producing regulatory peptides called miRNA-encoded Peptides (miPEPs).
  • 1.6K
  • 13 Feb 2023
Topic Review
Sphingolipidoses
Sphingolipidoses are inborn errors of metabolism due to the pathogenic mutation of genes that encode for lysosomal enzymes, transporters, or enzyme cofactors that participate in the sphingolipid catabolism. They represent a subgroup of lysosomal storage diseases characterized by the gradual lysosomal accumulation of the substrate(s) of the defective proteins.
  • 1.6K
  • 30 Mar 2023
Topic Review
Treatment Wetlands in Natural Swimming Ponds
Natural swimming ponds using treatment wetlands (TWs) as an element of treatment of swimming water are an ecologically beneficial alternative to conventional pools. Unlike conventional swimming pools, in natural swimming ponds, the water treatment avoids the use of chemical methods and is based on the phenomenon of water self-purification and the rhizofiltration capacity of repository macrophytes in TWs of the regeneration zone, as well as on typical physical filtering processes (e.g., straining, sedimentation, or flotation), physicochemical filtration (physical and chemical adsorption, mainly of phosphorus), and biological filtration (nitrification and denitrification). 
  • 1.6K
  • 30 May 2023
Topic Review
Artificial Intelligence in Translational Medicine
Between preclinical and clinical research, translational research is benefitting from computer-based approaches like Artificial Intelligence, resulting in breakthroughs for advancing human health. 
  • 1.6K
  • 17 Dec 2021
Topic Review
Trends of Adolescent Substance Use in Macau
Substance use, including the use of tobacco, alcohol, and illicit drugs has been found to be associated with many health and social problems throughout the world. Adolescents are always more vulnerable to taking risks and engaging in unhealthy or delinquent behaviors, such as cigarette smoking, alcohol drinking, and using illicit drugs. Most of the research on adolescent substance use is from either the U.S, Europe, or other non-Eastern countries, but very little attention is paid to those in the Greater China Region. As a special administrative region of China, Macau is known for its gambling industry, its proximity to the Golden Triangle, and its lenient drug law, all of which can be conducive to high-level drug use in the population, including its adolescents. Among the key results, the rates of cigarette smoking and illicit drug use were low to moderate while the rates of alcohol use were relatively high; cigarette smoking decreased during the period, but alcohol use and illicit drug use remained stable; Macau adolescents shared similar risk factors for substance use with adolescents elsewhere, but unique circumstances might exist to influence their alcohol consumption.
  • 1.6K
  • 11 Jul 2022
Topic Review
Blending Pulse and Wheat Flours on Baked Goods
Bread is one of the most widely consumed foods in all regions of the world. Wheat flour being its principal ingredient is a cereal crop low in protein. The protein content of a whole grain of wheat is about 12–15% and is deficit in some essential amino acids, for example, lysine. Conversely, the protein and fibre contents of legume crops are between 20 and 35% and 15 and 35%, respectively, depending on the type and cultivar of the legume. The importance of protein-rich diets for the growth and development of body organs and tissues as well as the overall functionality of the body is significant. The addition of plant-based protein flours has been shown to produce an improved quality characteristic, especially the nutritional quality aspect of bread.
  • 1.6K
  • 07 Nov 2022
Topic Review
O-GlcNAcylation in Liver Metabolism
O-linked b-N-acetyl-glucosaminylation (O-GlcNAcylation) is a type of protein glycosylation. It was first reported in the 1980s, broadening the knowledge of protein modification by sugars. O-GlcNAcylation is characterized as a process of adding an O-linked b-N-acetylglucosamine (O-GlcNAc) molecule to the threonine or serine residues of nuclear, cytoplasmic, and mitochondrial proteins under enzymatic modulation.
  • 1.6K
  • 15 Feb 2023
Topic Review
Plant Growth Regulation in Cell and Tissue Culture
Precise knowledge of all aspects controlling plant tissue culture and in vitro plant regeneration is crucial for plant biotechnologists and their correlated industry, as there is increasing demand for such scientific knowledge, which results in more productive and resilient in vitro plant propagation and acclimatization in the field. Surprisingly, but so far, researchers/industry-based protocols on the 60-year-old concepts ignore new plant physiology achievements. Namely, high nitrogen and halogens used in the culture medium and exogenous auxin/cytokinin ratio regulate plant morphogenesis.
  • 1.6K
  • 05 Feb 2024
Topic Review
Bone Products Bioequivalence Study
An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate), 400 IU vitamin D3, 50 mg magnesium, 7.5 mg zinc, 1 mg copper, 75 μg molybdenum, 250 μg boron per two tablets) were compared to a clinically proven bone formulation (27 mg natural genistein, 400 IU cholecalciferol, 500 mg elemental calcium (calcium carbonate) per tablet; the Squadrito formulation) in an 8-day steady-state pharmacokinetic (PK) study of healthy postmenopausal women (n = 30) randomized to receive 54 mg of genistein per day. Trough serum samples were obtained before the final dose on the morning of the ninth day followed by sampling at 1, 2, 4, 6, 8, 10, 12, 24, 36, 48, 72, and 96 hrs. Total serum genistein, after β-glucuronidase/sulfatase digestion, was measured by time-resolved fluorometric assay. Maximal time (T max), concentration (C max), half-life (T 1/2), and area under the curve (AUC) were determined for genistein in each formulation. Fosteum and the Squadrito study formulation were equivalent for genistein T max (2 hrs), C max (0.7 μM), T 1/2 (18 ± 6.9 versus 21 ± 4.9 hrs), and AUC (9221 ± 413 versus 9818 ± 1370 ng·hr/mL). The OTC supplement's synthetically derived genistein, however, showed altered T max (6 hrs), C max (0.57 μM), T 1/2 (8.3 ± 1.9 hrs), and AUC (6474 ± 287 ng·hr/mL). Differences in uptake may be due to multiple ingredients in the OTC supplement which interfere with genistein absorption.
  • 1.6K
  • 01 Nov 2020
Topic Review
Pathogenesis of COVID-19
The systemic manifestations commonly observed in COVID-19 patients include hypertension, arterial and venous thromboembolism, kidney disease, cerebrovascular disorders, and diabetes mellitus). These clinical findings strongly suggest that the virus is targeting the endothelium. Here we report a systematic and comprehensive evaluation of the evidence showing that the endothelium is a key target organ in COVID-19, playing a fundamental role in its pathogenesis.
  • 1.6K
  • 30 Oct 2020
Topic Review
Machine Learning in Gastroenterology/Endoscopy
Over time, machine learning (ML), a component of artificial intelligence (AI), has been implemented in a variety of medical specialties, such as radiology, pathology, gastroenterology, neurology, obstetrics and gynecology, ophthalmology, and orthopedics, with the goal of improving the quality of healthcare and medical diagnosis. In clinical gastroenterology practice, due to technological developments, estimates show that AI could have the ability to create a predictive model; for instance, it could develop an ML model that can stratify the risk in patients with upper gastrointestinal bleeding, establish the existence of a specific gastrointestinal disease, define the best treatment, and offer prognosis and prediction of the therapeutic response. In this context, by applying ML or deep learning (DL) (AI using neural networks), clinical management in gastroenterology can begin to focus on more personalized treatment centered on the patient and based on making the best individual decisions, instead of relying mostly on guidelines developed for a specific condition. Moreover, the goal of implementing these AI-based algorithms is to increase the possibility of diagnosing a gastrointestinal disease at early stage or the ability to predict the development of a particular condition in advance. Because both AI and gastroenterology encompass many subdomains, the interaction between them might take on various forms. In recent years, we have witnessed a large explosion of research in attempts to improve various fields of gastroenterology, such as endoscopy, hepatology, inflammatory bowel diseases, and many others, with the aid of ML. We also note that, because of the requirement to diagnose more patients with gastrointestinal cancers at an early stage of the disease, which is associated with curative treatment and better prognosis, many studies were developed to address improvement of the detection of these tumors with the aid of AI. The term ML, introduced for the first time in 1959 by Arthur Samuel from the IBM company, refers to an IT domain whereby a computer system can acquire the ability to “learn” by using data without specific programming and can therefore develop a predictive mathematical algorithm based on input data, using recognition of “features”. The ML “model” is subsequently able to adapt to new situations in which it becomes able to predict and make decisions.
  • 1.6K
  • 02 Feb 2021
Topic Review
Protease-Activated Receptors
Protease-activated receptors (PARs) are a class of G protein-coupled receptors (GPCRs) with a unique mechanism of activation, prompted by a proteolytic cleavage in their N-terminal domain that uncovers a tethered ligand, which binds and stimulates the same receptor.
  • 1.6K
  • 20 Feb 2021
Topic Review
Food Waste Biorefinery
Food waste biorefineries for the production of biofuels, platform chemicals, and other bio-based materials can significantly reduce a huge environmental burden and provides opportunities for a sustainable way of chemical and material production.
  • 1.6K
  • 17 Jun 2021
Topic Review
Microbiome in Oil Reservoirs
Microorganisms inhabiting subsurface petroleum reservoirs are key players in biochemical transformations. The interactions of microbial communities in these environments are highly complex and still poorly understood. This work aimed to assess publicly available metagenomes from oil reservoirs and implement a robust pipeline of genome-resolved metagenomics to decipher metabolic and taxonomic profiles of petroleum reservoirs worldwide. We noticed that the oil reservoirs with a lower level of intervention were the most similar to the potential functional core, while the oil fields with a long history of water injection had greater variation in functional profile. These results show how key microorganisms and their functions respond to the distinct physicochemical parameters and interventions of the oil field operations such as water injection and expand the knowledge of biogeochemical transformations in these ecosystems.
  • 1.6K
  • 03 Sep 2021
Topic Review
Antioxidant Therapy in Cancer
Cancer is characterized by increased oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of metabolic disturbances and signaling aberrations, can promote carcinogenesis and malignant progression by inducing gene mutations and activating pro-oncogenic signaling, providing a possible rationale for targeting oxidative stress in cancer treatment.
  • 1.6K
  • 29 Jul 2022
Topic Review
Lead-Acid/Lithium-Ion Hybrid Battery Energy Storage System
The huge success of electric vehicles across the world is challenged by a lack of infrastructure and a major increase in battery material prices. This challenge positions internal combustion engine vehicles (ICEVs) to remain a vehicle of choice. The majority of these vehicles use a lead-acid battery (LAB) for starting, lighting, and ignition (SLI) functions.
  • 1.6K
  • 29 Jul 2022
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