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Topic Review
Hunger (Motivational State)
Hunger and satiety are sensations. Hunger represents the physiological need to eat food. Satiety is the absence of hunger; it is the sensation of feeling full. Appetite is another sensation experienced with eating; it is the desire to eat food. There are several theories about how the feeling of hunger arises. A healthy, well-nourished individual can survive for weeks without food intake, with claims ranging from three to ten weeks. The sensation of hunger typically manifests after only a few hours without eating and is generally considered to be unpleasant. Satiety occurs between 5 and 20 minutes after eating. Hunger is also the most commonly used term in social science and policy discussions to describe the condition of people who suffer from a chronic lack of sufficient food and constantly or frequently experience the sensation of hunger, and can lead to malnutrition.
  • 1.6K
  • 06 Dec 2022
Topic Review
Degradation Mechanisms of Bioactive Compounds
The bioactive compounds in fruits, vegetables, herbs, and spices are very vulnerable and can be easily degraded by different factors, including enzymes, thermal treatment, pH, oxidation, light, and/or hydrolysis. Some of the main examples of degradation reactions include: oxidation and hydrolysis of vitamin C, oxidation of phenols, flavonoids, glycosides and hydrolysis of esters. Therefore, actions taken for preventing such degradation are critically important not only for producers, but also for consumers, for whom the presence of these compounds is desirable for health-related requirements. In particular, the degradation of bioactive compounds during thermal treatment (e.g., blanching, pasteurization, sterilization and/or drying) represents a severe problem that must be tackled in the food industry. 
  • 1.6K
  • 21 Jun 2023
Topic Review
Methods Used for Activation of Silent Biosynthetic Genes
Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. Enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. Various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi were discussed.
  • 1.6K
  • 10 Oct 2023
Topic Review
Snap-Off during Imbibition in Porous Media
The phenomenon of snap-off during imbibition in porous media, a fundamental two-phase fluid flow phenomenon, plays a crucial role in both crude oil production and carbon dioxide (CO2) utilization and storage. In porous media where two phases coexist, the instability of the phase interface may give rise to various displacement phenomena, including pore–body filling, piston-like displacement, and snap-off. Snap-off, characterized by the generation of discrete liquid droplets or gas bubbles, assumes paramount significance. 
  • 1.6K
  • 27 Nov 2023
Topic Review
Accessibility and Sustainability in Context of Healthcare Platforms
A health platform is an IT system that provides a common infrastructure for delivering healthcare services. Organizations, including hospitals, clinics, home care providers, and governments, can use healthcare platforms. Examples of healthcare platforms include electronic health records (EHRs) and computer systems that store patients’ medical information, including health records, test results, and medications.
  • 1.6K
  • 01 Dec 2023
Topic Review
RET Receptor Tyrosine Kinase
Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances binds ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiation, survival, migration, and metabolism. RET plays a pivotal role in the development of both peripheral and central nervous systems. RET is expressed from early stages of embryogenesis and remains expressed throughout all life stages. Mutations either activating or inhibiting RET result in several aggressive diseases, namely cancer and Hirschsprung disease. However, the physiological ligand-dependent activation of RET receptor is important for the survival and maintenance of several neuronal populations, appetite, and weight gain control, thus providing an opportunity for the development of disease-modifying therapeutics against neurodegeneration and obesity. In this review, we describe the structure of RET, its signaling, and its role in both normal development as well as in developmental disorders. We highlight the differences in the signaling and outcomes of constitutive and ligand-induced RET activation. Finally, we review the data on recently developed small molecular weight RET agonists and their potential for the treatment of various diseases.
  • 1.6K
  • 26 Oct 2020
Topic Review
SARS-CoV-2 and RBPs
The outbreak of a novel coronavirus SARS-CoV-2 responsible for the COVID-19 pandemic has caused a worldwide public health emergency. Due to the constantly evolving nature of the coronaviruses, SARS-CoV-2-mediated alterations on post-transcriptional gene regulations across human tissues remain elusive. In this study, we analyzed publicly available genomic datasets to systematically dissect the crosstalk and dysregulation of the human post-transcriptional regulatory networks governed by RNA-binding proteins (RBPs) and micro-RNAs (miRs) due to SARS-CoV-2 infection. We uncovered that 13 out of 29 SARS-CoV-2-encoded proteins directly interacted with 51 human RBPs, of which the majority of them were abundantly expressed in gonadal tissues and immune cells. We further performed a functional analysis of differentially expressed genes in mock-treated versus SARS-CoV-2-infected lung cells that revealed enrichment for the immune response, cytokine-mediated signaling, and metabolism-associated genes. This study also characterized the alternative splicing events in SARS-CoV-2-infected cells compared to the control, demonstrating that skipped exons and mutually exclusive exons were the most abundant events that potentially contributed to differential outcomes in response to the viral infection. A motif enrichment analysis on the RNA genomic sequence of SARS-CoV-2 clearly revealed the enrichment for RBPs such as SRSFs, PCBPs, ELAVs, and HNRNPs, suggesting the sponging of RBPs by the SARS-CoV-2 genome. 
  • 1.6K
  • 09 Nov 2020
Topic Review
CRISPR-Based Technologies in Yeasts
CRISPR, a family of DNA sequences found in the genomes of bacteria and archaea. Compared with traditional genetic engineering methods and other gene-editing alternatives, CRISPR/Cas9 is described as efficient, easy-to-use, and able to target multiple sites, besides being “nature-made,” as bacteria have been using it for millions of years. CRISPR is being tested in vineyards and wineries to target some of wine’s biggest challenges. Therefore, CRISPR opens brand new doors for winemakers using commercial yeasts when it comes to efficiently produce target flavors and reducing harmful compounds and off-odors.
  • 1.6K
  • 04 Feb 2021
Topic Review
European Map Butterfly Araschnia levana
The European map butterfly (Araschnia levana) looks different in spring and summer due to day length and temperature. If the butterfly’s caterpillars receive at least 16 h of light per day, the resulting butterfly hatches a few weeks later in summer with blackish wings (f. prorsa). However, if caterpillars receive less than 15.5 h of daylight, many overwinter as pupae. The imagos emerging in the following spring, have predominantly organge wings with black spots (f. levana). This whole process is guided by hormones and epigenetics.
  • 1.6K
  • 16 Apr 2021
Topic Review
Synthesis of Organoclays
Organoclays are effective adsorbents, prepared by intercalation or surface grafting of clays and clay minerals with various organic compounds. Organoclays have important practical applications as adsorbents of a wide range of organic pollutants and some inorganic contaminants.
  • 1.6K
  • 06 Aug 2021
Topic Review
Diffuse Axonal Injury
Diffuse axonal injuries (DAI) are the result of strong rotational and translational forces on the brain parenchyma, leading to cerebral oedema and neuronal death. DAI is typically characterized by coma without focal lesions at presentation and is defined by localized axonal damage in multiple regions of the brain parenchyma, often causing impairment of cognitive and neuro-vegetative function.
  • 1.6K
  • 05 May 2022
Topic Review
Macrophage Migration Inhibitory Factor in Renal Inflammation
Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, the regulatory role and molecular mechanisms of MIF in kidney diseases will be focused on.
  • 1.6K
  • 29 Jun 2022
Topic Review
Sobi2
Sobi2 (formerly written as SOBI2) is the abbreviation of Sigsiu Online Business Index 2. Sobi2 is a free of charge open source web directory component and content construction kit (CCK) for the Joomla! content management system (CMS). Sobi2 is written in the programming language PHP, also makes use of Javascript and requires the MySQL database environment for storage. It is best suited for low to medium-level traffic web-sites. Sobi2's development has been discontinued in 2011, when its successor, SobiPro comes out. Sobi2 was listed in the Joomla! Extensions Directory until all extensions for Joomla! 1.5 were removed in 2013. The listing still can be found in the Web Archive. As a component for Joomla! (up to version 1.5), Sobi2 made it possible to run and manage a directory in a Joomla! website. Sobi2 has features that made it stand out from other directory components at that time. It could be used as a web directory or as a directory to physical locations, like golf courses. It has a built-in integration with Google Maps (API key from Google is required). Sobi2 was built with a modular concept, where additional functionality was added via plug-ins. The Joomla extensions directory listed over 80 plug-ins for Sobi2 at that time.
  • 1.6K
  • 25 Oct 2022
Topic Review
Sex Determination in Dioecious Agricultural Plants
Unlike in animals, dioecy among flowering plants is a rare phenomenon. The vast majority of angiosperm species have a bisexual flower that combines male (androecium) and female (gynoecium) reproductive organs. However, about a quarter of species have dioecious flowers, which can be located within the same plant (monoecious) or on different plants (dioecious). The development of sequencing techniques, bioinformatics, and molecular biology has led to an increase in interest in the sex determination mechanisms among plants. It is noteworthy that a significant number of dioecious plants have economic value. At the same time, dioeciousness often complicates the growing process. This fact increases the relevance of studies on dioecious crops.
  • 1.6K
  • 15 Mar 2023
Topic Review
The Fra-1/AP-1 Oncoprotein
Among components of the AP-1 complex, the FOS-family transcription factor Fra-1, encoded by FOSL1, has emerged as a prominent therapeutic target. Fra-1 is overexpressed in most solid tumors, in response to the BRAF-MAPK, Wnt-beta-catenin, Hippo-YAP, IL-6-Stat3, and other major oncogenic pathways. In vitro functional analyses, validated in onco-mouse models and corroborated by prognostic correlations, show that Fra-1-containing dimers control tumor growth and disease progression. Fra-1 participates in key mechanisms of cancer cell invasion, Epithelial-to-Mesenchymal Transition, and metastatic spreading, by driving the expression of EMT-inducing transcription factors, cytokines, and microRNAs.
  • 1.6K
  • 06 May 2023
Topic Review
Calcium and Vitamin D Supplementation for Periodontal Disease
Periodontal disease is a complex disease that involves an imbalance between the oral microbiota and an individual’s inflammatory response. Moreover, the inflammatory response contributes to further imbalance; if left untreated, periodontal disease may result in tooth loss. Vitamin D is intricately involved in the regulation of calcium–phosphate homeostasis and bone mineral metabolism; considering that periodontal surgery usually includes regenerative therapy, adequate vitamin D and calcium levels are essential.
  • 1.6K
  • 19 Jul 2022
Topic Review
Quantum Rayleigh Annihilation of Entangled Photons and Quantum Local Realism
The interpretation of published experimental results intended to prove the existence of a quantum phenomenon of non-locality involving photonic entangled states did not take into consideration the existence of the quantum Rayleigh conversion of photons in dielectric media. This phenomenon leads to the existence of high levels of correlations between two independent photonic and linearly polarized quantum states generated after the entangled photons have been absorbed through the quantum Rayleigh conversion. Both pure and mixed individual states of polarization result in expressions normally associated with entangled photonic states, providing support for the view that the physical reality of quantum non-locality is highly questionable.
  • 1.6K
  • 28 Oct 2020
Topic Review
Sleep Stages Detection Using DL
Sleep is vital for one’s general well-being, but is often neglected, which has led to an increase in sleep disorders worldwide. Indicators of sleep disorders, such as sleep interruptions, extreme daytime drowsiness, or snoring, can be detected with sleep analysis. However, sleep analysis relies on visuals conducted by experts, and is susceptible to inter- and intra-observer variabilities. One way to overcome these limitations is to support experts with a programmed diagnostic tool (PDT) based on artificial intelligence for timely detection of sleep disturbances. Artificial intelligence technology, such as deep learning (DL), ensures that data are fully utilized with low to no information loss during training.
  • 1.6K
  • 31 Jan 2021
Topic Review
Hydroxyapatite in Oral Care Products
Calcium phosphate compounds form the inorganic phases of our mineralised tissues such as bone and teeth, playing an important role in hard tissue engineering and regenerative medicine. In dentistry and oral care products, hydroxyapatite (HA) is a stable and biocompatible calcium phosphate with low solubility being used for various applications such as tooth remineralisation, reduction of tooth sensitivity, oral biofilm control, and tooth whitening. 
  • 1.6K
  • 08 Sep 2021
Topic Review
Gliotoxins
Gliotoxin is a kind of epipolythiodioxopiperazine derived from different fungi that is characterized by a disulfide bridge. Gliotoxins can be biosynthesized by a gli gene cluster and regulated by a positive GliZ regulator. Gliotoxins show cytotoxic effects via the suppression the function of macrophage immune function, inflammation, antiangiogenesis, DNA damage by ROS production, peroxide damage by the inhibition of various enzymes, and apoptosis through different signal pathways. In the other hand, gliotoxins can also be beneficial with different doses. Low doses of gliotoxin can be used as an antioxidant, in the diagnosis and treatment of HIV, and as an anti-tumor agent in the future. Gliotoxins have also been used in the control of plant pathogens, including Pythium ultimum and Sclerotinia sclerotiorum.
  • 1.6K
  • 23 Dec 2021
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