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Topic Review
Andean Blueberry
Andean blueberry (Vaccinium floribundum Kunth), also known as mortiño, is a promising wild berry of the family Ericaceae that grows spontaneously in the Andean regions of Ecuador. The demand for these small (~8 mm diameter), black, and round fruits has been increasing due to their antioxidant characteristic, similar to other Vaccinium species, such as cranberry, blueberry, or bilberry, mostly related to the high content of (poly) phenolic compounds.
  • 1.6K
  • 14 May 2021
Topic Review
Nanoremediation Technologies
Nanoremediation technologies involve the use of reactive NPs for the conversion and detoxification of contaminants. The main mechanisms for remediation by NPs are catalysis and chemical reduction. In addition, adsorption is another removal mechanism facilitated by the NPs since NPs have high surface-area-to-mass ratios and different distribution of active sites, increasing the adsorption ability.
  • 1.6K
  • 20 Aug 2021
Topic Review
3D Printing Building Envelope Prefabricated
The Fourth Industrial Revolution represents the beginning of a profound change for the building sector. In the last decade, the perspective of shapes, materials, and construction techniques is evolving fast due to the additive manufacturing technology. On the other hand, even if the technology is growing fast and several 3D printed buildings are being developed worldwide, the potential of concrete 3D printing in building prefabrication remains unexplored. Consequently, the application of new digital fabrication technologies in the construction industry requires a redesign of the construction process and its components. This paper proposes a novel conception, design, and prototyping of a precast building envelope to be prefabricated with extrusion-based 3D concrete printing (3DCP). 
  • 1.6K
  • 20 Aug 2021
Topic Review
Sustainable Agriculture through Multidisciplinary Seed
Nanopriming can be a potential future target for sustainable agriculture with the current global supply versus demand trend. A fortification program consists of adding vitamins and minerals to processed foods as a public health measure to improve the nutritional quality of the food supply. The goal is to enhance the nutrient intake by the population.
  • 1.6K
  • 26 Sep 2021
Topic Review
Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems
Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists’ interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. 
  • 1.6K
  • 18 Mar 2022
Topic Review
Neuroinflammation in Friedreich’s Ataxia
Friedreich’s ataxia (FRDA) is a rare genetic disorder caused by mutations in the gene frataxin, encoding for a mitochondrial protein involved in iron handling and in the biogenesis of iron−sulphur clusters, and leading to progressive nervous system damage.
  • 1.6K
  • 10 Jun 2022
Topic Review
Potential Mechanisms of Poly- and Perfluoroalkylated Substances Carcinogenesis
Poly- and perfluoroalkylated substances (PFAS) are chemicals that persist and bioaccumulate in the environment and are found in nearly all human populations through several routes of exposure. Human occupational and community exposure to PFAS has been associated with several cancers, including cancers of the kidney, testis, prostate, and liver.
  • 1.6K
  • 18 Jul 2022
Topic Review
STEAP1–4 and Prostate Cancer
Six-Transmembrane Epithelial Antigen of the Prostate 1–4 (STEAP1–4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. STEAP1–4 can be used as a biomarker and therapeutic target for prostate cancer.
  • 1.6K
  • 24 Aug 2022
Topic Review
Antibacterial Quinolones
The antibacterial quinolones (QNs) and further developed fluoroquinolones (FQNs) represent one of the most important classes of antimicrobial agents from many points of view: activity spectrum, administrations, and tissue distribution, being primarily used to fight bacterial infections.
  • 1.6K
  • 08 Sep 2022
Topic Review
Electrical Contacts
An electrical contact is an electrical circuit component found in electrical switches, relays, connectors and circuit breakers. Each contact is a piece of electrically conductive material, typically metal. When a pair of contacts touch, they can pass an electrical current with a certain contact resistance, dependent on surface structure, surface chemistry and contact time; when the pair is separated by an insulating gap, then the pair does not pass a current. When the contacts touch, the switch is closed; when the contacts are separated, the switch is open. The gap must be an insulating medium, such as air, vacuum, oil, SF6. Contacts may be operated by humans in push-buttons and switches, by mechanical pressure in sensors or machine cams, and electromechanically in relays. The surfaces where contacts touch are usually composed of metals such as silver or gold alloys that have high electrical conductivity, wear resistance, oxidation resistance and other properties.
  • 1.6K
  • 04 Nov 2022
Topic Review
Three Corpses
The sanshi 三尸 "Three Corpses" or sanchong 三蟲 "Three Worms" are a Daoist physiological belief that demonic creatures live inside the human body, and they seek to hasten the death of their host. These three supernatural parasites allegedly enter the person at birth, and reside in the three dantian "energy centers", respectively located within the head, chest, and abdomen. After their human host dies, they are freed from the body and become malevolent ghosts. The pernicious Three Corpses/Worms work to harm their host's health and fate by initiating sicknesses, inviting other disease-causing agents into the body, and reporting their host's transgressions to the gods. The Three Corpses are supposed to keep records of their host's misdeeds, ascend to tian "heaven" bimonthly on the night of Chinese sexagenary gengshen 庚申 "57th of the 60-day cycle" while the host is sleeping, and file reports to the Siming 司命 "Director of Destinies" who deducts a certain number of days from the person's life for each misdeed. One way of avoiding this bureaucratic snitching is to stay awake for the entire gengshen day and night, thus preventing the Three Corpses from leaving one's body (a belief later assimilated into the Japanese Kōshin 庚申 tradition). For a Daoist adept to achieve the longevity of a xian "transcendent; immortal", it was necessary to expel the Three Corpses from the body. Since these evil spirits feed upon decaying matter produced by grains being digested in the intestines, the practice of bigu "abstinence from grains and cereals" is the first step towards expelling them. Bigu alone will not eliminate the Three Corpses, but weakens them to the point where they can be killed with waidan alchemical drugs such as cinnabar, and ultimately eliminated through neidan meditation techniques.
  • 1.6K
  • 28 Nov 2022
Topic Review
Unsustainable Tourism Approaches in Touristic Destinations
Large investments made because of high tourism revenues in touristic destinations can threaten balanced growth, ecological sensitivity and sustainable tourism principles.
  • 1.6K
  • 26 Jan 2024
Topic Review
Phenolic Dyed Textile Fabrics
Textile dyeing is known to have major environmental concerns, especially with the high use of toxic chemicals. The use of alternatives such as natural dyes rich in phenolic compounds has become extremely appealing in order to move towards a more sustainable circular economy. Phenolic dyes have the potential to functionalize textile fabrics with properties such as antimicrobial, antioxidant, and UV protection.
  • 1.6K
  • 30 Nov 2023
Topic Review
Immune Checkpoint Inhibitor-Related Myositis
Immune checkpoint inhibitor (ICI)-related inflammatory diseases, including polymyositis (PM) and dermatomyositis (DM), in patients suffering from neoplastic disorders represent a medical challenge. The treatment of these conditions has taken on new urgency due to the successful and broad development of cancer-directed immunological-based therapeutic strategies. While primary and secondary PM/DM phenotypes have been pathophysiologically characterized, a rational, stepwise approach to the treatment of patients with ICI-related disease is lacking. In the absence of high-quality evidence to guide clinical judgment, the available data must be critically assessed. In this literature review, we examine partially neglected immunological and clinical findings to obtain insights into the biological profiles of ICI-related PM/DM and potential treatment options. We show that differential diagnosis is essential to stratifying patients according to prognosis and therapeutic impact. Finally, we provide a comprehensive assessment of druggable targets and suggest a stepwise patient-oriented approach for the treatment of ICI-related PM/DM.
  • 1.6K
  • 28 Oct 2020
Topic Review
TMCs, TMNs as LOB catalyst
A large volume of research on lithium–oxygen (Li–O2) batteries (LOBs) has been conducted in the recent decades, inspired by their high energy density and power density. However, these future generation energy-storage devices are still subject to technical limitations, including a squat round-trip efficiency and a deprived rate-capability, due to the slow-moving electrochemical kinetics of both the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) over the surface of the cathode catalyst. Because the electrochemistry of LOBs is rather complex, only a limited range of cathode catalysts has been employed in the past. To understand the catalytic mechanisms involved and improve overall cell performance, the development of new cathode electrocatalysts with enhanced round-trip efficiency is extremely important. In this context, transition metal carbides and nitrides (TMCs and TMNs, respectively) have been explored as potential catalysts to overcome the slow kinetics of electrochemical reactions.  
  • 1.6K
  • 23 Nov 2020
Topic Review
P53
While viewed as the “guardian of the genome”, the importance of the tumor suppressor p53 protein has increasingly gained ever more recognition in modulating additional modes of action related to cell death. Slowly but surely, its importance has evolved from a mutated genetic locus heavily implicated in a wide array of cancer types to modulating lysosomal-mediated cell death either directly or indirectly through the transcriptional regulation of the key signal transduction pathway intermediates involved in this. Taken with its ability to directly modulate mitochondrial outer-membrane permeabilization (and cell death) collectively highlights the complex role that this protein undertakes at the molecular level
  • 1.6K
  • 07 Dec 2020
Topic Review
Chronic Atrial and Intestinal Dysrhythmia
Chronic atrial and intestinal dysrhythmia (CAID) is a disorder affecting the heart and the digestive system.
  • 1.6K
  • 24 Dec 2020
Topic Review
Cytokines
Cytokines are key molecules within the tumor microenvironment (TME) that can be used as biomarkers to predict the magnitude of anti-tumor immune responses. During immune monitoring, it has been customary to predict outcomes based on the abundance of a single cytokine, in particular IFN-γ or TGF-β, as a readout of ongoing anti-cancer immunity. However, individual cytokines within the TME can exhibit dual opposing roles. For example, both IFN-γ and TGF-β have been associated with pro- and anti-tumor functions. Moreover, cytokines originating from different cellular sources influence the crosstalk between CD4+ and CD8+ T cells, while the array of cytokines expressed by T cells is also instrumental in defining the mechanisms of action and efficacy of treatments. Thus, it becomes increasingly clear that a reliable readout of ongoing immunity within the TME will have to include more than the measurement of a single cytokine.
  • 1.6K
  • 05 Apr 2021
Topic Review
Shiga Toxins
Shiga toxins (Stxs) are classic bacterial toxins and major virulence factors of toxigenic Shigella dysenteriae and enterohemorrhagic Escherichia coli (EHEC). These toxins recognize a glycosphingolipid globotriaosylceramide (Gb3/CD77) as their receptor and inhibit protein synthesis in cells by cleaving 28S ribosomal RNA. They are the major cause of life-threatening complications such as hemolytic uremic syndrome (HUS), associated with severe cases of EHEC infection, which is the leading cause of acute kidney injury in children.
  • 1.6K
  • 08 Apr 2021
Topic Review
Chronic Dialysis Patients and Creatine
Creatine is a natural nitrogenous organic acid that is integral to energy metabolism, and is crucial for proper cell functioning [8,9]. Creatine can be charged to the high-energy product phosphocreatine by creatine kinase and ATP. In the human body, the majority of creatine (>90%) is present in skeletal muscle, cardiac muscle, smooth muscle, the brain, and in the nervous tissue. Furthermore, smaller amounts are present in other tissues and cell types, including the kidney, erythrocytes, and leucocytes.
  • 1.6K
  • 20 Aug 2021
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