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Topic Review
Pulsed Laser Ablation in Liquid for Gold Nanoparticle
The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose.  The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle.
  • 1.7K
  • 16 May 2022
Topic Review
History of Rheumatic Fever/ Rheumatic Heart Disease Control
Rheumatic heart disease and rheumatic fever (RHD/RF) contributed to a substantial health burden upon the entire globe in the 19th and 20th centuries. As advances in public health improved throughout regions of the world now considered to be high-income countries (HICs), it was largely eradicated in these settings. Regrettably, RHD/RF remain endemic in low- and middle-income countries (LMICs). The historical context within which RHD/RF control was achieved in HICs may be of interest to researchers and policymakers active in the resurgent interest in RHD/RF seen in the prior two decades.
  • 1.7K
  • 17 May 2022
Topic Review
Human Diseases with Mutations in the BRPF1-KAT6A/KAT6B Complex
The bromodomain and PHD finger–containing protein1 (BRPF1) is a member of family IV of the bromodomain-containing proteins that participate in the post-translational modification of histones. Patients with BRPF1 mutations often display intellectual disability or suffer from leukemia or medulloblastoma. BRPF1 is an activator and a scaffold protein of a multiunit complex, with other members being KAT6A/KAT6B, the inhibitor of growth 5 (ING5) or ING4 and MYST/Esa1-associated factor 6 (MEAF6). 
  • 1.7K
  • 09 Sep 2022
Topic Review
Mechanisms of Microbial Biostimulant Action
Sustainable farming of horticultural plants has been the focus of research during the last decade, paying significant attention to alarming weather extremities and climate change, as well as the pressure of biotic stressors on crops. Microbial biostimulants, including plant growth-promoting bacteria (PGPB) and arbuscular mycorrhizal fungi (AMF), have been proven to increase plant growth via both direct and indirect processes, as well as to increase the availability and uptake of nutrients, boosting soil quality, increasing plants’ tolerance to abiotic stress and increasing the overall quality attributes of various horticultural crops (e.g., vegetables, fruit, herbs). The positive effects of microbial biostimulants have been confirmed so far, mostly through symbiotic interactions in the plant–soil–microbes ecosystem, which are considered a biological tool to increase quality parameters of various horticultural crops as well as to decrease soil degradation. 
  • 1.7K
  • 21 Feb 2023
Topic Review
CRISPR/Cas-Based Cell Therapy for Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of insulin-producing β-cells in the pancreas by cytotoxic T-cells. To date, there are no drugs that can prevent the development of T1D. Insulin replacement therapy is the standard care for patients with T1D. This treatment is life-saving, but is expensive, can lead to acute and long-term complications, and results in reduced overall life expectancy. This has stimulated the research and development of alternative treatments for T1D. In this research, potential therapies for T1D are considered using cellular regenerative medicine approaches with a focus on CRISPR/Cas-engineered cellular products. However, CRISPR/Cas as a genome editing tool has several drawbacks that should be considered for safe and efficient cell engineering. In addition, cellular engineering approaches themselves pose a hidden threat. The purpose of this research is to critically discuss novel strategies for the treatment of T1D using genome editing technology. 
  • 1.7K
  • 26 Dec 2023
Topic Review
Deep Eutectic Systems as Alternative Solvents
Chemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. 
  • 1.7K
  • 28 Feb 2024
Topic Review
Languages, Dialects and Educational Achievement
This item focuses on the development of usage of Standard Dutch versus regional languages and dialects. It also explores the relation between language choice and language and mathematics test performance of young children. Data were collected in 2014 and the sample analyzed included 3,639 grade 2 pupils from 437 Dutch primary schools. The results of the present analyses were compared with those from analyses performed on similar data collected twenty years earlier, in 1994. Findings show that there has been dramatic decline in usage of regional languages and dialects. No correlation was found between language choice and language and mathematic test performance.  
  • 1.7K
  • 18 Nov 2020
Topic Review
Ransomware Detection, Avoidance, and Mitigation Scheme
Ransomware attacks have emerged as a major cyber-security threat wherein user data is encrypted upon system infection. Latest Ransomware strands using advanced obfuscation techniques along with offline C2 Server capabilities are hitting Individual users and big corporations alike. This problem has caused business disruption and, of course, financial loss. 
  • 1.7K
  • 13 Jan 2022
Topic Review
Cohesive Sediment Transport in River Systems
Mathematical modelling of cohesive sediment transport is a challenge because of the large number of governing parameters controlling the transport processes. These parameters have to be determined using a rotating circular flume for site specific sediments. The parameters that that need to be determined using a rotating circular flume during the application of the RIVFLOC model to different river systems include the critical shear stress for erosion of the cohesive sediment, critical shear stress for deposition according to the definition of Partheniades, critical shear stress for deposition according to the definition of Krone, the cohesion parameter governing the flocculation of cohesive sediment and a set of empirical parameters that define the density of the floc in terms of the size of the flocs. An examination of the variability of these parameters shows the need for testing site-specific sediments using a rotating circular flume to achieve a reliable prediction of the RIVFLOC model. Application of the model to various river systems has highlighted the need for including the entrapment process in a cohesive sediment transport model.
  • 1.7K
  • 28 Jan 2022
Topic Review
Sugar Beet N Fertilization Management
Sugar beet fertilization is a very complex agrotechnical measure for farmers. The main reason is that technological quality is equally important as sugar beet yield, but the increment of the root yield does not follow the root quality. Technological quality implies the concentration of sucrose in the root and the possibility of its extraction in the production of white table sugar. The great variability of agroecological factors that directly affect root yield and quality are possible good agrotechnics, primarily by minimizing fertilization. It should be considered that for sugar beet, the status of a single plant available nutrient in the soil is more important than the total amounts of nutrients in the soil. Soil analysis will show us the amount of free nutrients, the degree of soil acidity and the status of individual elements in the soil so that farmers can make a compensation plan. An estimate of the mineralizing ability of the soil, the N min, is very important in determining the amount of mineral nitrogen that the plant can absorb for high root yield and good technological quality.
  • 1.7K
  • 29 Apr 2022
Topic Review
Intrusive Thought
An intrusive thought is an unwelcome, involuntary thought, image, or unpleasant idea that may become an obsession, is upsetting or distressing, and can feel difficult to manage or eliminate. When such thoughts are associated with obsessive-compulsive disorder (OCD), depression, body dysmorphic disorder (BDD), and sometimes attention-deficit hyperactivity disorder (ADHD), the thoughts may become paralyzing, anxiety-provoking, or persistent. Intrusive thoughts may also be associated with episodic memory, unwanted worries or memories from OCD, post-traumatic stress disorder, other anxiety disorders, eating disorders, or psychosis. Intrusive thoughts, urges, and images are of inappropriate things at inappropriate times, and generally have aggressive, sexual, or blasphemous themes.
  • 1.7K
  • 10 Nov 2022
Topic Review
The Cytoskeleton of Contractile Vascular Smooth Muscle Cell
As a key element of the smooth muscle cell contractile apparatus, the actin cytoskeleton participates in the development of force by acting as a molecular track for the myosin cross bridge motor. At the same time, the actin cytoskeleton must transmit the force developed during contraction to the extracellular matrix and, thus, to neighboring cells. This propagation of force to the cell periphery and beyond is initiated in part on specifically localized cellular cortical actin filaments also involved in mechano-chemical transduction. During the contractile process itself and in response to extracellular structural and chemical alterations, the smooth muscle actin cytoskeletal remodels. This indicates that the cytoskeleton is a dynamic cellular organelle that adapts to the changes in cell shape and chemical cues.
  • 1.7K
  • 13 May 2022
Topic Review
Mueller Matrix Polarimetry in Biological and Agricultural Diagnostics
The Mueller matrix (4 × 4) most fully describes the interaction of an arbitrary object with fully or partially polarized electromagnetic radiation; therefore, the existing polarimetric methods can be generalized by the Mueller matrix formalism, and that generalization is termed Mueller matrix polarimetry (MMP). Mueller matrix measurements, being integrated into standard schemes of conventional optical methods, such as scatterometry, optical coherence tomography, fluorimetry, spectrophotometry and reflectometry, can significantly expand their capabilities in the characterization of biological systems and bioorganic materials.
  • 1.7K
  • 20 Jun 2022
Topic Review
Oxidative Stress in Chronic Obstructive Pulmonary Disease
Since chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, a specific anti-inflammatory therapy for this disease has not been established yet. Oxidative stress is recognized as a major predisposing factor to COPD related inflammatory responses, resulting in pathological features of small airway fibrosis and emphysema. 
  • 1.7K
  • 06 Feb 2023
Topic Review
Fascin
Fascin, an actin-binding protein, regulates many developmental migrations and contributes to cancer metastasis.
  • 1.7K
  • 21 Jan 2021
Topic Review
Foraminiferal EcoQS Assessment, Transitional Waters
Transitional waters straddle the interface between marine and terrestrial biomes and, among others, include fjords, bays, lagoons, and estuaries. These coastal systems are essential for transport and manufacturing industries and suffer extensive anthropogenic exploitation of their ecosystem services for aquaculture and recreational activities. These activities can have negative effects on the local biota, necessitating investigation and regulation. As a result of this, EcoQS (ecological quality status) assessment has garnered great attention as an essential aspect of governmental bodies’ legislative decision-making process. Assessing EcoQS in transitional water ecosystems is problematic because these systems experience high natural variability and organic enrichment and often lack information about their pre-human impact, baseline, or “pristine” reference conditions, knowledge of which is essential to many commonly used assessment methods. Here, foraminifera can be used as environmental sentinels, providing ecological data such as diversity and sensitivity, which can be used as the basis for EcoQS assessment indices. Fossil shells of foraminifera can also provide a temporal aspect to ecosystem assessment, making it possible to obtain reference conditions from the study site itself. These foraminifera-based indices have been shown to correlate not only with various environmental stressors but also with the most common macrofaunal-based indices currently employed by bodies such as the Water Framework Directive (WFD).
  • 1.7K
  • 28 Jul 2021
Topic Review
‘Chen Xi’ Rose
Flower color is one of the most prominent traits of rose flowers and determines their ornamental value. The ‘Chen Xi’ variety of rose has a very beautiful flower showing color changes during the blooming, which contributes a lot to its ornamental value. 
  • 1.7K
  • 22 Oct 2021
Topic Review
Marine Collagen
Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water-soluble, metabolically compatible, and highly accessible. 
  • 1.7K
  • 29 Mar 2022
Topic Review
Immunotherapy-Based Treatment Strategy for Autoimmune Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells by their own immune system, resulting in lifelong insulin deficiency. Continuous exogenous insulin replacement therapy is the current standard of care for T1D. Transplantation of primary pancreatic islets or the entire pancreas is a viable remedy for managing patients with autoimmune T1D. However, this strategy is not feasible due to several obstacles, including a scarcity of donors, islet cells, and poor vascular engraftment of islets post-transplantation, as well as the need for prolonged immune suppression. 
  • 1.7K
  • 18 Feb 2022
Topic Review
Historic Churches and Their Hygrothermal Environment
Historic churches are a class of building which embody significant cultural heritage; as a result, they are historically listed in recognition of the contribution they make to the built environment Simple on/off space heating systems are installed in many churches to increase human comfort. However, the conservation of the important historic artefacts and artwork contained within may not have been fully considered. 
  • 1.7K
  • 21 Jul 2022
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