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Topic Review
Structure of G Domain among G Proteins
The ancient guanine nucleotide-binding (G) proteins are a group of critical regulatory and signal transduction proteins, widely involved in diverse cellular processes of all kingdoms of life. YchF is a kind of universally conserved novel unconventional G protein that appears to be crucial for growth and stress response in eukaryotes and bacteria. YchF is able to bind and hydrolyze both adenine nucleoside triphosphate (ATP) and guanosine nucleoside triphosphate (GTP), unlike other members of the P-loop GTPases.
  • 1.7K
  • 04 May 2023
Topic Review
Plant Extracts as Skin Care and Therapeutic Agents
Natural ingredients have been used for centuries for skin treatment and care. Interest in the health effects of plants has recently increased due to their safety and applicability in the formulation of pharmaceuticals and cosmetics. Long-known plant materials as well as newly discovered ones are increasingly being used in natural products of plant origin. 
  • 1.7K
  • 19 Jan 2024
Topic Review Peer Reviewed
The Prosumer
In recent years, the concept of the prosumer has garnered extensive attention across various fields, including marketing, energy consumption, and innovation research. This attention is driven by the significant role prosumers play in developing more efficient, sustainable, and health-conscious market systems, propelled by advancements in social and technological domains. Broadly defined, a prosumer is an individual who acts as both a producer and a consumer. Originally coined by Toffler in the 1980s, the term describes individuals who blur the lines between producers and consumers by engaging in the creation of value for their own use or for others. Prosumers are seen as external partners who participate in co-creation processes with organizations, contributing to innovative outcomes and the production of the products and services they consume. The concept of the prosumer, individuals who simultaneously act as producers and consumers, has gained significant attention across various sectors. This entry explores the evolving role and impact of prosumers on sustainability, innovation, and market dynamics. A comprehensive literature review and empirical analysis were conducted to understand prosumer behavior and contributions. The findings reveal that the prosumers’ roles range from significantly enhancing sustainability by generating renewable energy to promoting personalized education via teacher–prosumer models. They also drive technological advancements in fields such as 3D printing and cryptocurrency. The study concludes that prosumers have the potential to foster a more resilient and inclusive economy, although challenges such as regulatory barriers and technological dependencies must be addressed to fully leverage their contributions.
  • 1.7K
  • 06 Sep 2024
Topic Review
Fibrodysplasia ossificans progressiva (FOP)
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare heritable disorder of connective tissues characterized by progressive heterotopic ossification in various skeletal sites.
  • 1.7K
  • 28 Sep 2020
Topic Review
Entomopathogen Isolation
Microbes that cause infections amongst insects leading to death or serious disabilities are known as entomopathogens. Entomopathogenic bacteria and fungi are quite frequently found in soils and insect cadavers. The first step in utilizing these microbes as biopesticides is to isolate them, and several culture media and insect baiting procedures have been tested in this direction. In this work, the authors review the current techniques that have been developed so far, in the last five decades, and display brief protocols which can be adopted for the isolations of these entomopathogens. Among bacteria, this study focuses on Serratia spp. and bacteria from the class Bacilli. Among fungi, the review focuses those from the order Hypocreales, for example, genera Beauveria, Clonostachys, Lecanicillium, Metarhizium, and Purpureocillium. The authors chose these groups of entomopathogenic bacteria and fungi based on their importance in the microbial biopesticide market.
  • 1.7K
  • 13 Jan 2021
Topic Review
Contaminants of Emerging Concern
Worldwide, the pollution of water bodies by contaminants of emerging concern (CECs) such as pharmaceuticals, endocrine disrupting compounds, flame retardants including brominated flame retardants (BFRs) and perfluorochemicals (PFCs), microplastics, nanomaterials, and algal toxins, to name just a few, is creating a new set of challenges to the conventional wastewater treatment facilities, which demonstrate inefficiency in removing/degrading many CECs. As a consequence, environmentalists started to detect the presence of some of those contaminants at alarming levels in certain countries, with possible negative effects on aquatic species and often increased potential for human health risks through exposure to the contaminated waters, or the reuse of treated wastewater in agriculture and household use. Such issues are more accentuated in the African continent due to various socio-economic problems giving rise to poor sanitation systems and serious shortages in wastewater treatment plants in many regions, making it difficult to tackle the problem of conventional pollutants, let alone to deal with the more challenging CECs. Thus, in order to effectively deal with this emerging environmental threat, African researchers are working to develop and optimize sound sampling and analytical procedures, risk assessment models, and efficient remediation technologies.
  • 1.7K
  • 06 Sep 2021
Topic Review
Cold Plasma Systems for Medicine
Plasma is the predominant state of matter in the known universe (it is estimated that up to 99% of matter is plasma), although not on our planet, where the conditions of pressure and temperature make normal the states of matter—solid, liquid, and gas—that in global terms are exotic.  If we add energy to a gas, we will partially or totally ionize it. In this way, we reach a new state of matter, plasma, made up of free electrons, atoms and molecules (electrically neutral particles), and ions. The energy needed to generate plasma can be supplied through electrical discharges in gases, in which free electrons take energy field and lose it through excitation and ionization processes of the atoms and molecules in the gas. The interaction of a plasma with a surface, either solid, liquid or belonging to a live system, is a complex process involving many different active species and reactions. The use of cold plasma for medical applications is at present in the rise as it has been proven as a powerful therapeutic tool for healing, desinfection  and surface functionalization
  • 1.7K
  • 01 Apr 2021
Topic Review
MSWI-BA in Cement-based Materials Review
Waste management is a vital environmental issue in the world today. Municipal solid wastes (MSWs) are discarded in huge quantities on a daily basis and need to be well controlled. Incineration is a common method for reducing the volume of these wastes, yet it produces ashes that require further assessment. Municipal solid waste incineration bottom ash (MSWI-BA) is the bulk byproduct of the incineration process and has the potential to be used in the construction sector
  • 1.7K
  • 08 May 2021
Topic Review
Mycobacterium Tuberculosis Complex
The Mycobacterium tuberculosis complex (MTBC) is a group of bacteria that cause tuberculosis (TB) in diverse hosts, including captive and free-ranging wildlife species. There is significant research interest in developing immunodiagnostic tests for TB that are both rapid and reliable, to underpin disease surveillance and control.
  • 1.7K
  • 04 Aug 2021
Topic Review
Defects and Heteroatoms and Supported Graphene Layers
The possibility of using graphene-based materials as “metal-free” catalysts is attracting enormous interest, since it reduces the need for precious or rare elements currently used in heterogeneous catalysis. However, free standing  and perfect graphene is known to be “perfectly inert”, while it is now well established that there is an essential role of defects and dopants in activating its chemical properties.
  • 1.7K
  • 02 Apr 2022
Topic Review
Structural/Phylogenetic Analysis of SARS-CoV-2 Spike Glycoprotein Variants
The SARS-CoV-2 pandemic, reported for the first time at the end of 2019 in the city of Wuhan (China), has spread worldwide in three years; it lead to the infection of more than 500 million people and about six million dead. SARS-CoV-2 has proved to be very dangerous for human health. Therefore, several efforts have been made in studying this virus. In a short time, about one year, the mechanisms of SARS-CoV-2 infection and duplication and its physiological effect on human have been pointed out. Moreover, different vaccines against it have been developed and commercialized. Since the beginning of the pandemic, SARS-CoV-2 has evolved; it has done so by accumulating mutations in the genome, generating new virus versions showing different characteristics, and which have replaced the pre-existing variants. In general, it has been observed that the new variants show an increased infectivity and cause milder symptoms. The latest isolated Omicron variants contain more than 50 mutations in the whole genome and show an infectivity 10-folds higher compared to the wild-type strain. 
  • 1.7K
  • 05 Sep 2022
Topic Review
The Chemistry of Reactive Oxygen Species Revisited
Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role in cellular signaling and regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing ROS becomes pathological and leads to oxidative stress and disease. The induction of oxidative stress is an imbalance between the production of radical species and the antioxidant defense systems, which can cause damage to cellular biomolecules, including lipids, proteins and DNA. Cellular and biochemical experiments have been complemented in various ways to explain the biological chemistry of ROS oxidants. However, it is often unclear how this translates into chemical reactions involving redox changes. 
  • 1.7K
  • 30 Sep 2022
Topic Review
Aphelion
The Aphelion Imaging Software Suite is a software suite that includes three base products - Aphelion Lab, Aphelion Dev, and Aphelion SDK for addressing image processing and image analysis applications. The suite also includes a set of extension programs to implement specific vertical applications that benefit from imaging techniques. The Aphelion software products can be used to prototype and deploy applications, or can be integrated, in whole or in part, into a user's system as processing and visualization libraries whose components are available as both DLLs or .Net components.
  • 1.7K
  • 27 Oct 2022
Biography
Robert J. Lang
Robert J. Lang (born May 4, 1961) is an United States physicist who is also one of the foremost origami artists and theorists in the world. He is known for his complex and elegant designs, most notably of insects and animals. He has studied the mathematics of origami and used computers to study the theories behind origami. He has made great advances in making real-world applications of origami t
  • 1.7K
  • 21 Nov 2022
Topic Review
September 1859 Geomagnetic Storm
The September 1859 geomagnetic storm (also known as the Carrington Event) was a powerful geomagnetic storm during solar cycle 10 (1855–1867). A solar coronal mass ejection (CME) hit Earth's magnetosphere and induced the largest geomagnetic storm on record on September 1–2, 1859. The associated "white light flare" in the solar photosphere was observed and recorded by British astronomers Richard C. Carrington and Richard Hodgson. The storm caused strong auroral displays and wrought havoc with telegraph systems. The now-standard unique IAU identifier for this flare is SOL1859-09-01. A solar storm of this magnitude occurring today would cause widespread electrical disruptions, blackouts and damage due to extended outages of the electrical grid. The solar storm of 2012 was of similar magnitude, but it passed Earth's orbit without striking the planet, missing by nine days.
  • 1.7K
  • 21 Nov 2022
Topic Review
A Promising Downsampling Alternative in a Neural Network
Downsampling, which aims to improve computational efficiency by reducing the spatial resolution of feature maps, is a critical operation in neural networks. Upsampling also plays an important role in neural networks. It is often used for image super-resolution, segmentation, and generation tasks via the reconstruction of high-resolution feature maps during the decoding stage in the neural network.
  • 1.7K
  • 04 Dec 2023
Topic Review
Aha! In perceptual Experience and Problem-Solving Cognition
The Gestalt psychologists’ theory of insight problem-solving was based on a direct parallelism between perceptual experience and higher-order forms of cognition (e.g., problem-solving). Similarly, albeit not exclusively, to the sudden recognition of bistable figures, these psychologists contended that problem-solving involves a restructuring of one’s initial representation of the problem’s elements, leading to a sudden leap of understanding phenomenologically indexed by the “Aha!” feeling. Over the last century, different scholars have discussed the validity of the Gestalt psychologists’ perspective, foremost using the behavioral measures available at the time. However, scientists have gained a deeper understanding of insight problem-solving due to the advancements in cognitive neuroscience.
  • 1.7K
  • 29 Dec 2023
Topic Review
Highway-rail grade crossing (HRGC) accidents
Highway-rail grade crossing (HRGC) accidents pose a serious risk of safety to highway users, including pedestrians trying to cross HRGCs. A significant increase in the number of HRGC accidents globally calls for greater research efforts, which are not limited to the analysis of accidents at HRGCs but also understanding user perception, driver behavior, potential conflicting areas at crossings, effectiveness of countermeasures and user perception towards them. HRGC safety is one of the priority areas in the State of Florida, since the state HRGCs experienced a total of 429 injuries and 146 fatalities between 2010 and 2019 with a significant increase in HRGC accidents over the last years.
  • 1.7K
  • 15 Aug 2021
Topic Review
Nanocellulose from Agricultural Wastes
Nanocellulose-based composites are characterized for being highly biocompatible and scarcely toxic, which are the the major reasons for its use in numerous biomedical applications. Incorporation of nanocellulose to drug delivery systems could control both the manner drugs are released and the interactions with target molecules, thus increasing the effectiveness of drug administration. Changes on nanocellulose surface must be carried out to link drugs, non-ionic chemicals with hydrophobic character, to the nanopolymer.
  • 1.7K
  • 18 Sep 2021
Topic Review
Emergency Department Overcrowding
It is certain and established that overcrowding represents one of the main problems that has been affecting global health and the functioning of the healthcare system in the last decades, and this is especially true for the emergency department (ED). Since 1980, overcrowding has been identified as one of the main factors limiting correct, timely, and efficient hospital care. The more recent COVID-19 pandemic contributed to the accentuation of this phenomenon, which was already well known and of international interest.
  • 1.7K
  • 23 Feb 2022
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