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Topic Review
Myeloid Neoplasms
Myeloid neoplasms encompass a very heterogeneous family of diseases characterized by the failure of the molecular mechanisms that ensure a balanced equilibrium between hematopoietic stem cells (HSCs) self-renewal and the proper production of differentiated cells. The origin of the driver mutations leading to preleukemia can be traced back to HSC/progenitor cells. Many properties typical to normal HSCs are exploited by leukemic stem cells (LSCs) to their advantage, leading to the emergence of a clonal population that can eventually progress to leukemia with variable latency and evolution. In fact, different subclones might in turn develop from the original malignant clone through accumulation of additional mutations, increasing their competitive fitness. This process ultimately leads to a complex cancer architecture where a mosaic of cellular clones—each carrying a unique set of mutations—coexists. The repertoire of genes whose mutations contribute to the progression toward leukemogenesis is broad. It encompasses genes involved in different cellular processes, including transcriptional regulation, epigenetics (DNA and histones modifications), DNA damage signaling and repair, chromosome segregation and replication (cohesin complex), RNA splicing, and signal transduction. Among these many players, transcription factors, RNA splicing proteins, and deubiquitinating enzymes are emerging as potential targets for therapeutic intervention. 
  • 1.7K
  • 23 Aug 2021
Topic Review
The Role of Flavonoids in Plant Terrestrialization
Plants evolved an impressive arsenal of specialized metabolites to cope with the novel environmental pressures imposed by the terrestrial habitat when moving from water. Flavonoids are maybe the most important specilized metabolites that show multifarious roles in the sucess of plant terrestrialization. These compounds modulated auxin transport and signaling and promoted the symbiosis between plants and fungi (e.g., arbuscular mycorrhizal, AM), a central event for the conquest of land by plants. AM improved the ability of early plants to take up nutrients and water from highly impoverished soils. Therefore, flavonoids were essential to plant development in the “new world” scarce of water and nutrients.
  • 1.7K
  • 30 May 2022
Topic Review
(594913) 2020 AV2
(594913) 2020 AV2, provisionally designated: 2020 AV2, is a large near-Earth asteroid discovered by the Zwicky Transient Facility on 4 January 2020. It is the first asteroid discovered to have an orbit completely within Venus's orbit, and is thus the first and only known member of the inner-Venusian provisionally-named Vatira population of Atira-class asteroids. 2020 AV2 has the smallest known aphelion and third-smallest known semi-major axis among all asteroids. With an absolute magnitude approximately 16.2, the asteroid is expected to be larger than 1 km in diameter.
  • 1.7K
  • 21 Oct 2022
Topic Review
Boreout
Boredom boreout syndrome is a psychological disorder that causes physical illness, mainly caused by mental underload at the workplace due to lack of either adequate quantitative or qualitative workload. One reason for boreout could be that the initial job description does not match the actual work. This theory was first expounded in 2007 in Diagnose Boreout, a book by Peter Werder and Philippe Rothlin, two Switzerland business consultants.
  • 1.7K
  • 25 Nov 2022
Topic Review
Extraction Techniques of Bioactive Compounds
Fruit wastes and/or by-products that food agro-industries accumulate are typically made up of underutilized residual biomasses that are rich in various bioactive functional components. Fruit wastes have been researched for the extraction of phenolic compounds, dietary fibers, and other bioactive substances, as they are rich sources of phytochemicals. Fruit and vegetable wastes from the agri-food sector are produced in enormous quantities and, due to their high moisture content and microbial load, can lead to significant environmental damage. Bioactive components could degrade quickly, even with the slightest alterations in extraction techniques. Therefore, it is necessary to ensure conditions that will stabilize the bioactive components before and after extraction. Choosing an appropriate optimized extraction technique is critical as it decides the final quality of the bioactive compound.
  • 1.7K
  • 26 May 2023
Topic Review
Thyroid Hormone Signaling
Thyroid hormones (TH) perform a plethora of actions in numerous tissues and induce an overall increase in metabolism, with an augmentation in energy demand and oxygen expenditure. Oxidants are required for normal thyroid-cell proliferation, as well as for the synthesis of the main hormones secreted by the thyroid gland, triiodothyronine (T3) and thyroxine (T4). 
  • 1.7K
  • 16 Jun 2023
Topic Review
Lupus
Lupus, the Latin word for "wolf," is a constellation located in the southern celestial hemisphere. Representing a wolf, it was one of the 48 constellations listed by Ptolemy, and is one of the 88 modern constellations recognized by the International Astronomical Union.
  • 1.7K
  • 15 Mar 2024
Topic Review
Stellar Chromospheric Variability
Chromospheric (magnetic) activity is evidence of the presence of strong and variable magnetic fields. Magnetically active chromospheres are predominantly found in cool stars with convective envelopes of spectral types F and later. Day- to year-long variability is associated with the evolution and rotational modulation of individual magnetically active regions.
  • 1.7K
  • 12 Jan 2022
Topic Review
Glutathione System from Cyanobacteria to Higher Eukaryotes
From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L-glutamyl-L-cysteinyl-glycine nucleophile tri-peptide, is the central player of this system that acts in redox homeostasis, detoxification and iron metabolism in most living organisms. GSH directly scavenges diverse reactive oxygen species (ROS), such as singlet oxygen, superoxide anion, hydrogen peroxide, hydroxyl radical, nitric oxide and carbon radicals. It also serves as a cofactor for various enzymes, such as glutaredoxins (Grxs), glutathione peroxidases (Gpxs), glutathione reductase (GR) and glutathione-S-transferases (GSTs), which play crucial roles in cell detoxication.
  • 1.7K
  • 08 Jun 2023
Topic Review
Age-Related Diseases
Aging is a multifactorial dynamic process that is influenced by a variety of external and internal variables, including environmental, demographic, and biopsychosocial factors, to determine the development and progression of age-related diseases, rather than being a solely static intrinsic process of cellular alterations.
  • 1.7K
  • 15 Apr 2021
Topic Review
Mineral Physics
Mineral physics is the study of mineralogical problems through the application of condensed matter physics and solid-state chemistry.  
  • 1.7K
  • 31 May 2021
Topic Review
Agastache mexicana
Mexico is the center of origin of the species popularly known as toronjil.  its use and commercialization for traditional Mexican medicine make it the most important member of the Agastache genus in Mexico. The species Agastache mexicana divides into two subspecies, based on anatomical characteristics and chemical composition: red lemon balm, Agastache mexicana Linton & Epling subspecies mexicana, and white toronjil, Agastache mexicana subspecies xolocotziana Bye, E.L. Linares & Ramamoorthy.
  • 1.7K
  • 22 Nov 2021
Topic Review
GLUT1
Glut1 is the main glucose transporter for glucose uptake and is expressed in nearly all mammalian cells. Glut1 is encoded by the Slc2a1 gene, and consists of a sugar-binding pocket facing the outer cell in the outward open conformation. Binding of glucose causes a conformational change so that Glut1 opens into the cytoplasm and release glucose inside the cell.  Glut1 exhibit a Michaelis–Menten constant (Km) about 1mM, that is less than the normal blood glucose level (5.5mM), resulting in the continuous transport of glucose inside cells at an essentially constant rate. Similar to the insulin-responsive glucose transporter Glut4, Glut1 cell surface localization is controlled by extrinsic signals. Up-regulation of GLUT1 and consequent increase in glucose uptake occur in some conditions that require extraordinary metabolic needs, such as in the case of tumors and in the case of T cell activation.
  • 1.7K
  • 20 Dec 2021
Topic Review
Stochastic Microsensors
Two three-dimensional (3D) stochastic microsensors based on immobilization of protoporphyrin IX (PIX) in single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT) decorated with copper (Cu) and gold (Au) nanoparticles were designed and used for the molecular recognition of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) in biological samples (brain tumor tissues, whole blood).
  • 1.7K
  • 22 Feb 2022
Topic Review
Rhamnus alaternus Plant
Rhamnus alaternus, is a wild-growing shrub, belonging to the Rhamnaceae family. Widely distributed in the Mediterranean basin, R. alaternus is used in the usual medicine in numerous countries, mostly Tunisia, Algeria, Morocco, Spain, France, Italy, and Croatia. A large number of disorders including dermatological complications, diabetes, hepatitis, and goiter problems can be treated by the various parts of R. alaternus (i.e., roots, bark, berries, and leaves). Several bioactive compounds were isolated from R. alaternus, including flavonoids, anthocyanins, and anthraquinones, and showed several effects such as antioxidant, antihyperlipidemic, antigenotoxic, antimutagenic, antimicrobial, and antiproliferative.
  • 1.7K
  • 16 Jun 2022
Topic Review
Spleen Reparative Regeneration
The spleen is the largest lymphoid unpaired parenchymal organ of the abdominal cavity found in all vertebrates. Spleen is able to regenerate, though not necessarily to the initial volume. The recovery lasts one month and preserves the architecture, albeit with an increase in the relative volume of lymphoid follicles. The renovated tissues, however, exhibit skewed functional profiles; notably, the decreased production of antibodies and the low cytotoxic activity of T cells, consistent with the decline of T-dependent zones and prolonged reduction in T cell numbers. Autotransplantations of splenic material are of particular clinical interest, as the procedure can possibly mitigate the development of post-splenectomy syndrome. Under these conditions, regeneration lasts 1-2 months, depending on the species. The transplants effectively destroy senescent erythrocytes, assist in microbial clearance, and produce antibodies, thus averting sepsis and bacterial pneumonia. Meanwhile, cellular sources of splenic recovery in such models remain obscure, as well as the time required for T and B cell number re-constitution.
  • 1.7K
  • 21 Jun 2022
Topic Review
The Age of Reason
The Age of Reason; Being an Investigation of True and Fabulous Theology is a work by English and American political activist Thomas Paine, arguing for the philosophical position of deism. It follows in the tradition of 18th-century British deism, and challenges institutionalized religion and the legitimacy of the Bible. It was published in three parts in 1794, 1795, and 1807. It was a best-seller in the United States, where it caused a short-lived deistic revival. British audiences, fearing increased political radicalism as a result of the French Revolution , received it with more hostility. The Age of Reason presents common deistic arguments; for example, it highlights what Paine saw as corruption of the Christian Church and criticizes its efforts to acquire political power. Paine advocates reason in the place of revelation, leading him to reject miracles and to view the Bible as an ordinary piece of literature, rather than a divinely-inspired text. It promotes natural religion and argues for the existence of a creator-god. Most of Paine's arguments had long been available to the educated elite, but by presenting them in an engaging and irreverent style, he made deism appealing and accessible to the masses. Originally distributed as unbound pamphlets, the book was also cheap, putting it within the reach of a large number of buyers. Fearing the spread of what it viewed as potentially-revolutionary ideas, the British government prosecuted printers and booksellers who tried to publish and distribute it. Nevertheless, Paine's work inspired and guided many free thinkers.
  • 1.7K
  • 27 Sep 2022
Topic Review
Emerita (Genus)
Emerita is a small genus of decapod crustaceans, known as sand crabs, sand bugs, sand fleas, or mole crabs. These small animals burrow in the sand in the swash zone and use their antennae for filter feeding.
  • 1.7K
  • 31 Oct 2022
Topic Review
Cadmium Recovery from Spent Ni-Cd Batteries
The significant increase in the demand for efficient electric energy storage during the last decade has promoted an increase in the production and use of Cd-containing batteries. On the one hand, the amount of toxic Cd-containing used batteries is growing, while on the other hand, Cd is on a list of critical raw materials (for Europe). Both of these factors call for the development of effective technology for Cd recovery from spent batteries. Alkaline nickel-cadmium (Ni-Cd) batteries are widely used as autonomous sources of industrial and household current (power banks) due to a successful combination of feasibility studies and achieved sustainable electrical characteristics. In recent decades, the market of secondary current sources for portable equipment has undergone significant changes, which leads to an intensive replacement of Ni-Cd batteries with lithium-ion (LIB) and nickel-metal-hydride.
  • 1.7K
  • 07 Feb 2022
Topic Review
Role of Anillin in Normal Cell
Anillin (ANLN) is an actin-binding protein that has been documented as a key factor in cell division, and it is a multi-domain protein that interacts with many proteins. ANLN is highly expressed in many types of site-specific cancerous tumours, including brain, lung, pancreas, and bone marrow cancer.
  • 1.7K
  • 02 Sep 2022
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