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Topic Review
Thermosensitive Gelling Rectal Systems
Thermosensitive gelling system is drug delivery system that becomes a gel at physiological temperature.  The transition sol-gel temperature (Tsol-gel) is below body temperature (<37◦C), making it possible to prepare liquid preparations, which gel back at body temperature. Thermosensitive gelling system could be used to rectal administration. Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. However, this form of drug dosage often feels alien and uncomfortable to a patient, encouraging refusal. Thermosensitive liquid suppositories are easier to administer to the anus as they remain liquid at lower temperatures. In addition, this rectal gel minimize the feeling of a foreign body compared with solid suppositories, does not cause any harm on mucosal layers and act as mucoadhesive to the rectal tissues preventing leakage after administration.
  • 2.0K
  • 29 Jul 2021
Topic Review
Nanoparticles as Electroactive Labels
Nanoparticles are emerging materials with outstanding potential for their use as labels in electrochemical immunosensing. Gold, silver and  quantum dots are the main components of such particles, thanks to their direct electroactivity (redox properties). Protein biomarkers of a variety of diseases, including tumour cells, are the target analytes on which such electrochemical immunosensors have been mostly applied.
  • 2.0K
  • 13 Oct 2021
Topic Review
Orthopedic Bioimplants
Significant research and development in the field of biomedical implants has evoked the scope to treat a broad range of orthopedic ailments that include fracture fixation, total bone replacement, joint arthrodesis, dental screws, and others. The success of a bioimplant depends not only upon its bulk properties, but also on its surface properties that influence its interaction with the host tissue. Various approaches of surface modification such as coating of nanomaterial have been employed to enhance antimicrobial activities of a bioimplant. These strategies showed promising results in orthopedics, e.g., improved bone repair and regeneration. However, the choice of materials, especially considering their degradation behavior and surface properties, plays a key role in long-term reliability and performance of bioimplants. Metallic biomaterials have evolved largely in terms of their bulk and surface properties including nano-structuring with nanomaterials to meet the requirements of new generation orthopedic bioimplants.
  • 2.0K
  • 31 Mar 2021
Topic Review
Applications of Metallic Glasses
Metallic glasses can be a perfect alternative to conventional crystalline biomaterials (such as 316L stainless steel, Ti or Ti-based alloys, Zr or Zr-based alloys, Co-Cr alloys, etc.) when used as coatings for surgical devices and implants inside the human body. Owing to their outstanding electrocatalytic activity and durability, metallic glasses can be considered prominent candidates for energy-storage and -conversion devices, such as fuel and electrolysis cells, and batteries. Metallic-glass systems are gaining substantial momentum in the micro- and nano-imprinting of optoelectronic devices.
  • 2.0K
  • 19 Dec 2023
Topic Review
Applications of Hydrogels for Wound Healing
Hydrogels represent a class of materials that are widely used in soft tissue engineering of skin, blood vessel, muscle, and fat. Hydrogels are three-dimensional (3D) networks consisting of physically or chemically crosslinked bonds of hydrophilic polymers. The insoluble hydrophilic structures demonstrate a remarkable potential to absorb wound exudates and allows oxygen diffusion to accelerate healing.
  • 2.0K
  • 05 Sep 2022
Topic Review
Applications of Graphene Oxide (GO) Materials
Graphene-based materials, due to their high sensitivity, inexpensive, fast response and simple operation, are utilized in the fabrication of biosensors based on various sensing methods, such as optical and electrochemical signaling. These materials are successful electrode materials due to their electrochemical characteristics, which can enhance the detection of biomoleculessuch as thrombin, oligonucleotides, ATP, amino corrosives, and dopamine. Biomolecules have an essential duty in all life activities, such as disease development, so the precise identification of biomolecules is necessary for disease diagnosis and therapy.
  • 2.0K
  • 17 Jun 2022
Topic Review
Design of Experiments in the Advancement of Biomaterial
Optimisation of tissue engineering (TE) processes requires models that can identify relationships between the parameters to be optimised and predict structural and performance outcomes from both physical and chemical processes. Design of Experiments (DoE) methods are commonly used for optimisation purposes in addition to playing an important role in statistical quality control and systematic randomisation for experiment planning. DoE is only used for the analysis and optimisation of quantitative data (i.e., number-based, countable or measurable), while it lacks the suitability for imaging and high dimensional data analysis.
  • 2.0K
  • 18 Jan 2023
Topic Review
Diatoms
Diatoms have an ability that is unique among the unicellular photoautotrophic organisms to synthesize an intricately ornamented siliceous (biosilica) exoskeleton with an ordered, hierarchical, three-dimensional structure on a micro- to nanoscale. The unique morphological, structural, mechanical, transport, photonic, and optoelectronic properties of diatomaceous biosilica make it a desirable material for modern technologies. This review presents a summary and discussion of published research on the metabolic insertion of chemical elements with specific functional activity into diatom biosilica. Included in the review is research on innovation in methods of synthesis of a new generation of functional siliceous materials, where the synthesis process is “outsourced” to intelligent microorganisms, referred to here as microtechnologists, by providing them with appropriate conditions and reagents.
  • 2.0K
  • 27 Oct 2020
Topic Review
Hydrogels Based on Supramolecular Strategies
Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. The sensible definition of supramolecular molecules is being set by investigators who, because of the different sensitivities of their methods and observational timescales, may have different views on as to what constitutes these supramolecular structures. The supramolecular interaction between some materials and guest molecules has endowed gels with the capacity for reversible gel−sol transformation. A plausible example has to do with self-healing, which is one of the most intriguing characteristics of biological or artificial systems, such as the particular and specific applications described below, due to its intrinsic importance. Thermodynamic stability plays an important role, for example, in the preparation of ophthalmic hydrogels and metallo-supramolecular hydrogels.
  • 2.0K
  • 19 Jun 2023
Topic Review
Oral Mucosal Epithelial Cells
The corneal surface is an essential organ necessary for vision, and its clarity must be maintained. The corneal epithelium is renewed by limbal stem cells, located in the limbus and in palisades of Vogt. Palisades of Vogt maintain the clearness of the corneal epithelium by blocking the growth of conjunctival epithelium and the invasion of blood vessels over the cornea. The limbal region can be damaged by chemical burns, physical damage (e.g., by contact lenses), congenital disease, chronic inflammation, or limbal surgeries. The degree of limbus damage is associated with the degree of limbal stem cells deficiency (partial or total). For a long time, the only treatment to restore vision was grafting part of the healthy cornea from the other eye of the patient or by transplanting a cornea from cadavers. The regenerative medicine and stem cell therapies have been applied to restore normal vision using different methodologies. The source of stem cells varies from embryonic stem cells, mesenchymal stem cells, to induced pluripotent stem cells. This review focuses on the use of oral mucosa epithelial stem cells and their use in engineering cell sheets to treat limbal stem cell deficient patients.
  • 2.0K
  • 30 Oct 2020
Topic Review
Green Chemistry Principles for Cellulose-Based Hydrogels
Hydrogels are 3D structures consisting of hydrophilic polymer networks. They can adsorb water and biological fluids in high quantities (up to 1000 times their dry weight). Cellulose is a hydrophilic material. It has inter- and intramolecular hydrogen bonds and van der Waals forces that cause many problems regarding its dissolution.
  • 2.0K
  • 02 Mar 2023
Topic Review
Waste Derivatives in Drilling Fluids
The increased production of waste materials is a significant concern due to their effect on public health and the environment. Mismanagement of food waste, in particular, has become a major global issue, thus prompting the need for better solutions that use these materials in different applications. Among various applications, food waste can be considered to be a sustainable alternative for additives in drilling fluids used in the oil and gas drilling industry. Chemical additives to drilling fluids are necessary components to facilitate drilling operations by enhancing the fluids’ properties, including rheology and filtrate loss. Studies have demonstrated that waste-derived materials, including food waste, have the potential to provide an environmentally safe alternative to toxic conventional chemical additives used in water-based drilling fluids. 
  • 2.0K
  • 17 Aug 2021
Topic Review
Additive Biomanufacturing with Collagen Inks
Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support biological function. Additive biomanufacturing has expanded the use of collagen biomaterial in various regenerative medicine and disease modelling application (e.g., skin, bone and cornea). 
  • 2.0K
  • 04 Mar 2022
Topic Review
Polymeric Nanoparticles for Drug Delivery
The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.
  • 2.0K
  • 27 Jul 2020
Topic Review
Bacterial Biofilms
Bacterial biofilm is a group of cooperative and coordinated unicellular microbes which are associated with physiological and structural complexity, and they are analogous to multicellular microorganisms.
  • 2.0K
  • 04 Jun 2021
Topic Review
Gadolinium-Based Oxide and Oxysulfide Particles
Gadolinium-Based Oxide and Oxysulfide Particles in the biomedical field
  • 2.0K
  • 14 Oct 2021
Topic Review
Clear Aligners - 3D Printing
The recent introduction of three-dimensional (3D) printing is revolutionizing dentistry and is even being applied to orthodontic treatment of malocclusion. Clear, personalized, removable aligners are a suitable alternative to conventional orthodontic appliances, offering a more comfortable and efficient solution for patients. Including improved oral hygiene and aesthetics during treatment. Contemporarily, clear aligners are produced by a thermoforming process using various types of thermoplastic materials. The thermoforming procedure alters the properties of the material, and the intraoral environment further modifies the properties of a clear aligner, affecting overall performance of the material. Direct 3D printing offers the creation of highly precise clear aligners with soft edges, digitally designed and identically reproduced for an entire set of treatment aligners; offering a better fit, higher efficacy, and reproducibility. Despite the known benefits of 3D printing and the popularity of its dental applications, very limited technical and clinical data are available in the literature about directly printed clear aligners. 
  • 2.0K
  • 14 Sep 2021
Topic Review
Collagen Derived from Fish Industry Waste
Fish collagen garnered significant academic and commercial featuring prospective applications in a variety of health-related industries, including food, medicine, pharmaceutics, and cosmetics. Due to its distinct advantages over mammalian-based collagen, including the reduced zoonosis transmission risk, the absence of cultural-religious limitations, the cost-effectiveness of manufacturing process, and its superior bioavailability, the use of collagen derived from fish wastes (i.e., skin, scales) quickly expanded. Moreover, by-products are low cost and the need to minimize fish industry waste’s environmental impact paved the way for the use of discards in the development of collagen-based products with remarkable added value.
  • 2.0K
  • 07 Feb 2023
Topic Review
Vat Photopolymerization
Vat photopolymerization (VP), including stereolithography (SLA), digital light processing (DLP), and volumetric printing, employs UV or visible light to solidify cell-laden photoactive bioresin contained within a vat in a point-by-point, layer-by-layer, or volumetric manner.
  • 2.0K
  • 11 Oct 2023
Topic Review
Phage Applications against Biofilms
Biofilms are clusters of bacteria that live in association with surfaces, attached to other bacterial cells and to the surface by an extracellular polymeric matrix. Biofilms are capable of adhering to a wide variety of surfaces, both biotic and abiotic, including human tissues, medical devices, and other materials, representing a major threat causing infectious diseases and economic losses. Unfortunately, current antibiotics and common disinfectants have shown limited ability to remove biofilms adequately. Here, phage-based treatments are proposed as promising alternatives for biofilm eradication, including phage therapy, phage-derived enzymes, genetically modified phages, and phages in combination with antibiotics.
  • 2.0K
  • 05 Nov 2020
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