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Topic Review
T-Cell Acute Lymphoblastic Leukemia
Thanks to the use of high-resolution genetic techniques to detect cryptic aberrations present in T-ALL, researchers now have a clearer view of the genetic landscape that explains the particular oncogenetic processes taking place in each T-ALL. They also have begun to understand relapse-specific mechanisms. To summarize the latest advances in the knowledge of the genome in T-ALL and highlight the areas where the research on this ALL subtype is progressing, thereby identifying the key issues that need to be addressed in the medium-to-long term to move forward in the applicability of this knowledge into clinics.
  • 1.8K
  • 02 Jun 2022
Topic Review
Recycling of Multilayer Waste Films
In a circular economy context with the dual problems of depletion of natural resources and the environmental impact of a growing volume of wastes, it is of great importance to focus on the recycling process of multilayered plastic films. First to the general concepts and summary of plastic waste management in general, making emphasis on the multilayer films recycling process. Then, in the second part, the focus is dealing with multilayer films manufacturing process, including the most common materials used for agricultural applications, their processing, and the challenges of their recycling, recyclability, and reuse. Hitherto, some prospects are discussed from eco-design to mechanical or chemical recycling approaches.
  • 1.8K
  • 20 Jun 2022
Topic Review
Three-Section Staff
The three-section staff, triple staff, three-part staff, sansetsukon in Japanese, or originally sanjiegun (Chinese: 三節棍; pinyin: sānjiégùn; Jyutping: saam1 zit3 gwan3, or Chinese: 三節鞭; pinyin: sānjiébiān three-sectional whip), is a Chinese flail weapon that consists of three wooden or metal staffs connected by metal rings or rope. The weapon is also known as 蟠龍棍 panlong gun, "coiling dragon staff". A more complicated version of the two section staff, the staves can be spun to gather momentum resulting in a powerful strike, or their articulation can be used to strike over or around a shield or other defense.
  • 1.8K
  • 10 Oct 2022
Topic Review
Anti-Diabetic Mechanisms of Glycyrrhizic acid and Its Derivatives
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease, which is characterized by hyperglycemia, chronic insulin resistance, progressive decline in β-cell function, and defect in insulin secretion. It has become one of the leading causes of death worldwide. There is no cure for T2DM, but it can be treated, and blood glucose levels can be controlled. It has been reported that diabetic patients may suffer from the adverse effects of conventional medicine. Therefore, alternative therapy, such as traditional Chinese medicine (TCM), can be used to manage and treat diabetes. Glycyrrhizic acid (GL) and its derivatives are suggested to be promising candidates for the treatment of T2DM and its complications. It is the principal bioactive constituent in licorice, one type of TCM.
  • 1.8K
  • 12 Oct 2022
Topic Review
Taxonomy of Banksia
As with other flowering plants, the taxonomy of Banksia has traditionally been based on anatomical and morphological properties of the Banksia flower, fruiting structure and seed, along with secondary characteristics such as leaf structure and growth habit. Increasingly, molecular evidence from DNA is providing important new insights into relationships within the genus and between this and other genera in the Proteaceae. The genus is placed in family Proteaceae, subfamily Grevilleoideae, tribe Banksieae and subtribe Banksiinae. The most recent complete revision is that published in Alex George's 1999 monograph for the Flora of Australia book series; this recognises two subgenera, three sections, 13 series, 77 species, 6 subspecies and 18 varieties, and treats the traditionally related genus Dryandra as separate but closely related. Recent molecular cladistic analyses have provided an alternative view in which Dryandra is shown to be nested inside, and hence should be included within, Banksia. This interpretation has been controversial in some circles, and is not universally accepted.
  • 1.8K
  • 20 Oct 2022
Topic Review
Astrophysics Data System
The SAO/NASA Astrophysics Data System (ADS) is an online database of over 16 million astronomy and physics papers from both peer reviewed and non-peer reviewed sources. Abstracts are available free online for almost all articles, and full scanned articles are available in Graphics Interchange Format (GIF) and Portable Document Format (PDF) for older articles. It was developed by the National Aeronautics and Space Administration (NASA), and is managed by the Smithsonian Astrophysical Observatory. ADS is a powerful research tool and has had a significant impact on the efficiency of astronomical research since it was launched in 1992. Literature searches that previously would have taken days or weeks can now be carried out in seconds via the ADS search engine, which is custom-built for astronomical needs. Studies have found that the benefit to astronomy of the ADS is equivalent to several hundred million US dollars annually, and the system is estimated to have tripled the readership of astronomical journals. Use of ADS is almost universal among astronomers worldwide, and therefore ADS usage statistics can be used to analyze global trends in astronomical research. These studies have revealed that the amount of research an astronomer carries out is related to the per capita gross domestic product (GDP) of the country in which he/she is based, and that the number of astronomers in a country is proportional to the GDP of that country, so the total amount of research done in a country is proportional to the square of its GDP divided by its population.
  • 1.8K
  • 28 Oct 2022
Topic Review
Advancement of the Multi-Action Plan Model
The Multi-Action Plan (MAP) model presents as an action-focused, sport-specific, mixed methods intervention model. MAP research characterized four Performance Types (PTs). Each PT operates on an affective, cognitive, behavioral, and psychophysiological level—across performance contexts. The authors propose three areas on how MAP could be extended: First, researchers argue that a better understanding of the phasing/timing of transitions between mental states during performance would greatly expand the MAP framework on a conceptual and applied level. Second,  the authors offer ideas on the role of socio-environmental precursors acting as cues for such transition processes. Third, the authors propose to clarify the role of effort and reward perception post-transition, particularly in relation to micro and macro timeframes.
  • 1.8K
  • 16 Dec 2022
Topic Review
Mechanisms of Bortezomib Resistance in Multiple Myeloma Cell
Bortezomib is the most effective chemotherapeutic drug used in the treatment of MM. This inhibitor is a dipeptide boronic acid analogue discovered in 1995 and is the premier in the class of chymotrypsin-like (CP) inhibitors. Bortezomib is a C-terminal boronic acid, and the boron atom is essential for inhibiting the proteasome activity because of its ability to specifically and tightly bind the β5 catalytic subunit. Boronates form tetrahedral adducts, which are further stabilized by a hydrogen bond between the N-terminal amino group of threonines and the hydroxyl groups of boronic acid. These bonds provide a higher influence for Bortezomib than other drugs developed for inhibition. It binds the proteasome with a high resolution, slowly dissociates, and provides a stable but reversible proteasome inhibition. Various mechanisms have been suggested to explain the multidrug resistance in cancer cells. Increased drug excretion, decreased drug uptake, activation of detoxification systems, inhibition of apoptosis, alterations in cell cycle regulation factors, and changes in drug targets are among the causes.
  • 1.8K
  • 17 Jan 2023
Topic Review
Caisson (Engineering)
In geotechnical engineering, a caisson (/ˈkeɪsən/ or /ˈkeɪsɒn/) is a watertight retaining structure used, for example, to work on the foundations of a bridge pier, for the construction of a concrete dam, or for the repair of ships. These are constructed such that the water can be pumped out, keeping the working environment dry. When piers are being built using an open caisson, and it is not practical to reach suitable soil, friction pilings may be driven to form a suitable sub-foundation. These piles are connected by a foundation pad upon which the column pier is erected.
  • 1.8K
  • 22 Nov 2022
Topic Review
AI Applications for Virtual Sensing of Underground Utilities
Accurately identifying the location and depth of buried utility assets became a considerable challenge in the construction industry, for which accidental strikes can cause important economic losses and safety concerns. While the collection of as-built utility locations is becoming more accurate, there still exists an important need to be capable of accurately detecting buried utilities in order to eliminate risks associated with digging. With advances in artificial intelligence (AI), an opportunity arose in conducting virtual sensing of buried utilities by combining robotics (e.g., drones), knowledge, and logic.
  • 1.8K
  • 18 May 2023
Topic Review
OS-Level Virtualisation
OS-level virtualization refers to an operating system paradigm in which the kernel allows the existence of multiple isolated user-space instances. Such instances, called containers (Solaris, Docker), Zones (Solaris), virtual private servers (OpenVZ), partitions, virtual environments (VEs), virtual kernel (DragonFly BSD) or jails (FreeBSD jail or chroot jail), may look like real computers from the point of view of programs running in them. A computer program running on an ordinary operating system can see all resources (connected devices, files and folders, network shares, CPU power, quantifiable hardware capabilities) of that computer. However, programs running inside of a container can only see the container's contents and devices assigned to the container. On Unix-like operating systems, this feature can be seen as an advanced implementation of the standard chroot mechanism, which changes the apparent root folder for the current running process and its children. In addition to isolation mechanisms, the kernel often provides resource-management features to limit the impact of one container's activities on other containers. The term "container," while most popularly referring to OS-level virtualization systems, is sometimes ambiguously used to refer to fuller virtual machine environments operating in varying degrees of concert with the host OS, e.g. Microsoft's "Hyper-V Containers."
  • 1.8K
  • 20 Oct 2022
Topic Review
Biochar-Based Materials for Wastewater Treatment
Biochar is an important, interesting, low-cost material with various agricultural, industrial, and scientific applications. Biochar is a name given to vegetable-derived charcoal, which can be used as an agent to improve soil and water quality. This carbon-rich substance can be produced by the carbonization of biomass residues (e.g., wood, dung, manure, or leaves) in thermal conversion processes, such as pyrolysis, torrefaction, and hydrothermal carbonization (HTC). Among them, pyrolysis is the most common process to obtain biochar under anaerobic conditions and high temperatures. In addition, heat, syngas, liquid fuels, and pyroligneous acid (wood vinegar) are also generated during this process.
  • 1.8K
  • 18 Jan 2024
Topic Review
Hydrogels
This entry briefly covers the existing knowledge on the lubrication mechanisms of hydrogels by discussing the main ideas, knowledge gaps and opportunities in the research area.
  • 1.8K
  • 21 Dec 2020
Topic Review
Polymer-Matrix Composites - Environmental Fatigue, Creep, Long-Term Durability
Polymer-matrix composites are widely used in engineering applications. Yet, environmental factors impact their macroscale fatigue and creep performances significantly, owing to several mechanisms acting at the microstructure level. Seawater, due to a combination of high salinity and pressures, low temperature and biotic media present, also contributes to the acceleration of fatigue and creep damage. Similarly, other liquid corrosive agents penetrate into cracks induced by cyclic loading and cause dissolution of the resin and breakage of interfacial bonds. UV radiation either increases the crosslinking density or scissions chains, embrittling the surface layer of a given matrix. Temperature cycles close to the glass transition damage the fibre–matrix interface, promoting microcracking and hindering fatigue and creep performance. The microbial and enzymatic degradation of biopolymers is also studied, with the former responsible for metabolising specific matrices and changing their microstructure and/or chemical composition. 
  • 1.8K
  • 07 Jul 2023
Topic Review
EMT Program in Breast cancer
Notch signaling is a primitive signaling pathway having various roles in the normal origin and development of each multicellular organisms. Therefore, any aberration in the pathway will inevitably lead to deadly outcomes such as cancer. It has now been more than two decades since Notch was acknowledged as an oncogene in mouse mammary tumor virus-infected mice. Since that discovery, activated Notch signaling and consequent up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer. Moreover, consistent over-expression of Notch ligands and receptors has been shown to correlate with poor prognosis in human breast cancer. Notch regulates a number of key processes during breast carcinogenesis, of which, one key phenomenon is epithelial–mesenchymal transition (EMT). EMT is a key process for large-scale cell movement during morphogenesis at the time of embryonic development. Cancer cells aided by transcription factors usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis. In this review, we recapitulate recent progress in breast cancer research that has provided new perceptions into the molecular mechanisms behind Notch-mediated EMT regulation during breast tumorigenesis.
  • 1.8K
  • 29 Oct 2020
Topic Review
Infant Gut Microbiota
Evidence is accumulating which shows that maternal transmission of microbes to the infant gut occurs prenatally, in utero. However, the first big wave of microbial colonization occurs after birth. Gut microbial dysbiosis in infant increase the risk of subsequent asthma through a number of perinatal factors such as diet, delivery mode, antibiotic exposure, maternal asthma during pregnancy and pre-gestational body mass index. Nutrition plays a fundamental role as a potent modifiable factor influencing the human gut microbiota composition, which provides new insights into therapeutic strategies aimed at manipulating the gut microbiota through dietary modification. There is very little evidence to date linking maternal dietary patterns during pregnancy with alterations in the infant gut microbiota. The effect of maternal dietary nutrient intake causes alterations in breast milk microbiota composition. There is however a paucity of human data examining the effects and underlying mechanisms of maternal diet on the infant gut microbiota shaping through the alteration of milk microbiota composition. Further long-term cohort studies are needed where the effect of maternal nutrition during pregnancy and lactation on the infant gut microbiota composition are studied in further detail in context of asthma development and may provide useful insights into potential mechanisms that could potentially reduce the risk of asthma.
  • 1.8K
  • 31 Jul 2020
Topic Review
Microbial Cell-Cell Chemical Communication Systems
The microbial cell–cell chemical communication systems include QS and host–pathogen communication systems. In 1994, Fuqua et al., coined the term of “quorum sensing” to describe an environmental sensing system that monitors the population density to coordinate the social behaviors of microorganisms. QS regulatory systems are characterized by the fact that microorganisms produce and release to the surrounding environment a diffffusible autoinducer or QS signal, which accumulates along with bacterial growth and induces target gene transcriptional expression when reaching a threshold concentration. Typically, a QS system contains a signal synthase, which produces QS signals, and a signal receptor that detect and response to QS signal in a population-dependent manner. In addition, microbial pathogens can also exploit the chemical molecules produced by host organisms as cross-kingdom signals to regulate virulence gene expression.
  • 1.8K
  • 18 Dec 2020
Topic Review
Nutcracker Syndrome
Left renal vein (LRV) entrapment, also known as nutcracker phenomenon if it is asymptomatic, is characterized by abnormality of outflow from the LRV into the inferior vena cava (IVC) due to extrinsic LRV compression, often accompanied by demonstrable lateral (hilar) dilatation and medial (mesoaortic) stenosis. Nutcracker syndrome, on the other hand, includes a well-defined set of symptoms, and the severity of these clinical manifestations is related to the severity of anatomic and hemodynamic findings. 
  • 1.8K
  • 25 Jan 2021
Topic Review
The Genetics of Hereditary Angioedema
Hereditary angioedema is a rare inherited disorder characterized by recurrent episodes of the accumulation of fluids outside of the blood vessels, causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway.
  • 1.8K
  • 23 Jun 2021
Topic Review
Artificial Intelligence in Water–Energy–Food Model
The role of artificial intelligence (AI) in the Water–Energy–Food (WEF) nexus under the lens of institutional, stakeholder, and innovation theories has been studied recently. Research on AI for WEF nexus management has adopted mostly a technical perspective, neglecting the relevance of management tools and the business model concept. An integrated approach for managing the nexus through AI technologies is proposed to meet sustainable and responsible business models. The gap between research and policy making could be filled by combining scientific data and policy needs with inclusive tools that are technically viable for sustainable resource utilization.
  • 1.8K
  • 20 Mar 2022
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