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Topic Review
Probiotics in cosmetics
Probiotics, defined as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host,” are becoming increasingly popular and marketable. The cosmetic industry has harnessed this potential by producing products claiming to contain probiotics. However, not all products marketed as such comply with the requirements for this claim.  
  • 1.8K
  • 10 Mar 2021
Topic Review
Prognostic Biomarkers of CLL
Chronic lymphocytic leukemia (CLL) is an extremely heterogeneous disease. With the advent of oral targeted agents (Tas) the treatment of CLL has undergone a revolution, which has been accompanied by an improvement in patient’s survival and quality of life. 
  • 1.8K
  • 27 Apr 2021
Topic Review
CNT-Based Chemical Sensors
Carbon nanotubes (CNTs) combine high electrical conductivity with high surface area and chemical stability, which makes them very promising for chemical sensing. 
  • 1.8K
  • 10 Feb 2022
Topic Review
Uturunku
Uturunku (Quechua for jaguar, Hispanicized spellings Uturunco, Uturuncu) is a dormant volcano in the Cordillera de Lípez in Potosí Department, Bolivia. It is located in the Sur Lípez Province, San Pablo de Lípez Municipality. It is in the Central Volcanic Zone of the Andes, and its highest summit is 6,008 metres (19,711 ft) above sea level. The volcano has two summits, with a fumarole field between them. The volcano's landforms include lava domes and lava flows. The volcano was sporadically active during the Pleistocene, with the most recent eruption dated at 271,000 years ago. Since then, Uturunku has displayed fumarolic activity. Starting in 1992, satellite observations have indicated a large area of regional uplift centered on Uturunku, which has been interpreted as an indication of large-scale magma intrusion under the volcano. This might be a prelude to large-scale volcanic activity, including "supervolcanic" activity and caldera formation.
  • 1.8K
  • 29 Sep 2022
Topic Review
Shooting Star (Spacecraft)
The Shooting Star is an expendable American cargo spacecraft (transport vehicle) developed by Sierra Nevada Corporation as part of the Dream Chaser Launch System. It attaches to the back of Dream Chaser® spaceplane serving as a Service Module and holding up to 4,536 kg (10,000 lb) of supplies, cargo and experiments for the International Space Station. It is launched by ULA's Vulcan rocket and is designed to transport supplies to the International Space Station (ISS) and return items to Earth. Shooting Star can support three unpressurized payloads weighing up to 500 kg (1,100 lb) each or one payload weighing as much as 1,500 kg (3,300 lb). Once the module is at the station, the Canadarm2 robotic arm would unload the externally attached payload and install it on the station's exterior. The Shooting Star module is versatile, supplying power and ECLSS for the Dream Chaser system. It can be customized for special mission needs, such as autonomous docking to ISS instead of berthing. Upon re-entry into Earth’s atmosphere, it also performs disposal of cargo from the International Space Station.
  • 1.8K
  • 27 Oct 2022
Topic Review
Different Pathophysiological Mechanisms of HIF-1α in Renal Disease
Partial pressure of oxygen (pO2) in the kidney is maintained at a relatively stable level by a unique and complex functional interplay between renal blood flow, glomerular filtration rate (GFR), oxygen consumption, and arteriovenous oxygen shunting. The vulnerability of this interaction renders the kidney vulnerable to hypoxic injury leading to different renal diseases. Hypoxia has long been recognized as an important factor in the pathogenesis of acute kidney injury (AKI), especially renal ischemia/reperfusion injury. Accumulating evidence suggests that hypoxia also plays an important role in the pathogenesis and progression of chronic kidney disease (CKD) and CKD-related complications, such as anemia, cardiovascular events, and sarcopenia. In addition, renal cancer is linked to deregulation of hypoxia pathways. Renal utilizes various molecular pathways to respond and adapt to changes in renal oxygenation. Particularly, hypoxia-inducible factor (HIF) (including HIF-1, 2, 3) has been shown to be activated in renal disease and plays a major role in the protective response to hypoxia. HIF-1 is a heterodimer that is composed of an oxygen-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. In renal diseases, the critical characteristic of HIF-1α is protective, but it also has a negative effect, such as in sarcopenia. This review summarizes the mechanisms of HIF-1α regulation in renal disease.
  • 1.8K
  • 02 Nov 2022
Topic Review
Recent Applications of Retro-Inverso Peptides
Retro-inverso peptides possess reversed sequences and chirality compared to the parent molecules maintaining at the same time an identical array of side chains and in some cases similar structure. The inverted chirality renders them less prone to degradation by endogenous proteases conferring enhanced half-lives and an increased potential as new drugs. However, given their general incapability to adopt the 3D structure of the parent peptides their application should be careful evaluated and investigated case by case.
  • 1.8K
  • 22 Sep 2021
Topic Review
Biological Activities of Mucuna Pruriens
Mature fruits of M. pruriens were harvested from Fort Hare University’s Research Farm located in Alice, South Africa. The collected seeds were pulverized in a standard process and taken to the laboratory for crude extraction and further treatments. Cytotoxic, antimalarial, and trypanocidal effects of crude extracts obtained from ethanol and water were tested, while the total phenolic, proanthocyanidin, and flavonoid contents of the aqueous extracts as well as their pharmacological activities were determined in vitro using 2,2-diphenyl-1-picrylhydrazyl ethanol (DPPH), ferric reducing antioxidant power (FRAP), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. Although the extracts showed mild antiparasitic (antiplasmodial and trypanocidal) effects, results from the cytotoxic experiment revealed that M. pruriens is not toxic to human cervix adenocarcinoma (HeLa) cells when tested using 50 µg/mL of extracts. It was observed that the seeds were remarkably rich in phenol (3730.1 ± 15.52 mg gallic acid equivalent (GAE)/g) compared to flavonoids (63.03 ± 1.95 mg quercetin equivalent (QE)/g) and proanthocyanidin (18.92 ± 1.09 mg catechin equivalent (CE)/g). Also, the antioxidant activities of the extracts were comparable to those of the standard antioxidant drugs (rutin and gallic acid) used, in a concentration-dependent manner. There was a direct relationship between phenolic acid content and antioxidant effects. It is therefore suggested that M. pruriens seeds be incorporated into human diets as a supplement to promote healthy living. Pharmaceutical industries with a particular interest in natural phenolic acids should consider using seeds of M. pruriens as pharmaceutical precursors. 
  • 1.8K
  • 09 Nov 2020
Topic Review
Air Pollution Policy in Israel
Since its establishment in 1948, the State of Israel has been oriented towards economic development and industrialization, with a transportation sector increasingly focused on private cars. In 1961, initial awareness of environmental risks led to the adoption of the Abatement of Nuisances Law, which served as the platform for air pollution policy for several decades, even as population growth and growth of the industrial sector, including fossil fuel power plants, led to a continuous increase in air pollution. In the early 2000s, the environmental movement in Israel criticized local air pollution policy as being out of date and started to promote a new Clean Air Law. The law, which was adopted in 2008 and came into force in 2011, was a watershed in air pollution policy in Israel. It includes ambient air quality values for 28 contaminants, emission permits for the industrial sector based on best available techniques (BAT), an enforcement system, and a unified and transparent monitoring system. This entry introduces the history of air pollution policy in Israel from 1948, through the 1961 and 2008 landmark legislations and their strengths and weaknesses, to the present. Also, it gives  recommendations for future air pollution policy in Israel.
  • 1.8K
  • 28 Oct 2020
Topic Review
Obsessive–Compulsive Personality Disorder
Obsessive–compulsive personality disorder (OCPD) is a cluster C personality disorder marked by an excessive need for orderliness, neatness, and perfectionism. Symptoms are usually present by the time a person reaches adulthood, and are visible in a variety of situations. The cause of OCPD is thought to involve a combination of genetic and environmental factors, namely problems with attachment. This is a distinct disorder from obsessive–compulsive disorder (OCD), and the relation between the two is contentious. Some studies have found high comorbidity rates between the two disorders but others have shown little comorbidity. Both disorders may share outside similarities—rigid and ritual-like behaviors, for example. Attitudes toward these behaviors differ between people affected with either of the disorders: for people with OCD, these behaviors are egodystonic, unwanted and involuntary, being the product of anxiety-inducing and involuntary thoughts. On the other hand, for people with OCPD, they are egosyntonic; the person perceives them as rational and wanted, being the result of, for example, strong adherence to routines, a desire for control, or a need for perfection. OCPD is highly comorbid with other personality disorders, autism spectrum, eating disorders, anxiety, mood disorders, and substance use disorders. The disorder is the most common personality disorder in the United States, and is diagnosed twice as often in males as in females, however, there is evidence to suggest the prevalence between men and women is equal.
  • 1.8K
  • 29 Sep 2022
Topic Review
Drain Fly
Drain flies, sink flies, filter flies, or sewer gnats (Psychodidae) are small true flies (Diptera) with short, hairy bodies and wings giving them a "furry" moth-like appearance, hence one of their common names, moth flies. There are more than 2,600 described species worldwide, most of them native to the humid tropics. This makes them one of the most diverse families of their order. Drain flies sometimes inhabit plumbing drains and sewage systems, where they are harmless, but cause persistent annoyance.
  • 1.8K
  • 01 Dec 2022
Topic Review
Deep Learning Approaches for Wildfires Using Satellite Data
Wildland fires are one of the most dangerous natural risks, causing significant economic damage and loss of lives worldwide. Every year, millions of hectares are lost, and experts warn that the frequency and severity of wildfires will increase in the coming years due to climate change. To mitigate these hazards, numerous deep learning models were developed to detect and map wildland fires, estimate their severity, and predict their spread. In this paper, we provide a comprehensive review of recent deep learning techniques for detecting, mapping, and predicting wildland fires using satellite remote sensing data. We begin by introducing remote sensing satellite systems and their use in wildfire monitoring. Next, we review the deep learning methods employed for these tasks, including fire detection and mapping, severity estimation, and spread prediction. We further present the popular datasets used in these studies. Finally, we address the challenges faced by these models to accurately predict wildfire behaviors, and suggest future directions for developing reliable and robust wildland fire models.
  • 1.8K
  • 24 May 2023
Topic Review
Bioaccessibility and Bioavailability of Carotenoids
The bioaccessibility of a carotenoid is defined as the maximum quantity of a carotenoid released from the food matrix that is available to be absorbed in the epithelial cells of the intestine. The fraction of an ingested compound that enters the bloodstream and performs its physiological functions is the definition of the bioavailability of a carotenoid.
  • 1.8K
  • 06 Jun 2023
Topic Review
Machine Learning in Smart Farming
Machine learning applications are having a great impact on the global economy by transforming the data processing method and decision making. Agriculture is one of the fields where the impact is significant, considering the global crisis for food supply. 
  • 1.8K
  • 01 Sep 2023
Topic Review
Aquatic and Terrestrial Invertebrate Welfare
Invertebrates are a diverse group of animals that make up the majority of the animal kingdom and encompass a wide array of species with varying adaptations and characteristics. Invertebrates are found in nearly all of the world’s habitats, including aquatic, marine, and terrestrial environments.
  • 1.8K
  • 16 Nov 2023
Topic Review
Mycobacteriophages for Drug-Resistant Tuberculosis Treatment
The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses the need to develop new therapeutic strategies. Mycobacteriophages are genetically diverse viruses that specifically infect mycobacterial hosts, including members of the M. tuberculosis complex. Here, we will review general features of mycobacteriophages and their mechanisms of M.tb killing, as well as their advantages and limitations as therapeutic and prophylactic agents against drug-resistant M.tb. 
  • 1.8K
  • 31 Mar 2021
Topic Review
Blockchain Technology in Logistics
The most successful applications of Blockchain Technology are still in the area of crypto-currencies, although both scientists and practitioners have discovered the potential of Blockchain Technology in Supply Chain Management. There is a significant theoretical literature on Blockchain Technology, but there exists a lack of published case studies and concrete examples.
  • 1.8K
  • 14 Jul 2021
Topic Review
Chemical and Cell-Based Antioxidant Assays
Antioxidants remain interesting molecules of choice for suppression of the toxic effects of free radicals in foods and human systems. The current practice involves the use of mainly synthetic molecules as potent antioxidant agents. However, due to the potential negative impact on human health, there is an intensive effort within the research community to develop natural alternatives with similar antioxidant efficacy but without the negative side effects of synthetic molecules. Still, the successful development of new molecules depends on the use of reliable chemical or cell culture assays to screen antioxidant properties. Chemical antioxidant assays include the determination of scavenging ability against free radicals such as DPPH, superoxide anion radicals, hydroxyl radicals, hydrogen peroxide, and nitric oxide. Other antioxidant tests include the ability of compounds to bind and sequester prooxidant metal cations, reduce ferric iron, and attenuate the rate of lipid oxidation. Ex vivo tests utilize cell cultures to confirm entry of the molecules into cells and the ability to quench synthetic intracellular free radicals or to stimulate the increased biosynthesis of endogenous antioxidants.
  • 1.8K
  • 19 Aug 2021
Topic Review
Firewall for Securing Smart Healthcare Environment
Firewalls today represent the first line of defense against major attacks, affecting both traditional and modern networks, and enforcing the protection of inside networks from external (and untrusted) networks. The application of an effective set of security practices and policies may indeed keep those systems safe and save entire businesses. Firewalls have a very important function of protecting, filtering, and controlling all traffic sent and received from the computer, Local Area Network (LAN), or Wide Local Area Network (WLAN) internal networks from unauthorized intrusions or external attacks.
  • 1.8K
  • 08 Oct 2021
Topic Review
Sleep Breathing and Sleep-Deprivation Physiology
Sleep-disordered breathing is associated with sleep deprivation. This sleep disruption interferes with the normal restorative functions of NREM and REM sleep, resulting in disruptions of breathing and cardiovascular function, changes in emotional reactivity, and cognitive decline in attention, memory, and decision making. As the human body goes through the different stages of sleep, physiological changes in the breathing mechanism are present. Sleep disorders, such as obstructive sleep apnea-hypopnea syndrome, are often associated with sleep-disordered breathing and sleep deprivation. Hypoxia and hypercapnia coexist with lack of sleep and undermine multiple functions of the body (e.g., cardiovascular system, cognition, immunity). Among the general population, athletes suffer from these consequences more during their performance. This concept supports the beneficial restorative effects of a good sleeping pattern.
  • 1.8K
  • 06 May 2022
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