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Topic Review
The ROR Pathway
The WNT pathway is one of the major signaling cascades frequently deregulated in human cancer. Binding of WNT ligands to their respective receptors can trigger various downstream signaling cascades centered around cell proliferation, survival or migration. In particular, WNT signaling via the receptor tyrosine kinase-like orphan receptors (RORs) has gained increasing attention in cancer research due to their overexpression in a multitude of tumor entities.
  • 1.8K
  • 19 Feb 2021
Topic Review
Melanoma
Melanoma is a malignant tumor that originates from melanocytes. Although melanoma mainly occurs in the skin (cutaneous melanoma), it can also occur in the eyes (uveal melanoma), gastrointestinal tract, oral mucosa and genital tract (mucosal melanoma) [1][2][3][4][5].
  • 1.8K
  • 07 Feb 2021
Topic Review
Hot Electrons in Plasmon-Sensitized TiO2
Hot carriers are electron-hole pairs formed by Landau damping or chemical interface damping of particle plasmons. The term “hot electrons” not only describes the individual electrons themselves, but also describes the Fermi–Dirac distribution of electrons in a solid albeit with an elevated effective temperature—the effective temperatures involved when considering the carrier kinetic energies and carrier densities in the solid, and not that of the solid itself- as opposed to thermal equilibrium. Typically, hot carriers lose their excess energy and relax to thermal equilibrium within a few picoseconds of formation due to a variety of scattering processes. Therefore, it is very difficult to extract useful work from hot carriers with thermodynamic efficiencies that are of interest for practical devices. However, heterojunctions of TiO2 with coinage metals have been consistently shown to be effective in utilizing hot carriers to perform useful work, such as driving a chemical reaction or generating an electric current. A secondary benefit of such TiO2-coinage metal heterojunctions is the "visible light sensitization" effect which allows broader harvesting of visible light. 
  • 1.8K
  • 24 May 2021
Topic Review
Serrated Pathway in Colorectal Cancer
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different subtypes that differ in their clinical and prognostic features. In the past decade, in addition to the conventional adenoma-carcinoma model, an alternative multistep mechanism of carcinogenesis, namely the “serrated pathway”, has been described. Approximately, 15 to 30% of all CRCs arise from neoplastic serrated polyps, a heterogeneous group of lesions that are histologically classified into three morphologic categories: hyperplastic polyps, sessile serrated adenomas/polyps, and the traditional serrated adenomas/polyps. Serrated polyps are characterized by genetic (BRAF or KRAS mutations) and epigenetic (CpG island methylator phenotype (CIMP)) alterations that cooperate to initiate and drive malignant transformation from normal colon mucosa to polyps, and then to CRC. The high heterogeneity of the serrated lesions renders their diagnostic and pathological interpretation difficult. 
  • 1.8K
  • 10 Sep 2021
Topic Review
Pathophysiology of Hemorrhagic Shock
The pathophysiology of hemorrhagic shock involves a decrease in systemic oxygen delivery to a level less than what is required to maintain cellular function.
  • 1.8K
  • 03 Nov 2021
Topic Review
Zooceuticals and Cosmetic Ingredients Derived from Animals
Many substances derived from animals are used as ingredients in the cosmetic industry and constitute a particular type of product: zooceuticals. The main ingredients used can come from insects, such as snail slime; land animals, such as lanolin; and marine animals, such as marine collagen. Today, they are used less than in the past for hygienic–sanitary, ethical, and ecological reasons. Moreover, some can give rise to irritative or allergic dermatitis. However, they still represent a fraction of the common ingredients in certain types of cosmetic products today.
  • 1.8K
  • 07 Mar 2022
Topic Review
Reinforcement Learning in Home Energy Management System
Artificial Intelligence, more specifically machine learning, is one of the key contributing factors that have helped realize Home Energy Management Systems today. Reinforcement Learning is a class of machine learning algorithms that is making deep inroads in various applications in energy management in smart homes. This machine learning paradigm allows an algorithmic entity, called an agent, to make sequences of decisions and implement actions from experience in the same manner as a human being. Reinforcement learning is increasingly being used in various home energy management applications today. This article surveys the application of this learning paradigm in smart home energy management. Applications have been divided into five broad categories, and the reinforcement learning approach applied in each case have been investigated separately, in terms of building types, objective functions, and algorithm classes.
  • 1.8K
  • 14 Sep 2022
Topic Review
SV40
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often persists as a latent infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription.
  • 1.8K
  • 26 Oct 2022
Topic Review
Dragon Boat
A dragon boat is a human-powered watercraft originating from the Pearl River Delta region of China 's southern Guangdong Province. These were made of teak, but in other parts of China, different kinds of wood are used. It is one of a family of traditional paddled long boats found throughout Asia, Africa, the Pacific islands, and Puerto Rico. The sport of dragon boat racing has its roots in an ancient folk ritual of contending villagers, which dates back 2000 years throughout southern China, and even further to the original games of Olympia in Ancient Greece . Both dragon boat racing and the ancient Olympiad included aspects of religious observances and community celebrations, along with competitions. Dragon boat racing has been a traditional Chinese paddled watercraft activity for over 2000 years and began as a modern international sport in Hong Kong in 1976. These boats are typically made of carbon fiber, fiberglass, and other lightweight materials. For competition events, dragon boats are generally rigged with decorative Chinese dragon heads and tails. At other times (such as during training), decorative regalia is usually removed, although the drum often remains aboard for drummers to practice. For races, there are 18-20 people in a standard boat, and 8-10 in a small boat, not including the steersperson (helm) and the drummer. In December 2007, the central government of the People's Republic of China added the Dragon Boat Festival, along with the Qingming and Mid-Autumn festivals, to the schedule of national holidays.
  • 1.8K
  • 05 Nov 2022
Topic Review
Blister
A blister is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma. However, blisters can be filled with blood (known as "blood blisters") or with pus (for instance, if they become infected). The word "blister" entered English in the 14th century. It came from the Middle Dutch bluyster and was a modification of the Old French blostre, which meant a leprous nodule—a rise in the skin due to leprosy. In dermatology today, the words vesicle and bulla refer to blisters of smaller or greater size, respectively. To heal properly, a blister should not be popped unless medically necessary. If popped, the excess skin should not be removed because the skin underneath needs the top layer to heal properly.
  • 1.8K
  • 09 Nov 2022
Topic Review
Dietary Interventions in Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, affecting ~7% of children and adolescents. Specific dietary interventions have been proposed as coadjuvant treatments in this disorder. These include nutritional supplements with vitamins, minerals, and polyunsaturated fatty acids; microbiome-targeted interventions with pre-, pro-, and synbiotics; and specific diets such as restriction or elimination diets. Regarding nutritional supplements, only vitamin D and vitamin D + magnesium appear to improve ADHD symptoms when baseline levels of vitamin D are insufficient/deficient. As for biotics, evidence has only been found for Lactobacillus rhamnosus GG and for multi-species probiotic supplementation. Elimination diets have scarce evidence and lead to nutritional deficiencies, so caution is advised.
  • 1.8K
  • 30 Nov 2022
Topic Review
Conditional Frontier Analysis (DEA)
Conditional Frontier Analysis is part of the Nonparametric Robust Estimators proposed to overcome some drawbacks in the traditional Data Envelopment Analysis (DEA) and Free Disposal Hull (FDH) measures for the technical efficiency. In special, this methodology extends the nonparametric input/output production technology to robustly account for extreme values or outliers in the data, and allow measuring the effect of external environmental variables on the efficiency of Decision Making Units (DMUs). 
  • 1.8K
  • 01 May 2021
Topic Review
Genetics of Primary Aldosteronism
Primary aldosteronism (PA) is the most common form of secondary hypertension, with a prevalence of 5–10% among patients with hypertension. PA is mainly classified into two subtypes: aldosterone-producing adenoma (APA) and bilateral idiopathic hyperaldosteronism. Recent developments in genetic analysis have facilitated the discovery of mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, CACNA1H, CLCN2, and CTNNB1 in sporadic or familial forms of PA in the last decade. These findings have greatly advanced our understanding of the mechanism of excess aldosterone synthesis, particularly in APA. Most of the causative genes encode ion channels or pumps, and their mutations lead to depolarization of the cell membrane due to impairment of ion transport. Depolarization activates voltage-gated Ca2+ channels and intracellular calcium signaling and promotes the transcription of aldosterone synthase, resulting in overproduction of aldosterone. 
  • 1.8K
  • 07 May 2021
Topic Review
Fyn
Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family kinases (SFKs) involved in multiple transduction pathways in the central nervous system (CNS) including synaptic transmission, myelination, axon guidance, and oligodendrocyte formation. Almost one hundred years after the original description of Fyn, this protein continues to attract extreme interest because of its multiplicity of actions in the molecular signaling pathways underlying neurodevelopmental as well as neuropathologic events. Fyn is a common factor in healthy and diseased brains that targets different proteins and shapes different transduction signals according to the neurological conditions. In particular, Fyn mediates signaling pathways involved in neuronal differentiation and plasticity that have been subjected to considerable attention lately, opening the fascinating scenario to target Fyn TK for the development of potential therapeutic interventions for the treatment of CNS injuries and certain neurodegenerative disorders like Alzheimer's disease.
  • 1.8K
  • 05 Nov 2020
Topic Review
Fibromyalgia Symptoms Overview
Fibromyalgia syndrome (FMS) can be conceptualized as a chronic disorder characterized by widespread musculoskeletal pain and other accompanying symptoms such as fatigue, insomnia, depression, anxiety and cognitive impairments. The etiology of FMS remains unknown, being one of the most accepted hypothesis the presence of central sensitization to pain and impairments in endogenous pain inhibitory mechanisms. The history of the development of FMS concept reveals how other symptoms -apart from pain- has become also relevant in FMS diagnosis and treatment. The central symptom of FMS is pain. FMS patients generally report high levels of clinical pain, which are related to greater impairments in health related quality of life, cognitive abilities and disease course. Fatigue and sleeping difficulties are also common symptoms of FMS. Fatigue have shown positive associations with pain, stiffness, sleep problems, increased body mass index, FMS severity, tenderness, disability, cognitive complaints, anxiety and depression. The majority of FMS patients report poor sleep quality, take longer to fall asleep, generally wake up during the night, sleep fewer hours, and usually wake up unrefreshed. Emotional disturbances (i.e., depression, anxiety) are also frequent in FMS. In fact, depression and anxiety disorders have showed a negative impact on the clinical course and work capacity of FMS patients. Cognitive impairments are also a relevant symptom in FMS. The most common complaints among FMS patients are executive function deficits, attention problems, forgetfulness, concentration difficulties, and mental slowness. Regarding the most frequent treatments for FMS, these can be classified as non-psychological and psychological. The former includes analgesic drugs, adjuvant drugs (i.e., antidepressants, benzodiazepines, anticonvulsants, etc.), nerve blocks, electrostimulation at different levels, infiltrations, etc. The psychological therapies with the most evidence are cognitive-behavioral, acceptance and commitment therapy and mindfulness. FMS is associated with a severe reduction of health related quality of life and psychosocial impairments. It is necessary to take all FMS symptoms and its relations into account in order to provide a more tailored and effective treatment, as well as, to improve the health related quality of life of FMS patients.
  • 1.8K
  • 26 Oct 2020
Topic Review
Cu Homeostasis in Bacteria
Copper is an essential transition metal which is also toxic to cell.. Organisms have developed sophisticated pathways to import, traffic, store and deliver copper to cuproproteins. They also export its excess outsite of the cell to protect themselves from oxidative stress. The pathways contains specific importers, chaperons, storage proteins and exporters. Expression of the corresponding structural genes is conrolled by copper availability via sensors and response regulation transcription factors described below.
  • 1.8K
  • 08 Feb 2021
Topic Review
Bio-Inspired Hierarchical Fibres
Several naturally occurring biological systems, such as bones, nacre or wood, display hierarchical architectures with a central role of the nanostructuration that allows reaching amazing properties such as high strength and toughness. Developing such architectures in man-made materials is highly challenging, and recent research relies on this concept of hierarchical structures to design high-performance composite materials. This review deals more specifically with the development of hierarchical fibres by the deposition of nano-objects at their surface to tailor the fibre/matrix interphase in (bio)composites. Fully synthetic hierarchical fibre reinforced composites are described, and the potential of hierarchical fibres is discussed for the development of sustainable biocomposite materials with enhanced structural performance. Based on various surface, microstructural and mechanical characterizations, this review highlights that nano-objects coated on natural fibres (carbonnanotubes, ZnO nanowires, nanocelluloses) can improve the load transfer and interfacial adhesion between the matrix and the fibres, and the resulting mechanical performances of biocomposites. Indeed, the surface topography of the fibres is modified with higher roughness and specific surface area, implying increased mechanical interlocking with the matrix. As a result, the interfacial shear strength (IFSS) between fibres and polymer matrices is enhanced, and failure mechanisms can bemodified with a crack propagation occurring through a zig-zag path along interphases.
  • 1.8K
  • 29 May 2021
Topic Review
DSGSDs on Mars
Deep-Seated Gravitational Slope Deformations (DSGSDs) are a set of slow and complex gravity-driven deformational processes, involving entire slopes (or large portions of them) over long time intervals. These phenomena have been identified on Mars since the early 2000s, and several detailed studies were conducted on them.
  • 1.8K
  • 29 Apr 2021
Topic Review
Barriers to Sustainable Farming Practices
Research has a critical role in supporting the implementation of farming practices that are appropriate for meeting food and climate security for a growing global population. Notwithstanding progress towards more sustainable agricultural production, the rate of change varies across and within regions and is, overall, too slow. Understanding what is and is not working at the implementation level and, critically, providing justified explanations on outcomes, is an important contribution of the literature. It is suggested that a greater application of theory in adoption research could increase the contribution of the literature. 
  • 1.8K
  • 10 May 2021
Topic Review
Mangrove Blue Carbon Stocks
Mangrove forests play an important role in mitigating climate change but are threatened by aquaculture expansion (shrimp ponds). The change of land use from natural environments to productive uses, generates a change in the balance and carbon sequestration and storaging. In mangrove forest the carbon stocks are larger than in other tropical forest. Addtionally, soil mangrove forest represent 40-80% of Cardon stocks.  These reasons are the evidence of mangrove forest need to be included in REED programs and conservation strategies.
  • 1.8K
  • 06 Jul 2021
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