Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Camila Xu -- 1082 2022-10-26 01:30:41

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. SV40. Encyclopedia. Available online: https://encyclopedia.pub/entry/31452 (accessed on 24 September 2026).
HandWiki. SV40. Encyclopedia. Available at: https://encyclopedia.pub/entry/31452. Accessed September 24, 2026.
HandWiki. "SV40" Encyclopedia, https://encyclopedia.pub/entry/31452 (accessed September 24, 2026).
HandWiki. (2022, October 26). SV40. In Encyclopedia. https://encyclopedia.pub/entry/31452
HandWiki. "SV40." Encyclopedia. Web. 26 October, 2022.
SV40
Edit

SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors in animals, but most often persists as a latent infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription.

polyomavirus polyomaviruses sv40

References

  1. Poulin, D. L.; Decaprio, J. A. (2006). "Is There a Role for SV40 in Human Cancer?". Journal of Clinical Oncology 24 (26): 4356–65. doi:10.1200/JCO.2005.03.7101. PMID 16963733.  https://dx.doi.org/10.1200%2FJCO.2005.03.7101
  2. Lowe, D. B.; Shearer, M. H.; Jumper, C. A.; Kennedy, R. C. (2007). "SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen". Cellular and Molecular Life Sciences 64 (7–8): 803–14. doi:10.1007/s00018-007-6414-6. PMID 17260087.  https://dx.doi.org/10.1007%2Fs00018-007-6414-6
  3. Shah, K. V. (2007). "SV40 and human cancer: A review of recent data". International Journal of Cancer 120 (2): 215–23. doi:10.1002/ijc.22425. PMID 17131333.  https://dx.doi.org/10.1002%2Fijc.22425
  4. Moens, U; Van Ghelue, M; Johannessen, M (2007). "Oncogenic potentials of the human polyomavirus regulatory proteins". Cellular and Molecular Life Sciences 64 (13): 1656–78. doi:10.1007/s00018-007-7020-3. PMID 17483871.  https://dx.doi.org/10.1007%2Fs00018-007-7020-3
  5. Barbanti-Brodano, G; Sabbioni, S; Martini, F; Negrini, M; Corallini, A; Tognon, M (2004). "Simian virus 40 infection in humans and association with human diseases: results and hypotheses". Virology 318 (1): 1–9. doi:10.1016/j.virol.2003.09.004. PMID 15015494.  https://dx.doi.org/10.1016%2Fj.virol.2003.09.004
  6. "Studies Find No Evidence That SV40 is Related to Human Cancer". National Cancer Institute, National Institutes of Health. 23 August 2004. http://www.cancer.gov/newscenter/newsfromnci/2004/sv40. 
  7. Engels, E. A.; Chen, J; Hartge, P; Cerhan, J. R.; Davis, S; Severson, R. K.; Cozen, W; Viscidi, R. P. (2005). "Antibody Responses to Simian Virus 40 T Antigen: A Case-Control Study of Non-Hodgkin Lymphoma". Cancer Epidemiology, Biomarkers & Prevention 14 (2): 521–4. doi:10.1158/1055-9965.epi-04-0441. PMID 15734981.  https://dx.doi.org/10.1158%2F1055-9965.epi-04-0441
  8. Engels, Eric A.; Katki, Hormuzd A.; Nielsen, Nete M.; Winther, Jeanette F.; Hjalgrim, Henrik; Gjerris, Flemming; Rosenberg, Philip S.; Frisch, Morten (2003). "Cancer Incidence in Denmark Following Exposure to Poliovirus Vaccine Contaminated with Simian Virus 40". JNCI Journal of the National Cancer Institute 95 (7): 532–9. doi:10.1093/jnci/95.7.532. PMID 12671021.  https://dx.doi.org/10.1093%2Fjnci%2F95.7.532
  9. Institute of Medicine (US) Immunization Safety Review Committee; Stratton, K.; Almario, D. A.; McCormick, M. C. (2002). Stratton, Kathleen; Almario, Donna A.; McCormick, Marie C.. eds. Immunization Safety Review: SV40 Contamination of Polio Vaccine and Cancer. The National Academy of Sciences. pp. 19–84. doi:10.17226/10534. ISBN 978-0-309-08610-3. http://www.nap.edu/openbook.php?record_id=10534&page=19. 
  10. Kroczynska, B; Cutrone, R; Bocchetta, M; Yang, H; Elmishad, A G; Vacek, P; Ramos-Nino, M; Mossman, BT et al. (2006). "Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters". Proceedings of the National Academy of Sciences of the United States of America 103 (38): 14128–33. doi:10.1073/pnas.0604544103. PMID 16966607. Bibcode: 2006PNAS..10314128K.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1599923
  11. Pershouse, MA; Heivly, S; Girtsman, T (2006). "The role of SV40 in malignant mesothelioma and other human malignancies". Inhalation Toxicology 18 (12): 995–1000. doi:10.1080/08958370600835377. PMID 16920674.  https://dx.doi.org/10.1080%2F08958370600835377
  12. NIH/National Cancer Institute (2004-08-25). "Studies Find No Evidence That Simian Virus 40 Is Related To Human Cancer". Science Daily. https://www.sciencedaily.com/releases/2004/08/040825092736.htm. 
  13. Hilleman MR (1998). "Discovery of simian virus 40 (SV40) and its relationship to poliomyelitis virus vaccines.". Dev Biol Stand 94: 183–90. PMID 9776239.  http://www.ncbi.nlm.nih.gov/pubmed/9776239
  14. Carroll-Pankhurst, C; Engels, EA; Strickler, HD; Goedert, JJ; Wagner, J; Mortimer EA Jr. (Nov 2001). "Thirty-five year mortality following receipt of SV40- contaminated polio vaccine during the neonatal period.". Br J Cancer 85 (9): 1295–7. doi:10.1054/bjoc.2001.2065. PMID 11720463.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2375249
  15. Fanning, E; Zhao, K (2009). "SV40 DNA replication: from the A gene to a nanomachine". Virology 384 (2): 352–359. doi:10.1016/j.virol.2008.11.038. PMID 19101707.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2718763
  16. Sowd, GA; Fanning, E (2012). "A wolf in sheep's clothing: SV40 co-opts host genome maintenance proteins to replicate viral DNA". PLOS Pathogens 8 (11): e1002994. doi:10.1371/journal.ppat.1002994. PMID 23144614.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3493471
  17. Raghava, Smita; Giorda, Kristina M.; Romano, Fabian B.; Heuck, Alejandro P.; Hebert, Daniel N. (2011-06-30). "The SV40 Late Protein VP4 Is a Viroporin that Forms Pores to Disrupt Membranes for Viral Release". PLOS Pathogens 7 (6): e1002116. doi:10.1371/journal.ppat.1002116. PMID 21738474.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3128117
  18. DeCaprio, James A.; Garcea, Robert L. (April 2013). "A cornucopia of human polyomaviruses". Nature Reviews Microbiology 11 (4): 264–276. doi:10.1038/nrmicro2992. PMID 23474680.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3928796
  19. Henriksen, Stian; Rinaldo, Christine Hanssen (2020-04-29). "Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin?". mSphere 5 (2): e00019-20. doi:10.1128/mSphere.00019-20. PMID 32188744.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7082134
  20. Daniels, Robert; Hebert, Daniel N. (2020-04-29). "In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin". mSphere 5 (2): e00187-20. doi:10.1128/mSphere.00187-20. PMID 32188752.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=7082142
  21. Yamamoto, Hiroshi; Shimojo, H (August 1971). "Multiplicity reactivation of human adenovirus type 12 and simian virus 40 irradiated by ultraviolet light". Virology 45 (2): 529–31. doi:10.1016/0042-6822(71)90355-2. PMID 4328814.  https://dx.doi.org/10.1016%2F0042-6822%2871%2990355-2
  22. Hall, J. D. (1982). "Repair of psoralen-induced crosslinks in cells multiply infected with SV40". Molecular & General Genetics 188 (1): 135–8. doi:10.1007/bf00333007. PMID 6294477.  https://dx.doi.org/10.1007%2Fbf00333007
  23. Michod, Richard E.; Bernstein, Harris; Nedelcu, Aurora M. (2008). "Adaptive value of sex in microbial pathogens". Infection, Genetics and Evolution 8 (3): 267–85. doi:10.1016/j.meegid.2008.01.002. PMID 18295550.  https://dx.doi.org/10.1016%2Fj.meegid.2008.01.002
  24. Eibl, R. H.; Kleihues, P; Jat, P. S.; Wiestler, O. D. (1994). "A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen". The American Journal of Pathology 144 (3): 556–64. PMID 8129041.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1887088
  25. Sweet, B. H.; Hilleman, M. R. (November 1960). "The vacuolating virus, S.V. 40". Proceedings of the Society for Experimental Biology and Medicine 105 (2): 420–427. doi:10.3181/00379727-105-26128. PMID 13774265.  https://dx.doi.org/10.3181%2F00379727-105-26128
  26. Eddy, B. E.; Borman, G. S.; Grubbs, G. E.; Young, R. D. (May 1962). "Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40". Virology 17: 65–75. doi:10.1016/0042-6822(62)90082-x. PMID 13889129.  https://dx.doi.org/10.1016%2F0042-6822%2862%2990082-x
  27. Reddy, V. B.; Weissman, S. M. (May 1978). "The genome of simian virus 40". Science 200 (4341): 494–502. doi:10.1126/science.205947. PMID 205947. Bibcode: 1978Sci...200..494R.  https://dx.doi.org/10.1126%2Fscience.205947
  28. Fiers, W; Contreras, R; Haegemann, G; Rogiers, R; Van De Voorde, A; Van Heuverswyn, H; Van Herreweghe, J; Volckaert, G et al. (May 1978). "Complete nucleotide sequence of SV40 DNA". Nature 273 (5658): 113–20. doi:10.1038/273113a0. PMID 205802. Bibcode: 1978Natur.273..113F.  https://dx.doi.org/10.1038%2F273113a0
More
Upload a video for this entry
Information
Subjects: Microbiology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 1.8K
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 26 Oct 2022
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service