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Topic Review
FOB (Shipping)
FOB, "Free On Board", is a term in international commercial law specifying at what point respective obligations, costs, and risk involved in the delivery of goods shift from the seller to the buyer under the Incoterms standard published by the International Chamber of Commerce. FOB is only used in non-containerized sea freight or inland waterway transport. As with all Incoterms, FOB does not define the point at which ownership of the goods is transferred. The term FOB is also used in modern domestic shipping within the United States to describe the point at which a seller is no longer responsible for shipping cost. Ownership of a cargo is independent from Incoterms. In international trade, ownership of the cargo is defined by the bill of lading or waybill.
  • 1.8K
  • 13 Oct 2022
Topic Review
Non-Helical Models of DNA Structure
In the history of molecular biology, non-helical or "side-by-side" models of DNA were proposed in the 1970s as a challenge to the standard double-helical model. The non-helical models attempted to solve problems relating to the topology of circular DNA chromosomes during replication. These theories were briefly considered seriously as a minority viewpoint, but they were later largely rejected due to X-ray crystallography of DNA duplexes and later the nucleosome core particle, as well as the discovery of topoisomerases, and these non-double-helical models are not currently accepted by the mainstream scientific community.
  • 1.8K
  • 12 May 2023
Topic Review
Hellhole
Hellhole is a large and deep pit cave in Germany Valley, eastern West Virginia. It is the 7th longest cave in the United States and is home to almost half of the world's population of Virginia big-eared bats. At 518 feet (158 meters), Hellhole is the deepest of several caves in the Valley. Hellhole has had a long and storied association with the National Speleological Society dating back to the creation of that organization in the early 1940s. Many basic caving techniques (e.g., the single rope technique) were developed in Hellhole's 154-foot (47 meter) entrance drop.
  • 1.8K
  • 02 Nov 2022
Topic Review
Occipital Epilepsy
Occipital epilepsy is a neurological disorder that arises from excessive neural activity in the occipital lobe of the brain that may or may not be symptomatic. Occipital lobe epilepsy is fairly rare, and may sometimes be misdiagnosed as migraine when symptomatic. Epileptic seizures are the result of synchronized neural activity that is excessive, and may stem from a failure of inhibitory neurons to regulate properly. It is a disorder with focal seizures in the occipital lobe of the brain. There are two main types of this epilepsy, each consisting of focal seizures- Gastaut and Panayiotopoulos (Pan.). Other names for the Gastaut type include benign epilepsy of childhood with occipital paroxysms (BECOP) and late-onset occipital epilepsy. Pan. is also known as self-limiting focal epilepsy of childhood with occipital paroxysms and early-onset benign partial epilepsy with occipital paroxysms. There may be no known cause of this type of seizure, but these epilepsies may occur for a variety of reasons, such as brain tumors, infection, trauma and lesions, and idiopathic onset. Seizures originate in the occipital lobe and account for 5 to 10 percent of all epileptic seizure types. Generally, this type of epilepsy can have an onset anywhere from 1–17 years old in children, but the patient prognosis is good. Since the event is located in the occipital lobe, symptoms may occur spontaneously and include visual stimuli.
  • 1.8K
  • 14 Nov 2022
Topic Review
Electrospun Polymer Nanofibers
Electrospun polymer nanofibers constitute one of the most important nanomaterials with diverse applications. Nanofibers are classified as fibers with a ratio of length to thickness in the order of one thousand, or nanomaterials that have at least one dimension of 100 nm or less. A nanofiber with a diameter of ∼100 nm can have a specific surface area up to 1000 m2/g. Nanofibers can be produced by selecting the proper combination of polymers and additives, and using appropriate production techniques based on several essential characteristics that impact criteria of the intended particular application area. Electrospinning of polymer nanofibers is a widely used for investigation of their properties for uses in quite diverse applications. Attractive properties of electrospun nanofibers include the extremely high specific surface area, high porosity (typically 90%), light weight, controllable pore size, flexibility in surface functionalities, large permeability, excellent mechanical properties, high aspect ratio, and length up to many centimeters. Due to their exceptional characteristics, electrospun polymer nanofibers are used in many applications, which include biomedical technology, such as tissue engineering, wound healing and dressing, and drug delivery systems. In addition they have diverse uses in  sensors and biosensors applications, air filtration, defense applications, energy devices and protective textiles.
  • 1.8K
  • 12 Jan 2023
Topic Review
Salt in Low Back Pain and Comorbid Conditions
Low back pain is the world’s leading disability, but the etiology of the majority of low back pain is non-specific with no known cause. Moreover, overuse of opioids to treat low back pain is a widespread problem. Many global populations consume excess sodium chloride, which can lead to fluid overload in hypervolemia, and cause swelling and temporary weight gain associated with low back pain. Numerous conditions comorbid with low back pain are also potentially mediated by excessive salt intake, including migraine headache, hypertension, cardiovascular disease, venous thromboembolism, liver disease, respiratory disorders, chronic kidney disease, pregnancy complications, and multiple sclerosis.
  • 1.8K
  • 14 Mar 2024
Topic Review
Plant Host Defense Peptides: Snakins
Plant host defense peptides (HDPs), also known as antimicrobial peptides (AMPs), are regarded as one of the most prevalent barriers elaborated by plants to combat various infective agents. HDPs are arbitrarily referred to as small, thermal stable, and positively charged peptides, generally comprising peptides of less than 100 amino acid residues with an overall net charge of +2 to +9, and molecular weight of 4 to 9 kDa. Plant HDPs can be classified into at least eight major families, including defensins, thionins, non-specific lipid-transfer proteins (LTPs), hevein-like peptides, Snakins, knottins, α-hairpinins, and cyclotides, among which the Snakin family peptide has been reported to be the most abundant potential AMP that is active against fungal and bacterial pathogens. The Snakin/GASA family peptides consist of 12 cysteine residues, being the foremost cysteine-rich peptides among different classes of plant HDPs.
  • 1.8K
  • 01 Apr 2021
Topic Review
The Use of Collagen in Bone Tissue Engineering
Synthetic bone substitute materials (BSMs) are becoming the general trend of replacing autologous grafting for bone tissue engineering (BTE) in orthopedic research and clinical practice. As the main component of bone matrix, collagen type I has been playing a critical role in the construction of ideal synthetic BSMs for decades. Significant strides have been made in the field of collagen research, including the exploration of various collagen types, structure and sources, the optimization of preparation techniques, modification technologies, and the manufacture of various collagen-based materials. However, the poor mechanical properties, fast degradation, and lack of osteoconductive activity of collagen-based materials caused inefficient bone replacement and limited their translation into clinical reality. In the area of BTE, so far, attempts focused on the preparation of collagen-based biomimetic BSMs together with other inorganic materials and bioactive substances. By reviewing the approved products on the market, this manuscript updates the latest applications of collagen-based materials in bone regeneration and highlights the potential for further development in the field of BTE over the next ten years.
  • 1.8K
  • 08 Mar 2023
Topic Review
Sensor Data for Mobile Robots
Autonomous robots that assist humans in day to day living tasks are becoming increasingly popular. Autonomous mobile robots operate by sensing and perceiving their surrounding environment to make accurate driving decisions. A combination of several different sensors such as LiDAR, radar, ultrasound sensors and cameras are utilized to sense the surrounding environment of autonomous vehicles. These heterogeneous sensors simultaneously capture various physical attributes of the environment. Such multimodality and redundancy of sensing need to be positively utilized for reliable and consistent perception of the environment through sensor data fusion. However, these multimodal sensor data streams are different from each other in many ways, such as temporal and spatial resolution, data format, and geometric alignment. For the subsequent perception algorithms to utilize the diversity offered by multimodal sensing, the data streams need to be spatially, geometrically and temporally aligned with each other. A typical approach is to use a geometrical model to spatially align the two sensor outputs, followed by a Gaussian Process (GP) regression-based resolution matching algorithm to interpolate the missing data with quantifiable uncertainty. 
  • 1.8K
  • 09 Nov 2020
Topic Review
PirAB from Vibrio parahaemolyticus and AHPND in Shrimp
PirAB is a potent toxin which can causes 100% mortality in shrimp, the toxin produce masive sloughing of the epithelial cells of the shrimp hepatopancreas, kown as acute hepatopancreatic necrosis diseaseas (AHPND) in diseased penaeid shirmp. This toxin is produced by specific strains of Vibrio parahaemolyticus, which harbors a plasmid of ~70 kbp (pVA1) containing the pirAVp and pirBVp genes that encode PirAB toxin.   
  • 1.8K
  • 20 Apr 2022
Topic Review
Very Low-Calorie Ketogenic Diet for Hypercortisolism Comorbidities Treatment
A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less than 800 kcal/day), low carbohydrate intake (<50 g/day) and normoproteic (1–1.5 g of protein/kg of ideal body weight) contents. It induces a significant weight loss and an improvement in lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. Cushing’s syndrome (CS) is characterized by an endogenous or exogenous excess of glucocorticoids and shows many comorbidities including cardiovascular disease, obesity, type 2 diabetes mellitus and lipid disorders. 
  • 1.8K
  • 22 Jun 2022
Topic Review
Fluorescent Probes in Cellulo Recognitions of Alkaline Phosphatases
Alkaline phosphatase (ALP) is one of the vital phospho-ester bond cleaving biocatalysts that has inevitable significance in cellular systems, viz., early-stage osteoblast differentiation, cell integrity in tissues, bone mineralization, cancer biomarker, liver dysfunction, cellular osmotic pressure, protein folding and many more. Variation from optimal levels of ALP in intra and extracellular fluids can cause severe diseases, including death. Due to these reasons, ALP is considered as a vital biomarker for various preclinical and medical diagnosis. Fluorescence image-based diagnosis is the most widely used method, owing to its simplicity, robustness, non-invasive properties and excellent spatio-temporal resolution (up to the nM/pM level), as compared to conventional analytical techniques, such as the electroanalytical method, nuclear magnetic resonance (NMR) and high-performance liquid chromatography (HPLC). Most of the reviews reported for ALP’s recognition in the literature scarcely explain the structurally related, photophysical and biophysical parameters; and the sub-cellular localizations. Considering these facts, in order to enhance the opto-analytical parameters of fluorescence-based diagnostic materials at the cellular level, herein we have systematically documented recent developments in the opto-analytical capabilities of quencher-free probes for ALP, used in in vitro (biological buffers) to in cellulo conditions, along with in vivo models. 
  • 1.8K
  • 03 Sep 2022
Topic Review
Suwa Daimyōjin Ekotoba
The Suwa Daimyōjin Ekotoba (諏方大明神画詞 or 諏訪大明神絵詞 "Illustrated Record of Suwa Daimyōjin (Shrine)"), also known as Suwa Daimyōjin Go-engi Shidai (諏訪大明神御縁起次第 "Order of Legends (Engi) of Suwa Daimyōjin (Shrine)") or Suwa(-sha) Engi Emaki (諏方（社）縁起絵巻 "Illustrated Legends of Suwa (Shrine)"), was a twelve (originally ten) volume set of emakimono or painted handscrolls completed in 1356 (Enbun 1), during the Nanboku-chō period. Originally describing and depicting legends concerning the Suwa Grand Shrine in Shinano Province (modern-day Nagano Prefecture) and its deity as well as its various religious festivals as performed during the Middle Ages, the original scrolls containing the illustrations were eventually lost, with only the text being preserved in various manuscripts.
  • 1.8K
  • 20 Oct 2022
Topic Review
Jupiter (Rocket Family)
The Jupiter family of super heavy-lift launch vehicles was part of the proposed DIRECT Shuttle-Derived Launch Vehicle architecture. It was intended to be the alternative to the Ares I and Ares V rockets which were under development for the US Project Constellation. Major benefits were projected from re-using as much hardware and facilities from the Space Shuttle program as possible, including cost savings, experience with existing hardware, and preserving the workforce.
  • 1.8K
  • 23 Nov 2022
Topic Review
COVID-19 Pandemic on Changes in Consumer Purchasing Behavior
The coronavirus has wreaked havoc on the global economy before the eyes of the entire world. Due to evolving consumer needs and expectations during the pandemic, the supply and demand for various goods and services varied from the pre-COVID-19 period.
  • 1.8K
  • 01 Apr 2024
Topic Review
Remote Sensing Data Fusion
With the growth of satellite and airborne-based platforms, remote sensing is increasing attention in the last decades. Everyday, sensors acquire data with different modalities and several resolutions. Leveraging on their complementary properties is a key scientific challenge, usually called remote sensing data fusion.
  • 1.8K
  • 22 Feb 2021
Topic Review
Flavivirus Infection
The flaviviruses are important human pathogens, and a deeper understanding of the virus–host cell interaction is required to identify cellular targets that can be used as therapeutic candidates. Flaviviruses hijack several cellular functions, such as exosome-mediated cell communication during infection, which is modulated by the delivery of the exosomal cargo of pro- or antiviral molecules to the receiving host cells. Therefore, to study the role of exosomes during flavivirus infections is essential to identify molecular factors that may contribute to the development of new strategies to block viral infections. This review explores the implications of exosomes in flavivirus dissemination and transmission from the vector to human host cells, as well as their involvement in the host immune response. Although several studies have been performed to identify and characterize cellular and viral molecules released in exosomes, the role of these components in viral pathogenesis is unclear. Further studies will determine the balance between protective and harmful exosomes secreted by flavivirus infected cells, the characteristics and components that distinguish them both, and how they could be a factor that determines the infection outcome.
  • 1.8K
  • 29 Jul 2020
Topic Review
Landscape
“Landscape” is a broad and slippery term, with strong connections to the history of art, the history of territorial possession, and the cultural artifacts of human occupation in specific places.
  • 1.8K
  • 16 Jan 2022
Topic Review
Cross-Sectoral Digital Platform and Innovation Ecosystem Development
A cross-sectoral ecosystem is considered to be a mechanism for the cross-sectoral interaction of an unlimited number of actors of a certain technological sector of the economy in a platform-based single digital circuit that provides digital tools and services to ensure accelerated growth and reduce costs through synergy from multilateral interaction based on common rules and principles of self-government, digital transparency, networking, and equality for all participants.
  • 1.8K
  • 12 Nov 2021
Topic Review
Milas
Milas (Ancient Greek:, Mylasa) is an ancient city and the seat of the district of the same name in Muğla Province in southwestern Turkey. The city commands a region with an active economy and very rich in history and ancient remains, the territory of Milas containing a remarkable twenty-seven archaeological sites of note. The city was the first capital of ancient Caria and of the Anatolian beylik of Menteşe in mediaeval times. The nearby Mausoleum of Hecatomnus is classified as a UNESCO World Heritage Site. Milas is focused on agricultural and aquacultural processing, related industrial activities, services, transportation (particularly since the opening of Milas-Bodrum Airport), tourism and culture. The centre lies about 20 km from the coast and is closer to the airport than Bodrum itself, with many late arrival passengers of the high season increasingly opting to stay in Milas rather than in Bodrum where accommodation is likely to be difficult to find. Milas district covers a total area of 2167 km2 and this area follows a total coastline length of 150 km, both to the north-west in the Gulf of Güllük and to the south along the Gulf of Gökova, and to these should be added the shores of Lake Bafa in the north divided between the district area of Milas and that of Aydın district of Söke. Along with the province seat of Muğla and the province's southernmost district of Fethiye, Milas is among the prominent settlements of south-west Turkey, these three centers being on a par with each other in terms of all-year population and the area their depending districts cover. Five townships have their own municipalities, and a total of 114 villages depend on Milas, distinguishing the district with a record number of dependent settlements for a very wide surrounding region. Milas center is situated on a fertile plain at the foot of Mount Sodra, on and around which sizable quarries of white marble are found and have been used since very ancient times.
  • 1.8K
  • 07 Nov 2022
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