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Topic Review
Dynamic Crosslinking Hydrogel Dressings
One of the most advanced, promising and commercially feasible research issues in the field of hydrogel dressings is to obtain functions to achieve improved therapeutic effects and even intelligent wound repair. In addition to the advantages of ordinary hydrogel dressings, functional hydrogel dressings can also adjust their chemical/physical properties to meet different wound types, respond accordingly, actively create a healing environment conducive to wound repair, and control drug release to provide lasting benefits.
  • 2.0K
  • 12 May 2023
Topic Review
Safety, Toxicity of Phage Therapy
Lytic bacteriophages (phages) have been known to be a potential antibacterial agent for over a century since their first formal discovery and application as a treatment against human bacterial infections in the 1920s. Though subsequent success of antibiotics had quelled investigations into phage as potential anti-infectives, increasing antibiotic resistance has hastened the reemergence of interest in phage therapy. Despite attractive advantages, including widespread prevalence, activity against multidrug-resistant (MDR) bacteria, high specificity, and activity against biofilms, phage therapy is still not considered a mainstream treatment due to several obstacles. First, the lack of reliable data regarding its safety and efficacy in clinical settings. Second, appropriate regulatory guidelines specific to phage therapeutics have not been developed. Finally, the pharmaceutical and biotech industries have not yet developed economical and scalable production processes for widespread adoption of phage therapy. While much progress has been made, many questions remain, such as the safety and toxicity of phage preparations.
  • 2.0K
  • 21 Jul 2021
Topic Review
Effect of Accelerating Methods on Gas Nitriding
Gas nitriding, as a surface modification technology to improve the wear resistance of workpiece surfaces, is widely used in wind turbine gears, pressure vessel gears, high-precision die casting abrasives, and other areas. However, the gas nitriding time is too long, reaching 40–60 h, which reduces the efficiency of nitriding and hinders the development of gas nitriding. Therefore, various accelerating methods are born accordingly. There are five common accelerating methods are summarized: process parameter optimization, surface mechanical nano-crystallization, surface-active catalysis, surface pre-oxidation, and surface laser treatment. 
  • 2.0K
  • 13 Nov 2023
Topic Review
Red Mud Liquid Media Recycling
Bauxite residue, known as red mud, is a by-product of alumina production using the Bayer process. Currently, its total global storage amounts to over 4.6 billion tons, including about 600 million tons in Russia. The total global storage of red mud occupies large areas, leading to environmental damage and increasing environmental risks. Moreover, it contains a significant amount of sodium, which is easily soluble in subsoil water; therefore, a sustainable approach for comprehensive recycling of red mud is necessary. The bauxite residue contains valuable elements, such as aluminum, titanium, and scandium, which can be recovered using liquid media.
  • 2.0K
  • 22 Jun 2021
Topic Review
P-Glycoprotein Inhibitors
P-gp inhibitors are compounds that block or bypass P-gp efflux. The concurrent administration of P-gp inhibitors with P-gp substrates can prevent the expulsion of these substrates and increase their therapeutic effects. Researchers have identified, studied, and evaluated various P-gp inhibitors, including small molecules, natural products, and pharmaceutically inert excipients.
  • 2.0K
  • 18 Aug 2021
Topic Review
Mediterranean Coastal Lagoons
Coastal lagoons are shallow bodies of water, close to the sea, generally separated from it by a sandy bar that has produced the closure of an ancient marine gulf. They are mostly the result of the accumulation of sands and gravels of continental origin that are dragged to the coast by a river and whose accumulation is also due to the action of persistent currents. 
  • 2.0K
  • 23 May 2022
Topic Review
Personalization and Games
Personalizing gameful systems to each user is important because personalized interactive systems are more effective than one-size-fits-all approaches. It requires a dynamic adaptation to the user’s behaviors in response to any situation. This approach offers users system-tailored content and services, developing content and functionality for each need based on the user’s characteristics.
  • 2.0K
  • 16 May 2022
Topic Review
X-ray Single-Crystal Diffraction
X-ray single-crystal diffraction (XRSCD) is regarded as the most reliable strategy for absolute configuration determination. Differences in the X-ray anomalous scattering effect of each atom are used to determine the absolute configuration of molecules and can provide the precise spatial position of all of the atoms in a compound in the solid state, including how the atoms are connected, the molecular conformation, and accurate bond length and bond angle data. The strength of the anomalous scattering effect is proportional to the electron cloud density of the atom, which is manifested as the stronger anomalous scattering effect of the atom with a larger atomic number.
  • 2.0K
  • 01 Jun 2022
Topic Review
Surplus Food in Blind Box Form
Surplus foods are fresh raw material of food that has not been processed, and a large number of surplus foods are discarded and wasted every day. As a new business model, a surplus food blind box can attract consumers to purchase to reduce food waste. 
  • 2.0K
  • 24 Jun 2022
Topic Review
Dynapenic Obesity and Sarcopenic Obesity
Ageing is associated with changes in body composition, such as low muscle mass (sarcopenia), decreased grip strength or physical function (dynapenia), and accumulation of fat mass. When the accumulation of fat mass synergistically accompanies low muscle mass or reduced grip strength, it results in sarcopenic obesity and dynapenic obesity, respectively. 
  • 2.0K
  • 08 Aug 2022
Topic Review
Smart Distribution Mechanisms
To enhance the reliability and resilience of power systems and achieve reliable delivery of power to end users, smart distribution networks (SDNs) play a vital role. The conventional distribution network is transforming into an active one by incorporating a higher degree of automation. Replacing the traditional absence of manual actions, energy delivery is becoming increasingly dependent on intelligent active system management. As an emerging grid modernization concept, the smart grid addresses a wide range of economic and environmental concerns, especially by integrating a wide range of active technologies at distribution level. At the same time, these active technologies are causing a slew of technological problems in terms of power quality and stability. 
  • 2.0K
  • 19 Dec 2022
Topic Review
Structure of Blood–Brain Barrier and Substance Transportation
The complex structure of the blood–brain barrier (BBB), which blocks nearly all large biomolecules, hinders drug delivery to the brain and drug assessment, thus decelerating drug development. Conventional in vitro models of BBB cannot mimic some crucial features of BBB in vivo including a shear stress environment and the interaction between different types of cells. There is a great demand for a new in vitro platform of BBB that can be used for drug delivery studies.
  • 2.0K
  • 01 Mar 2023
Topic Review
Regulation of CD36 Expression and Activity in Cancer
Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in many different types of cancer, notably breast, brain, and ovarian cancers. While it is arguably most well-known for its fatty acid uptake functions, it is also involved in regulating cellular adhesion, immune response, and apoptosis depending on the cellular and environmental contexts.
  • 2.0K
  • 15 Jun 2023
Topic Review
CD44
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to chemo- and radiotherapy.
  • 2.0K
  • 28 Dec 2021
Topic Review
Sesquiterpenoids Specially Produced by Fungi
Fungi are widely distributed in the terrestrial environment, freshwater, and marine habitat. Only approximately 100,000 of these have been classified although there are about 5.1 million characteristic fungi all over the world. These eukaryotic microbes produce specialized metabolites and participate in a variety of ecological functions, such as quorum detection, chemical defense, allelopathy, and maintenance of symbiosis. Fungi therefore remain an important resource for the screening and discovery of biologically active natural products. Sesquiterpenoids are arguably the richest natural products from plants and micro-organisms. The rearrangement of the 15 high-ductility carbons gave rise to a large number of different skeletons. At the same time, abundant structural variations lead to a diversification of biological activity. 
  • 2.0K
  • 06 Dec 2021
Topic Review
Machine Learning Applications in Microgrid Management System
The advent of renewable energy sources (RESs) in the power industry has revolutionized the management of these systems due to the necessity of controlling their stochastic nature. Deploying RESs in the microgrid (MG) as a subset of the utility grid is a beneficial way to achieve their countless merits in addition to controlling their random nature. Since a MG contains elements with different characteristics, its management requires multiple applications, such as demand response (DR), outage management, energy management, etc. The MG management can be optimized using machine learning (ML) techniques applied to the applications. This objective first calls for the microgrid management system (MGMS)’s required application recognition and then the optimization of interactions among the applications.
  • 2.0K
  • 16 Dec 2022
Topic Review
Isorhamnetin Glycosides as Phytonutrients
Isorhamnetin glycosides (IGs) are a class of essential flavonoids derived from dietary and medicinal plants such as Opuntia ficus-indica, Hippophae rhamnoides, and Ginkgo biloba.
  • 2.0K
  • 06 May 2023
Topic Review
RAB7 Protein
RAB7 is a small guanosine triphosphatase (GTPase) extensively studied as regulator of vesicular trafficking. Indeed, its role is fundamental in several steps of the late endocytic pathway, including endosome maturation, transport from early endosomes to late endosomes and lysosomes, clustering and fusion of late endosomes and lysosomes in the perinuclear region and lysosomal biogenesis. Besides endocytosis, RAB7 is important for a number of other cellular processes among which, autophagy, apoptosis, signaling, and cell migration. Given the importance of RAB7 in these cellular processes, the interest to study the role of RAB7 in cancer progression is widely grown.
  • 2.0K
  • 31 Aug 2021
Topic Review
Pegasus in Popular Culture
The winged, divine horse Pegasus has been a prominent figure in modern popular culture.
  • 2.0K
  • 28 Sep 2022
Topic Review
IBM Optical Mark and Character Readers
IBM designed, manufactured and sold optical mark and character readers from 1960 until 1984. The IBM 1287 is notable as being the first commercially sold scanner capable of reading handwritten numbers.
  • 2.0K
  • 17 Nov 2022
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