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Topic Review
Pilar (Boat)
Ernest Hemingway owned a 38-foot (12 m) fishing boat named Pilar. It was acquired in April 1934 from Wheeler Shipbuilding in Brooklyn, New York, for $7,495. "Pilar" was a nickname for Hemingway's second wife, Pauline, and also the name of the woman leader of the partisan band in his 1940 novel of the Spanish Civil War, For Whom the Bell Tolls. Hemingway regularly fished off the boat in the waters of Key West, Florida, Marquesas Keys, and the Gulf Stream off the Cuban coast. He made three trips with the boat to the Bimini islands wherein his fishing, drinking, and fighting exploits drew much attention and remain part of the history of the islands. In addition to fishing trips on Pilar, Hemingway contributed to scientific research which included collaboration with the Smithsonian Institution. Several of Hemingway's books were influenced by time spent on the boat, most notably, The Old Man and the Sea (1953) and Islands in the Stream (1970). The yacht also inspired the name of Playa Pilar (Pilar Beach) on Cayo Guillermo. A smaller replica of the boat is depicted in the opening and other scenes in the 2012 film Hemingway & Gellhorn.
  • 2.0K
  • 15 Nov 2022
Topic Review
VI-based Inverters
The transition from the synchronous generator (SG)-based conventional power generation to converter-based renewable energy sources (RES) deteriorates the frequency stability of the power system due to the intermittency of wind and photovoltaic (PV) generation. Unlike conventional power generation, the lack of rotational inertia becomes the main challenge to interface RES with the electrical grid via power electronic converters. In the past several years, researchers have addressed this issue by emulating the behavior of SG mathematically via pulse width modulation (PWM) controller linked to conventional inverter systems. These systems are technically known as VI-based inverters, which consist of virtual synchronous machine (VSM), virtual synchronous generator (VSG), and synchronverter.
  • 2.0K
  • 30 Oct 2020
Topic Review
Nutrition in Elderly Cancer Therapy
The continuous increase in life expectancy results in a steady increase of cancer risk, which consequently increases the population of older adults with cancer. Older adults have their age-related nutritional needs and often suffer from comorbidities that may affect cancer therapy. They frequently are malnourished and present advanced-stage cancer. Therefore, this group of patients requires a special multidisciplinary approach to optimize their therapy and increase quality of life impaired by aging, cancer, and the side effects of therapy. Evaluation strategies, taking advantage of comprehensive geriatric assessment tools, including the comprehensive geriatric assessment (CGA), can help individualize treatment. As epigenetics, an emerging element of the regulation of gene expression, is involved in both aging and cancer and the epigenetic profile can be modulated by the diet, it seems to be a candidate to assist with planning a nutritional intervention in elderly populations with cancer.
  • 2.0K
  • 09 Nov 2020
Topic Review
Smart Building
Buildings are among the largest energy consumers in the world. As new technologies have been developed, great advances have been made in buildings, turning conventional buildings into smart buildings. These smart buildings have allowed for greater supervision and control of the energy resources within the buildings, taking steps to energy management strategies to achieve significant energy savings. The forecast of energy consumption in buildings has been a very important element in these energy strategies since it allows adjusting the operation of buildings so that energy can be used more efficiently.
  • 2.0K
  • 15 Dec 2020
Topic Review
Transcription Factors
Transcription factors (TFs) are regulatory proteins that are responsible for the mechanistic control of gene transcription.
  • 2.0K
  • 25 Jan 2021
Topic Review
Corrosion Inhibition of Metal Surfaces Mediated by 1,2,3-Triazoles
Corrosion is generally viewed as the destructive consequence of chemical reaction between a metal or metal alloy and its environment that contains corrosive agents. Compared to inorganic corrosion inhibitors, the organic ones are less toxic, can be also used at low concentrations, and have a better film-forming ability. The adsorption properties of organic corrosion inhibitors are primarily linked to the presence of both π-electrons from aromatic rings and heteroatoms in the molecular structures. Indeed, organic compounds containing nitrogen, phosphorus, sulfur, and oxygen atoms have been extensively investigated as corrosion inhibitors of metals and their alloys in acidic environments. In this respect, triazole derivatives are the most used nitrogen-containing organic inhibitors, in particular the family of 1,2,3-triazoles prepared under click chemistry regime by the prolific copper-catalyzed azide cycloaddition reactions. 
  • 2.0K
  • 10 Feb 2022
Topic Review
Therapeutic Potential of Carica papaya Leaf against Thrombocytopenia
Thrombocytopenia is a clinical manifestation that refers to the low platelet count, i.e., <150 × 103/μL, of blood, resulting in imbalanced hemostasis, which leads to several fatal complications. The causative factors vary greatly, but, as a consequence, they interfere with platelet production and promote destruction, leading to death. Carica papaya leaf has unique therapeutic and medicinal characteristics against thrombocytopenia, and this is supported by scientific studies. Secondary metabolites and minerals in the leaf, such as carpaine and quercetin, promote platelet production, inhibit platelet destruction, and maintain platelet membrane through gene expression activity and the ceasing of viral proteases, respectively. Phytochemical profiles of C. papaya leaf revealed the presence of flavonoids, alkaloids, phenols, cardiac glycosides, tannins, terpenes, and saponins, which impart therapeutic potential to the leaf. The therapeutic benefits of the leaf include immunomodulatory, antiviral, antidiabetic, anticancer, antimalarial, antiangiogenic, antibacterial, and antioxidant activities. Several conducted scientific research studies have proved the efficacy of C. papaya leaf against thrombocytopenia, expanding the implication of natural sources to eradicate numerous ailments.
  • 2.0K
  • 24 May 2022
Topic Review
Phytochemical Information and Pharmacology of European Orchids
The Orchidaceae family has thousands of members, and most of them are mentioned in the folk medicine of nations around the world. The use of terrestrial orchids in European and Mediterranean regions has been reported since ancient times. Plant collection for human use is still listed as one of the main threats for terrestrial orchids (i.e. harvesting for Salep), alongside other menacing factors such as wrong habitat management and disturbance to symbionts, such as pollinators and mycorrhizal fungi. Here, phytochemical data are discussed to evaluate the presence of bioactive compounds of pharmacological relevance. Furthermore, it is debated whether the presence of these compounds could support the therapeutic employment of the different orchid organs.
  • 2.0K
  • 09 Feb 2023
Topic Review
Mast Cell Activation Syndrome
Mast cell activation syndrome (MCAS) is a medical condition recognised relatively recently, over whose definition and inclusion criteria there is still much debate in the literature. Some authors view it as a set of acute and severe systemic symptoms originating in mast cells’ abnormal number or reactivity, with clear laboratory inclusion criteria, while others see it as an immune/inflammatory systemic condition, acute and/or chronic, with manifestations ranging from mild to severe, including anaphylaxis, caused by mediators released from activated mast cells. At present the established diagnostic criteria are still a matter of debate, and there is still no certainty whether cases of MCAS are not missed versus the possibility of over-diagnosis.
  • 2.0K
  • 24 Jul 2023
Topic Review
Drug Delivery for Cardiovascular Diseases
Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year, representing one third of global mortality. As existing therapies still have limited success, due to the inability to control the biodistribution of the currently approved drugs, the quality of life of these patients is modest. The advent of nanomedicine has brought new insights in innovative treatment strategies.
  • 2.0K
  • 08 Dec 2020
Topic Review
Connexin 26
Connexin 26, one of the smallest connexins, is expressed in diverse epithelial tissue and mutations in this protein are associated with hearing loss, skin and eye conditions of differing severity.
  • 2.0K
  • 26 Jan 2021
Topic Review
Machine Learning-Based Fusion Model
The launch of GRACE satellites has provided a new avenue for studying the terrestrial water storage anomalies (TWSA) with unprecedented accuracy. However, the coarse spatial resolution greatly limits its application in hydrology researches on local scales. To overcome this limitation, this study develops a machine learning-based fusion model to obtain high-resolution (0.25°) groundwater level anomalies (GWLA) by integrating GRACE observations in the North China Plain. 
  • 2.0K
  • 25 Mar 2021
Topic Review
Lipoprotein Lipase Regulation in Atherosclerosis
Lipoprotein lipase (LPL) plays a major role in the lipid homeostasis mainly by mediating the intravascular lipolysis of triglyceride rich lipoproteins. Impaired LPL activity leads to the accumulation of chylomicrons and very low-density lipoproteins (VLDL) in plasma, resulting in hypertriglyceridemia. While low-density lipoprotein cholesterol (LDL-C) is recognized as a primary risk factor for atherosclerosis, hypertriglyceridemia has been shown to be an independent risk factor for cardiovascular disease (CVD) and a residual risk factor in atherosclerosis development.
  • 2.0K
  • 01 Aug 2021
Topic Review
Mitochondrial Genetic and Epigenetic Regulations in Cancer
Mitochondria are dynamic organelles managing crucial processes of cellular metabolism and bioenergetics. Enabling rapid cellular adaptation to altered endogenous and exogenous environments, mitochondria play an important role in many pathophysiological states, including cancer. Being under the control of mitochondrial and nuclear DNA (mtDNA and nDNA), mitochondria adjust their activity and biogenesis to cell demands. In cancer, numerous mutations in mtDNA have been detected, which do not inactivate mitochondrial functions but rather alter energy metabolism to support cancer cell growth. Increasing evidence suggests that mtDNA mutations, mtDNA epigenetics and miRNA regulations dynamically modify signalling pathways in an altered microenvironment, resulting in cancer initiation and progression and aberrant therapy response. 
  • 2.0K
  • 10 Aug 2022
Topic Review
Level Design
Level design, or environment design, is a discipline of game development involving creation of video game levels—locales, stages, or missions. This is commonly done using a level editor, a game development software designed for building levels; however, some games feature built-in level editing tools.
  • 2.0K
  • 08 Oct 2022
Topic Review
Pax (Command)
Pax is an archiving utility available for various operating systems and defined since 1995. Rather than sort out the incompatible options that have crept up between tar and cpio, along with their implementations across various versions of Unix, the IEEE designed new archive utility pax that could support various archive formats with useful options from both archivers. The pax command is available on Unix and Unix-like operating systems and on IBM i, Microsoft Windows NT, and Windows 2000. In 2001, IEEE defined a new pax format which is basically tar with additional extended attributes. The format is not supported by pax commands in most Linux distributions and in FreeBSD, but it is supported by tar commands from GNU and FreeBSD; the format is further supported by pax commands in AIX, Solaris and HP-UX. The name "pax" is an acronym for portable archive exchange. The command invocation and structure is somewhat a unification of both tar and cpio.
  • 2.0K
  • 04 Nov 2022
Topic Review
Heart Failure with Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) remains a poorly characterized syndrome with many unknown aspects related to different patient profiles, various associated risk factors and a wide range of aetiologies. It comprises several pathophysiological pathways, such as endothelial dysfunction, myocardial fibrosis, extracellular matrix deposition and intense inflammatory system activation.
  • 2.0K
  • 18 Jan 2023
Topic Review
System Structure of Appointment Scheduling
In the face of an increasingly high-demand environment for outpatients, achieving a balance between allocation of limited medical resources and patient satisfaction has considerable social and economic benefits. Therefore, appointment scheduling (AS) system operation is used in clinics and hospitals, and its operation optimization research is of great significance.
  • 2.0K
  • 23 Feb 2024
Topic Review
Benzil
Benzil (BZ) can be converted almost quantitatively to benzoyl peroxide (BP) in aerated polymer films upon irradiation at >400 nm (i.e., the long-wavelength edge of the n→π* absorption band of BZ, where BP does not absorb).
  • 2.0K
  • 20 Sep 2021
Topic Review
Corrosion and Scaling in Geothermal Heat Exchangers
Geothermal power is an attractive and environmentally friendly energy source known for its reliability and efficiency. Unlike some renewables like solar and wind, geothermal energy is available consistently, making it valuable for mitigating climate change. Heat exchangers play a crucial role in geothermal power plants, particularly in binary cycle plants, where they represent a significant portion of capital costs. Protecting these components from deterioration is essential for improving plant profitability. Corrosion is a common issue due to direct contact with geothermal fluid, which can lead to heat exchanger failure.
  • 2.0K
  • 31 Oct 2023
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