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Topic Review
Cofilin and Actin Dynamics
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons express cofilin-1 as the major isoform, but ADF and cofilin-2 are also expressed. All isoforms bind preferentially and cooperatively along ADP-subunits in F-actin, affecting the filament helical rotation, and when either alone or when enhanced by other proteins, promotes filament severing and subunit turnover.
  • 2.1K
  • 25 Oct 2021
Topic Review
Selection of Stationary Phases in Supercritical Fluid Chromatography
The greatest challenge in the analysis of herbal components lies in their variety and complexity. Various emerging analytical techniques have offered significant support for complicated component analysis, with breakthroughs in selectivity, sensitivity, and rapid analysis. Among these techniques, supercritical fluid chromatography (SFC) has attracted much attention because of its high column efficiency and environmental protection. SFC can be used to analyze a wide range of compounds, including non-polar and polar compounds, making it a prominent analytical platform. 
  • 2.1K
  • 20 Jul 2022
Topic Review
Citrus-Processing Wastewater
Citrus processing industry, one of the most important agro-industry, produces large volumes of wastewater (CPWW). The large variability of these volume is coupled to physico-chemical characteristics of CPWW. The qualitative and quantitative variability of CPWW are discussed and the severe constraints for its disposal are presented. 
  • 2.1K
  • 31 Jul 2020
Topic Review
Molecular Iodine-Catalyzed Reactions
Department of Mathematics and Natural Sciences, College of Sciences and Human Studies, Deanship of Research, Prince Mohammad Bin Fahd University, Al Khobar 31952, KSA; Email: bimalbanik10@gmail.com; bbanik@pmu.edu.sa In continuation of our research on the synthesis of diverse organic molecules, we report here molecular iodine-catalyzed diverse synthetic processes. These methods are efficient and produce products in high yield. The success of molecular iodine-catalyzed reactions depends on the release of hydroiodic acid in the reaction media.
  • 2.1K
  • 01 Jun 2020
Topic Review
Battery-Driven Fast Marine Vehicles
Entry of the design and technological challenges of zero emission, battery driven fast marine vehicles. Whereas slow and medium speed all electrical ships have been successfully introduced, it remains to prove that fast battery driven ships are feasible. The entry addresses the key design and technological issues, assesses the present state of the art and of the associated technology and concludes on the way ahead.
  • 2.1K
  • 23 Nov 2020
Topic Review
Green Finance
The concept of green finance, also known as green investments, is widely employed in academia and business, and have a variety of meanings. Green finance (GF) is a developing concept that lacks a clear and universal definition. However, the goal of GF is to balance the advancement of monetary events, environmental stability, and ecological protection to accomplish long-term development. 
  • 2.1K
  • 09 Oct 2021
Topic Review
High Pressure Processing for Gelatinization and Nutrients Infusion
High pressure processing (HPP) is a novel technology that involves subjecting foods to high hydrostatic pressures of the order of 100–600 MPa. This technology has been proven successful for inactivation of numerous microorganisms, spores and enzymes in foods, leading to increased shelf life. HPP is not limited to cold pasteurization but has many other applications. The focus of this entry is to explore other applications of HPP, such as gelatinization, forced water absorption and infusion of nutrients. The use of high pressure in producing cold gelatinizing effects, imparting unique properties to food and improving food quality has also been discussed, highlighting the latest published studies and the innovative methods adopted.
  • 2.1K
  • 30 Nov 2021
Topic Review
Density Profile of Liquid-Metal-Vapor Interface
Several metals and many alloys are in liquid form around room temperature, e.g., mercury (Hg, −38.8 °C), francium (Fr, 8.0 °C), cesium (Sc, 28.5 °C), gallium (Ga, 29.8 °C), the eutectic mercury-based alloys, and the eutectic gallium-based alloys. If eutectic, liquid metal alloys can be in liquid form that has been used in practical applications, replacing mercury. Liquid metals have high thermal and electric conductivity and have been used to conduct heat and electricity between non-metallic and metallic surfaces. They have also been used as thermal interface materials between coolers and processors. Concerning these metals, our understanding of the liquid-vapor interface is critical for proper applications. This entry summarizes the basic features of the density distribution of liquid metal-vapor interface, which are advanced based on pseudo-potential representation and numerical simulation at the University of Chicago.
  • 2.1K
  • 30 Dec 2020
Topic Review
Modern Seed Technology
There are three major types of seed treating/coating equipment: dry powder applicator, rotary pan, and pelleting pan with the provisions to apply dry powders, liquids, or a combination of both. Additional terms for coatings produced from these types of equipment include dry coating, seed dressing, film coating, encrustments, and seed pelleting. The seed weight increases for these different coating methods ranges from <0.05% to >5000% (>100,000-fold range). 
  • 2.1K
  • 08 Jan 2022
Topic Review
Post-Traumatic Stress Disorder and Thalamus
Post-traumatic stress disorder is a common mental disorder, with high lifetime prevalence approximately 6–10% . The prevalence of PTSD in trauma-exposed people has been approximately 20%. PTSD is induced by traumatic stress including life threatening, actual or threatened severe injury, and sexual violence. In DSM-V criteria, PTSD has the following symptoms: intrusion of unwanted memory updates related to traumatic stress, avoidance for reminders, negative alterations in mood, and hyper-arousal. Conservatively, fear-conditioned learning involving the amygdala has been considered one of the causative factors.
  • 2.1K
  • 03 Mar 2021
Topic Review
Biomethane Production of Distillery Stillage
Distillery stillage has a high energy potential (13.6 MJ/kg TS, 10.4 MJ/kg COD), which indicates that it can be processed via anaerobic digestion and is a suitable substrate for conversion into energy. Distillery stillage consists of compounds that are easily biodegraded during anaerobic digestion, such as proteins, lipids, and carbohydrates. Among the carbohydrates, the concentration of cellulose can be on the level of 32.2%, hemicelluloses—20.9%, and lignin—3.2% in the distillery stillage obtained from maize.
  • 2.1K
  • 16 Nov 2021
Topic Review
Bioactivities of Red Pitaya Fruits
Pitahaya, or the pitaya fruit, is a well-known member of the Cactaceae family and is widely cultivated in tropical and subtropical areas. Pitaya fruit is classified based on the colour of pulp and peel, namely white-pulp with pink peel pitaya (Hylocereus undatus), red-pulp with pink peel pitaya (Hylocereus polyrhizus) and white-pulp with yellow skin (Hylocereus megulanthus).
  • 2.1K
  • 22 Mar 2022
Topic Review
Bio-Preservation of Bread: Adopting Wholesome Strategies
Bread is a food that is commonly recognized as a very convenient type of food, but it is also easily prone to microbial attack. As a result of bread spoilage, a significant economic loss occurs to both consumers and producers. The bakery industry has sought to identify treatments that make bread safe and with an extended shelf-life to address this economic and safety concern, including replacing harmful chemical preservatives. New frontiers, on the other hand, have recently been explored. Alternative methods of bread preservation, such as microbial fermentation, utilization of plant and animal derivatives, nanofibers, and other innovative technologies, have yielded promising results. 
  • 2.1K
  • 01 Mar 2022
Topic Review
Poultry Parasitic Diseases
Parasitic infections are a major public health concern affecting millions of people universally. The medicinal importance of natural herbs depends upon their bioactive ingredients, which are originated from crude plants, consequently leading to the specific action on the body. Due to the limited availability of effective drugs and high cost, the development of drug resistance in several harmful parasites and microbes leads to huge economic losses in the poultry industry.
  • 2.1K
  • 19 Apr 2022
Topic Review
Application of SLAM in Autonomous Driving
The applications of Simultaneous Localization and Mapping (SLAM) for autonomous driving with respect to different driving scenarios, vehicle system components and the characteristics of the SLAM approaches are discussed. A real-world road test is presented to demonstrate a multi-sensor-based modernized SLAM procedure for autonomous driving. The numerical results show that a high-precision 3D point cloud map can be generated by the SLAM procedure with the integration of Lidar and GNSS/INS.
  • 2.1K
  • 29 Mar 2023
Topic Review
Combating 131I Side Effects in Thyroid Cancer
Thyroid cancer is the most common endocrine cancer, and its prevalence has been increasing for decades. Approx. 95% of differentiated thyroid carcinomas are treated using 131iodine (131I), a radionuclide with a half-life of 8 days, to achieve optimal thyroid residual ablation following thyroidectomy. However, while 131I is highly enriched in eliminating thyroid tissue, it can also retain and damage other body parts (salivary glands, liver, etc.) without selectivity, and even trigger salivary gland dysfunction, secondary cancer, and other side effects. 
  • 2.1K
  • 29 Jun 2023
Topic Review
Volatile Fatty Acid recovery
Volatile fatty acids (VFAs) are low-molecular-weight carboxylic acids containing two to six carbon atoms that are produced as the final product of acidogenic fermentation in anaerobic digestion process.
  • 2.1K
  • 28 Sep 2021
Topic Review
Computer-Aided Drug Discovery for SMA
Spinal muscular atrophy (SMA), one of the leading inherited causes of child mortality, is a rare neuromuscular disease arising from loss-of-function mutations of the survival motor neuron 1 (SMN1) gene, which encodes the SMN protein. When lacking the SMN protein in neurons, patients suffer from muscle weakness and atrophy, and in the severe cases, respiratory failure and death. Several therapeutic approaches show promise with human testing and three medications have been approved by the U.S. Food and Drug Administration (FDA) to date. Despite the shown promise of these approved therapies, there are some crucial limitations, one of the most important being the cost. The FDA-approved drugs are high-priced and are shortlisted among the most expensive treatments in the world. The price is still far beyond affordable and may serve as a burden for patients. The blooming of the biomedical data and advancement of computational approaches have opened new possibilities for SMA therapeutic development. 
  • 2.1K
  • 09 Oct 2021
Topic Review
Tumor Suppressor
A tumor suppressor gene, or anti-oncogene, is a gene that regulates a cell during cell division and replication. If the cell grows uncontrollably, it will result in cancer. When a tumor suppressor gene is mutated, it results in a loss or reduction in its function; in combination with other genetic mutations this could allow the cell to grow abnormally. The loss of function for these genes may be even more significant in the development of human cancers, compared to the activation of oncogenes. Tumor suppressor genes can be grouped into the following categories caretaker genes, gatekeeper genes, and more recently landscaper genes. Caretaker genes ensure stability of the genome via DNA repair and subsequently when mutated allow mutations to accumulate. Meanwhile gatekeeper genes directly regulate cell growth by either inhibiting cell cycle progression or inducing apoptosis. Lastly landscaper genes regulate growth by contributing to the surrounding environment, when mutated can cause an environment that promotes unregulated proliferation. The classification schemes are evolving as medical advances are being made from fields including molecular biology, genetics, and epigenetics.
  • 2.1K
  • 25 Oct 2022
Topic Review
Technology Transfer
Technology transfer (TT), also called transfer of technology (TOT), is the process of transferring (disseminating) technology from the person or organization that owns or holds it to another person or organization, in an attempt to transform inventions and scientific outcomes into new products and services that benefit society. Technology transfer is closely related to (and may arguably be considered a subset of) knowledge transfer. A comprehensive definition of technology transfer today includes the notion of collaborative process as it became clear that global challenges could be resolved only through the development of global solutions. Knowledge and technology transfer plays a crucial role in connecting innovation stakeholders and moving inventions from creators to public and private users. Intellectual property (IP) is an important instrument of technology transfer, as it establishes an environment conducive to sharing research results and technologies. Analysis in 2003 showed that the context, or environment, and motives of each organization involved will influence the method of technology transfer employed. The motives behind the technology transfer were not necessarily homogenous across organization levels, especially when commercial and government interests are combined. The protection of IP rights enables all parties, including universities and research institutions to ensure ownership of the scientific outcomes of their intellectual activity, and to control the use of IP in accordance with their mission and core values. IP protection gives academic institutions capacity to market their inventions, attract funding, seek industrial partners and assure dissemination of new technologies through means such as licensing or creation of start-ups for the benefit of society.
  • 2.1K
  • 26 Oct 2022
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