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Topic Review
Linguistic Insecurity
Linguistic insecurity comprises feelings of anxiety, self-consciousness, or lack of confidence in the mind of a speaker surrounding the use of their own language. Often, this anxiety comes from speakers' belief that their use of language does not conform to the perceived standard and/or the style of language expected by the speakers' interlocutor(s). Linguistic insecurity is situationally induced and is often based on a feeling of inadequacy regarding personal performance in certain contexts, rather than a fixed attribute of an individual. This insecurity can lead to stylistic, and phonetic shifts away from an affected speaker's default speech variety; these shifts may be performed consciously on the part of the speaker, or may be reflective of an unconscious effort to conform to a more prestigious or context-appropriate style of speech. Linguistic insecurity is linked to the perception of speech styles in any community, and so may vary based on socioeconomic class and gender. It is also especially pertinent in multilingual societies.
  • 2.1K
  • 16 Nov 2022
Topic Review
Bland–Altman Agreement Analysis
The Bland–Altman Limits of Agreement is a popular and widespread means of analyzing the agreement of two methods, instruments, or raters in quantitative outcomes. An agreement analysis could be reported as a stand-alone research article but it is more often conducted as a minor quality assurance project in a subgroup of patients, as a part of a larger diagnostic accuracy study, clinical trial, or epidemiological survey. Consequently, such an analysis is often limited to brief descriptions in the main report. Therefore, in several medical fields, it has been recommended to report specific items related to the Bland–Altman analysis. Seven proposals were identified from a MEDLINE/PubMed search on March 03, 2020, three of which were derived by reviewing anesthesia journals. Broad consensus was seen for the a priori establishment of acceptability benchmarks, estimation of repeatability of measurements, description of the data structure, visual assessment of the normality and homogeneity assumption, and plotting and numerically reporting both bias and the Bland–Altman Limits of Agreement, including respective 95% confidence intervals. Abu-Arafeh et al. provided the most comprehensive and prudent list, identifying 13 key items for reporting (Br. J. Anaesth. 2016, 117, 569–575). The 13 key items should be applied by researchers, journal editors, and reviewers in the future, to increase the quality of reporting Bland–Altman agreement analyses.
  • 2.1K
  • 27 Oct 2020
Topic Review
Preeclampsia
Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often develop a severe prothrombotic state, potentially resulting in life-threatening thrombosis and thromboembolism. The cause of this thrombotic complication is multi-factorial, involving endothelial cells, platelets, adhesive ligands, coagulation, and fibrinolysis. Increasing evidence has shown that hemostatic cells and factors undergo oxidative modifications during the systemic inflammation found in PE patients. However, it is largely unknown how these oxidative modifications of hemostasis contribute to development of the PE-associated prothrombotic state. This knowledge gap has significantly hindered the development of predictive markers, preventive measures, and therapeutic agents to protect women during pregnancy.
  • 2.1K
  • 08 Dec 2020
Topic Review
The Experience Economy
The term "Experience Economy" was first used in a 1998 article by B. Joseph Pine II and James H. Gilmore describing the experience economy as the next economy following the agrarian economy, the industrial economy, and the most recent service economy. The concept had been previously researched by many authors. Pine and Gilmore argue that businesses must orchestrate memorable events for their customers, and that memory itself becomes the product: the "experience". More advanced experience businesses can begin charging for the value of the "transformation" that an experience offers, e.g., as education offerings might do if they were able to participate in the value that is created by the educated individual. This, they argue, is a natural progression in the value added by the business over and above its inputs. Although the concept of the experience economy was initially focused in business, it has crossed into tourism, architecture, nursing, urban planning and other fields. The Experience Economy is also considered the main underpinning for customer experience management.
  • 2.1K
  • 19 Oct 2022
Topic Review
Current Role of Immunotherapy in Lung Cancer
Immunotherapy is an ever-expanding field in lung cancer treatment research. The lung cancer treatment paradigm has been completely changed by immunotherapy; however, less than half of the treated patients obtain a response, and an even smaller proportion achieve a long survival.
  • 2.1K
  • 27 Dec 2022
Topic Review
Crumb Rubber
The crumb rubber (CR) recycled from waste tyres could be a viable alternative in achieving green pavements that offer exciting new markets to global investors. Adding CR into flexible pavements enhances their performance and ensures environmental sustainability.
  • 2.1K
  • 08 Dec 2023
Topic Review
Properties of Pistacia lentiscus L.
Pistacia lentiscus L. (PlL) is a wild-growing shrub rich in terpenoids and polyphenols, the oil and extracts of which have been widely used against inflammation and infections, and as wound healing agents.
  • 2.1K
  • 11 May 2021
Topic Review
Plant-Derived Nutraceuticals in the Treatment of Tendinitis
In tendinitis, as a very common and painful condition disabling musculoskeletal functionality and still lacking sustainable treatment, various plant-derived compounds have been demonstrated to affect inflammation and promote tissue healing, thus representing promising bio-active treatment agents in tendinitis therapy.
  • 2.1K
  • 24 May 2022
Topic Review
Neuropharmacological Effects of Terpenoids
Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disorders.
  • 2.1K
  • 28 Sep 2022
Topic Review
Theory of Everything
In philosophy, a theory of everything (ToE) is an ultimate, all-encompassing explanation or description of nature or reality. Adopting the term from physics, where the search for a theory of everything is ongoing, philosophers have discussed the viability of the concept and analyzed its properties and implications. Among the questions to be addressed by a philosophical theory of everything are: "Why is reality understandable?" – "Why are the laws of nature as they are?" – "Why is there anything at all?"
  • 2.1K
  • 30 Nov 2022
Topic Review
Metformin
Metformin is a metabolic modulator widely used to treat type II diabetes and metabolic syndrome patients. It shows a safe profile and its use in additional indications, such as cancer, is an important matter of investigation.
  • 2.1K
  • 09 Dec 2020
Topic Review
Crystallization Behavior and Quality of Frozen Meat
Preservation of meat through freezing entails the use of low temperatures to extend a product’s shelf-life, mainly by reducing the rate of microbial spoilage and deterioration reactions. Characteristics of meat that are important to be preserve include tenderness, water holding capacity, color, and flavor. In general, freezing improves meat tenderness, but negatively impacts other quality attributes. The extent to which these attributes are affected depends on the ice crystalline size and distribution, which itself is governed by freezing rate and storage temperature and duration.
  • 2.1K
  • 18 Nov 2021
Topic Review
Eridanus
Eridanus, the constellation named after the ancient Greek river god, is a sprawling celestial feature stretching across the southern sky. It is the sixth largest of the 88 modern constellations, rich in diverse astronomical treasures.
  • 2.1K
  • 15 Mar 2024
Topic Review
Delay Defects in Nanoscale Digital VLSI Circuits
As technology scales down, digital VLSI (very large-scale integration) circuits are prone to many manufacturing defects. These defects may result in functional and delay-related circuit failures. The number of test escapes grows when technology is downscaled. Small delay defects (SDDs) and hidden delay defects (HDDs) are of critical importance in industries since they are the source of most test escapes and reliability problems.
  • 2.1K
  • 30 Sep 2022
Topic Review
Retinal Organization
The retinal arhitecture is similar across all vertebrates despite the morphological and functional peculiarities. The retina is composed of two main parts: the single-layred retinal pigment epithelium and the multilayred neuroretina which includes a number of neuronal and glial cell types. Homeobox genes from different classes are accepted as critical for eye field specification and retinal cells type differentiation by a broad array of loss- or gain-of-function models. Among these genes are some that are known to cause inherited retinal diseases (IRDs) that disturb the formation, function, and survival of rod and cone photoreceptors, ganglion cells, or retinal pigment epithelial cells [4,6–8]. The advances in the field of genetics and high-throughput next-generation sequencing and cell technologies allow for deepening of knowledge of the genetic basis of inherited retinal diseases (IRDs), as well as improve their diagnostics and therapy.
  • 2.1K
  • 22 Sep 2021
Topic Review
Property of Phytosterols
Phytosterols are functional ingredients with known efficacy and safety. Phytosterols are found as free sterols or as their esters with fatty acids. Although phytosterol esters are soluble in oil and have been used in many commercial foods, it has been difficult to similarly use free phytosterols since they are insoluble in water and practically insoluble in oil. Phytosterols are attractive, functional ingredients for preventing arteriosclerotic diseases since they reduce serum total cholesterol and LDL-cholesterol levels.
  • 2.1K
  • 12 Aug 2022
Topic Review
Climate State
Climate state describes a state of climate on Earth and similar terrestrial planets based on a thermal energy budget, such as the greenhouse or icehouse climate state. The main climate state change is between periodical glacial and interglacial cycles in Earth history, studied from climate proxies. The climate system is responding to the current climate forcing and adjusts following climate sensitivity to reach a climate equilibrium, Earth's energy balance. Model simulations suggest that the current interglacial climate state will continue for at least another 100,000 years, due to CO2 emissions - including complete deglaciation of the Northern Hemisphere.
  • 2.1K
  • 16 Nov 2022
Topic Review
Global Supply Chain Finance
Global supply chain finance refers to the set of solutions available for financing specific goods and/or products as they move from origin to destination along the supply chain. It is related to a quickly growing use of a battery of technologies and financial business practices that allow for discounting of Accounts Receivable and financing of companies' confirmed Accounts Payable. A global supply chain refers to the network created among different worldwide companies producing, handling, and distributing specific goods and/or products.
  • 2.1K
  • 21 Nov 2022
Topic Review
Clustering Techniques in Autonomous Driving Applications
Autonomous vehicles (AVs) rely on advanced sensory systems, such as Light Detection and Ranging (LiDAR), to function seamlessly in intricate and dynamic environments. LiDAR produces highly accurate 3D point clouds, which are vital for the detection, classification, and tracking of multiple targets.
  • 2.1K
  • 21 Jul 2023
Topic Review
Selected Solid-State Electrolytes
Electrolytes are key components in electrochemical storage systems, which provide an ion-transport mechanism between the cathode and anode of a cell. As battery technologies are in continuous development, there has been growing demand for more efficient, reliable and environmentally friendly materials. Solid-state lithium ion batteries (SSLIBs) are considered as next-generation energy storage systems and solid electrolytes (SEs) are the key components for these systems. Compared to liquid electrolytes, SEs are thermally stable (safer), less toxic and provide a more compact (lighter) battery design. However, the main issue is the ionic conductivity, especially at low temperatures. So far, there are two popular types of SEs: (1) inorganic solid electrolytes (InSEs) and (2) polymer electrolytes (PEs). Among InSEs, sulfide-based SEs are providing very high ionic conductivities (up to 10−2 S/cm) and they can easily compete with liquid electrolytes (LEs). On the other hand, they are much more expensive than LEs. PEs can be produced at less cost than InSEs but their conductivities are still not sufficient for higher performances. 
  • 2.1K
  • 16 Mar 2021
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