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Topic Review
PET Biomarkers in Mitochondrial Dysfunction
There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve the stratification of patients into clinical trials and, potentially, help to drive the treatment landscape towards the precision medicine paradigm. The rapidly growing field of neuroimaging offers valuable tools to investigate disease pathophysiology and molecular pathways in humans, with the potential to capture the whole disease course starting from preclinical stages. Positron emission tomography (PET) combines the advantages of a versatile imaging technique with the ability to quantify, to nanomolar sensitivity, molecular targets in vivo. There is an increasing body of literature implicating dysfunction of mitochondria and endoplasmic reticulum dynamics, energy metabolism and oxidative stress within the molecular paradigm of age-related neurodegenerative diseases. The development of novel PET radioligands enables the in vivo investigation of mitochondrial and ER dysfunction in age-related neurodegenerative diseases.
  • 2.2K
  • 21 Feb 2021
Topic Review
AMPs Nisin and Food Preservation
This study reports the application of antimicrobial peptides (AMPs) in food preservation because of their ability to inactivate spores and spore-forming bacteria. The review focused more on nisin, which is one of the sufficiently characterised AMPs for use in the food industry. The mechanisms of spore-forming bacteria inactivation, the effectiveness of using nisin AMP alone and the synergistic effect of combining AMPs with other non-thermal emerging technologies were explored.
  • 2.2K
  • 24 Sep 2021
Topic Review Peer Reviewed
A Working Definition of Fake News
Current literature on fake news is rather abundant and mainly focused on history, variety, and types, rather than processes. This review draws on current literature to build a working definition of fake news focused on its present relevance to journalism and political communication contemporary debate, distinguishing it from non-pertinent conceptual varieties and contributing to a much-needed clarification on the subject. We performed a qualitative analysis of the literature published between 2016 and 2020. Data were extracted from Web of Science and Scopus. We define fake news as a type of online disinformation with misleading and/or false statements that may or may not be associated with real events, intentionally designed to mislead and/or manipulate a specific or imagined public through the appearance of a news format with an opportunistic structure (title, image, content) to attract the reader’s attention in order to obtain more clicks and shares and, therefore, greater advertising revenue and/or ideological gain. 
  • 2.2K
  • 23 Sep 2022
Topic Review
Impact of Oxidative Stress on Pediatrics Syndromes
Oxidative stress is a condition determined by an imbalance between antioxidant and oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed, it causes both necrosis and cell apoptosis, determining cellular aging, increased carcinogenesis, vascular stiffening, increased autoimmune diseases, and muscle decay. 
  • 2.2K
  • 01 Nov 2022
Topic Review
COVID-19 Treatment
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable economic distress globally and a significant loss of life. Sadly, the vulnerable and immunocompromised in our societies seem to be more susceptible to severe COVID-19 complications. Notably, there are several significant risk factors for severe COVID-19 infection. These include the presence of poor nutritional status and pre-existing noncommunicable diseases (NCDs) such as diabetes mellitus, chronic lung diseases, cardiovascular diseases (CVD), obesity, and various other diseases that render the patient immunocompromised. These diseases are characterized by systemic inflammation, which may be a common feature of these NCDs, affecting patient outcomes against COVID-19. As a result, various antiviral treatments and anti-inflammatory agents are under investigation for their potential therapeutic value. The section presented below originates from the following article [1].
  • 2.2K
  • 06 Nov 2020
Topic Review
Micro-/Nanoencapsulated Fragrances and Flavours
Flavours and fragrances are volatile compounds of large interest for different applications. Due to their high tendency of evaporation and, in most cases, poor chemical stability, these compounds need to be encapsulated for handling and industrial processing. Encapsulation, indeed, resulted in being effective at overcoming the main concerns related to volatile compound manipulation, and several industrial products contain flavours and fragrances in an encapsulated form for the final usage of customers. Several organic or inorganic materials have been investigated for the production of coated micro- or nanosystems intended for the encapsulation of fragrances and flavours, among them, polymeric coating, leading to the formation of micro- or nanocapsules with a core-shell architecture, as well as a molecular inclusion complexation with cyclodextrins, are still the most used. 
  • 2.2K
  • 21 Dec 2020
Topic Review
Crackdown
Crackdown is a series of action-adventure video games created by David Jones and published by Xbox Game Studios. The series takes place in a futuristic dystopian city controlled and enforced by a secret organization called the Agency. The games center on the Agency's super soldiers, known as 'Agents', as they fight threats ranging from various criminal syndicates, a terrorist group known as 'Cell', and zombie-like monsters called 'Freaks'. Games of the series have been developed by various game developers, with the first game Crackdown completed by Realtime Worlds on February 20, 2007, and a sequel called Crackdown 2 developed by Ruffian Games on July 6, 2010. Both games were released for the Xbox 360. A third installment Crackdown 3 developed by Sumo Digital was released on February 15, 2019 for Xbox One and Microsoft Windows. Although Crackdown started as a game that was released with access codes for the Halo 3 multiplayer beta, the game itself has been met with positive critical reception and won several video game awards. Critics praised the sandbox style third-person shooter for allowing the ability to cause massive destruction in a non-linear gameplay, while also criticizing the series for lacking an actual story. The series has garnered mostly positive reception and commercial success.
  • 2.2K
  • 20 Oct 2022
Topic Review
Fyne
Fyne is a free and open-source cross-platform widget toolkit for creating graphical user interfaces (GUIs) across desktop and mobile platforms. Fyne uses OpenGL to provide cross-platform graphics. It is inspired by the principles of Material Design to create applications that look and behave consistently across all platforms. It is licensed under the terms of the 3-clause BSD License, supporting the creation of free and proprietary applications. In December 2019 Fyne became the most popular GUI toolkit for Go, by GitHub star count and in early February 2020 it was trending as #1 project in GitHub trending ranks.
  • 2.2K
  • 24 Oct 2022
Biography
Sankara Bhagavadpada
Dr. Sankara Bhagavadpada [1] is an Indian Advaitic spiritual teacher, author & Vedic astrologer[2] from Chennai, Tamil Nadu, India.[3] Dr. Sankara Bhagavadpada was born Shankar Ramachandran, on May 1, 1948 in Madras, India. In his boyhood years, he came under the benevolent spiritual & philosophical influence of his mother and his philosopher-friend Sri Bhagavan.[4] In 1971, he secured his M
  • 2.2K
  • 27 Dec 2022
Topic Review
Design of Experiments in the Advancement of Biomaterial
Optimisation of tissue engineering (TE) processes requires models that can identify relationships between the parameters to be optimised and predict structural and performance outcomes from both physical and chemical processes. Design of Experiments (DoE) methods are commonly used for optimisation purposes in addition to playing an important role in statistical quality control and systematic randomisation for experiment planning. DoE is only used for the analysis and optimisation of quantitative data (i.e., number-based, countable or measurable), while it lacks the suitability for imaging and high dimensional data analysis.
  • 2.2K
  • 18 Jan 2023
Topic Review Peer Reviewed
Examining and Working Across Differences—Older People from Culturally and Linguistically Diverse Backgrounds in Australia
Australia’s older population from culturally and linguistically diverse (CALD) backgrounds presents unique challenges for aged care and public policy due to their varied migration histories, cultural practices, and language barriers. This essay explores the demographic trends, historical migration perspectives, intergenerational dynamics, and health system interactions among older CALD Australians. Cultural nuances significantly influence attitudes towards caregiving, independence, and aged care, highlighting the necessity for culturally competent care models. Policies like the National Ageing and Aged Care Strategy emphasize inclusion, empowerment, and culturally appropriate service delivery. Key challenges include combating ageism, addressing healthcare access disparities, and fostering community engagement. Effective strategies involve culturally tailored interventions, enhanced communication, and proactive policy frameworks. The findings underscore the importance of a collaborative approach between communities, healthcare providers, and policymakers to ensure equitable and inclusive care for CALD populations, promoting dignity, well-being, and cultural preservation among Australia’s diverse elderly communities.
  • 2.2K
  • 12 Mar 2025
Topic Review
IMAGe Anomaly
The combination of intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies is commonly known by the acronym IMAGe. This rare syndrome has signs and symptoms that affect many parts of the body.
  • 2.2K
  • 04 Jan 2021
Topic Review
Plant Stress Detection by Thermography
Leaf and canopy temperature is a valuable indicator of the physiological status of plants, responding to both biotic and abiotic stressors. Thermography, often combined with other imaging sensors and data-mining techniques, is crucial in the implementation of a more automatized, precise and sustainable agriculture.
  • 2.2K
  • 25 Jan 2021
Topic Review
Surface-Enhanced Raman Scattering
The efficiency of the generation of Raman spectra by molecules adsorbed on some substrates (or placed at a very close distance to some substrates) may be many orders of magnitude larger than the efficiency of the generation of Raman spectra by molecules that are not adsorbed. This effect is called surface-enhanced Raman scattering (SERS). In the first SERS experiments, nanostructured plasmonic metals have been used as SERS-active materials. Later, other types of SERS-active materials have also been developed.
  • 2.2K
  • 10 Feb 2021
Topic Review
TiO2 as Water Splitting Photocatalyst
Hydrogen produced from water using photocatalysts driven by sunlight is a sustainable way to overcome the intermittency issues of solar power and provide a green alternative to fossil fuels. TiO2 has been used as a photocatalyst since the 1970s due to its low cost, earth abundance, and stability. There has been a wide range of research activities in order to enhance the use of TiO2 as a photocatalyst using dopants, modifying the surface, or depositing noble metals. However, the issues such as wide bandgap, high electron-hole recombination time, and a large overpotential for the hydrogen evolution reaction (HER) persist as a challenge. Here, we review state-of-the-art experimental and theoretical research on TiO2 based photocatalysts and identify challenges that have to be focused on to drive the field further. We conclude with a discussion of four challenges for TiO2 photocatalysts—non-standardized presentation of results, bandgap in the ultraviolet (UV) region, lack of collaboration between experimental and theoretical work, and lack of large/small scale production facilities. We also highlight the importance of combining computational modeling with experimental work to make further advances in this exciting field.
  • 2.2K
  • 24 Mar 2021
Topic Review
Electrochemical Devices
Electrochemical devices enable the measurement of a wide variety of ions, such as hydrogen ions, electrolytes, heavy metals, and nutrients.
  • 2.2K
  • 21 Jan 2022
Topic Review
LuaJIT
LuaJIT is a tracing just in time compiler for the Lua programming language.
  • 2.2K
  • 21 Oct 2022
Topic Review
Critical Mineral Raw Materials
Since 2011, the European Commission assesses a 3-year list of Critical Raw Materials (CRMs) for the EU economy within its Raw Materials Initiative. To date, 14 CRMs were identified in 2011, 20 in 2014 and 27 in 2017. These materials are mainly used in energy transition and digital technologies.
  • 2.2K
  • 25 Oct 2022
Topic Review
¡Democracia Real YA!
¡Democracia Real YA! (DRY, Spanish for Real Democracy NOW!), also known as Plataforma Democracia Real Ya! (Real Democracy NOW Platform!), is a grassroots citizens' organization that was started in March 2011 in Spain. It sparked the political movement of May 15, 2011 (15M) whose protests gained worldwide attention. The protests been compared to the May 1968 social movement in France. ¡Democracia Real YA! is associated with approximately 200 smaller organizations. ¡Democracia Real YA! states in its manifesto that it is a broad social movement, dedicated to nonviolent protest, and that maintains no affiliation with any political party or labor union. It has not appointed any single leader and is unwilling to join any of the existing political bodies. It is, however, not an entirely apolitical movement. ¡Democracia Real YA! considers the current political and economic system incapable of listening to and representing its citizens and therefore demands changes to the current social and economic policies, which have led many people into unemployment, loss of their homes, and poverty. The organization denounces the way big businesses and banks dominate the political and economic sphere and aims to propose a series of solutions to these problems through grassroots participatory democracy and direct democracy, which is based on people's assemblies and consensus decision making. The movement drew inspiration from the 2009 Icelandic financial crisis protests, the Arab Spring, the 2010–11 Greek protests and the 2010–11 revolutions in Tunisia. The protest movement gained momentum on May 15 with a camping occupation in Madrid's main square, the Puerta del Sol, spreading to squares in 57 other major and smaller cities in Spain, and then to Spanish embassies all around the world. In April 2012 some of the initiators of the movement, following an Extraordinary General Meeting of the Platform held in Leganes, the movement split announcing the creation of an organizational structure and rules as a partnership, taking the same name, Asociación Democracia Real Ya, which caused the rejection of part of the rest of the members of the movement. Thus, there are currently active platform Real Democracy Now! on the one hand, and the association DRY on the other hand.
  • 2.2K
  • 26 Oct 2022
Topic Review
Ice Boat
An ice boat (often spelled as "iceboat") is a boat or purpose-built framework similar in functional design to a sail boat but fitted with skis or runners (skates) and designed to run over ice instead of through (liquid) water. Ice yachting is the sport of sailing and racing iceboats. Sail-able ice is known in the sport as "hard water" versus sailing on liquid or "soft" water. A related sport, land sailing, utilizes a configuration with an iceboat-like fuselage or frame equipped with wheels instead of runners. Iceboats commonly used for racing are usually only for one person, but several classes of two-seat and multiple-seat iceboats are more or less common. On some boats, a "side car" can be fitted to take others along for a ride.
  • 2.2K
  • 31 Oct 2022
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