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Topic Review
Ambidextrous Organization
Organizational ambidexterity refers to an organization's ability to be efficient in its management of today's business and also adaptable for coping with tomorrow's changing demand. Just as being ambidextrous means being able to use both the left and right hand equally, organizational ambidexterity requires the organizations to use both exploration and exploitation techniques to be successful.
  • 2.2K
  • 07 Nov 2022
Topic Review
UNAVCO
UNAVCO is a non-profit university-governed consortium that facilitates geoscience research and education using Geodesy. UNAVCO is funded by the National Science Foundation (NSF) and The National Aeronautics and Space Administration (NASA) to support geoscience research around the world. UNAVCO operates the GAGE Facility (Geodetic Facility for the Advancement of Geoscience) on behalf of the NSF and NASA. As a university-governed consortium, UNAVCO supports the goals of the academic scientific community. UNAVCO has 120 US academic members and supports over 110 organizations globally as associate members.
  • 2.2K
  • 17 Nov 2022
Topic Review
PIEZO1
PIEZO1 is ubiquitously expressed in cells in different kinds of tissues throughout the body, which can sense physical or mechanical stimuli and translate them into intracellular electrochemical signals to regulate organism functions. In particular, PIEZO1 appears in complex interactive regulatory networks as a central node, governing normal and pathological functions in the body. PIEZO1 converts mechanical stimuli (strain) into biochemical signals, inducing alterations in protein conformation and activating intracellular biochemical signaling pathways.
  • 2.2K
  • 09 Feb 2023
Topic Review
Organic Amendments for Mitigation of Plants' Salinity Stress
To reduce excess soil salinity, plant scientists are employing techniques such as sub-soiling, mixing sand, seed bed preparation, and salt scraping, as well as modern agronomic practices, hydrophilic polymer, gypsum, sulfur acids, green manuring, humic substance, farm yard manures, irrigation system, and salt-tolerant crops. Different organic amendments such as the application of vermi-compost (VC), vermi-wash (VW), biochar (BC), plant growth promoting rhizobacteria (PGPR), and bio-fertilizers (BF) are being used widely to ameliorate the negative consequences of soil salinity. The organic amendments mitigate salt stress via a wide range of mechanisms, including the regulation of ionic homeostasis, antioxidant enzyme activities, and the reduction of oxidative damage. Several studies described that PGPR and BC relieved the negative effects of salinity by increasing the photosynthetic rate, antioxidant enzyme functions, secondary metabolites accumulation, and decreasing ROS in plants. Organic amendments such as VC and VW include a variety of plant growth-regulating components such as micro and macro elements, vitamins, enzymes, and hormones that have been shown to reduce the harmful effects of salts on plants. 
  • 2.2K
  • 03 Nov 2022
Topic Review
Short Peptides
Short peptides should not include more than 45 amino acids.
  • 2.2K
  • 19 Feb 2021
Topic Review
Spermidine
Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation.
  • 2.2K
  • 04 Aug 2022
Topic Review
Ecosystem Services Provided by Kelp Forests
Ecosystem services (ES) are defined as the benefits that humans obtain from ecological systems. These include services such as food and fresh water and climate regulation, among others that make human life possible. This concept is established as a “policy advocacy tool” since it helps with management practices. 
  • 2.2K
  • 14 Nov 2022
Topic Review
William Jennings Bryan Presidential Campaign, 1896
In 1896, William Jennings Bryan ran unsuccessfully for President of the United States. Bryan, a former Democratic congressman from Nebraska, gained his party's presidential nomination in July of that year after electrifying the Democratic National Convention with his Cross of Gold speech. He was defeated in the general election by the Republican candidate, former Ohio governor William McKinley. Born in 1860, Bryan grew up in rural Illinois and in 1887 moved to Nebraska, where he practiced law and entered politics. He won election to the House of Representatives in 1890, and was re-elected in 1892, before mounting an unsuccessful US Senate run. He set his sights on higher office, believing he could be elected president in 1896 even though he remained a relatively minor figure in the Democratic Party. In anticipation of a presidential campaign, he spent much of 1895 and early 1896 making speeches across the United States; his compelling oratory increased his popularity in his party. Bryan often spoke on the issue of the currency. The economic Panic of 1893 had left the nation in a deep recession, which still persisted in early 1896. Bryan and many other Democrats believed the economic malaise could be remedied through a return to bimetallism, or free silver—a policy they believed would inflate the currency and make it easier for debtors to repay loans. Bryan went to the Democratic convention in Chicago as an undeclared candidate, whom the press had given only a small chance of becoming the Democratic nominee. His 'Cross of Gold' speech, given to conclude the debate on the party platform, immediately transformed him into a favorite for the nomination, and he won it the next day. The Democrats nominated Arthur Sewall, a wealthy Maine banker and shipbuilder, for vice president. The left-wing Populist Party (which had hoped to nominate the only silver-supporting candidate) endorsed Bryan for president, but found Sewall unacceptable, substituting Thomas E. Watson of Georgia. Abandoned by many gold-supporting party leaders and newspapers after the Chicago convention, Bryan undertook an extensive tour by rail to bring his campaign to the people. He spoke some 600 times, to an estimated 5,000,000 listeners. His campaign focused on silver, an issue that failed to appeal to the urban voter, and he was defeated. The 1896 race is generally seen as a realigning election. The coalition of wealthy, middle-class and urban voters that defeated Bryan kept the Republicans in power for most of the time until 1932. Although defeated in the election, Bryan's campaign made him a national figure, which he remained until his death in 1925.
  • 2.2K
  • 26 Dec 2022
Topic Review
Curcuma longa L. Essential Oil
Curcuma longa L. rhizome essential oil is a valuable product in pharmaceutical industry due to its wide beneficial health effects.
  • 2.2K
  • 09 Feb 2021
Topic Review
Non-Spiking Neuron
Non-spiking neurons are neurons that are located in the central and peripheral nervous systems and function as intermediary relays for sensory-motor neurons. They do not exhibit the characteristic spiking behavior of action potential generating neurons. Non-spiking neural networks are integrated with spiking neural networks to have a synergistic effect in being able to stimulate some sensory or motor response while also being able to modulate the response.
  • 2.2K
  • 16 Dec 2022
Topic Review
Porphyry Mo Deposits
Porphyry Mo deposits are the most important type of Mo resource. They result from a high oxygen fugacity of the parent magma, which acts as an effective indicator for evaluating the mineralization. In the ore-forming system of porphyry Mo deposits, sulfur exists mainly as sulfate in highly oxidized magma but as sulfide in ores. What triggers the reduction in the mineralization system that leads to sulfide precipitation has not yet been determined. 
  • 2.2K
  • 28 Jul 2023
Topic Review
Small Molecules for Corneal Neovascularization
Multiple natural-source and synthetic small molecules have been tested preclinical for treating corneal neovascularization. Such small molecules include synthetic inhibitors of the vascular endothelial growth factor (VEGF) receptor and other tyrosine kinases, plus repurposed antimicrobials, as well as natural source-derived flavonoid and non-flavonoid phytochemicals, immunosuppressants, vitamins, and histone deacetylase inhibitors.
  • 2.2K
  • 17 Aug 2020
Topic Review
Slope Stability
The issue of slope stability is one of the most important and yet most difficult geotechnical problems. Assessing slope stability is particularly difficult because of the many uncertainties involved in the process. To take these uncertainties into account, probabilistic methods are used, and the reliability approach is adopted. There are many methods for reliability assessment of earth slope stability. However, there is no system that would organize all of these methods in an unambiguous way. In fact, these methods can be classified in different ways: by assignment to a deterministic classification of methods, by description of uncertainties of soil parameters, by level of reliability according to the theory of reliability, etc. The huge number of articles summarizing the research in this field, but in various “disordered” directions, certainly do not facilitate the understanding or ultimately the practical application of the reliability approach by the engineer. We propose a universal classification system of reliability methods for evaluating the stability of earth slopes. This proposal is preceded by a brief literature review of both historical background and contemporary study on reliability analysis of earth slope stability.
  • 2.2K
  • 17 Aug 2021
Biography
Herman Branson
Herman Russell Branson (August 14, 1914 – June 7, 1995) was an African-American physicist, chemist, best known for his research on the alpha helix protein structure, and was also the president of two colleges. Branson received his B.S. from Virginia State College in 1936, and his Ph.D. in physics from the University of Cincinnati, under the direction of Boris Padolsky, in 1939. His thesis w
  • 2.2K
  • 15 Dec 2022
Topic Review
Kounotori Integrated Tether Experiment
Kounotori 6 (こうのとり6号機), also known as HTV-6, is the sixth flight of the H-II Transfer Vehicle, an uncrewed cargo spacecraft launched to resupply the International Space Station. It was launched at 13:26:47 UTC on 9 December 2016 aboard H-IIB launch vehicle from Tanegashima Space Center.
  • 2.2K
  • 27 Oct 2022
Topic Review
SCORE
SCORE is a scorewriter program, written in FORTRAN for MS-DOS by Stanford University Professor Leland Smith (1925–2013) with a reputation for producing very high-quality results. It was widely used in engraving during the 1980s and 1990s and continues to have a small, dedicated following of engravers, many of whom regard it as the world's best music-engraving program due to its ability to position symbols precisely on the page. Several publications set using SCORE have earned Paul Revere and German Musikpresse engraving awards.
  • 2.2K
  • 08 Nov 2022
Topic Review
Stationary Action Principle
The stationary action principle – also known as the principle of least action – is a variational principle that, when applied to the action of a mechanical system, yields the equations of motion for that system. The principle states that the trajectories (i.e. the solutions of the equations of motion) are stationary points (a.k.a. critical points) of the system's action functional. The term "least action" is a historical misnomer since the principle has no minimality requirement: the value of the action functional need not be minimal (even locally) on the trajectories. The principle can be used to derive Newtonian, Lagrangian and Hamiltonian equations of motion, and even general relativity (see Einstein–Hilbert action). In relativity, a different action must be minimized or maximized. The classical mechanics and electromagnetic expressions are a consequence of quantum mechanics. The stationary action method helped in the development of quantum mechanics. In 1933, the physicist Paul Dirac demonstrated how this principle can be used in quantum calculations by discerning the quantum mechanical underpinning of the principle in the quantum interference of amplitudes. Subsequently Julian Schwinger and Richard Feynman independently applied this principle in quantum electrodynamics. The principle remains central in modern physics and mathematics, being applied in thermodynamics, fluid mechanics, the theory of relativity, quantum mechanics, particle physics, and string theory and is a focus of modern mathematical investigation in Morse theory. Maupertuis' principle and Hamilton's principle exemplify the principle of stationary action. The action principle is preceded by earlier ideas in optics. In Ancient Greece , Euclid wrote in his Catoptrica that, for the path of light reflecting from a mirror, the angle of incidence equals the angle of reflection. Hero of Alexandria later showed that this path was the shortest length and least time. Scholars often credit Pierre Louis Maupertuis for formulating the principle of least action because he wrote about it in 1744 and 1746. However, Leonhard Euler discussed the principle in 1744, and evidence shows that Gottfried Leibniz preceded both by 39 years.
  • 2.2K
  • 14 Oct 2022
Topic Review
Selective Autophagy in Age-Associated Pathologies
Selective autophagy degrades a plethora of autophagic cargo, which is targeted upon specific cellular insults. Defective mitochondria (mitophagy), protein aggregates (aggrephagy) or pathogenic bacteria (xenophagy) are selective autophagy triggers. Atg8 proteins interact and recruit selective autophagic receptors, which contain LIR (LC3-interacting) motifs (W/F/Y-X-X-L/I/V), with upstream negatively charged residues for higher affinity interactions, as well as, post-translational modifications, such as phosphorylation.
  • 2.2K
  • 07 Sep 2021
Topic Review
Women of Color
Women of color (singular: woman of color, sometimes abbreviated as WOC) is a phrase used to describe female non-whites. The political term "women of color" surfaced in the violence against women movement. In the late seventies it unified all women experiencing multiple layers of marginalization with race or ethnicity as a common issue.
  • 2.2K
  • 17 Oct 2022
Topic Review
The NLRP3 Inflammasome
As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome can be activated by various endogenous and exogenous danger signals. Activation of this cytosolic multiprotein complex triggers the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and initiates pyroptosis, an inflammatory form of programmed cell death. The NLRP3 inflammasome fuels both chronic and acute inflammatory conditions and is critical in the emergence of inflammaging. Recent advances have highlighted that various metabolic pathways converge as potent regulators of the NLRP3 inflammasome. This review focuses on our current understanding of the metabolic regulation of the NLRP3 inflammasome activation, and the contribution of the NLRP3 inflammasome to inflammaging.
  • 2.2K
  • 24 Aug 2020
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