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Topic Review
Pathophysiology of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) encompasses a group of heterogeneous diseases that entail chronic, relapsing gastrointestinal tract inflammation of inexactly known etiology and pathogenesis. IBD is clinically classified as Crohn’s disease (CD) or ulcerative colitis (UC) based on symptoms, disease location, and histopathological characteristics.
  • 2.2K
  • 28 Jan 2023
Topic Review
The NLRP3 Inflammasome
As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome can be activated by various endogenous and exogenous danger signals. Activation of this cytosolic multiprotein complex triggers the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and initiates pyroptosis, an inflammatory form of programmed cell death. The NLRP3 inflammasome fuels both chronic and acute inflammatory conditions and is critical in the emergence of inflammaging. Recent advances have highlighted that various metabolic pathways converge as potent regulators of the NLRP3 inflammasome. This review focuses on our current understanding of the metabolic regulation of the NLRP3 inflammasome activation, and the contribution of the NLRP3 inflammasome to inflammaging.
  • 2.2K
  • 24 Aug 2020
Topic Review
Reverse Osmosis
Reverse osmosis is the leading technology for desalination of brackish water and seawater, important for solving the growing problems of fresh water supply.
  • 2.2K
  • 23 Jul 2021
Topic Review
Corvids in Urban Environments
With regard to their high adaptability to human settlements and global distribution, corvid birds (crows, ravens, jays, etc.) are good models to understand the impacts of urbanization on wildlife. At least 30 corvid species have become successfully accustomed or adapted to urbanized environments. The availability of easily accessible food and artificial nesting sites, coupled with low levels of predation, were found as the most important factors benefitting corvids in cities around the world. 
  • 2.2K
  • 13 Dec 2021
Topic Review Video
Blockchain Acceptance Models
Blockchain is a promising breakthrough technology that is highly applicable in manifold sectors. The adoption of blockchain technology is accompanied by a range of issues and challenges that make its implementation complicated. To facilitate the successful implementation of blockchain technology, several blockchain adoption frameworks have been developed. However, selecting the appropriate framework based on the conformity of its features with the business sector may be challenging for decision-makers. 
  • 2.2K
  • 18 Feb 2022
Topic Review
Mineral Processing
In the field of extractive metallurgy, mineral processing, also known as ore dressing, is the process of separating commercially valuable minerals from their ores.
  • 2.2K
  • 27 Oct 2022
Topic Review
Behavioral Neuroscience
Behavioral neuroscience, also known as biological psychology, biopsychology, or psychobiology, is the application of the principles of biology to the study of physiological, genetic, and developmental mechanisms of behavior in humans and other animals.
  • 2.2K
  • 23 Nov 2022
Topic Review
Migraine
Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels stimulates nociceptors and induces cortical spreading depression. Studies investigating nitric oxide (NO) donors support the indicated hypothesis that pain is amplified when acutely administered. We provide an alternate hypothesis which, if substantiated, may provide therapeutic opportunities for attenuating migraine frequency and severity. We suggest that in migraines, heightened sympathetic tone results in progressive central microvascular constriction. Suboptimal parenchymal blood flow, we suggest, activates nociceptors and triggers headache pain onset. Administration of NO donors could paradoxically promote constriction of the microvasculatureas a consequence of larger upstream central artery vasodilatation. Inhibitors of NO production are reported to alleviate migraine pain. We describe how constriction of larger upstream arteries, induced by NO synthesis inhibitors, may result in a compensatory dilatory response of the microvasculature. The restoration of central capillary blood flow may be the primary mechanism for pain relief. Attenuating the propensity for central capillary constriction and promoting a more dilatory phenotype may reduce frequency and severity of migraines. We propose consideration of two dietary nutraceuticals for reducing migraine risk: L-arginine and aged garlic extracts.
  • 2.2K
  • 25 Dec 2020
Topic Review
NMR in Milk Protein Structure
Milk proteins have a complex structure which changes as a result of applied treatment. The newly developed structural conformations of proteins exert influence on the quality of the final product. Structural characterization of milk proteins was successfully performed using NMR. This predominately refers to complete structural assignment on whey proteins and elucidation of sequential fragments of caseins.    As a non destructive method, NMR is a powerful tool which observe the nuclei of atoms immersed in large magnetic field producing radio sensitive signal. The produced signal gives information of the spatial orientation of the molecules and thus tertiary structure of proteins. 
  • 2.2K
  • 27 Oct 2020
Topic Review
Clean Ethanol from CO2 Reduction
Using renewable energy to convert CO2 to a clean fuel ethanol can not only reduce carbon emission by the utilization of CO2 as feedstock, but also store renewable energy as the widely used chemical and high-energy-density fuel, being considered as a perfect strategy to address current environment and energy issues. Developing efficient electrocatalysts, photocatalysts, and photoelectrocatalysts for CO2 reduction is the most crucial keystone for achieving this goal. Considerable progresses in CO2-based ethanol production have been made over the past decades. This review provides the general principles and summarizes the latest advancements of electrocatalytic, photocatalytic and photoelectrocatalytic CO2 conversion to ethanol. Furthermore, the main challenges and proposed future prospects are illustrated for further development of the clean fuel ethanol production.
  • 2.2K
  • 24 Nov 2020
Topic Review
Risk-Based Flood Management
“Flood management” refers to the general method involved in flood prevention and subsequent flood loss, whereas “risk-based flood management” is the combination of all of the actions that aim at the amelioration of the overall activities in a floodplain.
  • 2.2K
  • 21 Jan 2021
Topic Review
Room Temperature Sodium Sulfur Batteries
Lithium metal batteries have achieved large-scale application, but still have limitations such as poor safety performance and high cost, and limited lithium resources limit the production of lithium batteries. The construction of these devices is also hampered by limited lithium supplies. Therefore, it is particularly important to find alternative metals for lithium replacement. Sodium has the properties of rich in content, low cost and ability to provide high voltage, which makes it an ideal substitute for lithium. Sulfur-based materials have attributes of high energy density, high theoretical specific capacity and are easily oxidized. They may be used as cathodes matched with sodium anodes to form a sodium-sulfur battery. Traditional sodium-sulfur batteries are used at a temperature of about 300 °C. In order to solve problems associated with flammability, explosiveness and energy loss caused by high-temperature use conditions, most research is now focused on the development of room temperature sodium-sulfur batteries. Regardless of safety performance or energy storage performance, room temperature sodium-sulfur batteries have great potential as next-generation secondary batteries. This article summarizes the working principle and existing problems for room temperature sodium-sulfur battery, and summarizes the methods necessary to solve key scientific problems to improve the comprehensive energy storage performance of sodium-sulfur battery from four aspects: cathode, anode, electrolyte and separator.
  • 2.2K
  • 06 Apr 2021
Topic Review
Aircraft 4D Trajectory Prediction in Civil Aviation
Aircraft four dimensional (4D, including longitude, latitude, altitude and time) trajectory prediction is a key technology for existing automation systems and the basis for future trajectory-based operations. The trajectory prediction is the process of estimating the future states of the aircraft based on the current aircraft state, estimation of the pilot and controller intent, expected environmental conditions, and computer models of aircraft performance and procedures.
  • 2.2K
  • 23 Feb 2022
Topic Review
Humus
Etymologically the word "humus" means ground, dirt; the meaning of "homo" or "human" is near to earthling or being of the earth, earth here referring to the ground, or dirt (https://sites.psu.edu/josephvadella/2017/09/08/origins-of-human/). Essentially the words humus and human mean "connected to the earth", earth understood as dust, soil, dirt. The best way to express such a concept comes from an ancient religious Latin sentence: "pulvis est et pulvis reverteris", solemnly pronounced by priests as they deposited a pinch of ash on the believers' heads. Consider that earth has also become the name of the whole planet Earth, and that the Lovelock's Gaia hypothesis assigns the planet the functioning of a quasi-organism (https://en.wikipedia.org/wiki/Gaia_hypothesis). The notion of humus contains and makes explicit the very concept of all existing matter. What is matter (living or not), if always, at a given cyclical moment, matter is forced to disappear by a principle which founds the future of this same matter? Understanding even partially this principle is useful for every single individual and for the whole of the co-evolving society.
  • 2.2K
  • 01 Aug 2022
Topic Review
Proxy Modeling Highlighting Applications for Reservoir Engineering
Numerical models can be used for many purposes in oil and gas engineering, such as production optimization and forecasting, uncertainty analysis, history matching, and risk assessment. However, subsurface problems are complex and non-linear, and making reliable decisions in reservoir management requires substantial computational effort. Proxy models have gained much attention in recent years. They are advanced non-linear interpolation tables that can approximate complex models and alleviate computational effort. Proxy models are constructed by running high-fidelity models to gather the necessary data to create the proxy model. Once constructed, they can be a great choice for different tasks such as uncertainty analysis, optimization, forecasting, etc. The application of proxy modeling in oil and gas has had an increasing trend in recent years, and there is no consensus rule on the correct choice of proxy model. As a result, it is crucial to better understand the advantages and disadvantages of various proxy models.
  • 2.2K
  • 05 Sep 2022
Topic Review
Polyamines
Polyamines (PAs), such as putrescine (PUT), spermine (SPE), and spermidine (SPD), are organic polycationic alkylamines, which are synthesized from L-ornithine or by the decarboxylation of amino acids. They are found in all living cells and mammalian cells contain a millimolar concentration of PAs. In 1678, the SPE was first identified by Van Leeuwenhoek as crystals in dried semen but not in fresh ones.
  • 2.2K
  • 28 Jun 2021
Topic Review
Electrochemical Detection for Antibody Detection
Detection of biomarkers has raised much interest recently due to the need for disease diagnosis and personalized medicine in future point-of-care systems. Among various biomarkers, antibodies are an important type of detection target due to their potential for indicating disease progression stage and the efficiency of therapeutic antibody drug treatment. In this review, electrochemical and optical detection of antibodies are discussed. Specifically, creating a non-label and reagent-free sensing platform and construction of an anti-fouling electrochemical surface for electrochemical detection are suggested. For optical transduction, a rapid and programmable platform for antibody detection using a DNA-based beacon is suggested as well as the use of bioluminescence resonance energy transfer (BRET) switch for low cost antibody detection. These sensing strategies have demonstrated their potential for resolving current challenges in antibody detection such as high selectivity, low operation cost, simple detection procedures, rapid detection, and low-fouling detection. This review provides a general update for recent developments in antibody detection strategies and potential solutions for future clinical point-of-care systems.
  • 2.2K
  • 23 Oct 2020
Topic Review
Drugs’ Use in Mass Culture
Drugs in mass culture are uncritical, positive, or neutral representations of drug use that can be encountered in mass cultural products and media. Such representations can be seen in films, music, literature, websites, commercially marketed everyday products such as food, clothing, cosmetics, and celebrities' statements and attitudes towards drugs, among others. Some studies suggest a causal relationship between the representation of drug use in mass culture content and the liberalization of attitudes towards psychoactive substances and the decision to use these substances by the recipients of such content.
  • 2.2K
  • 25 Jun 2021
Topic Review
Campylobacter Upsaliensis
Campylobacter upsaliensis is a gram negative bacteria in the Campylobacter genus. C. upsaliensis is found worldwide, and is a common cause of Campylobacteriosis in humans, as well as gastroenteritis in dogs. Human infections are primarily associated with raw or undercooked meat and contaminated water sources, however there is some zoonotic risk associated with the spread from dogs. C. upsaliensis primarily affects the gastrointestinal tract as it damages gastrointestinal epithelial cells. There are many methods for detecting C.upsaliensis including PCR and ELISA, however there is no current gold standard in detection techniques. Infection is typically self limiting, however there is antimicrobial therapy available.
  • 2.2K
  • 30 Sep 2022
Topic Review
Imaging Findings of Lung Nodule or Mass
Systemic endemic mycoses are a group of dimorphic fungi prevalent in specific geographical locations. Histoplasma capsulatum, Coccidioides spp., Blastomyces dermatitidis, Cryptococcosis gattii, and Paracoccidioides brasiliensis are the primary pulmonary fungal pathogens of otherwise healthy people. Acute or chronic fungal infections may manifest as solitary or multiple lung nodules or masses. The most frequent pathogens are histoplasmosis, coccidioidomycosis, cryptococcosis, and blastomycosis. The nodules have a nonspecific appearance, may be ill or well-defined, have regular or spiculated borders, and may also demonstrate cavitation or ground glass halo.
  • 2.2K
  • 04 Nov 2022
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