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Topic Review
T Cells and Adaptive Immune System in SARS-CoV-2
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prior COVID-19 research on immunogens understandably focused on nAb responses, with less interest in overall cellular immunity. Interestingly, there is data accumulating which suggests that T cell responses are an important player in both natural and adaptive immunity as well as vaccine protection against chronic COVID-19 disease.
  • 2.3K
  • 20 Feb 2023
Topic Review
Effect of Digital Citizenship on Prevention of Cybercrime
Digital citizenship refers to the competence to navigate digital environments in a responsible and safe manner, and to engage actively and respectfully in these spaces. It involves understanding how to use digital technology effectively and ethically, while also respecting the rights and privacy of others. The growing prevalence of cybercrime, particularly among young adults, necessitates the promotion of digital citizenship to educate students about responsible online behavior and to equip them with the skills to mitigate cyber risks.
  • 2.3K
  • 28 Aug 2023
Topic Review Video
Physicochemical Processes Leading to Plasma-Driven Solution Electrolysis
A new type of electrolysis, initially known as the contact glow-discharge electrolysis (CGDE) and, more recently, as the plasma-driven solution electrolysis (PDSE), has attracted attention as an alternative method of hydrogen production. PDSE is a nontypical electrochemical process in which electric plasma is formed in the glow discharges excited by the direct or pulsed current in a gas–vapor envelope in the vicinity of the discharge electrode immersed in the electrolytic solution. The yield of chemicals in PDSE (i.e., the ratio of the moles of the product formed to the moles of electrons consumed in a chemical reaction) is several times higher than the Faradaic production of chemicals (predicted by Faraday’s law). In PDSE, new chemical compounds can also be synthesized, which does not happen using Faradaic electrolysis.
  • 2.3K
  • 31 Oct 2022
Topic Review
Genus Ochrobactrum
Ochrobactrum spp. are found in a wide range of environments including soils and water. They are non-enteric, Gram-negative organisms that are closely related to the genus Brucella. Several species of this genus have now been characterised and implicated as opportunistic pathogens in multiple outbreaks. This entry gives a brief overview of the Genus Ochrobactrum.
  • 2.3K
  • 27 Nov 2020
Topic Review Peer Reviewed
Homocysteine Thiolactone: Biology and Сhemistry
Homocysteine thiolactone is a five-membered cyclic thioester of amino acid homocysteine. It is generated from homocysteine as a result of an error-editing reaction, principally, of methionyl-tRNA synthetase. An elevated level of homocysteine thiolactone is associated with cardiovascular diseases, strokes, atherosclerosis, neurological abnormalities, etc., presumably because it reacts to the side chain of protein lysine causing protein damage and autoimmune responses. It is not only an important metabolite but also a versatile building block for organic and bioorganic synthesis. This entry contains data on the homocysteine thiolactone formation, metabolism, toxicity mechanism in vivo, and the bioorganic chemistry applications as a powerful synthetic tool in polymer science, sustainable materials development, and probes. 
  • 2.3K
  • 13 Apr 2022
Topic Review
Romantic Love and Sleep
“Romantic love is a motivational state typically associated with a desire for long-term mating with a particular individual. It occurs across the lifespan and is associated with distinctive cognitive, emotional, behavioural, social, genetic, neural, and endocrine activity in both sexes. Throughout much of the life course, it serves mate choice, courtship, sex, and pair-bonding functions. It is a suite of adaptations and by-products that arose sometime during the recent evolutionary history of humans”. Sleep is common in the animal kingdom, although it takes various forms. Sleep in humans is defined “on the basis of both behaviour of the person while asleep and the related physiologic changes that occur to the waking brain’s electrical rhythm in sleep”. Behavioural characteristics of sleep include lack of mobility or slight mobility, closed eyes, a characteristic species-specific sleeping posture, reduced response to external stimulation, quiescence, increased reaction time, elevated arousal threshold, impaired cognitive function, and a reversible unconscious state. It includes non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. Non-rapid eye movement sleep is characterised by synchronised electroencephalographic activity, mildly reduced muscle tone, and slow rolling eye movements. Rapid eye movement sleep is characterised by theta or saw tooth waves and desynchronised electroencephalographic activity, moderately to severely reduced or absent muscle tone, and rapid eye movements. There are three stages of NREM sleep (i.e., N1, N2, N3) and one stage of REM sleep.
  • 2.3K
  • 27 Jan 2022
Topic Review
Clostridium Difficile Infection
Clostridium difficile infection (CDI or C-dif) is a symptomatic infection due to the spore-forming bacterium, Clostridium difficile. Symptoms include watery diarrhea, fever, nausea, and abdominal pain. It makes up about 20% of cases of antibiotic-associated diarrhea. Complications may include pseudomembranous colitis, toxic megacolon, perforation of the colon, and sepsis. Clostridium difficile infection is spread by bacterial spores found within feces. Surfaces may become contaminated with the spores with further spread occurring via the hands of healthcare workers. Risk factors for infection include antibiotic or proton pump inhibitors use, hospitalization, other health problems, and older age. Diagnosis is by stool culture or testing for the bacteria's DNA or toxins. If a person tests positive but has no symptoms, the condition is known as C. difficile colonization rather than an infection. Prevention is by hand washing, terminal room cleaning in hospital, and limiting antibiotic use. Discontinuation of antibiotics may result in resolution of symptoms within three days in about 20% of those infected. Often the antibiotics metronidazole, vancomycin or fidaxomicin will cure the infection. Retesting after treatment, as long as the symptoms have resolved, is not recommended, as the person may remain colonized. Recurrences have been reported in up to 25% of people. Some tentative evidence indicates fecal microbiota transplantation and probiotics may decrease the risk of recurrence. C. difficile infections occur in all areas of the world. About 453,000 cases occurred in the United States in 2011, resulting in 29,000 deaths. Rates of disease globally have increased between 2001 and 2016. Women are more often affected than men. The bacterium was discovered in 1935 and found to be disease-causing in 1978. In the United States, health–care associated infections increase the cost of care by US$1.5 billion each year.
  • 2.3K
  • 07 Nov 2022
Topic Review
Relevance (Law)
Relevance, in the common law of evidence, is the tendency of a given item of evidence to prove or disprove one of the legal elements of the case, or to have probative value to make one of the elements of the case likelier or not. Probative is a term used in law to signify "tending to prove." Probative evidence "seeks the truth". Generally in law, evidence that is not probative (doesn't tend to prove the proposition for which it is proffered) is inadmissible and the rules of evidence permit it to be excluded from a proceeding or stricken from the record "if objected to by opposing counsel." A balancing test may come into the picture if the value of the evidence needs to be weighed versus its prejudicial nature.
  • 2.3K
  • 15 Nov 2022
Topic Review Video
Chaos and Order in the Atmosphere
The Lorenz 1963 and 1969 models have been applied for revealing the chaotic nature of weather and climate and for estimating the atmospheric predictability limit. Recently, an in-depth analysis of classical Lorenz models (LMs) and newly developed, generalized Lorenz models suggested a revised view that “The atmosphere possesses chaos and order; it includes, as examples, emerging organized systems (such as tornadoes) and time varying forcing from recurrent seasons”, in contrast to the conventional view of “weather is chaotic”. The revised view focuses on distinct predictability and time varying multistability. Distinct predictability suggests limited predictability for chaotic solutions and unlimited predictability (or up to their lifetime) for non-chaotic solutions. To support the revised view, multistability (for attractor coexistence) and monostability (for single-type solutions) are first illustrated using kayaking and skiing as an analogy. Additionally, this entry provides a list of non-chaotic weather systems and a short list of suggested future tasks.
  • 2.3K
  • 29 Nov 2022
Topic Review
Plant Species and Expression Systems on Vaccines Production
Use of plant cells as vaccine production hosts is appropriate for the expression of complex antigens in a cost-efficient manner. Recombinant proteins can be produced using various expression systems, each of which has its own benefits and disadvantages pertaining to the yield, time required for expression and the costs incurred in this process.
  • 2.3K
  • 18 Jan 2023
Topic Review
Understanding Invasion, Ecological Adaptations, Management of Bactrocera dorsalis
Bactrocera dorsalis (Hendel, 1912) (Diptera: Tephritidae), commonly known as the oriental fruit fly, is a highly destructive pest that globally infests fruits and vegetables, resulting in significant annual economic losses. Initially detected in Taiwan Island, it has rapidly expanded its distribution range to various regions in mainland China since the 1980s, with a continuous northward spread. To mitigate the damage caused by this pest, extensive efforts have been undertaken to comprehend its ecological and physiological adaptations and develop management strategies.
  • 2.3K
  • 21 Sep 2023
Topic Review
Flavonoid Production in Plant Metabolic Engineering
Flavonoids are secondary metabolites that represent a heterogeneous family of plant polyphenolic compounds. The research has determined that the health benefits of fruits and vegetables, as well as the therapeutic potential of medicinal plants, are based on the presence of various bioactive natural products, including a high proportion of flavonoids. In plant metabolite research, flavonoids have become the center of attention due to their significant bioactivity associated with anti-cancer, antioxidant, anti-inflammatory, and anti-microbial activities.
  • 2.3K
  • 31 Jan 2023
Biography
Johann Friedrich Blumenbach
Johann Friedrich Blumenbach (11 May 1752 – 22 January 1840) was a German physician, naturalist, physiologist, and anthropologist. He was one of the first to explore the study of the human being as an aspect of natural history. His teachings in comparative anatomy were applied to his classification of human races, of which he claimed there were five, Caucasian, Mongolian, Malayan, Ethiopian, an
  • 2.3K
  • 16 Nov 2022
Topic Review
Sustainable Value Chain Management
Sustainable value chain management requires finding a balance between the economic, social, and environmental spheres, inside and outside the organizations, in all business functions/processes related to value chain formation. Managers for sustainable management need to have adequate and high-quality financial and non-financial information. They are crucial during times of economic crises (such as those associated with the COVID 19 pandemic). Functional controllers, through their competence and having the appropriate tools to carry out their tasks, can fully meet the information needs of managers in creating a sustainable value chain.
  • 2.3K
  • 06 Jul 2021
Topic Review
Medical Applications of Chitin
Chitin is a universal biopolymer that is found in microbes, plants, fungi, the exoskeleton of insects, various species of algae, and bottom-feeding crustaceans. This (1–4)-linked N-acetyl-ß-D-glucosamine polysaccharide can be readily processed with simple chemical procedures without putting a species at risk. Chitin has garnered interest as an alternative substance that can be used in the medical, environmental, and agricultural sectors.
  • 2.3K
  • 29 Mar 2022
Topic Review
Theoretical Background of Explainable Artificial Intelligence
Artificial intelligence (AI) and machine learning (ML) have recently been radically improved and are now being employed in almost every application domain to develop automated or semi-automated systems. To facilitate greater human acceptability of these systems, explainable artificial intelligence (XAI) has experienced significant growth over the last couple of years with the development of highly accurate models but with a paucity of explainability and interpretability. XAI methods are mostly developed for safety-critical domains worldwide, deep learning and ensemble models are being exploited more than other types of AI/ML models, visual explanations are more acceptable to end-users and robust evaluation metrics are being developed to assess the quality of explanations.
  • 2.3K
  • 16 Mar 2022
Topic Review
Zero Liquid Discharge System for the Tannery Industry
The tannery industry is characterized by the consumption of a large quantity of water, around 30–40 m3 for processing 1000 kg of hide or skin. This amount becomes wastewater, containing about 300 kg of different chemicals, mainly refractory organic compounds, with high chemical oxygen demand (COD), total dissolved salts (TDS), chromium, and evolution of toxic gases, such as ammonia and sulfides, etc. The remaining tanning chemicals are released as effluent having high resistance against biological degradation, becoming a serious environmental issue. The Zero Liquid Discharge (ZLD) system serves to ensure zero water emission, as well as treatment facilities by recycling, recovery, and reuse of the treated wastewater using advanced cleanup technology. The international scenario shows the implementation of ZLD thanks to pressure from regulatory agencies. The ZLD system consists of a pre-treatment system with conventional physicochemical treatment, tertiary treatment, softening of the treated effluent, reverse osmosis (RO) treatment for desalination, and thermal evaporation of the saline reject from RO to separate the salts. By adopting this system, water consumption is reduced. Moreover, ZLD also becomes effective in disaster mitigation in areas where the tannery industry is a strong economic actor. 
  • 2.3K
  • 27 Jun 2022
Topic Review
Prenuptial Agreement
A prenuptial agreement, antenuptial agreement, or premarital agreement (commonly referred to as a prenup), is a written contract entered into by a couple prior to marriage or a civil union that enables them to select and control many of the legal rights they acquire upon marrying, and what happens when their marriage eventually ends by death or divorce. Couples enter into a written prenuptial agreement to supersede many of the default marital laws that would otherwise apply in the event of divorce, such as the laws that govern the division of property and retirement benefits and savings, and the right to seek alimony (spousal support) with agreed-upon terms that provide certainty and clarify their marital rights. A premarital agreement may also contain waivers of a surviving spouse’s right to claim an elective share of the estate of the deceased spouse. In some countries, including the United States , Belgium and the Netherlands, the prenuptial agreement not only provides for what happens in the event of a divorce, but also to protect some property during the marriage, for instance in case of a bankruptcy. Many countries, including Canada , France , Italy, and Germany , have matrimonial regimes, in addition to, or some cases, in lieu of prenuptial agreements. Postnuptial agreements are similar to prenuptial agreements, except that they are entered into after a couple is married. When divorce is imminent, postnuptial agreements are referred to as separation agreements.
  • 2.3K
  • 25 Oct 2022
Topic Review
DAISY Digital Talking Book
DAISY (Digital Accessible Information SYstem) is a technical standard for digital audiobooks, periodicals and computerized text. DAISY is designed to be a complete audio substitute for print material and is specifically designed for use by people with "print disabilities", including blindness, impaired vision, and dyslexia. Based on the MP3 and XML formats, the DAISY format has advanced features in addition to those of a traditional audio book. Users can search, place bookmarks, precisely navigate line by line, and regulate the speaking speed without distortion. DAISY also provides aurally accessible tables, references and additional information. As a result, DAISY allows visually impaired listeners to navigate something as complex as an encyclopedia or textbook, otherwise impossible using conventional audio recordings. DAISY multimedia can be a book, magazine, newspaper, journal, computerized text or a synchronized presentation of text and audio. It provides up to six embedded "navigation levels" for content, including embedded objects such as images, graphics, and MathML. In the DAISY standard, navigation is enabled within a sequential and hierarchical structure consisting of (marked-up) text synchronized with audio. DAISY 2 was based on XHTML and SMIL. DAISY 3 is a newer technology, also based on XML, and is standardized as ANSI/NISO Z39.86-2005. The DAISY Consortium was founded in 1996 and consists of international organizations committed to developing equitable access to information for people who have a print disability. The consortium was selected by the National Information Standards Organization (NISO) as the official maintenance agency for the DAISY/NISO Standard.
  • 2.3K
  • 09 Nov 2022
Topic Review
Canadian Arctic Archipelago
The Canadian Arctic Archipelago, also known as the Arctic Archipelago, is a group of islands north of the Canada mainland. Situated in the northern extremity of North America and covering about 1,424,500 km2 (550,000 sq mi), this group of 36,563 islands in the Arctic Sea comprises much of the territory of Northern Canada – most of Nunavut and part of the Northwest Territories. The Canadian Arctic Archipelago is showing some effects of global warming, with some computer estimates determining that melting there will contribute 3.5 cm (1.4 in) to the rise in sea levels by 2100.
  • 2.3K
  • 15 Nov 2022
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