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Topic Review
Preparation and Purification of In Vitro-Transcribed-mRNA-Based Molecules
The Corona Virus Disease 2019 (COVID-19) pandemic poses a disruptive impact on public health and the global economy. Fortunately, the development of COVID-19 vaccines based on in vitro transcribed messenger RNA (IVT mRNA) has been a breakthrough in medical history, benefiting billions of people with its high effectiveness, safety profile, and ease of large-scale production. This success is the result of decades of continuous RNA research, which has led to significant improvements in the stability and expression level of IVT mRNA through various approaches such as sequence optimization and improved preparation processes. IVT mRNA sequence optimization has been shown to have a positive effect on enhancing mRNA expression level. The innovation of IVT mRNA purification technology is also indispensable, as the purity of IVT mRNA directly affects success of downstream vaccine preparation processes and the potential for inducing unwanted side effects in therapeutic applications. Despite the progress made, challenges related to IVT mRNA sequence design and purification still require further attention to enhance the quality of IVT mRNA in the future.
  • 2.6K
  • 06 Sep 2023
Topic Review
Eptifibatide
Eptifibatide is a glycoprotein IIb/IIIa inhibitor that blocks different pathways in platelet activation and aggregation.
  • 2.6K
  • 11 Apr 2023
Topic Review
Biomass Pyrolysis Processes for Bioenergy Production
Bioenergy has emerged to be among the primary choices for the short- and medium-term replacement of fossil fuels and the reduction in greenhouse gas (GHG) emissions. The most practical method for transforming biomass into biofuel is thermochemical conversion, which may be broken down into combustion, torrefaction, pyrolysis, hydrothermal liquefaction, and gasification.
  • 2.6K
  • 08 Aug 2023
Topic Review
Plant Sterols in Diabetes Management
The plant-based food we consume often contains many sterol-based bioactive compounds. It is well documented that these compounds could effectively manage the processes of insulin metabolism and cholesterol regulation. Insulin resistance followed by hyperglycemia often results in oxidative stress level enhancement and increased reactive oxygen species production. At the molecular level, these changes induce apoptosis in pancreatic cells and hence lead to insulin insufficiency. Studies have proved that plant sterols can lower inflammatory and oxidative stress damage connected with DNA repair mechanisms. The effective forms of phyto compounds are polyphenols, terpenoids, and thiols abundant in vegetables, fruits, nuts, and seeds. The available conventional drug-based therapies for the prevention and management of diabetes are time-consuming, costly, and with life-threatening side effects. Thereby, the therapeutic management of diabetes with plant sterols available in our daily diet is highly welcome as there are no side effects. 
  • 2.6K
  • 08 Dec 2021
Topic Review
Electric Turbo Compound
An Electric Turbo Compound (ETC) system is defined where a turbine coupled to a generator (turbogenerator) is located in the exhaust gas flow of a reciprocating engine to harvest waste heat energy and convert it into electrical power. An example of an ETC system is where a turbogenerator is located downstream of a turbocharger turbine of an Internal Combustion Engine (ICE). The power generated from the ETC system can be used to feed into an electrical grid or provide power to local electrical loads such as engine auxiliaries. ETC systems are commercially available for stationary power gensets and at an advanced stage of development for automotive applications as a solution to the challenge of improving the fuel efficiency of gas and diesel engines by recovering waste energy from the exhaust gases.
  • 2.6K
  • 25 Oct 2022
Biography
Friedrich Hund
Friedrich Hermann Hund (4 February 1896 – 31 March 1997) was a Germany physicist from Karlsruhe known for his work on atoms and molecules.[1] Hund worked at the Universities of Rostock, Leipzig, Jena, Frankfurt am Main, and Göttingen. Hund worked with such prestigious physicists as Schrödinger, Dirac, Heisenberg, Max Born, and Walter Bothe. At that time, he was Born's assistant, working
  • 2.6K
  • 18 Nov 2022
Topic Review
Tissuome
In biology, tissue is a biological organizational level between cells and a complete organ. A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are then formed by the functional grouping together of multiple tissues. The English word "tissue" derives from the French word "tissu", the past participle of the verb tisser, "to weave". The study of tissues is known as histology or, in connection with disease, as histopathology. Xavier Bichat is considered as the "Father of Histology". Plant histology is studied in both plant anatomy and physiology. The classical tools for studying tissues are the paraffin block in which tissue is embedded and then sectioned, the histological stain, and the optical microscope. Developments in electron microscopy, immunofluorescence, and the use of frozen tissue-sections have enhanced the detail that can be observed in tissues. With these tools, the classical appearances of tissues can be examined in health and disease, enabling considerable refinement of medical diagnosis and prognosis.
  • 2.6K
  • 03 Jan 2023
Topic Review
Fundamentals of Coupled Bulk Acoustic Wave MEMS Resonators
Bulk acoustic wave (BAW) resonators are a type of Micro-Electro-Mechanical System (MEMS) device experiencing acoustic wave propagation through the bulk of the medium. Combining the approach of coupled resonators with BAW resonators has recently led to achieving better performance and new functionalities. In particular, coupled BAW resonators based on lateral vibration modes are studied due to its advantages.
  • 2.6K
  • 06 Jun 2022
Topic Review
Sustainability in the Beef Cattle Industry in Brazil
Brazil is one of the world’s biggest beef producers and its largest exporter. However, beef cattle ranching is a leading cause of deforestation and habitat conversion in the Brazilian Amazon, which challenges sustainable development.
  • 2.6K
  • 16 Mar 2023
Topic Review
Chitosan-based Flame-Retardant Systems
During the last decade, the utilization of chitin, and in particular its deacetylated form, i.e. chitosan, for flame retardant purposes, has represented quite a novel and interesting application, very far from the established uses of this bio-sourced material. In this entry, chitosan is a carbon source that can be successfully exploited, often in combination with intumescent products, in order to provide different polymer systems (namely, bulky materials, fabrics and foams) with high flame retardant (FR) features. Besides, this specific use of chitosan in flame retardance is well suited to a green and sustainable approach.
  • 2.6K
  • 22 Oct 2020
Topic Review
Adaptive Response to Environmental Stress
Exposure of living organisms to environmental stress triggers defensive responses resulting in the activation of protective processes. Whenever exposure occurs at low doses, defensive effects overwhelm the adverse effects of the exposures; this adapative situation is referred as ‘hormesis’. Environmental, physical and nutritional hormetins lead to the stimulation and strengthening of the maintenance and repair systems in cells and tissues. Exercise, heat and irradiation are examples of physical hormetins, which activate heat shock-, DNA repair- and anti-oxidative-stress responses. The health promoting effect of many bio-actives in fruits and vegetables can be seen as the effect of mildly toxic compounds triggering this adaptive stimulus. Numerous studies indicate that living organisms possess the ability to adapt to adverse environmental conditions studies as examplified by the fact that DNA damage and gene expression profiling in populations living in the environment with high levels of air pollution do not correspond to the concentrations of pollutants. The molecular mechanisms of the hormetic response include modulation of (a) transcription factor Nrf2 activating the synthesis of glutathione and the subsequent protection of the cell; (b) DNA methylation; and (c) microRNA. These findings provide evidence that hormesis is a toxicological event, occurring at low exposures doses to environmental stressors, having benefit for the maintenance of healthy status.
  • 2.6K
  • 26 Oct 2020
Topic Review
Antibiotic Resistance
Antibiotics are defined as natural or synthetic chemicals inhibiting both the growth and survival of microorganisms. These compounds have been used as essential therapeutics for nearly a century. With the human population growth increasingly, antibiotics become preventive agents in the agricultural and animal industry. The multi-faceted global use and misuse of antibiotics led to the evolution of bacteria into antibiotic resistant species. Advantageous mutations cause antibiotic tolerance, which is transmitted to offspring (vertical evolution) or to another bacteria via conjugation, transduction, or transformation mode (horizontal evolution), that are then are then passed down to progeny (vertical evolution). Antibiotic resistance progressively increased mortality from multidrug-resistant bacterial infections, threatening public health. Probiotics, essential oils, vaccines, and antibodies to antibiotic resistant bacteria emerge as primary or adjunct preventive measures or therapies against multidrug-resistant bacterial infections. Bacteriophages and predatory bacteria, as well as utilization of bacterial communication quorum sensing considered as new ecosystem-influenced methods to tackle multidrug-resistant bacteria. Mechanisms of dissemination and the development of antibiotic resistance genes vary in the context of nutrition and related clinical, agricultural, veterinary, and environmental settings, this need to be accounted in selections of preventive and therapeutic countermeasures. 
  • 2.6K
  • 05 Feb 2022
Topic Review
FFAG Accelerator
A Fixed-Field Alternating Gradient accelerator (FFAG) is a circular particle accelerator concept on which development was started in the early 50s, and that can be characterized by its time-independent magnetic fields (fixed-field, like in a cyclotron) and the use of strong focusing (alternating gradient, like in a synchrotron). Thus, FFAG accelerators combine the cyclotron's advantage of continuous, unpulsed operation, with the synchrotron's relatively inexpensive small magnet ring, of narrow bore. Although the development of FFAGs had not been pursued for over a decade starting from 1967, it has regained interest since the mid-1980s for usage in neutron spallation sources, as a driver for muon colliders and to accelerate muons in a neutrino factory since the mid-1990s. The revival in FFAG research has been particularly strong in Japan with the construction of several rings. This resurgence has been prompted in part by advances in RF cavities and in magnet design.
  • 2.6K
  • 01 Nov 2022
Topic Review
G Suite
G Suite is a suite of cloud computing, productivity and collaboration tools, software and products developed by Google, first launched on August 28, 2006 as Google Apps for Your Domain. G Suite comprises Gmail, Hangouts, Calendar, and Currents for communication; Drive for storage; Docs, Sheets, Slides, Keep, Forms, and Sites for productivity and collaboration; and, depending on the plan, an Admin panel and Vault for managing users and the services. It also includes the digital interactive whiteboard Jamboard. While these services are free to use for consumers, G Suite adds enterprise features such as custom email addresses at a domain (@yourcompany.com), option for unlimited cloud storage (depending on plan and number of members), additional administrative tools and advanced settings, as well as 24/7 phone and email support. Being based in Google's data centers, data and information is saved instantly and then synchronized to other data centers for backup purposes. Unlike the free, consumer-facing services, G Suite users do not see advertisements while using the services, and information and data in G Suite accounts do not get used for advertisement purposes. Furthermore, G Suite administrators can fine-tune security and privacy settings. As of April 2020, G Suite had 6 million paying businesses, and 120 million G Suite for Education users.
  • 2.6K
  • 04 Nov 2022
Topic Review
Proof-of-Work System
A Proof-of-Work (PoW) system (or protocol, or function) is an economic measure to deter denial of service attacks and other service abuses such as spam on a network by requiring some work from the service requester, usually meaning processing time by a computer. The concept was invented by Cynthia Dwork and Moni Naor as presented in a 1993 journal article. The term "Proof of Work" or PoW was first coined and formalized in a 1999 paper by Markus Jakobsson and Ari Juels. An early example of the proof-of-work system used to give value to a currency is the shell money of the Solomon Islands. A key feature of these schemes is their asymmetry: the work must be moderately hard (but feasible) on the requester side but easy to check for the service provider. This idea is also known as a CPU cost function, client puzzle, computational puzzle or CPU pricing function. It is distinct from a CAPTCHA, which is intended for a human to solve quickly, rather than a computer. Proof of space (PoSpace) proposals apply the same principle by proving a dedicated amount of memory or disk space instead of CPU time. Proof-of-Stake, Proof of bandwidth, and other approaches have been discussed in the context of cryptocurrency. Proof of ownership aims at proving that specific data are held by the prover.
  • 2.6K
  • 07 Nov 2022
Topic Review
Hsp70 and Hsp90
Hsp70, Hsp90, and their co-chaperones are crucial members of the proteostasis network that are able to recognize misfolded proteins, aberrant condensates and protein aggregates, triaging proteins for refolding or degradation. These members of the chaperome are considered major sentinels impeding the molecular processes that lead to cell damage in the course of degenerative proteinopathies. Indeed, Hsp70, Hsp90 and their co-chaperones are increasingly recognized as therapeutic targets for the development of treatments against prevalent protein misfolding diseases.
  • 2.6K
  • 23 Dec 2020
Topic Review
Eco-Innovation
Eco-innovation refers to “the production, assimilation or exploitation of a product, production process, service or management or business method that is novel to the organization (developing or adopting it) and which results, throughout its life cycle, in a reduction of environmental risk, pollution and other negative impacts of resources use (including energy use) compared to relevant alternatives”. Eco-innovation has been used as a synonym for “environmental innovation”, “green innovation,” and “sustainable innovation” depending on the author and the outlet where the research is published.
  • 2.6K
  • 01 Jun 2021
Topic Review
Collective Behavior
Collective behavior refers to the spontaneous and unstructured actions of individuals within a group or society. Unlike more predictable forms of behavior guided by established norms and institutions, collective behavior emerges when people respond to a situation or event in ways that are often unplanned and can be unconventional.
  • 2.6K
  • 25 Jan 2024
Topic Review
Perseus
Perseus, a prominent constellation in the northern celestial hemisphere, is named after the legendary Greek hero known for slaying the monstrous Gorgon Medusa. Located near the celestial equator, Perseus is recognizable for its distinctive "W" shape formed by its brightest stars and is rich in fascinating deep-sky objects.
  • 2.6K
  • 15 Mar 2024
Topic Review
Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles
Coumarins are a family of benzopyrones (1,2-benzopyrones or 2H-[1]benzopyran-2-ones), which represent an important family of oxygen-containing heterocycles, widely distributed in nature. Since coumarins have versatile applications, the synthesis trials of different structures of the coumarin-based scaffold were attempted. Among all the heterocycles built on α-pyrone moiety of coumarin, the furan ring was the only available structure in nature. Thus, it has inspired a lot of researchers to replace the oxygen with other heteroatoms. Wide varieties of heterocycles were constructed by a synthetic pathway to introduced furans, pyrroles, thiophenes, and selenophenes as a fused ring that characterized by a single heteroatom to the α-pyrone moiety of coumarin. 
  • 2.6K
  • 05 Apr 2021
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