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Topic Review
Emblica officinalis for the Treatment of Hyperlipidemia
The ayurvedic herb Emblica officinalis (E. officinalis) is a gift to mankind to acquire a healthy lifestyle. It has great therapeutic and nutritional importance. Emblica officinalis, also known as Indian gooseberry or Amla, is a member of the Euphorbiaceae family. Amla is beneficial for treating illnesses in all its forms. The most crucial component is a fruit, which is also the most common. It is used frequently in Indian medicine as a restorative, diuretic, liver tonic, refrigerant, stomachic, laxative, antipyretic, hair tonic, ulcer preventive, and for the common cold and fever. Hyperlipidemia is also known as high cholesterol or an increase in one or more lipid-containing blood proteins. Various phytocompounds, including polyphenols, vitamins, amino acids, fixed oils, and flavonoids, are present in the various parts of E. officinalis. E. officinalis has been linked to a variety of pharmacological effects in earlier studies, including hepatoprotective, immunomodulatory, antimicrobial, radioprotective, and hyperlipidemic effects.
  • 2.9K
  • 10 Feb 2023
Topic Review
UV Filters
The use of sunscreens is a recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union. However, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. 
  • 2.9K
  • 05 May 2022
Topic Review
Goal Pursuit
Goal pursuit is the process of attempting to achieve a desired future outcome. This generally follows goal setting, the process of forming these desires.
  • 2.9K
  • 08 Dec 2022
Topic Review
GENCODE
GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed as part of the pilot phase of the ENCODE project to identify and map all protein-coding genes within the ENCODE regions (approx. 1% of Human genome). Given the initial success of the project, GENCODE now aims to build an “Encyclopedia of genes and genes variants” by identifying all gene features in the human and mouse genome using a combination of computational analysis, manual annotation, and experimental validation, and annotating all evidence-based gene features in the entire human genome at a high accuracy. The result will be a set of annotations including all protein-coding loci with alternatively transcribed variants, non-coding loci with transcript evidence, and pseudogenes.
  • 2.9K
  • 08 Nov 2022
Topic Review
Aetiology and Pathophysiology of Parkinson’s and Alzheimer’s Disease
Neurodegeneration is hallmarked by the progressive loss of dopaminergic neurons and/or a significant increase in protein aggregates in the brain. Neurodegenerative diseases are a leading cause of death worldwide with over 15 million people currently suffering from either Parkinson’s disease (PD) or Alzheimer’s disease (AD). PD is often characterized by both motor and non-motor symptoms, including muscle rigidity, tremors and bradykinesia, with AD displaying symptoms of confusion and dementia.
  • 2.9K
  • 22 Mar 2023
Topic Review
Stem Cell Therapy
Neurodegenerative diseases resulting from the progressive loss of structure and/or function of neurons contribute to different paralysis degrees and loss of cognition and sensation. The lack of successful curative therapies for neurodegenerative disorders leads to a considerable burden on society and a high economic impact. Over the past 20 years, regenerative cell therapy, also known as stem cell therapy, has provided an excellent opportunity to investigate potentially powerful innovative strategies for treating neurodegenerative diseases.
  • 2.9K
  • 08 Mar 2021
Topic Review
Neelum–Jhelum Hydroelectric Project
During underground construction, the behavior of the ground is influenced by characteristics of the rock mass with situ stresses and ground water, cross section of the excavation area, excavation method, and the rate of excavation. These fundamental features are considered to ensure the support and stability of underground excavations and achieve long-term successful operation. However, the ground composition of the Himalayas hinders tunnel excavation, especially in case of mechanized tunneling; this causes time and cost overruns. This study has reviewed the recently completed Neelum–Jhelum Hydroelectric Project; the project complexities, geological environments involving significant overburden and tectonic stresses, and effects of the excavation method on tunnel stability were analyzed. 
  • 2.9K
  • 22 Mar 2021
Topic Review
Natural Antioxidants in Cosmetic Formulation
A natural antioxidant can be a single pure compound/isolate, a combination of compounds, or plant extracts; these antioxidants are widely used in cosmetic products.
  • 2.9K
  • 19 Apr 2022
Topic Review
Remote Sensing Methods for Flood Prediction
Floods are a major cause of loss of lives, destruction of infrastructure, and massive damage to a country’s economy. Floods, being natural disasters, cannot be prevented completely; therefore, precautionary measures must be taken by the government, concerned organizations such as the United Nations Office for Disaster Risk Reduction and Office for the coordination of Human Affairs, and the community to control its disastrous effects. Floods are uncertain depending on several climatic and environmental factors, and therefore are difficult to predict. A classification framework is presented which classifies the remote sensing technologies being used for flood prediction into three types, which are: multispectral, radar, and light detection and ranging (LIDAR). 
  • 2.9K
  • 21 Mar 2022
Topic Review
Salvadora persica
Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects.
  • 2.9K
  • 17 Jun 2021
Topic Review
Graphene Oxide
Graphene oxide (GO) is a chemical compound with a form similar to graphene that consists of one-atom-thick two-dimensional layers of sp2-bonded carbon. Graphene oxide exhibits high hydrophilicity and dispersibility. Thus, it is difficult to be separated from aqueous solutions. Therefore, functionalization with magnetic nanoparticles is performed in order to prepare a magnetic GO nanocomposite that combines the sufficient adsorption capacity of graphene oxide and the convenience of magnetic separation. Moreover, the magnetic material can be further functionalized with different groups to prevent aggregation and extends its potential application. Until today, a plethora of magnetic GO hybrid materials have been synthesized and successfully employed for the magnetic solid-phase extraction of organic compounds from environmental, agricultural, biological, and food samples. The developed GO nanocomposites exhibit satisfactory stability in aqueous solutions, as well as sufficient surface area. Thus, they are considered as an alternative to conventional sorbents by enriching the analytical toolbox for the analysis of trace organic compounds.
  • 2.9K
  • 15 Jan 2021
Topic Review
C-TreeACE
c-treeACE is a database engine developed by FairCom Corporation. Software developers typically embed the c-treeACE engine within the applications that they create and then deploy the application and engine together as an integrated solution. The most recent edition is c-treeACE V11.5, which was released in November 2017. At its core, c-treeACE uses a record-oriented, Indexed Sequential Access Method (ISAM) structure offering high speed indexing mechanisms over those files. Developers can use these direct access methods to design the data and index structures that closely parallel the needs of their application. This paradigm is sometimes referred to as an application-specific database or an embedded database because of the tightly coupled nature of the application and database. The nature of c-treeACE allows it to be used in a range of products including: embedded systems that require limited disk and memory footprint and silent operation; shrink-wrap products developed by ISVs that require cross-platform support, minimal maintenance, and mass deployment; and enterprise systems that depend on performance and more precision control of database operations than a traditional enterprise database offers. Two versions of the product are available. c-treeACE Express is freely available for development from FairCom's web site and supports only the client/server architecture. The client-side libraries are precompiled, making it easy to use for evaluation. c-treeACE Professional is licensed separately and supports all architectures and includes full source code for the client libraries and much of the source code for the server. c-treeACE is one of few databases that specialize in making data locked into legacy database architecture available to modern APIs while minimizing time, resources and risks involved in modernization projects. c-treeACE combines the benefits of NoSQL such as high performance, low latency and precise data access control, with the flexbility of SQL interfaces.
  • 2.9K
  • 24 Nov 2022
Topic Review
Role of Environmental Accounting
Environmental accounting (EA) can be a way toward solving the issue of environmental degradation and shifting toward sustainable solutions. One of the significant reasons for EA is the role of industrial and commercial activities in environmental contamination.
  • 2.9K
  • 15 Jun 2022
Topic Review
Bya (Unit)
A year is the orbital period of a planetary body, for example, the Earth, moving in its orbit around the Sun. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by change in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons are generally recognized: spring, summer, autumn and winter. In tropical and subtropical regions, several geographical sectors do not present defined seasons; but in the seasonal tropics, the annual wet and dry seasons are recognized and tracked. A calendar year is an approximation of the number of days of the Earth's orbital period, as counted in a given calendar. The Gregorian calendar, or modern calendar, presents its calendar year to be either a common year of 365 days or a leap year of 366 days, as do the Julian calendars; see below. For the Gregorian calendar, the average length of the calendar year (the mean year) across the complete leap cycle of 400 years is 365.2425 days. The ISO standard ISO 80000-3, Annex C, supports the symbol a (for Latin annus) to represent a year of either 365 or 366 days. In English, the abbreviations y and yr are commonly used. In astronomy, the Julian year is a unit of time; it is defined as 365.25 days of exactly 86,400 seconds (SI base unit), totalling exactly 31,557,600 seconds in the Julian astronomical year. The word year is also used for periods loosely associated with, but not identical to, the calendar or astronomical year, such as the seasonal year, the fiscal year, the academic year, etc. Similarly, year can mean the orbital period of any planet; for example, a Martian year and a Venusian year are examples of the time a planet takes to transit one complete orbit. The term can also be used in reference to any long period or cycle, such as the Great Year.
  • 2.9K
  • 01 Dec 2022
Topic Review
Human Cytomegalovirus
Human cytomegalovirus (HCMV) expresses a variety of viral regulatory proteins that undergo close interaction with host factors including viral-cellular multiprotein complexes. The HCMV protein kinase pUL97 represents a viral CDK ortholog (vCDK) that determines the efficiency of HCMV replication via phosphorylation of viral and cellular substrates. A hierarchy of functional importance of individual pUL97-mediated phosphorylation events has been discussed, however, the most pronounced pUL97-dependent phenotype could be assigned to viral nuclear egress, as illustrated by genetic ORF-UL97 deletion or pharmacological pUL97 inhibition. Despite earlier data pointing to a cyclin-independent functionality, experimental evidence increasingly emphasized the role of pUL97-cyclin complexes. Consequently, the knowledge about pUL97 involvement in host interaction, viral nuclear egress and additional replicative steps led to the postulation of pUL97 as an antiviral target. Indeed, validation experiments in vitro and in vivo confirmed the sustainability of this approach. Consequently, current investigations of pUL97 in antiviral treatment go beyond the known pUL97-mediated ganciclovir prodrug activation and henceforward include pUL97-specific kinase inhibitors. Among a number of interesting small molecules analyzed on experimental and preclinical stages, maribavir is presently investigated in clinical studies and, in the near future, might represent a first kinase inhibitor applied in the field of antiviral therapy.
  • 2.9K
  • 29 Oct 2020
Topic Review
Mycosporine-Like Amino Acids as Sunscreen
Prolonged exposure to harmful ultraviolet radiation (UVR) can induce many chronic or acute skin disorders in humans. To protect themselves, many people have started to apply cosmetic products containing UV-screening chemicals alone or together with physical sunblocks, mainly based on titanium–dioxide (TiO2) or zinc-oxide (ZnO2). However, it has now been shown that the use of chemical and physical sunblocks is not safe for long-term application, so searches for the novel, natural UV-screening compounds derived from plants or bacteria are gaining attention. Certain photosynthetic organisms such as algae and cyanobacteria have evolved to cope with exposure to UVR by producing mycosporine-like amino acids (MAAs). These are promising substitutes for chemical sunscreens containing commercially available sunblock filters. The use of biopolymers such as chitosan for joining MAAs together or with MAA-Np (nanoparticles) conjugates will provide stability to MAAs similar to the mixing of chemical and physical sunscreens. 
  • 2.9K
  • 21 May 2021
Biography
J. Gayle Beck
J. Gayle Beck is a licensed clinical psychologist who specializes in trauma stress disorders[1] and anxiety disorders.[2] She is the Lillian and Morrie Moss Chair of Excellence in the Department of Psychology at the University of Memphis. Beck was President of the Society of Clinical Psychology, American Psychological Association (APA) Division 12, in 2012[3] and President of the Association fo
  • 2.9K
  • 04 Jan 2023
Topic Review
CEA-708
CEA-708 is the standard for closed captioning for ATSC digital television (DTV) streams in the United States and Canada . It was developed by the Electronic Industries Alliance. Unlike RLE DVB and DVD subtitles, CEA-708 captions are low bandwidth and textual like traditional EIA-608 captions and EBU Teletext subtitles. However, unlike EIA-608 byte pairs, CEA-708 captions are not able to be modulated on an ATSC receiver's NTSC VBI line 21 composite output and must be pre-rendered by the receiver with the digital video frames, they also include more of the Latin-1 character set, and include stubs to support full UTF-32 captions, and downloadable fonts. CEA-708 caption streams can also optionally encapsulate EIA-608 byte pairs internally, a fairly common usage. CEA-708 captions are injected into MPEG-2 video streams in the picture user data. The packets are in picture order, and must be rearranged just like picture frames are. This is known as the DTVCC Transport Stream. It is a fixed-bandwidth channel that has 960 bit/s typically allocated for backward compatible "encapsulated" Line 21 captions, and 8640 bit/s allocated for CEA-708 captions, for a total of 9600 bit/s. The ATSC A/53 Standard contains the encoding specifics. The main form of signalling is via a PSIP caption descriptor which indicates the language of each caption and if formatted for "easy reader" (3rd grade level for language learners) in the PSIP EIT on a per event basis and optionally in the H.222 PMT only if the video always sends caption data. CEA-708 caption decoders are required in the U.S. by FCC regulation in all 13" (33 cm) diagonal or larger digital televisions. Further, some broadcasters are required by FCC regulations to caption a percentage of their broadcasts.
  • 2.9K
  • 20 Oct 2022
Topic Review
Brain Lymphatic Drainage System
In 2012, Iliff et al., for the first time, identified a novel structure in the brain called the glymphatic system. This system is considered as a crucial fluid-clearance system in the brain.
  • 2.9K
  • 07 Apr 2022
Topic Review
Guided Wave Ultrasonic Testing
Guided wave ultrasonic testing (GWUT) method is an effective method for long-distance inspection of inaccessible and coated structures from a single point of testing. It propagates inspection wave all through the structure without point-to-point scanning, hence, minimizes inspection drudgery and enhances work throughput per day.
  • 2.9K
  • 25 Feb 2021
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