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Topic Review Peer Reviewed
Deep Eutectic Solvents and Pharmaceuticals
Deep eutectic solvents (DES) are eutectic mixtures that present a deviation from the ideal thermodynamic solid–liquid phase behavior, where a significant depression in the melting temperature occurs. If properly designed and chosen, DES may be liquid at room and the human body’s temperatures and display a biocompatible character, thus representing relevant options in the pharmaceutical field. Accordingly, DES have been studied as alternative solvents or in formulations of pharmaceuticals to improve their solubility and stability. Depending on the DES components, these mixtures might exhibit interesting biological activities compatible with several applications. The use of DES as functional agents or as novel liquid forms of active pharmaceutical ingredients (API-DES) with the goal of improving bioavailability, permeability and therapeutic efficacy of a given API stands as alternative strategies in the pharmaceutical field for drug delivery purposes.
  • 2.9K
  • 13 Apr 2022
Topic Review
Corrosion Cracking in Palladium
Cathodic corrosion is evidenced by the formation of transient complexes of palladium. It is obvious to see a peak of palladium transient by cyclic voltammetry for different amounts of deposited hydrogen expressed as a current during back-diffusion. Therefore, in the part located at the surface of electrolyte, drastic structural changes lead to loss of cohesion and cracking. The objective of this project is to take into account the mechanical constraints formed by diffusion of hydrogen or isotope and the cathodic corrosion produced by formation of superficial hydride transients, both responsible of destruction of palladium or alloyed cathode. To know the origin of these, it was necessary to discriminating the damaging effects encountered.
  • 2.9K
  • 02 Nov 2020
Topic Review
SmartISM
Interpretive Structural Modeling (ISM) is a technique to establish the interrelationships between elements of interest in a specific domain through experts’ knowledge of the context of the elements. Every discipline is expanding its frontier and multiple disciplinary approaches have become essential to solve complex problems. This leads to the study of a large number of constructs of interests simultaneously. These constructs may have been identified in theory or practice. Warfield in the 1970’s developed a technique to establish an interrelationship model between variables known as interpretive structural modeling (ISM). The holistic picture of important constructs in the structured form derived from ISM technique helps the practitioners to solve the problem effectively. This technique is widely used due to its simplistic procedure and profound value addition in problem solving in different domains.
  • 2.9K
  • 23 Aug 2021
Topic Review
Management of Municipal Solid Waste Management
Municipal solid waste (MSW) management has become a major concern for developing countries. The physical and chemical aspects of MSW management and infrastructure need to be analyzed critically to solve the existing socio-economic problem. Depending on the socio-economic framework of a country, several MSW management procedures have been established, including landfilling, thermal treatment, and chemical treatment. Most of the MSW produced in underdeveloped and developing countries such as Bangladesh, India, and Pakistan is dumped into open landfills, severely affecting the environment. Waste-to-Energy (WTE) projects based on thermal treatments, e.g., incineration, pyrolysis, and gasification, can be feasible alternatives to conventional technologies. 
  • 2.9K
  • 26 Sep 2022
Topic Review
Flashbulb Memory
A flashbulb memory is a highly detailed, exceptionally vivid "snapshot" of the moment and circumstances in which a piece of surprising and consequential (or emotionally arousing) news was learned about. The term "flashbulb memory" suggests the surprise, indiscriminate illumination, detail, and brevity of a photograph; however flashbulb memories are only somewhat indiscriminate and are far from complete. Evidence has shown that although people are highly confident in their memories, the details of the memories can be forgotten. Flashbulb memories are one type of autobiographical memory. Some researchers believe that there is reason to distinguish flashbulb memories from other types of autobiographical memory because they rely on elements of personal importance, consequentiality, emotion, and surprise. Others believe that ordinary memories can also be accurate and long-lasting if they are highly distinctive, personally significant, or repeatedly rehearsed. Flashbulb memories have six characteristic features: place, ongoing activity, informant, own affect, other affect, and aftermath. Arguably, the principal determinants of a flashbulb memory are a high level of surprise, a high level of consequentiality, and perhaps emotional arousal.
  • 2.9K
  • 17 Nov 2022
Topic Review
2015 Guru Granth Sahib Desecration Controversy
The 2015 Guru Granth Sahib desecration (also known as the 2015 Guru Granth Sahib sacrilege) refers to a series of desecration incidents of the Sikh Guru Guru Granth Sahib and subsequent protests that took place in Punjab, India in October 2015. The first incident of desecration was reported from Bargari, Faridkot district, where 110 torn Angs (literally body part means pages) of the holy Guru were found on 12 October. On the early morning hours of 14 October, two Sikh protesters were shot dead by the police as the peaceful protesters were sitting in demonstration.
  • 2.9K
  • 30 Nov 2022
Topic Review
Industrial Crystallization of Citrate
The citrate industry has a wide range of applications in food, pharmaceutical, and other fields. As a common class of food additives and functional supplements with tremendous development potential and strong core competitiveness, particles with good powder characteristics and functionalization are becoming one of the primary directions in the evolution of citrate into the high-end market.
  • 2.9K
  • 11 Aug 2023
Topic Review
Biomaterials for Ophthalmic Applications
Ophthalmology is the branch of medicine that deals with diseases of the eye, the organ responsible for vision, and its attachments. Biomaterials can be made with different types of materials and can replace or improve a function or an organ, specifically the eye in the case of ophthalmic biomaterials. Biomaterials are substances that interact with biological systems for a medical purpose, either as a therapeutic (treat, augment, repair, or replace a tissue function of the body) or a diagnostic agent, and have continued to improve over the years, leading to the creation of new biomaterials.
  • 2.9K
  • 22 Jun 2022
Topic Review
Mycosporine-Like Amino Acids as Sunscreen
Prolonged exposure to harmful ultraviolet radiation (UVR) can induce many chronic or acute skin disorders in humans. To protect themselves, many people have started to apply cosmetic products containing UV-screening chemicals alone or together with physical sunblocks, mainly based on titanium–dioxide (TiO2) or zinc-oxide (ZnO2). However, it has now been shown that the use of chemical and physical sunblocks is not safe for long-term application, so searches for the novel, natural UV-screening compounds derived from plants or bacteria are gaining attention. Certain photosynthetic organisms such as algae and cyanobacteria have evolved to cope with exposure to UVR by producing mycosporine-like amino acids (MAAs). These are promising substitutes for chemical sunscreens containing commercially available sunblock filters. The use of biopolymers such as chitosan for joining MAAs together or with MAA-Np (nanoparticles) conjugates will provide stability to MAAs similar to the mixing of chemical and physical sunscreens. 
  • 2.9K
  • 21 May 2021
Topic Review
Production of Mono-, Few-, and Multi-Layer Graphene
Mono-, few-, and multi-layer graphene can be synthesized using various methods, including micromechanical exfoliation, chemical vapour deposition, and chemical methods such as oxidizing graphene into graphene oxide and then reducing it chemically or thermally.
  • 2.9K
  • 26 Oct 2022
Topic Review
Seed Waste from Custard Apple
Annona squamosa L. (custard apple or sugar apple), belonging to the Annonaceae family, is a small tree or shrub that grows natively in subtropical and tropical regions. Seeds of the custard apple have been employed in folk medicines because of the presence of bioactive chemicals/compounds such as alkaloids, flavonoids and phenolic compounds and acetogenins and cyclopeptides that are responsible for various biological activities. The seeds also show the presence of tannins, vitamin C, vitamin E and a higher content of amino acids. From investigations, it has been shown that the seeds of A. squamosa have considerable potential to be used as an antibacterial, hepatoprotective, antioxidant and antitumor/anticancer agent. Cyclosquamosin B, extracted from the custard apple seed, possesses vasorelaxant properties. Tocopherols and fatty acids, notably oleic acid and linoleic acid, are also found in the seed oil. A. squamosa seeds contain a high amount of annonaceous acetogenins compounds, which are potent mitochondrial complex I inhibitors and have high cytotoxicity. A survey primarily based on the nutritional, phytochemical and biological properties showed that A. squamosa seeds can be used for the discovery of novel products, including pharmaceutical drugs.
  • 2.9K
  • 01 Nov 2022
Biography
Arthur Eddington
Sir Arthur Stanley Eddington OM FRS[1] (28 December 1882 – 22 November 1944) was an English astronomer, physicist, and mathematician. He was also a philosopher of science and a populariser of science. The Eddington limit, the natural limit to the luminosity of stars, or the radiation generated by accretion onto a compact object, is named in his honour. Around 1920, he anticipated the discover
  • 2.9K
  • 14 Nov 2022
Topic Review
Human Schistosomiasis in Nigeria
Schistosomiasis, also known as bilharzia, is a major parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma that live in fresh waterways in tropical and subtropical zones. Over 200 million people are infected globally, 90% of whom live in sub-Saharan Africa. Nigeria has the highest burden of schistosomiasis in this region. Elimination programmes have focused on human infections, with limited attention on infections in livestock that could be transmissible to humans, i.e. zoonotic schistosomiasis. This is now recognized as a risk factor for increased transmission and recrudescence of infection of more than one schistosome species, as well as of potential hybrid variants. Members of farming communities who herd grazing cattle, goats and sheep in proximity to rivers containing Bulinus freshwater snails that are the intermediate host of asexual lifecycle stages are particularly at risk of becoming infected through daily contact with contaminated water.
  • 2.9K
  • 21 Feb 2023
Topic Review Peer Reviewed
SARS-CoV-2 Associated Pulmonary Pathology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel entry in the betacoronaviridae group of coronaviruses. This is the second member of this group, and the third of the family overall to emerge in the last 20 years, which has caused significant health concerns due to the clinical severity and spread of the disease it causes—coronavirus disease identified in 2019 (COVID-19). While initially emerging as a respiratory disease, and while most cases experience symptoms predominantly from this system, SARS-CoV-2 has emerged as a multisystem pathogen. From a pathomorphological point of view, the severity of changes in the respiratory system can be summed up as diffuse alveolar damage—desquamation of the alveolar epithelium with exudative and proliferative changes—pulmonary hyaline membranes, Clara cell hyperplasia, squamous cell metaplasia, and fibrosis. The second most prominent way the disease affects the lung is through endotheliitis—damage to the endothelial cells of the pulmonary vasculature, predominantly affecting the medium and large caliber blood vessels that cause the well-established clinical phenomenon of thrombosis/thromboembolism of the pulmonary vasculature. As the spread of the disease continues with the emergence of new variants and the number of cases continues to grow, including a large percentage of recurrent cases, it is essential to remember that the viral effects are not only acute but, due to the proliferative phenomena, can produce chronic sequelae. Therefore, in the background of dwindling publication interest, it is critical to focus on the histopathological aspects of the pulmonary disease, with the goal of better understanding the effects of the virus on the organism and identifying probable future complications after infection.
  • 2.9K
  • 08 Oct 2022
Topic Review
Nuclear Receptor Superfamily
The nuclear receptor superfamily comprises a large group of proteins with functions essential for cell signaling, survival, and proliferation. There are multiple distinctions between nuclear superfamily classes defined by hallmark differences in function, ligand binding, tissue specificity, and DNA binding. In this review, we utilize the initial classification system, which defines subfamilies based on structure and functional difference. The defining feature of the nuclear receptor superfamily is that these proteins function as transcription factors. The loss of transcriptional regulation or gain of functioning of these receptors is a hallmark in numerous diseases. For example, in prostate cancer, the androgen receptor is a primary target for current prostate cancer therapies. Targeted cancer therapies for nuclear hormone receptors have been more feasible to develop than others due to the ligand availability and cell permeability of hormones. 
  • 2.9K
  • 12 Aug 2021
Topic Review
Advanced Bioengineered Skin Equivalents
The formation of severe scars still represents the result of the closure process of extended and deep skin wounds. To address this issue, different bioengineered skin substitutes have been developed but a general consensus regarding their effectiveness has not been achieved yet. It will be shown that bioengineered skin substitutes, although representing a valid alternative to autografting, induce skin cells in repairing the wound rather than guiding a regeneration process. Repaired skin differs from regenerated skin, showing high contracture, loss of sensitivity, impaired pigmentation and absence of cutaneous adnexa (i.e., hair follicles and sweat glands). This leads to significant mobility and aesthetic concerns, making the development of more effective bioengineered skin models a current need. The objective of this review is to determine the limitations of either commercially available or investigational bioengineered skin substitutes and how advanced skin tissue engineering strategies can be improved in order to completely restore skin functions after severe wounds.
  • 2.9K
  • 30 Jul 2020
Topic Review
β-Endorphin
β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist of mu opioid receptors, which can be found throughout the body, brain, and cells of the immune system that regulate a diverse set of systems. As an agonist of the body’s opioid receptors, β-endorphins are most noted for their potent analgesic effects, but they also have their involvement in reward-centric and homeostasis-restoring behaviors, among other effects. These effects have implicated the peptide in psychiatric and neurodegenerative disorders, making it a research target of interest.
  • 2.9K
  • 16 Apr 2021
Topic Review
Salvadora persica
Salvadora persica (SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects.
  • 2.9K
  • 17 Jun 2021
Topic Review
Encoding (Memory)
Memory has the ability to encode, store and recall information. Memories give an organism the capability to learn and adapt from previous experiences as well as build relationships. Encoding allows a perceived item of use or interest to be converted into a construct that can be stored within the brain and recalled later from long-term memory. Working memory stores information for immediate use or manipulation which is aided through hooking onto previously archived items already present in the long-term memory of an individual.
  • 2.9K
  • 17 Nov 2022
Topic Review
Solar-Powered Plant Protection Equipment
Solar photovoltaic (PV) devices present a positive approach to sustainable crop production by reducing crop loss in various ways. This might result in the extensive use of PV devices in the near future. PV-based plant protection equipment/devices are primarily utilized in protecting crops from birds, weeds, or insects. The utilization of PV systems for different applications constitutes a new era in agriculture, horticulture, and forest sectors. A PV system is a potential alternative, offering more opportunities in operating different types of electricity-based agricultural equipment. The development of devices with simple construction/operation for plant protection may work well on small-scale farms.
  • 2.9K
  • 28 Nov 2022
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