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Topic Review
Aspartate in Cell Proliferation and Survival
Aspartate is a precursor for nucleotide synthesis and  is indispensable for cell proliferation. Moreover, the malate–aspartate shuttle plays a key role in redox balance, and a deficit in aspartate can lead to oxidative stress. It is now recognized that aspartate biosynthesis is largely governed by mitochondrial metabolism, including respiration and glutaminolysis in cancer cells. Therefore, under conditions that suppress mitochondrial metabolism, including mutations, hypoxia, or chemical inhibitors, aspartate can become a limiting factor for tumor growth and cancer cell survival.
  • 3.1K
  • 15 Jul 2022
Biography
Uma Narayan
Uma Narayan (born 16 April 1958) is an Indian feminist scholar, and a Professor of Philosophy at Vassar College. She is the author of Dislocating Cultures: Identities, Traditions and Third World Feminism in which Narayan disputes feminism as a solely Western notion and intrusion, while challenging assumptions that India n feminism is based on Western models. In particular, a notion of homogen
  • 3.1K
  • 30 Dec 2022
Topic Review
Ventilation-Perfusion Mismatch in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a heterogenous condition that is characterized by the development of inflammatory pulmonary edema and life-threatening hypoxemia, and it accounts for nearly 25% of patients who require mechanical ventilation. Acute respiratory distress syndrome (ARDS) remains an important clinical challenge with a mortality rate of 35–45%. It is being increasingly demonstrated that the improvement of outcomes requires a tailored, individualized approach to therapy, guided by a detailed understanding of each patient’s pathophysiology. In patients with ARDS, disturbances in the physiological matching of alveolar ventilation (V) and pulmonary perfusion (Q) (V/Q mismatch) are a hallmark derangement. The perfusion of collapsed or consolidated lung units gives rise to intrapulmonary shunting and arterial hypoxemia, whereas the ventilation of non-perfused lung zones increases physiological dead-space, which potentially necessitates increased ventilation to avoid hypercapnia.
  • 3.1K
  • 12 Jan 2023
Topic Review
Nepalese Army On Buffer Zone
Recent years have seen various advancements in exploration and the progress of arm forces throughout the world. Nepal is in the buffer zone. The people of Nepal sometimes face unhealthy pressure from India and sometimes from China. Indeed, the founding father of modern Nepal, King Prithvi Narayan Shah's dictum, "Nepal as a yam between two boulders". The people of the Northern part of Nepal are somehow similar cultures with Tibet(China) and they need to adjust with the people of Tibet. Similarly, east, west, and south parts of Nepal has somehow similar culture with India and they need to adjust with the people of India. This article reviews top-cited recent literature and made a compact analytical review on the buffer zone which can be useful for new researchers.
  • 3.1K
  • 05 Jan 2021
Topic Review
Ocular Medication Routes of Administration
Ocular drug administration encompasses a range of routes, each with its own advantages and limitations. The available methods include systemic delivery (such as oral, intravenous, and subcutaneous routes) as well as local delivery options (including topical eye drops, periocular or intravitreal injections, and intravitreal implants). While these approaches can be effective in delivering medications to the eye, they also have inherent drawbacks, which will be explored in greater detail in this entry. Notably, understanding the strengths and limitations of these ocular drug administration routes is crucial for optimizing therapy and achieving the desired therapeutic outcomes while minimizing potential adverse effects.   
  • 3.1K
  • 04 Dec 2023
Topic Review
High-Dynamic-Range Imaging
In photography and videography, HDR or high-dynamic-range imaging is the set of techniques used to reproduce a greater range of luminosity than that which is possible with standard photographic techniques. Standard techniques allow differentiation only within a certain range of brightness. Outside this range, no features are visible because in the brighter areas everything appears pure white, and pure black in the darker areas. The ratio between the maximum and the minimum of the tonal value in an image is known as the dynamic range. HDR is useful for recording many real-world scenes containing very bright, direct sunlight to extreme shade, or very faint nebulae. High-dynamic-range (HDR) images are often created by capturing and then combining several different, narrower range, exposures of the same subject matter. The two primary types of HDR images are computer renderings and images resulting from merging multiple low-dynamic-range (LDR) or standard-dynamic-range (SDR) photographs. HDR images can also be acquired using special image sensors, such as an oversampled binary image sensor. Due to the limitations of printing and display contrast, the extended luminosity range of input HDR images has to be compressed to be made visible. The method of rendering an HDR image to a standard monitor or printing device is called tone mapping. This method reduces the overall contrast of an HDR image to facilitate display on devices or printouts with lower dynamic range, and can be applied to produce images with preserved local contrast (or exaggerated for artistic effect). "HDR" may refer to the overall process, to the HDR imaging process, or to HDR imaging represented on a low-dynamic-range display such as a screen or standard .jpg image.
  • 3.1K
  • 28 Oct 2022
Topic Review
Water Yam (Dioscorea alata)
Anthracnose disease caused by a fungus Colletotrichum gloeosporioides is the primary cause of yield loss in water yam (Dioscorea alata), the widely cultivated species of yam. Resistance to yam anthracnose disease (YAD) is a prime target in breeding initiatives to develop durable-resistant cultivars for sustainable management of the disease in water yam cultivation.
  • 3.1K
  • 24 Feb 2022
Topic Review
Continuum Robots for Medical Applications
Traditional rigid robot application in the medical field is limited due to the limited degrees of freedom caused by their material and structure. Inspired by trunk, tentacles, and snakes, continuum robot (CR) could traverse confined space, manipulate objects in complex environment, and conform to curvilinear paths in space. The continuum robot has broad prospect in surgery due to its high dexterity, which can reach circuitous areas of the body and perform precision surgery. Recently, many efforts have been done by researchers to improve the design and actuation methods of continuum robots. Several continuum robots have been applied in clinic surgical interventions and demonstrated superiorities to conventional rigid-link robots.
  • 3.1K
  • 13 Jan 2021
Topic Review
Cytokinins in Horticultural Fruit Crops
Cytokinins (CKs) are a chemically diverse class of plant growth regulators, exhibiting wide-ranging actions on plant growth and development, hence their exploitation in agriculture for crop improvement and management. Their coordinated regulatory effects and cross-talk interactions with other phytohormones and signaling networks are highly sophisticated, eliciting and controlling varied biological processes at the cellular to organismal levels. In this review, we briefly introduce the mode of action and general molecular biological effects of naturally occurring CKs before highlighting the great variability in the response of fruit crops to CK-based innovations. We present a comprehensive compilation of research linked to the application of CKs in non-model crop species in different phases of fruit production and management. By doing so, it is clear that the effects of CKs on fruit set, development, maturation, and ripening are not necessarily generic, even for cultivars within the same species, illustrating the magnitude of yet unknown intricate biochemical and genetic mechanisms regulating these processes in different fruit crops. Current approaches using genomic-to-metabolomic analysis are providing new insights into the in planta mechanisms of CKs, pinpointing the underlying CK-derived actions that may serve as potential targets for improving crop-specific traits and the development of new solutions for the preharvest and postharvest management of fruit crops. Where information is available, CK molecular biology is discussed in the context of its present and future implications in the applications of CKs to fruits of horticultural significance.
  • 3.1K
  • 27 Aug 2020
Topic Review
Dolomite as a Filler in a Polymer Composite
Polymers are being used in many applications all around the world. However, there are some drawbacks in the properties of polymers that could hamper their usage in certain applications. Therefore, a new material polymer composite was introduced. A polymer composite is a polymer-based material with the addition of a filler. Many researchers have reported the improvement in the properties of a polymer when a filler was introduced. This helps minimize the disadvantages of using a polymer. Fillers are materials added to resins or binders (polymer/concrete/metal/ceramic) to improve their specific properties as they are turned into a new form of material called a “composite.” Dolomite is a type of sedimentary carbonate rock that consists mainly of dolomite mineral. The use of dolomite in a polymer composite system has gained increasing attention in recent years after researchers successfully proved that it is capable of improving mechanical and physical properties of various polymeric materials. 
  • 3.1K
  • 09 Aug 2022
Topic Review
Mushroom Poisoning
Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Its symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produced by the fungus. Mushroom poisoning is usually the result of ingestion of wild mushrooms after misidentification of a toxic mushroom as an edible species. The most common reason for this misidentification is a close resemblance in terms of color and general morphology of the toxic mushrooms species with edible species. To prevent mushroom poisoning, mushroom gatherers familiarize themselves with the mushrooms they intend to collect, as well as with any similar-looking toxic species. The safety of eating wild mushrooms may depend on methods of preparation for cooking.
  • 3.1K
  • 19 Oct 2022
Topic Review
Organic Fouling
Organic fouling in the forward osmosis process is complex and influenced by different parameters in the forward osmosis such as type of feed and draw solution, operating conditions and type of membrane. In this article, we reviewed organic fouling in the forward osmosis focussing on wastewater treatment applications. Model organic foulants used in the forward osmosis literature were highlighted, followed by the characteristics of organic foulants when real wastewater are used as feed solutions. The present study evaluated various physical and chemical cleaning protocols for organic fouled membrane and the efficiency of cleaning methods for the removal of organic fouling in the forward osmosis process. The study made recommendations on future cleaning technologies such as Ultraviolet and Ultrasound. Generally, a combination of physical and chemical cleaning is the best for restoring the water flux in the FO process.
  • 3.1K
  • 27 Oct 2020
Topic Review
Syngeneic Tumor Models
Developments in cancer immunotherapy mean that complex cancer animal models which accurately relfect the tumor and its environment are required now more than ever. Mice remain good animals to investigate as they are relatively inexpensive, have short reproductive cycle, exhibit high tumor growth rates, and can be genetically modified. Despite being good models, some drugs which look promising in murine models still fail when trialed in humans. Increasing reliability is essential and the tumor model must reflect the tumor and its microenvironment including immune cells, to which the action of immunotherapeutic drugs are directed. This review investigates discusses the current immunocompetent and immunocompromised mouse models used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.
  • 3.1K
  • 09 Nov 2020
Topic Review
Major Losses in Wheat Combine Harvester Operation
Wheat harvesting is one of the most important links in the whole wheat production process. In China, the wheat planting areas are wide, and the patterns are diversified. In addition, the problem of harvest losses caused by the numerous brands and low performance of domestic combine harvesters has always existed. Any losses during harvesting will result in less income for the farmers.
  • 3.1K
  • 28 Nov 2022
Topic Review
Citizen-Centric Smart Cities
The citizen-centric smart city is conceptualised from the citizenship perspective which stressed on the citizen's responsibilities and participatory governance practices in a smart city (Malek, Lim and Yigitcanlar, 2021). This conception argues that instead of the traditional view on fulfilling the citizen's needs, the citizens should co-produce, participate and contribute to building the smart city together with the government and corporates.
  • 3.1K
  • 14 Sep 2021
Topic Review
Volumetric Muscle Loss
Volumetric muscle loss (VML) is the massive wasting of skeletal muscle tissue due to traumatic events or surgical ablation. This pathological condition exceeds the physiological healing process carried out by the muscle itself, which owns remarkable capacity to restore damages but only when limited in dimensions. Upon VML occurring, the affected area is severely compromised, heavily influencing the affected person’s quality of life. Overall, this condition is often associated with chronic disability, which makes the return to duty of highly specialized professional figures (e.g., military personnel or athletes) almost impossible. The actual treatment for VML is based on surgical conservative treatment followed by physical exercise; nevertheless, the results, in terms of either lost mass and/or functionality recovery, are still poor. On the other hand, the efforts of the scientific community are focusing on reconstructive therapy aiming at muscular tissue void volume replenishment by exploiting biomimetic matrix or artificial tissue implantation. Reconstructing strategies represent a valid option to build new muscular tissue not only to recover damaged muscles, but also to better socket prosthesis in terms of anchorage surfaces and reinnervation substrates for reconstructed mass. 
  • 3.1K
  • 26 May 2021
Topic Review
Solution-Processed Organic Phototransistors and Their Recent Developments
Today, more disciplines are intercepting each other, giving rise to “cross-disciplinary” research. Technological advancements in material science and device structure and production have paved the way towards development of new classes of multi-purpose sensory devices. Organic phototransistors (OPTs) are photo-activated sensors based on organic field-effect transistors that convert incident light signals into electrical signals. The organic semiconductor (OSC) layer and three-electrode structure of an OPT offer great advantages for light detection compared to conventional photodetectors and photodiodes, due to their signal amplification and noise reduction characteristics. Solution processing of the active layer enables mass production of OPT devices at significantly reduced cost. The chemical structure of OSCs can be modified accordingly to fulfil detection at various wavelengths for different purposes. Organic phototransistors have attracted substantial interest in a variety of fields, namely biomedical, medical diagnostics, healthcare, energy, security, and environmental monitoring. Lightweight and mechanically flexible and wearable OPTs are suitable alternatives not only at clinical levels but also for point-of-care and home-assisted usage.
  • 3.1K
  • 27 Jan 2022
Topic Review
Weichselian Glaciation
Weichselian glaciation[upper-alpha 1] refers to the last glacial period and its associated glaciation in northern parts of Europe. In the Alpine region it corresponds to the Würm glaciation. It was characterized by a large ice sheet (the Fenno-Scandian ice sheet) that spread out from the Scandinavian Mountains and extended as far as the east coast of Schleswig-Holstein, the March of Brandenburg and Northwest Russia. In Northern Europe it was the youngest of the glacials of the Pleistocene ice age. The preceding warm period in this region was the Eemian interglacial. The last cold period began about 115,000 years ago and ended 11,700 years ago. Its end corresponds with the end of the Pleistocene epoch and the start of the Holocene. The German geologist Konrad Keilhack (de) (1858-1944) named Weichselian glaciation using the German-language name (Weichsel) of the River Vistula (Polish: Wisła) in present-day Poland.
  • 3.1K
  • 14 Oct 2022
Topic Review
Massive Parallel Sequencing
Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged in 1994-1998 and have been commercially available since 2005. These technologies use miniaturized and parallelized platforms for sequencing of 1 million to 43 billion short reads (50-400 bases each) per instrument run. Many NGS platforms differ in engineering configurations and sequencing chemistry. They share the technical paradigm of massive parallel sequencing via spatially separated, clonally amplified DNA templates or single DNA molecules in a flow cell. This design is very different from that of Sanger sequencing—also known as capillary sequencing or first-generation sequencing—that is based on electrophoretic separation of chain-termination products produced in individual sequencing reactions.
  • 3.1K
  • 29 Sep 2022
Topic Review
Mars (Planet)
Mars is the fourth planet from the Sun in our solar system and is named after Mars, the Roman god of war. Mars is also known as the "Red Planet" due to its reddish appearance when seen from Earth. The prefix areo-, from the Greek god of war, Ares, refers to Mars in the same way geo- refers to Earth. Until the first flyby of Mars by Mariner 4 in 1965, it was thought that Mars had channels of liquid water. Observations later showed that these channels do not exist. Still, of all the planets in our solar system other than Earth, Mars is the most likely to harbor liquid water, and perhaps life. Its rotational period and seasonal cycles are also similar to those of the Earth. It has the highest mountain in the solar system, Olympus Mons, the largest canyon in the solar system, Valles Marineris, and polar ice caps. Mars has two moons, Phobos and Deimos, which are small and oddly-shaped. These may be captured asteroids similar to 5261 Eureka, a Mars trojan asteroid. Mars can be seen from Earth by the naked eye. Its apparent magnitude reaches -2.9, a brightness surpassed only by Venus, the Moon, and the Sun. For much of the year, Jupiter may appear brighter to the naked eye than Mars. Mars is currently host to four orbiting spacecraft, more than any planet other than Earth. It is also home to the two Mars Exploration Rovers, Spirit and Opportunity.
  • 3.1K
  • 21 Nov 2022
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