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Topic Review
Computer-Human Interaction and Collaboration
Through a series of projects carried out by the Computer–Human Interaction and COllaboration (CHICO) group of the University of Castilla-La Mancha, some proposals are presented to improve the current e-Learning systems by making use of different paradigms of human-computer interaction. Synchronous and asynchronous collaborative systems, ubiquitous computing, and augmented reality can improve the current learning environments. 
  • 3.1K
  • 18 Mar 2021
Topic Review
The Proteasome System
The proteasome system is a large and complex molecular machinery responsible for the degradation of misfolded, damaged, and redundant cellular proteins. When proteasome function is impaired, unwanted proteins accumulate, which can lead to several diseases including age-related and neurodegenerative diseases. Enhancing proteasome-mediated substrate degradation with small molecules may therefore be a valuable strategy for the treatment of various neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s diseases. 
  • 3.1K
  • 24 Mar 2022
Topic Review Peer Reviewed
Recent Advances in Research on Molecular Mechanisms of Fungal Signaling
Biochemical signaling is one of the key mechanisms to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number of signaling proteins and a multitude of transitions inside and outside the cell. Many components of signaling pathways are functionally pleiotropic, which means they have several functions. A single stimulus often results in multiple responses, a distinct response can be triggered by numerous stimuli and signals initiated by different stimuli are often transduced via commonly used network components. This review sheds light on the most important molecular mechanisms of cellular signaling in fungi and consequently provides a comprehensive overview about the current state of research on the road to understand the impact of signal transduction in eukaryotic microorganisms.
  • 3.1K
  • 23 Sep 2022
Topic Review
Apocarotenoids
Carotenoid-derived apocarotenoids (CDCs) are formed by the oxidative cleavage of carbon–carbon double bonds in the carotenoid backbones either by carotenoid cleavage enzymes (CCDs) or via the exposure of carotenoids to ROS. Many of these apocarotenoids play key regulatory roles in plant development as growth simulators and inhibitors, signalling molecules, including as abscisic acid  and strigolactones, and have roles in plant defence against pathogens and herbivores. Others act as flavour and aroma compounds in fruit pericarp, flowers and seeds. The diverse variety of carotenoids (+700) means that the potential apocarotenoid products represent a significant number of natural compounds.
  • 3.1K
  • 03 Nov 2021
Topic Review
Power Estimation for Electric Vehicles’s Lithium-Ion Batteries
State of power (SOP), as one of the key states of lithium-ion batteries, is defined as the peak power capability that a battery could deliver or receive over a prediction window while keeping the battery within the safe operating area. By this definition, most existing methods for online SOP estimation employ an equivalent-circuit model (ECM) to simulate battery dynamic behaviour in a prediction window and assume batteries operating at three operation modes, namely the constant current (CC), constant voltage (CV), and constant current constant voltage (CCCV) modes. Accordingly, three online SOP estimation methods have been developed with different basic principles, and many efforts have been made in the past decades for the improved performance of online SOP estimation from three aspects: (1) model structure; (2) online parameter identification technique; and (3) SOP estimation algorithm. 
  • 3.1K
  • 05 Jan 2022
Topic Review
Archimedes Screw Turbines
Archimedes Screws Turbines (ASTs) are a new form of generators for small hydroelectric powerplants that could be applied even in low head sites. ASTs offer a clean and renewable source of energy. They are safer for wildlife and especially fish. The low rotation speed of ASTs reduces negative impacts on aquatic life and fish. Considering the flexibility and advantages of ASTs, they offer economic, social, and environmental advantages to support sustainable development to: - Increase the number of suitable sites and maximize power generation.- Retrofit old dams or upgrade current dams or mills to make them economically (power generation) and environmentally (renewable energy) reasonable.- Reduce the hydroelectricity major operational and/or maintenance costs.- Reduce the disturbance of natural erosion and sedimentation processes.- Make hydropower generation safer for aquatic wildlife, especially for fish.- Generate electricity for small communities, developing countries, and regions with limited access to the power grid or other infrastructures, or regions that are hard to access or connect to the power grid.  
  • 3.1K
  • 12 Jan 2022
Topic Review
BSD Licenses
BSD licenses are a family of permissive free software licenses, imposing minimal restrictions on the use and distribution of covered software. This is in contrast to copyleft licenses, which have share-alike requirements. The original BSD license was used for its namesake, the Berkeley Software Distribution (BSD), a Unix-like operating system. The original version has since been revised, and its descendants are referred to as modified BSD licenses. BSD is both a license and a class of license (generally referred to as BSD-like). The modified BSD license (in wide use today) is very similar to the license originally used for the BSD version of Unix. The BSD license is a simple license that merely requires that all code retain the BSD license notice if redistributed in source code format, or reproduce the notice if redistributed in binary format. The BSD license (unlike some other licenses e.g. GPL) does not require that source code be distributed at all.
  • 3.1K
  • 16 Nov 2022
Topic Review
Planet-Hosting Stars
Planet-hosting stars are stars which host planets, therefore forming planetary systems. This article describes the correlations between stars' characteristics and the characteristics of the planets that orbit them, and other connections between stars and their planets.
  • 3.1K
  • 23 Nov 2022
Topic Review
Cybersecurity: A Historical Overview of Attacks
This research provides a comprehensive overview of the history of cybersecurity attacks and institutions working to fight them. It covers the early days of cyber attacks, the rise of hacking and cybercrime, notable cyber attacks such as Code Red, Stuxnet, Target, and WannaCry, and institutions fighting cyberattacks, including the National Security Agency, Federal Bureau of Investigation, Department of Homeland Security, and Cybersecurity and Infrastructure Security Agency. The research also discusses open challenges and future directions in the field, such as the need for new technologies and policies to combat increasingly complex cyber threats, and the importance of investing in cybersecurity education. This research aims to provide policymakers, researchers, and the general public with a better understanding of the history of cybersecurity and the ongoing efforts to promote a safer and more secure digital world.
  • 3.1K
  • 22 May 2023
Topic Review
Palm Oil Background
Palm oil plantations cover millions of hectares worldwide, which encompass a significant portion of global trade. Palm oil trees, or Arecaceae, are a genus of stemless, tree-like monocot plants that thrive in the tropics and are extremely valuable to humans and the ecosystem. The African oil palm, or Elaeis guineensis, is the most prominent palm species native to West Africa, cultivated for its oil-rich fruit as a semiwild food source for over 7000 years. The tree produces a profusion of fruit bunches yearly with each containing between 1000 and 3000 fruits.
  • 3.1K
  • 14 Jul 2022
Topic Review
Optical Biomedical Sensors
The optical biomedical sensor industry has grown enormously over the past few years and is expected to grow more in the forthcoming days because of the extensive need for point-of-care testing devices. Researchers all over the world are working on the implementation of highly sensitive, reliable, portable, and inexpensive biomedical appliances, which can revolutionize this market. Optical biosensing is a vast topic, and numerous optical sensing techniques have been presented over the years.These techniques and corresponding technological platforms enabling the manufacturing of optical biomedical sensors of different types.the most representative cases are integrated optical biosensors, vertical grating couplers, plasmonic sensors, surface plasmon resonance optical fiber biosensors, and metasurface biosensors, Photonic crystal-based biosensors, thin metal films biosensors, and fiber Bragg grating biosensors，these optical biomedical sensors might enable the identification of symptoms of deadly illnesses in their early stages; thus, potentially saving a patient’s life. 
  • 3.1K
  • 05 May 2021
Topic Review
Plant Nutrition under Climate Change
The climate is one of the key elements impacting several cycles connected to soil and plant systems, as well as plant production, soil quality, and environmental quality. Due to heightened human activity, the rate of CO2 is rising in the atmosphere. Changing climatic conditions (such as temperature, CO2, and precipitation) influence plant nutrition in a range of ways, comprising mineralization, decomposition, leaching, and losing nutrients in the soil.
  • 3.1K
  • 26 Jan 2022
Topic Review
DNA-Based Biosensors
Due to superior biocompatibility, thermal stability, and alternative functionalization, deoxyribonucleic acid (DNA) is becoming a fascinating biological material used for biosensing. It is widely acknowledged that DNA and its assembly structure can be applied for detecting specific targets, including nucleic acids, proteins, metal ions, and small biological molecules. With the development of DNA nanotechnology, dynamic networks based on DNA hybridization can be used to amplify the signals of biosensors.
  • 3.1K
  • 07 Apr 2022
Topic Review
Pathophysiology of the Metabolic Syndrome
Metabolic syndrome (MetS) is a disease that has a complex etiology. It is defined as the co-occurrence of several pathophysiological disorders, including obesity, hyperglycemia, hypertension, and dyslipidemia.
  • 3.1K
  • 22 Apr 2022
Topic Review
Anaxagoras
Anaxagoras (/ˌænækˈsæɡərəs/; Greek: Ἀναξαγόρας, Anaxagoras, "lord of the assembly"; c. 500 – c. 428 BC) was a Pre-Socratic Greek philosopher. Born in Clazomenae at a time when Asia Minor was under the control of the Persian Empire, Anaxagoras came to Athens. According to Diogenes Laërtius and Plutarch, in later life he was charged with impiety and went into exile in Lampsacus; the charges may have been political, owing to his association with Pericles, if they were not fabricated by later ancient biographers. Responding to the claims of Parmenides on the impossibility of change, Anaxagoras described the world as a mixture of primary imperishable ingredients, where material variation was never caused by an absolute presence of a particular ingredient, but rather by its relative preponderance over the other ingredients; in his words, "each one is... most manifestly those things of which there are the most in it". He introduced the concept of Nous (Cosmic Mind) as an ordering force, which moved and separated out the original mixture, which was homogeneous, or nearly so. He also gave a number of novel scientific accounts of natural phenomena. He deduced a correct explanation for eclipses and described the Sun as a fiery mass larger than the Peloponnese, as well as attempting to explain rainbows and meteors.
  • 3.1K
  • 24 Oct 2022
Topic Review
Compounds of Zinc
Compounds of zinc are chemical compounds containing the element zinc which is a member of the group 12 of the periodic table. The oxidation state of most compounds is the group oxidation state of +2. Zinc may be classified as a post-transition main group element with zinc(II). Zinc compounds are noteworthy for their nondescript behavior, they are generally colorless (unlike other elements with the oxidation number +2, which are usually white), do not readily engage in redox reactions, and generally adopt symmetrical structures.
  • 3.1K
  • 25 Nov 2022
Topic Review
Agent-Based Models and Simulations Tools
Agent-based models (ABMs) are one of the most effective and successful methods for analyzing real-world complex systems by investigating how modeling interactions on the individual level (i.e., micro-level) leads to the understanding of emergent phenomena on the system level (i.e., macro-level). ABMs represent an interdisciplinary approach to examining complex systems, and the heterogeneous background of ABM users demands comprehensive, easy-to-use, and efficient environments to develop ABM simulations. Many tools, frameworks, and libraries exist, each with its characteristics and objectives.
  • 3.1K
  • 01 Feb 2023
Topic Review
Faults in a Photovoltaic System
Photovoltaic systems are prone to breaking down due to harsh conditions. In photovoltaic systems, various types of faults can cause power loss in some way. To improve the reliability of these systems, diagnostic methods using Machine Learning (ML) have been developed. 
  • 3.1K
  • 15 Mar 2024
Topic Review
Hericium Erinaceus for Depressive Disorder
Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion’s mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. 
  • 3.1K
  • 30 Oct 2020
Topic Review
Weismann Barrier
The Weismann barrier has long been regarded as a basic tenet of biology. However, upon close examination of its historical origins and August Weismann's own writings, questions arise as to whether such a status is warranted. As scientific research has advanced, the persistence of the concept of the barrier has left us with the same dichotomies Weismann contended with over 100 years ago: germ or soma, gene or environment, hard or soft inheritance. 
  • 3.1K
  • 30 Jan 2021
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