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Topic Review
Hericium Erinaceus for Depressive Disorder
Depression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion’s mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. 
  • 3.1K
  • 30 Oct 2020
Topic Review
Apocarotenoids
Carotenoid-derived apocarotenoids (CDCs) are formed by the oxidative cleavage of carbon–carbon double bonds in the carotenoid backbones either by carotenoid cleavage enzymes (CCDs) or via the exposure of carotenoids to ROS. Many of these apocarotenoids play key regulatory roles in plant development as growth simulators and inhibitors, signalling molecules, including as abscisic acid  and strigolactones, and have roles in plant defence against pathogens and herbivores. Others act as flavour and aroma compounds in fruit pericarp, flowers and seeds. The diverse variety of carotenoids (+700) means that the potential apocarotenoid products represent a significant number of natural compounds.
  • 3.1K
  • 03 Nov 2021
Topic Review
Rice Industry Value Chain and by-products valorization
The quantity of organic waste generated by agricultural sectors is continually increasing due to population growth and rising food demand. Rice is the primary consumable food in Asia. However, many stakeholders follow a linear economic model such as the “take–make–waste” concept. This linear model leads to a substantial environmental burden and the destruction of valuable resources without gaining their actual value. Because these by-products can be converted into energy generating and storage materials, and into bio-based products by cascading transformation processes within the circular economy concept, waste should be considered a central material.
  • 3.1K
  • 18 Apr 2023
Topic Review Peer Reviewed
COVID-19-Associated Encephalopathy (COVEP): Basic Aspects of Neuropathology
SARS-CoV-2, a member of the betacoronavirus group and causative agent of COVID-19, is a virus affecting multiple systems, not only the respiratory. One of the systems affected by the virus is the central nervous system, with neuropathological studies reporting a wide set of morphological phenomena—neuroinflammation, vascular and blood-brain barrier alterations, neurodegeneration, and accelerated aging, while contradicting data is present on the direct neuroinvasive potential of the virus and active viral replication within neurons. The depicted changes, other than an acute effect (which may contribute to the death of the patient) also have chronic sequelae in the context of post-COVID syndrome cognitive impediments, sleep, and mood disorders. The following chapter describe the basic neuropathological aspects of SARS-CoV-2 as based on the present evidence in scientific literature and propose the term COVEP—COVID-associated encephalopathy—to unite the undisputed effects of the infection on nervous system morphology and function.
  • 3.1K
  • 28 Nov 2022
Topic Review
Bus Scheduling with Evolutionary Optimization
In public transport operations, vehicles tend to bunch together due to the instability of passenger demand and traffic conditions. Fluctuation of the expected waiting times of passengers at bus stops due to bus bunching is perceived as service unreliability and degrades the overall quality of service. For assessing the performance of high-frequency bus services, transportation authorities monitor the daily operations via Transit Management Systems (TMS) that collect vehicle positioning information in near real-time. This work explores the potential of using Automated Vehicle Location (AVL) data from the running vehicles for generating bus schedules that improve the service reliability and conform to various regulatory constraints. The computer-aided generation of optimal bus schedules is a tedious task due to the nonlinear and multi-variable nature of the bus scheduling problem. For this reason, this work develops a two-level approach where (i) the regulatory constraints are satisfied and (ii) the waiting times of passengers are optimized with the introduction of an evolutionary algorithm. This work also discusses the experimental results from the implementation of such an approach in a bi-directional bus line operated by a major bus operator in northern Europe.
  • 3.1K
  • 29 Oct 2020
Topic Review
Composting Technology of Brewer's Grains
The brewing industry is characterized by the large production of by-products. Following the fundamentals of a circular economy, several attempts to recycle brewers’ spent grain (BSG) have been investigated. However, little information is available on its use for composting.
  • 3.1K
  • 13 Jan 2021
Topic Review
Sodium Alginate
Alginian sodu (Na-Alg) jest rozpuszczalnym w wodzie, obojętnym i liniowym polisacharydem. Jest pochodną kwasu alginowego, który zawiera kwasy 1,4-β-d-mannuronowy (M) i α-l-guluronowy (G) i ma wzór chemiczny (NaC6H7O6). Wykazuje właściwości rozpuszczalne w wodzie, nietoksyczne, biokompatybilne, biodegradowalne i nieimmunogenne. Był używany do różnych zastosowań biomedycznych, wśród których najbardziej obiecujące są dostarczanie leków, dostarczanie genów, opatrywanie ran i ich gojenie.
  • 3.1K
  • 02 Feb 2021
Topic Review
Perfume and Flavor Engineering
The Perfumery Ternary Diagram enables us to determine the dominant odor for each perfume composition.
  • 3.1K
  • 29 Jun 2021
Topic Review
Influence of Mindfulness on Men’s Sexual Activity
Mindfulness practice and mindfulness-based interventions are widely known, especially for women’s sexuality. The practice of mindfulness favours different variables of male sexuality, such as satisfaction and sexual functioning or genital self-image. Mindfulness-based interventions represent a valuable and promising contribution.
  • 3.1K
  • 06 Mar 2023
Topic Review
Almond By-Products
Almond (Prunus dulcis(Mill.) D. A. Webb, Prunus amygdalus Batch, or Amygdalus communis L.) constitutes the most produced nut worldwide, thanks to its exceptional nutritional composition, including low sugar content, high levels of proteins, unsaturated fatty acids, vitamins, and minerals, as well as health-enhancing phytochemicals.
  • 3.1K
  • 18 Aug 2021
Topic Review
Factors Affecting Electrospinning
Electrospinning can produce continuous nanofibers from a variety of materials. Processional, physical, systemic, and solution parameters, among others, impact the fiber morphology and properties of electrospun fibers.
  • 3.1K
  • 13 Apr 2023
Topic Review
Coffee Berry Borer (Hypothenemus hampei)
Coffee berry borer (CBB) is the most serious insect pest of coffee worldwide, causing more than US$500M in damages annually. Reduction in the yield and quality of coffee results from the adult female CBB boring into the coffee fruit and building galleries for reproduction, followed by larval feeding on the bean itself.
  • 3.1K
  • 23 Dec 2020
Topic Review
Q'eqchi' Language
The Q'eqchi' language, also spelled Kekchi, K'ekchi', or kekchí, is one of the Mayan languages, spoken within Q'eqchi' communities in Guatemala and Belize.
  • 3.1K
  • 14 Oct 2022
Topic Review
Thyme
A perennial wild shrub from the Lamiaceae family and native to the Mediterranean region, thyme is considered an important wild edible plant studied for centuries for its unique importance in the food, pharmaceutical, and cosmetic industry. Thyme is loaded with phytonutrients, minerals and vitamins. It is pungent in taste, yet rich in moisture, proteins, crude fiber, minerals and vitamins. Its chemical composition may vary with geographical location but is mainly composed of flavonoids and antioxidants.
  • 3.1K
  • 07 Jun 2022
Topic Review
Turtles in Malaysia
Approximately 356 species of turtles inhabit saltwater and freshwater habitats globally, except in Antarctica. Twenty-four species of turtles have been reported in Malaysia, four of which are sea turtles. The state of Terengganu harbored the highest number of turtles, with 17 different reported species. 
  • 3.1K
  • 19 Sep 2022
Topic Review
Social Innovation
This entry briefly recounts the history of social innovation and how it went from a descriptive term to a practice-based notion and, finally, to a scientific concept, while highlighting the major transformations it experienced. The text mentions some current debates, before presenting our own definition of social innovation. This definition incorporates contributions from other commonly used definitions while maintaining is operative potential. It also allows to clearly pinpoint what distinguishes social innovation from other types of innovation. The entry ends up with criteria for identifying social innovations.
  • 3.1K
  • 31 Jan 2023
Topic Review
CO2 Storage in Shale Reservoirs
As a new “sink” of CO2 permanent storage, the depleted shale reservoir is very promising compared to the deep saline aquifer. To provide a greater understanding of the benefits of CO2 storage in a shale reservoir, a comparative study is conducted by establishing the full-mechanism model, including the hydrodynamic trapping, adsorption trapping, residual trapping, solubility trapping as well as the mineral trapping corresponding to the typical shale and deep saline aquifer parameters from the Ordos basin in China. The results show that CO2 storage in the depleted shale reservoir has merits in storage safety by trapping more CO2 in stable immobile phase due to adsorption and having gentler and ephemeral pressure perturbation responding to CO2 injection. The effect of various CO2 injection schemes, namely the high-speed continuous injection, low-speed continuous injection, huff-n-puff injection and water alternative injection, on the phase transformation of CO2 in a shale reservoir and CO2-injection-induced perturbations in formation pressure are also examined. With the aim of increasing the fraction of immobile CO2 while maintaining a safe pressure-perturbation, it is shown that an intermittent injection procedure with multiple slugs of huff-n-puff injection can be employed and within the allowable range of pressure increase, and the CO2 injection rate can be maximized to increase the CO2 storage capacity and security in shale reservoir.
  • 3.1K
  • 11 Jan 2021
Topic Review
COVID-19 Vaccine
A COVID‑19 vaccine is a hypothetical vaccine in development against coronavirus disease 2019 (COVID‑19). Although no candidate has completed clinical trials to prove its safety and efficacy, there are multiple efforts in progress to develop one. As of July 2020, there are 24 vaccine candidates planned or undergoing clinical trials, with two beginning Phase III and seven in Phase I-II. Previous attempts to develop a vaccine against the coronavirus diseases SARS and MERS established considerable knowledge about the structure and function of coronaviruses – which accelerated rapid development during early 2020 of varied technology platforms for a COVID‑19 vaccine – but all the previous coronavirus vaccine candidates failed in early-stage clinical trials, with none being advanced to licensing. The Coalition for Epidemic Preparedness Innovations (CEPI) – which is organizing a US$2 billion worldwide fund for rapid investment and development of vaccine candidates – indicated in April that a vaccine may be available under emergency use protocols in less than 12 months or by early 2021. On 4 May 2020, the WHO organized a telethon which received US$8.1 billion in pledges from forty countries to support rapid development of vaccines to prevent COVID‑19 infections. At the same time, the WHO also announced deployment of an international "Solidarity trial" for simultaneous evaluation of several vaccine candidates reaching Phase II-III clinical trials.
  • 3.1K
  • 09 Nov 2022
Topic Review
Biomechanical Energy Harvesting from the Human Body
Energy harvesters serve as continuous and long-lasting sources of energy that can be integrated into wearable and implantable sensors and biomedical devices. Biomechanical energy is one of the largest categories and one of the most utilized among all other energy sources.
  • 3.1K
  • 28 Nov 2022
Topic Review
Gyrotrons
Gyrotrons are among the most powerful sources of coherent radiation that operate in CW and long pulse regimes in the sub-THz and the THz frequency ranges of the electromagnetic spectrum, i.e. between 0.3 THz and 3.0 THz (corresponding to wavelengths from 1.0 to 0.1 mm). This region, which spans between the frequency bands occupied by various electronic and photonic devices, respectively, is habitually called a THz power gap. The underlying mechanism of the operation of the gyrotron involves a formation of bunches of electrons gyrating in a helical electron beam and their synchronous interaction with a fast (i.e. having a superluminal phase velocity) electromagnetic wave, producing a bremsstrahlung radiation. In contrast to the slow-wave tubes, which utilize tiny structures with dimensions comparable to the wavelength of the radiation, the gyrotrons have a simpler resonant system (cavity resonator) with dimensions that are much greater than the wavelength. This allows much more powerful electron beams to be used and thus higher output powers to be achieved. Although in comparison with the classical microwave tubes the gyrotrons are characterized by greater volume and weight due to the presence of bulky parts (such as superconducting magnets and massive collectors where the energy of the spent electron beam is dissipated) they are much more compact and can easily be embedded in a sophisticated laboratory equipment (e.g. spectrometers, technological systems, etc.) than other devices such as free-electron lasers (FEL) and radiation sources based on electron accelerators. Nowadays, the gyrotrons are used as powerful sources of coherent radiation in the wide fields of high-power sub-THz and THz science and technologies [1][2][3].
  • 3.1K
  • 29 Oct 2020
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