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Topic Review
Pleiotropic Anticancer of Withaferin A
Withaferin A, a natural bioactive molecule isolated from the Indian medicinal plant Withania somnifera (L.) Dunal, has been reported to impart anticancer activities against various cancer cell lines and preclinical cancer models by modulating the expression and activity of different oncogenic proteins.
  • 1.6K
  • 16 Feb 2023
Topic Review
Neural Stem Cell
Stem cells have extensive proliferative potential and the ability to differentiate into one or more mature cell types. The mechanisms by which stem cells accomplish self-renewal provide fundamental insight into the origin and design of multicellular organisms. These pathways allow the repair of damage and extend organismal life beyond that of component cells, and they probably preceded the evolution of complex metazoans.
  • 1.6K
  • 11 Mar 2021
Topic Review
Plasmin/Plasminogen System in Tumor Microenvironment
Plasmin is an enzyme which is responsible for digesting several proteins that hold the tissues surrounding solid tumors together.
  • 1.6K
  • 23 Jun 2021
Topic Review
Principle of Liquid Crystal Biosensors
Liquid crystals (LCs) are phase transition materials that exist between the liquid and the crystal states, and they can flow as liquids and also have properties such as birefringence of crystals. LCs have been widely used as sensitive elements to construct LC biosensors based on the principle that specific bonding events between biomolecules can affect the orientation of LC molecules.
  • 1.6K
  • 25 Aug 2022
Topic Review
Diet and Male Fertility
Nutrition can affect, negatively or positively, sperm quality and this effect depends on both quantitative and qualitative aspects of the diet, such as calorie content of each macronutrient (carbohydrates, protein, and fats), as well as on the specific fatty acid composition, carbohydrates, and protein profiles. While a Western diet is considered a risk factor for male infertility, the Mediterranean diet seems to protect against male infertility; moreover, the role of a vegetarian habitus in the preservation of sperm quality is controversial. Since diet may be an important modifiable determinant of male reproductive potential,  the role of daily nutrient exposure needs to be highlighted to preserve male fertility or to prevent male infertility. 
  • 1.6K
  • 06 May 2023
Topic Review
Strategies to Increase HDR-Dependent CRISPR-Cas9 Mediated Genome Editing
CRISPR (Clustered regularly interspaced short palindromic repeats) technology affords a simple and robust way to edit the genomes of cells, providing powerful tools for basic research and medicine. While using Cas9 to cleave a genomic site is very efficient, making a specific mutation at that site is much less so, as it depends on the endogenous DNA repair machinery. Various strategies have been developed to increase the efficiency of knock-in mutagenesis, mostly focusing on improving homology-directed repair (HDR) while reducing non-homologous end joining (NHEJ). Some approaches affect these repair mechanisms globally, while others target their modulations to the site of the Cas9-induced double-strand break (DSB). Other innovations serve to increase the specificity and the efficiency of the editing mechanisms. In addition, methods such as base editing and prime editing produce knock-in mutations without a DSB.
  • 1.6K
  • 19 Oct 2022
Topic Review
Application of Prime Editing to Liver Hereditary Diseases
Gene therapy holds tremendous potential in the treatment of inherited diseases. Unlike traditional medicines, which only treat the symptoms, gene therapy has the potential to cure the disease by addressing the root of the problem: genetic mutations. The discovery of CRISPR/Cas9 in 2012 paved the way for the development of those therapies. Improvement of this system led to the recent development of an outstanding technology called prime editing. This system can introduce targeted insertions, deletions, and all 12 possible base-to-base conversions in the human genome. Since the first publication on prime editing in 2019, groups all around the world have worked on this promising technology to develop a treatment for genetic diseases. Liver diseases are currently the most studied field for human gene therapy by prime editing. To date, prime editing has been attempted in preclinical studies for tyrosinemia type 1, alpha-1-antitrypsin deficiency, phenylketonuria, DGAT1-deficiency, bile salt export pump deficiency, liver cancer, and for a liver disease caused by a mutation in the DNMT1 gene.
  • 1.6K
  • 21 Feb 2023
Topic Review
Anthocyanins and Hepatoprotection
Anthocyanins are water-soluble, colored compounds of the flavonoid class, abundantly found in the fruits, leaves, roots, and other parts of the plants. The fruit berries are prime sources and exhibit different colors. The anthocyanins utility as traditional medicament for liver protection and cure, and importance as strongest plants-based anti-oxidants have conferred these plants products different biological activities. These activities include anti-inflammation, liver protective, analgesic, and anti-cancers, which have provided the anthocyanins an immense commercial value, and has impelled their chemistry, biological activity, isolation, and quality investigations as prime focus. 
  • 1.6K
  • 11 Mar 2022
Topic Review
Human Amnion-Derived Stem Cells
Human amnion-derived stem cells (hADSCs) are referred as the cells of possessing the abilities of self-renew and differentiation, which are isolated from human amnion and include human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs).
  • 1.6K
  • 28 Sep 2021
Topic Review
Insulin-like Growth Factor 1 Signaling in Mammalian Hearing
Insulin-like growth factor 1 (IGF-1) is a peptide hormone belonging to the insulin family of proteins. Almost all of the biological effects of IGF-1 are mediated through binding to its high-affinity tyrosine kinase receptor (IGF1R), a transmembrane receptor belonging to the insulin receptor family. Factors, receptors and IGF-binding proteins form the IGF system, which has multiple roles in mammalian development, adult tissue homeostasis, and aging. Consequently, mutations in genes of the IGF system, including downstream intracellular targets, underlie multiple common pathologies and are associated with multiple rare human diseases. Here we review the contribution of the IGF system to our understanding of the molecular and genetic basis of human hearing loss by describing, (i) the expression patterns of the IGF system in the mammalian inner ear; (ii) downstream signaling of IGF-1 in the hearing organ; (iii) mouse mutations in the IGF system, including upstream regulators and downstream targets of IGF-1 that inform cochlear pathophysiology; and (iv) human mutations in these genes causing hearing loss.
  • 1.6K
  • 22 Oct 2021
Topic Review
The NIMA Family of Kinases
The Never in mitosis gene A (NIMA) family of serine/threonine kinases is a diverse group of protein kinases implicated in a wide variety of cellular processes, including cilia regulation, microtubule dynamics, mitotic processes, cell growth, and DNA damage response. The founding member of this family was initially identified in Aspergillus and was found to play important roles in mitosis and cell division. The yeast family has one member each, Fin1p in fission yeast and Kin3p in budding yeast, also with functions in mitotic processes, but, overall, these are poorly studied kinases.
  • 1.6K
  • 12 Apr 2022
Topic Review
Microglia in Prion Diseases
Prion diseases are rare transmissible neurodegenerative disorders caused by the accumulation of a misfolded isoform (PrPSc) of the cellular prion protein (PrPC) in the central nervous system (CNS). Neuropathological hallmarks of prion diseases are neuronal loss, astrogliosis, and enhanced microglial proliferation and activation. As immune cells of the CNS, microglia participate both in the maintenance of the normal brain physiology and in driving the neuroinflammatory response to acute or chronic (e.g., neurodegenerative disorders) insults. Microglia involvement in prion diseases, however, is far from being clearly understood.
  • 1.6K
  • 20 Nov 2020
Topic Review
Protein-Based Targeting Self-Assembling Nanoparticles for Biomedical Applications
Targeted nanoparticles of different origins are considered as new-generation diagnostic and therapeutic tools. Targeted protein self-assembling nanoparticles circumvent this problem since proteins are encoded in DNA and the final protein product is produced in only one possible way. The combination of the endless biomedical potential of protein carriers as nanoparticles and the standardized protein purification protocols will make significant progress in “magic bullet” creation possible, bringing modern biomedicine to a new level. The entry focused on the currently existing platforms for targeted self-assembling protein nanoparticles based on transferrin, lactoferrin, casein, lumazine synthase, albumin, ferritin, and encapsulin proteins, as well as on proteins from magnetosomes and virus-like particles. The applications of these self-assembling proteins for targeted delivery in vitro and in vivo are thoroughly discussed, including bioimaging applications and different therapeutic approaches, such as chemotherapy, gene delivery, and photodynamic and photothermal therapy. 
  • 1.6K
  • 08 Mar 2023
Topic Review
Aptasensors and Aptamers
A kind of biosensor using aptamers as BRE is known as aptasensor. Aptamers are synthetic single-stranded oligonucleotide sequences (RNA or DNA) with high specificity and affinity to bind a variety of target classes including proteins, peptides, drugs, small molecules, whole cells, inorganic and organic molecules, etc.
  • 1.6K
  • 19 Apr 2021
Topic Review
Plant-Endophyte Interaction
Plants interact with diverse microbial communities and share complex relationships with each other. The intimate association between microbes and their host mutually benefit each other and provide stability against various biotic and abiotic stresses to plants. Endophytes are heterogeneous groups of microbes that live inside the host tissue without showing any apparent sign of infection.
  • 1.6K
  • 06 Sep 2022
Topic Review
Combining Experimental and Computational Methods
The integration of experimental and computational methods can assist and enrich the interpretation of the experimental results, providing new detailed molecular understanding of the systems.
  • 1.6K
  • 14 Jan 2021
Topic Review
Mitochondrial Carriers
Mitochondrial carriers play a fundamental role in cellular metabolism, connecting mitochondrial with cytosolic reactions. By transporting substrates across the inner membrane of mitochondria, they contribute to many processes that are central to cellular function. The genome of Saccharomyces cerevisiae encodes 35 members of the mitochondrial carrier family, most of which have been functionally characterized.
  • 1.6K
  • 23 Sep 2021
Topic Review
β-hydroxybutyrate as an Anti-Aging Metabolite
The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and alternatively serve as a fuel source for peripheral tissues including the brain, heart, and skeletal muscle. β-HB is currently considered not solely an energy substrate for maintaining metabolic homeostasis but also acts as a signaling molecule of modulating lipolysis, oxidative stress, and neuroprotection. Besides, it serves as an epigenetic regulator in terms of histone methylation, acetylation, β-hydroxybutyrylation to delay various age-related diseases. In addition, studies support endogenous β-HB administration or exogenous supplementation as effective strategies to induce a metabolic state of nutritional ketosis. The purpose of this review article is to provide an overview of β-HB metabolism and its relationship and application in age-related diseases. Future studies are needed to reveal whether β-HB has the potential to serve as adjunctive nutritional therapy for aging.
  • 1.6K
  • 19 Oct 2021
Topic Review
Role of Anillin in Normal Cell
Anillin (ANLN) is an actin-binding protein that has been documented as a key factor in cell division, and it is a multi-domain protein that interacts with many proteins. ANLN is highly expressed in many types of site-specific cancerous tumours, including brain, lung, pancreas, and bone marrow cancer.
  • 1.6K
  • 02 Sep 2022
Topic Review
The Role of ABC Transporters in the Skin
ABC transporters are expressed in skin cells to protect them against harmful xenobiotics. These transmembrane proteins have a number of additional functions that ensure skin homeostasis. 
  • 1.6K
  • 03 Jan 2023
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