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Topic Review
CD19-CAR-T Cells
CD19-targeted chimeric antigen receptor (CAR) T (CD19-CAR-T) cell therapy usually causes B cell aplasia because of “on-target off-tumor” toxicity. The aim of the study was to assess the concept that the introduction of an inhibitory CAR (iCAR) into CAR-T cells could alleviate the side effect of CD19-CAR-T cell therapy. The results showed that CD19-CAR-T cells with a novel KIR/PD-1-based inhibitory CAR (iKP-19-CAR-T) exhibited more naïve, less exhausted phenotypes and preserved a higher proportion of central memory T cells (TCM). Furthermore, iKP-19-CAR-T cells exerted the similar level of cytotoxicity on CD19+HLA-C1- Burkitt’s lymphoma cells compared to CD19-CAR-T cells while sparing CD19+HLA-C1+ healthy human B cells both in vitro and in the xenograft model. Our data demonstrates that the KIR/PD-1-based inhibitory CAR can be a promising strategy to avoid B cell aplasia caused by CD19-CAR-T cell therapy.  
  • 2.0K
  • 26 Oct 2020
Topic Review
Vaccine Technology in Bovine Theileriosis
Theileriosis is a blood piroplasmic disease that adversely affects the livestock industry, especially in tropical and sub-tropical countries. It is caused by haemoprotozoan of the Theileria genus, transmitted by hard ticks and which possesses a complex life cycle. The infection and treatment method (ITM) is currently used in the control and prevention of T. parva infection, and recombinant vaccines are still under evaluation. The use of gene gun immunization against T. parva infection has been recently evaluated.
  • 2.0K
  • 26 Oct 2020
Topic Review
Balancing Immune System to Treat Rheumatoid Arthritis
Rheumatoid arthritis (RA) and other autoimmune inflammatory diseases are examples of imbalances within the immune system (disrupted homeostasis) that arise from the effects of an accumulation of environmental and habitual insults over a lifetime, combined with genetic predispositions. The Ligand Epitope Antigen Presentation System (LEAPS) therapies are capable of inhibiting ongoing disease progression in animal models. Whereas DMARDs ablate or inhibit specific proinflammatory cytokines or cells and JAK inhibitors (jakinibs) inhibit the receptor activation cascade for expression of proinflammatory cytokines, the LEAPS therapeutic vaccines specifically modulate the ongoing antigen-specific, disease-driving, proinflammatory T memory cell responses. This decreases disease presentation and changes the cytokine conversation to decrease the expression of inflammatory cytokines while increasing the expression of regulatory cytokines. 
  • 2.0K
  • 09 May 2022
Topic Review
Tumor Temperature
The temperature of a solid tumor is often dissimilar to baseline body temperature and, compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of a tumor is dependent on metabolic activity and vascularization and can change due to tumor progression, treatment, or cancer type.
  • 1.9K
  • 13 Sep 2022
Topic Review
Tumor Necrosis Factor in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a complex and heterogenous disease; what differentiates patients with RA are the number of affected joints, antibodies and serum cytokines levels, and the severity of joint destruction. TNF (tumor necrosis factor) is a proinflammatory cytokine which exerts multiple biological activities in RA. Blocking TNF with antibodies became a standard of modern RA therapy in patients not responding to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), e.g., methotrexate.
  • 1.8K
  • 15 Mar 2022
Topic Review
Cytotoxicity and Phagocytosis in Immunity
The immune system has evolved to protect organisms from infections caused by bacteria, viruses, and parasitic pathogens. In addition, it provides regenerative capacities, tissue maintenance, and self/non-self recognition of foreign tissues. In general, innate immunity is a fast and non-specific response associated with the presence of humoral and cellular elements. By contrast, adaptive immunity uses the induction of specialized cells such as B and T lymphocytes and molecules including the major histocompatibility complex (MHC), B-cell receptors (BCR), T-cell receptors (TCR), immunoglobulins (Ig), and antibodies to confer immunological memory and very high specificity thus fighting against a previously recognized infection. Both kinds of immune responses rely on two main cellular activities which are phagocytosis and cytotoxicity. These cellular immune mechanisms have been found at the earliest evolutionary stages of multicellular animals and diversified into a wide heterogeneous repertoire of effector cells through evolution.
  • 1.8K
  • 04 Aug 2021
Topic Review
The Role of Wnt
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment and local immunomodulation. We focus specifically on preclinical and clinical data supporting the hypothesis that strategies targeting Wnt signaling could act as adjuncts for cancer therapy, either in combination with chemotherapy or immunotherapy, in a variety of tumor types.
  • 1.8K
  • 29 Oct 2020
Topic Review
Sjögren’s Syndrome Pathogenic Molecular Pathways
Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by the lymphocytic infiltration of exocrine glands and the production of autoantibodies to self-antigens. The involvement of the exocrine glands drives the pathognomonic manifestations of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) that define sicca syndrome.
  • 1.8K
  • 01 Nov 2022
Topic Review
Eye Diseases Associated with Oral Pathogens
Even before the advancement of sophisticated molecular biology techniques, eye diseases were regarded as manifestations of infections in the mouth. A few of the ancient studies interrelated the resolution of the given disease upon elimination of oral sepsis by extraction of the infected teeth. In this context, bacteria and or their toxic metabolites and reflex nervous irritation were considered to be the crucial factors. In successive years, the concept of “oral foci of infection” lost its attention. Nonetheless, there are many studies successively acknowledged periodontitis as a risk factor in the pathogenesis of assorted inflammatory eye diseases including scleritis, iritis, glaucoma, diabetic retinopathy (DR), uveitis, retinitis pigmentosa (RP), and Sjogren syndrome (SS).
  • 1.8K
  • 27 Jun 2022
Topic Review
FDA-Approved Multiple Sclerosis Drugs
The molecular effects of traditional and more recently FDA-approved Multiple Sclerosis (MS) drugs on four CNS cell types.
  • 1.8K
  • 26 Oct 2020
Topic Review
Endocannabinoid System (ECS)
The endocannabinoid system (ECS) is an essential signaling system in mammal physiology regulating several biological and disease conditions. ECS’s three main components are (i) cannabinoids receptors (CBR) CBR-1 and CBR-2; (ii) signaling molecules that are lipid-based termed the “endocannabinoids” (EC), endogenous ligands of the CBRs; and (iii) enzymes responsible for synthesizing and degrading ECs. ECS regulates multiple physiological processes, such as brain plasticity and neuronal development, cell death, inflammation, sleep, appetite, pain, and anxiety.
  • 1.8K
  • 24 Mar 2022
Topic Review
Senescence-Associated Secretory Phenotype
The Senescence-Associated Secretory Phenotype (SASP), also known as Senescence-Messaging Secretome (SMS), is one of the fundamental characteristics of the senescent cell, consisting in the abundant secretion of generally proinflammatory compounds in the tissue microenvironment.
  • 1.7K
  • 16 Apr 2021
Topic Review
NLRP3 Inflammasome Regulatory Mechanisms
The inflammasome is an intracellular molecular complex, which is mainly involved in innate immunity. Inflammasomes are formed in response to danger signals, associated with infection and injury, and mainly regulate the secretion of interleukin-1β and interleukin-18. Inflammasome dysregulation is known to be associated with various diseases and conditions, and its regulatory mechanisms have become of great interest in recent years. In the colon, inflammasomes have been reported to be associated with autophagy and the microbiota, and their dysregulation contributes to colitis and. However, the detailed role of inflammasomes in inflammatory bowel disease is still under debate because the mechanisms that regulate the inflammasome are complex and the inflammasome components and cytokines show seemingly contradictory multiple effects. 
  • 1.7K
  • 18 Jan 2021
Topic Review
T Cells and Adaptive Immune System in SARS-CoV-2
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prior COVID-19 research on immunogens understandably focused on nAb responses, with less interest in overall cellular immunity. Interestingly, there is data accumulating which suggests that T cell responses are an important player in both natural and adaptive immunity as well as vaccine protection against chronic COVID-19 disease.
  • 1.7K
  • 20 Feb 2023
Topic Review
PANoptosis
Consideration of the totality of biological effects from cell death in multiple studies has led to the conceptualization of PANoptosis, a unique inflammatory cell death pathway that integrates components from other cell death pathways. PANoptosis is implicated in driving innate immune responses and inflammation and cannot be individually accounted for by pyroptosis, apoptosis, or necroptosis alone. PANoptosis is regulated by multifaceted macromolecular complexes called PANoptosomes.
  • 1.7K
  • 02 Jun 2022
Topic Review
CD44 Receptor
CD44 is a receptor described as a single span transmembrane glycoprotein without kinase activity whose ubiquitous and constitutive expression has been observed on many different cells.
  • 1.7K
  • 18 Mar 2021
Topic Review
Pathophysiology of Cerebral Malaria and Treatment
Plasmodium falciparum causes over 90 percent of all malaria infections. Children under the age of 5 years and pregnant women were the most susceptible groups affected by malaria. The World Health Organization (WHO) has characterized malaria as severe and uncomplicated. Delays in the detection and treatment of an uncomplicated infection of P. falciparum malaria lead to complications of severe cerebral malaria (CM). CM is usually caused by P. falciparum, but Plasmodium vivax is rarely responsible for CM complications. CM is a severe neurological complication caused by Plasmodium falciparum infection, resulting in high mortality rates. CM is characterized by brain tissue hemorrhage, the accumulation of infected red blood cells and mononuclear cells in brain microvessels, and blood-brain barrier (BBB) disruption. 
  • 1.7K
  • 11 Jul 2022
Topic Review
T-Cell Receptor Repertoire Sequencing and Its Applications
The immune system is a dynamic feature of each individual and a footprint of our unique internal and external exposures. Indeed, the type and level of exposure to physical and biological agents shape the development and behavior of this complex and diffuse system. Many pathological conditions depend on how our immune system responds or does not respond to a pathogen or a disease or on how the regulation of immunity is altered by the disease itself. T-cells are important players in adaptive immunity and, together with B-cells, define specificity and monitor the internal and external signals that our organism perceives through its specific receptors, TCRs and BCRs, respectively. Today, high-throughput sequencing (HTS) applied to the TCR repertoire has opened a window of opportunity to disclose T-cell repertoire development and behavior down to the clonal level. Although TCR repertoire sequencing is easily accessible today, it is important to deeply understand the available technologies for choosing the best fit for the specific experimental needs and questions. Here, an updated overview of TCR repertoire sequencing strategies, providers and applications to infectious diseases and cancer to guide researchers’ choice through the multitude of available options is provided. The possibility of extending the TCR repertoire to HLA characterization will be of pivotal importance in the near future to understand how specific HLA genes shape T-cell responses in different pathological contexts and will add a level of comprehension that was unthinkable just a few years ago.
  • 1.6K
  • 24 Aug 2022
Topic Review
Tumor-Associated Macrophages in Targeting Solid Cancers
Macrophages are effector cells of the innate immune system, which can play a crucial role in the generation of anti-tumor immunity through their ability to phagocytose cancer cells and present tumor antigens to the cells of adaptive immunity. However, the macrophages that are recruited to the tumor microenvironment predominantly play pro-tumorigenic roles. Several strategies targeting pro-tumorigenic functions and harnessing the anti-tumorigenic properties of macrophages have shown promising results in preclinical studies, and a few of them have also advanced to clinical trials. 
  • 1.6K
  • 06 Jan 2023
Topic Review
Roles of the CXCL8-CXCR1/2 Axis in Cancer
In humans, Interleukin-8 (IL-8 or CXCL8) is a granulocytic chemokine with multiple roles within the tumor microenvironment (TME), such as recruiting immunosuppressive cells to the tumor, increasing tumor angiogenesis, and promoting epithelial-to-mesenchymal transition (EMT). 
  • 1.6K
  • 29 Mar 2022
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