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Topic Review
Rectal Prolapse
Rectal prolapse is a condition that can cause significant social impairment and negatively affects quality of life. Surgery is the mainstay of treatment, with the aim of restoring the anatomy and correcting the associated functional disorders.
  • 879
  • 28 Jul 2021
Topic Review
Electromagnetic Microrobotic Platforms for Biomedical Applications
Magnetic microrobotics is a promising technology for improving minimally invasive surgery (MIS) with the ambition of enhancing patient care and comfort. The potential benefits include limited incisions, less hemorrhaging and postoperative pain, and faster recovery time. To achieve this, a key issue relies on the design of a proper electromagnetic actuation (EMA) setup which is based on the use of magnetic sources. The magnetic field and its gradient generated by the EMA platform is then used to induce magnetic torque and force for microrobot manipulations inside the human body. Like any control systems, the EMA system must be adapted to the given controlled microrobot and customized for the application. 
  • 871
  • 24 Jan 2022
Topic Review
The History of Blood Vessel Anastomosis
Surgical technique and technology frequently coevolve. The brief history of blood vessel anastomosis is full of famous names. While the techniques pioneered by these surgeons have been well described, the technology that facilitated their advancements and their inventors deserve recognition. The mass production of laboratory microscopes in the mid-1800s allowed for an explosion of interest in tissue histology. This improved understanding of vascular physiology and thrombosis laid the groundwork for Carrel and Guthrie to report some of the first successful vascular anastomoses. In 1916, McLean discovered heparin. Twenty-four years later, Gordon Murray found that it could prevent thrombosis when performing end-to-end anastomosis. These discoveries paved the way for the first-in-human kidney transplantations. Otolaryngologists Nylen and Holmgren were the first to bring the laboratory microscope into the operating room, but Jacobson was the first to apply these techniques to microvascular anastomosis. His first successful attempt in 1960 and the subsequent development of microsurgical tools allowed for an explosion of interest in microsurgery, and several decades of innovation followed.
  • 837
  • 15 Mar 2022
Topic Review
The Bone Regeneration
Bone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells.
  • 825
  • 13 May 2021
Topic Review
Helix
Helices are the most common secondary structural elements in many functional proteins and have attracted much interest when examining the formation kinetics from a coil structure. Measurements describing the timescale to a helix from a coiled structure have been substantially improved with the availability of spectrophotometers with a dramatically improved time resolution. Early studies showed that helix–coil transitions occur in the 100-nanosecond range with a model helix near room temperature.
  • 821
  • 01 Feb 2022
Topic Review
Augmented Reality in Surgery
Augmented reality (AR) is an innovative system that enhances the real world by superimposing virtual objects on reality. The application of AR in image-guided surgery (IGS) can be an increasingly important opportunity for the treatment of patients. In particular, AR allows one to see 3D images projected directly onto patients thanks to the use of special displays.
  • 792
  • 09 Aug 2022
Topic Review
The Association of Gut Microbiota in Gastrointestinal-Cancer Therapies
The gut microbiome of patients with gastrointestinal cancer undergoes specific changes during different therapies such as surgery, chemotherapy and radiation. Likewise, complications of these therapies are associated with specific changes in the microbiome. 
  • 773
  • 02 Nov 2021
Topic Review
Cystine and Theanine
Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine. It is one of the strongest antioxidants in the body and important for adjusting immune function. Cystine and theanine (γ-glutamylethylamide) provide substrates of GSH, cysteine and glutamic acid, promoting the synthesis of GSH.
  • 773
  • 11 Jan 2022
Topic Review
Classifying Oligometastatic Non-Small Cell Lung Cancer
Oligometastatic non-small cell lung cancer (NSCLC) represents a subset of patients with limited metastatic spread and the potential for achieving long-term survival, or even cure, with LCT to all sites of disease. Patient selection for aggressive local treatment of oligometastatic NSCLC would be facilitated by a common definition of what constitutes oligometastasis. The definition of oligometastasis by LCT treatment feasibility is vague and elusive, particularly in the context of ever-improving local treatment modalities.
  • 768
  • 10 Dec 2021
Topic Review
Cardiothoracic Surgical Critical Care Medicine
Cardiothoracic surgical critical care medicine (CT-CCM) is a medical discipline centered on the perioperative care of diverse groups of patients. With an aging demographic and an increase in burden of chronic diseases the utilization of cardiothoracic surgical critical care units is likely to escalate. Given these projections, it is important to assess the state of cardiothoracic surgical intensive care, to develop goals and objectives for the future, and to identify knowledge gaps in need of scientific inquiry.
  • 767
  • 09 Jan 2023
Topic Review
Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is considered superior to endoscopic mucosal resection as an endoscopic resection because of its higher en bloc resection rate, but it is more difficult to perform. As ESD techniques have become more common, and the range of treatment by ESD has expanded, the number of possible complications has also increased, and endoscopists need to manage them.
  • 765
  • 18 Jun 2021
Topic Review
Effect of Sodium Fluorescein on High-Grade Gliomas
High-grade gliomas (HGG) are the most common primary malignant brain cancer in adults. Complete surgical removal of HGG is known to increase the overall survival and progression-free survival. Fluorescence-guided surgery with 5-aminolevulinic acid (5-ALA) increases gross total resection considerably compared to white light surgery (65% vs. 36%). Recently, an off-label fluorophore, sodium fluorescein (SF), has become popular in fluorescence-guided surgery due to numerous utility benefits compared to 5-ALA, including lower cost, non-toxicity, easy administration during surgery and a wide indication for other CNS tumors.
  • 759
  • 28 Feb 2022
Topic Review
Liver Surgery
Major high-risk surgery (HRS) exposes patients to potential perioperative adverse events. Hepatic resection of colorectal metastases can surely be included into the HRS class of operations. Limiting such risks is the main target of the perioperative medicine.
  • 758
  • 24 May 2021
Topic Review
Treatment of Peritoneal Metastasis
Surgical and locoregional treatments of peritoneal metastasis have gained increasing acceptance. Apart from systemic chemotherapy and surgical removal of the tumor, locoregional therapies such as cytoreductive surgery (CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC) or pressurized intraperitoneal aerosol chemotherapy (PIPAC) may improve tumor control. 
  • 728
  • 25 Feb 2022
Topic Review
Correlation of Tumor Location and Sleep Disturbance
Sleep disturbance can occur when sleep centers of the brain, regions that are responsible for coordinating and generating healthy amounts of sleep, are disrupted by glioma growth or surgical resection. Several disorders cause disruptions to the average duration, quality, or patterns of sleep, resulting in sleep disturbance.
  • 720
  • 28 Jun 2023
Topic Review
Regenerative Treatment for Osteoarthritis Disease
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure. The etiology of OA is multifactorial. Currently, therapies are mainly addressing the physical and occupational aspects of osteoarthritis using pharmacologic pain treatment and/or surgery to manage the symptomatology of the disease with no specific regard to disease progression or prevention.
  • 719
  • 14 Jun 2022
Topic Review
Nanoscalpel for Cancer Treatment
Magnetomechanical therapy is one of the most promising areas in tumor microsurgery. The nanoscalpel can become a tool sufficient for cancer microsurgery. In order to achieve this, It should meet the following requirements: (1) to be nano- or micro-sized; (2) to have affinity and specificity for targets on tumor cells; (3) to have the ability for remote control. This nano- or microscalpel should include at least two components: (1) a physical nanostructure (particle, disk, plate) capable of converting a magnetic moment into a mechanical moment; and (2) a ligand molecule (antibody, aptamer, etc.) that allows the scalpel to accurately target tumor cells. The most suitable structures for nanoscalpel are anisotropic, magnetic micro- or nanodiscs with high saturation magnetization and no remanent magnetization. This type of material would facilitate remote control of the scalpel through a magnetic field. In addition, anisotropy enhances the transmigration of discs to the tumor. Today, four types of magnetic microdiscs are used for tumor destruction: synthetic antiferromagnetic P-SAF (perpendicular) and SAF (planar), vortex Py and three-layer non-magnetic-ferromagnetic-non-magnetic systems with flat quasi-dipole magnetic structures.
  • 705
  • 25 Jun 2021
Topic Review
Adult Abdominal Tuberculosis Diagnosis
Tuberculosis is a common systemic infection with the bacteria Mycobacterium tuberculosis, which is primarily found in the lungs and causes caseous inflammation in lung tissue and other organs. Tuberculosis is an infectious disease that spreads via the air. Tuberculosis is an endemic disease in developing countries, due to the wide spread of acquired immunodeficiency syndrome (AIDS), it might represent a problem in developed countries, as well. Only around one-fifth of patients diagnosed with abdominal TB have pulmonary disease. 
  • 702
  • 29 Mar 2022
Topic Review
Infectious complications after esophagectomy for esophageal cancer
Despite advances in the perioperative management of esophagectomy, it is still a highly invasive procedure for esophageal cancer and is associated with severe postoperative complications. The two major postoperative infectious complications after esophagectomy are pulmonary complications and anastomotic leakage. 
  • 689
  • 21 Oct 2021
Topic Review
Chitosan-Based Materials and Devices
Chitosan is one of the most studied polysaccharides in recent decades for its biomedical application. This polymer is derived from chitin, the main component in the exoskeleton of insects and crustaceans, a homopolymer consisting of β-(1→4)-N-acetyl-D-glucosamine. The degree of deacetylation of chitosan depends on the conditions applied during the deacetylation process—such as temperature or sodium hydroxide concentration—and determines various properties of the polymer, such as pKa, solubility, and viscosity. Chitosan has been used in a broad assortment of medical materials and devices. Each system benefits from the properties that chitosan can provide for surgical applications. The shape, porosity, consistency, and size of the fabricated systems can be precisely tuned for the intended application.
  • 688
  • 11 Jul 2022
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