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Topic Review
Growth Factors Regulation in Angiogenesis
Cardiovascular disease (CVD) remains a major cause of morbidity and mortality all over the world. Angiogenesis is controlled by cell–cell and cell-extracellular matrix (ECM) interactions through crosstalk between vascular endothelial growth factor (VEGF) and Notch signaling mechanisms. 
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  • 31 May 2023
Topic Review
Halophytes of the Mediterranean Basin
Halophytes represent an ancient and remarkable ecological group of annual or perennial plants with very complex features, whose definition and classification are still not univocal and often controversial. The species belonging to this group are very different from an ecological, morpho–physiological, and taxonomic point of view. Therefore, their definition can be subjective and vary a lot in the literature according to the different interpretations. However, following the most popular definition used in the literature, halophytes can be identified as plants that grow naturally, and complete their life cycle in environments that contain a higher salt content than most plant species can tolerate.
  • 4.7K
  • 23 Mar 2022
Topic Review
List of Aircraft (H)
This is a list of aircraft in alphabetical order beginning with 'H'.
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  • 08 Nov 2022
Topic Review
Biomarkers in FLT3 Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation of clonal myeloid blast cells that are incapable of maturation to leukocytes. AML is the most common leukemia in adults and remains a highly fatal disease with a five-year survival rate of 24%. More than 50% of AML patients have mutations in the FLT3 gene, rendering FLT3 an attractive target for small-molecule inhibition. Currently, there are several FLT3 inhibitors in the clinic, and others remain in clinical trials. However, these inhibitors face challenges due to lack of efficacy against several FLT3 mutants. Therefore, the identification of biomarkers is vital to stratify AML patients and target AML patient population with a particular FLT3 mutation.
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  • 03 Mar 2022
Topic Review
Avalokiteśvara
Avalokiteśvara or Padmapani (/ˌʌvəloʊkɪˈteɪʃvərə/ UV-əl-oh-kih-TAY-shvər-ə; Sanskrit: अवलोकितेश्वर) is a bodhisattva who embodies the compassion of all Buddhas. This bodhisattva is variably depicted, described and portrayed in different cultures as either male or female. In Tibet, he is known as Chenrezik, and in Cambodia as អវលោកិតេស្វរៈ.Cite error: Invalid tag; refs with no name must have content In Chinese Buddhism, Avalokiteśvara has evolved into the somewhat different female figure Guanyin. In Japan this figure is known as Kanzeon or Kannon.
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  • 17 Oct 2022
Topic Review
Alcohol
In chemistry, alcohol is an organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. The term alcohol originally referred to the primary alcohol ethanol (ethyl alcohol), which is used as a drug and is the main alcohol present in alcoholic drinks. An important class of alcohols, of which methanol and ethanol are the simplest members, includes all compounds for which the general formula is CnH2n+1OH. Simple monoalcohols that are the subject of this article include primary (RCH2OH), secondary (R2CHOH) and tertiary (R3COH) alcohols. The suffix -ol appears in the IUPAC chemical name of all substances where the hydroxyl group is the functional group with the highest priority. When a higher priority group is present in the compound, the prefix hydroxy- is used in its IUPAC name. The suffix -ol in non-IUPAC names (such as paracetamol or cholesterol) also typically indicates that the substance is an alcohol. However, many substances that contain hydroxyl functional groups (particularly sugars, such as glucose and sucrose) have names which include neither the suffix -ol, nor the prefix hydroxy-.
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  • 27 Oct 2022
Topic Review
Degrees of Freedom (Physics and Chemistry)
In physics and chemistry, a degree of freedom is an independent physical parameter in the formal description of the state of a physical system. The set of all states of a system is known as the system's phase space, and the degrees of freedom of the system are the dimensions of the phase space. The location of a particle in three-dimensional space requires three position coordinates. Similarly, the direction and speed at which a particle moves can be described in terms of three velocity components, each in reference to the three dimensions of space. If the time evolution of the system is deterministic (where the state at one instant uniquely determines its past and future position and velocity as a function of time) such a system has six degrees of freedom. If the motion of the particle is constrained to a lower number of dimensions – for example, the particle must move along a wire or on a fixed surface – then the system has fewer than six degrees of freedom. On the other hand, a system with an extended object that can rotate or vibrate can have more than six degrees of freedom. In classical mechanics, the state of a point particle at any given time is often described with position and velocity coordinates in the Lagrangian formalism, or with position and momentum coordinates in the Hamiltonian formalism. In statistical mechanics, a degree of freedom is a single scalar number describing the microstate of a system. The specification of all microstates of a system is a point in the system's phase space. In the 3D ideal chain model in chemistry, two angles are necessary to describe the orientation of each monomer. It is often useful to specify quadratic degrees of freedom. These are degrees of freedom that contribute in a quadratic function to the energy of the system. Depending on what one is counting, there are several different ways that degrees of freedom can be defined, each with a different value.
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  • 25 Nov 2022
Topic Review
Mindfulness
Mindfulness is the psychological process of purposely bringing one's attention to experiences occurring in the present moment without judgment which one develops through the practice of meditation and through other training. Mindfulness derives from sati, a significant element of Buddhist traditions, and based on Zen, Vipassanā, and Tibetan meditation techniques. Though definitions and techniques of mindfulness are wide-ranging, Buddhist traditions explain what constitutes mindfulness such as how past, present and future moments arise and cease as momentary sense impressions and mental phenomena. Individuals who have contributed to the popularity of mindfulness in the modern Western context include Thích Nhất Hạnh (1926– ), Herbert Benson (1935– ), Jon Kabat-Zinn (1944– ), and Richard J. Davidson (1951– ). Clinical psychology and psychiatry since the 1970s have developed a number of therapeutic applications based on mindfulness for helping people experiencing a variety of psychological conditions. Mindfulness practice has been employed to reduce depression, to reduce stress, anxiety, and in the treatment of drug addiction. Programs based on mindfulness models have been adopted within schools, prisons, hospitals, veterans' centers, and other environments, and mindfulness programs have been applied for additional outcomes such as for healthy aging, weight management, athletic performance, helping children with special needs, and as an intervention during the perinatal period. Clinical studies have documented both physical- and mental-health benefits of mindfulness in different patient categories as well as in healthy adults and children. Research studies have shown a positive relationship between trait mindfulness (see below) and psychological health. The practice of mindfulness appears to provide therapeutic benefits to people with psychiatric disorders, including moderate benefits to those with psychosis. Studies also indicate that rumination and worry contribute to a variety of mental disorders, and that mindfulness-based interventions can reduce both rumination and worry. Further, the practice of mindfulness may be a preventive strategy to halt the development of mental-health problems. There is also evidence that suggest engaging in mindfulness meditation may influence physical health. For example, the psychological habit of repeatedly dwelling on stressful thoughts (i.e., rumination) appears to intensify the physiological effects of the stressor (as a result of the continual activation of the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis) with the potential to lead to physical health related clinical manifestations. Studies indicate that mindfulness meditation, which brings about reductions in rumination, may alter these biological clinical pathways. Further, research indicates that mindfulness may favourably influence the immune system as well as inflammation,Cite error: Closing missing for tag
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  • 12 Oct 2022
Topic Review
Bicentric Quadrilateral
In Euclidean geometry, a bicentric quadrilateral is a convex quadrilateral that has both an incircle and a circumcircle. The radii and center of these circles are called inradius and circumradius, and incenter and circumcenter respectively. From the definition it follows that bicentric quadrilaterals have all the properties of both tangential quadrilaterals and cyclic quadrilaterals. Other names for these quadrilaterals are chord-tangent quadrilateral and inscribed and circumscribed quadrilateral. It has also rarely been called a double circle quadrilateral and double scribed quadrilateral. If two circles, one within the other, are the incircle and the circumcircle of a bicentric quadrilateral, then every point on the circumcircle is the vertex of a bicentric quadrilateral having the same incircle and circumcircle. This is a corollary of Poncelet's porism, which was proved by the French mathematician Jean-Victor Poncelet (1788–1867).
  • 4.7K
  • 02 Nov 2022
Biography
Jürgen Habermas
Jürgen Habermas (born 18 June 1929) is a German philosopher and sociologist in the tradition of critical theory and pragmatism. His work addresses communicative rationality and the public sphere. Associated with the Frankfurt School, Habermas's work focuses on the foundations of epistemology and social theory, the analysis of advanced capitalism and democracy, the rule of law in a critical soc
  • 4.7K
  • 28 Nov 2022
Topic Review
Telugu Script
Telugu script (Telugu: తెలుగు లిపి, romanized: Telugu lipi), an abugida from the Brahmic family of scripts, is used to write the Telugu language, a Dravidian language spoken in the India n states of Andhra Pradesh and Telangana as well as several other neighbouring states. The Telugu script is also widely used for writing Sanskrit texts and to some extent the Gondi language. It gained prominence during the Eastern Chalukyas also known as Vengi Chalukya era. It shares extensive similarities with the Kannada script, as it has evolved from Kadamba and Bhattiprolu scripts of the Brahmi family. In 2008, Telugu language was given the status of Classical Languages of India, this status owes to its rich history and heritage.
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  • 14 Oct 2022
Topic Review
Muscle Tone Physiology
The simple definition of tone as the resistance to passive stretch is physiologically a complex interlaced network encompassing neural circuits in the brain, spinal cord, and muscle spindle. Disorders of muscle tone can arise from dysfunction in these pathways and manifest as hypertonia or hypotonia. The loss of supraspinal control mechanisms gives rise to hypertonia, resulting in spasticity or rigidity. On the other hand, dystonia and paratonia also manifest as abnormalities of muscle tone, but arise more due to the network dysfunction between the basal ganglia and the thalamo-cerebello-cortical connections. 
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  • 19 May 2021
Topic Review
Challenges to Renewable Energy Transition in China
Climate change and energy issues have become the prominent global challenge and a major concern of China. China’s energy sector, which heavily relies on fossil energy, especially coal, is the largest contributor to China’s carbon emissions. According to the International Energy Agency (IEA), China’s energy consumption accounts for nearly 90% of China’s total CO2 emissions in 2020. The carbon neutrality target poses a huge challenge to China’s energy system, causing energy transition to be the key to the overall decarbonization of China’s economy and society.
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  • 07 Dec 2022
Topic Review
Hotels' Services and Amenities for Family Tourism
Travelling families are interested in urban tourism due to its cognitive and entertainment aspects. Some expectations of parents travelling with children are the same independent of the accommodation location. It can be stated that the most important factor regarding family tourism, which should make the services and amenities offered by hotels diverse, is the age of children. It is their age that determines childrens’ needs and interests from the earliest period of infancy to early school age. The biggest challenge for the hoteliers is to prepare an offer that meets the expectations of families with children of different ages (the greater the age difference is, the more difficult it becomes to meet parents’ requirements regarding amenities and hotel facilities).
  • 4.7K
  • 04 Aug 2022
Topic Review
Start School Later Movement
The movement to start school later consists of efforts by health care professionals, sleep scientists, educators, economists, legislators, parents, students, and other concerned citizens to restore a later start to the school day. Based on a growing body of evidence that starting middle and high schools too early in the morning is unhealthy, counterproductive, and incompatible with adolescent sleep needs and patterns. During the second half of the 20th century, many public schools in the United States began shifting instructional time earlier than the more conventional bell time, thought to be about 9 a.m. Today it is common for American schools to begin the instructional day in the 7 a.m. hour and end about seven hours later, around 2 p.m. Most sleep research suggests that morning classes should begin no earlier than 8:30 a.m. for middle and high school students. Advocates of a return to later school start times argue that sleep and school hours should be viewed as a public health issue, citing evidence linking early school start times to widespread sleep deprivation among teenagers as well as a wide array of acute and chronic physical, psychological, and educational problems. Not only do students consistently get significantly more sleep on school nights when their schools move to later start times, but later school hours have been consistently linked with improved school performance, reduced impulsiveness, and greater motivation, as well as with lower rates of depression, tardiness, truancy, and morning automobile accidents. Recent (2011) studies suggest that early school start times disproportionately hurt economically disadvantaged students and may even negatively impact future earning potential of students, offsetting any financial savings to the school system attributed to earlier hours.
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  • 06 Oct 2022
Topic Review
Financial Accounting and Sustainability Accounting
A phenomenon in development of accounting knowledge is the generalisation of accounting  principles and concepts from the traditional (financial) domain/context to the sustainability domain/context. This phenomenon draws debates between two schools. Some scholars support the way of simulation, maintaining it is necessary and inevitable for sustainability accounting researchers and practitioners to draw knowledge the financial accounting that has been familiar for them. But some scholars take a critical stance against the simulation, arguing that it is too difficult to apply financial accounting concepts to sustainability practices, for the two accounting contexts are significantly different from each other. But the sustainability accounting application of the materiality concept indicates another side of the phenomenon. That is, sustainability accounting academy should neither give up or discourage the way of generalisation, nor simply and directly simulate the definitions and practices of financial accounting concepts. 
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  • 29 Oct 2020
Topic Review
Smallpox Vaccine
The smallpox vaccine is the first vaccine to be developed against a contagious disease. In 1796, the British doctor Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus. Cowpox served as a natural vaccine until the modern smallpox vaccine emerged in the 20th century. From 1958 to 1977, the World Health Organization (WHO) conducted a global vaccination campaign that eradicated smallpox, making it the only human disease to be eradicated. Although routine smallpox vaccination is no longer performed on the general public, the vaccine is still being produced to guard against bioterrorism, biological warfare, and monkeypox. The term vaccine derives from the Latin word for cow, reflecting the origins of smallpox vaccination. Edward Jenner referred to cowpox as variolae vaccinae (smallpox of the cow). The origins of the smallpox vaccine became murky over time, especially after Louis Pasteur developed laboratory techniques for creating vaccines in the 19th century. Allan Watt Downie demonstrated in 1939 that the modern smallpox vaccine was serologically distinct from cowpox, and vaccinia was subsequently recognized as a separate viral species. Whole-genome sequencing has revealed that vaccinia is most closely related to horsepox, and the cowpox strains found in Great Britain are the least closely related to vaccinia.
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  • 14 Apr 2023
Topic Review
Prussian Blue
Efficient water remediation methods towards the extraction of 137Cs are being studied. Prussian blue (PB) and its analogs have shown very high efficiencies in the capture of 137Cs+ ions.
  • 4.7K
  • 07 Jun 2021
Topic Review
Creation–Evolution Controversy
The creation–evolution controversy (also termed the creation vs. evolution debate or the origins debate) involves an ongoing, recurring cultural, political, and theological dispute about the origins of the Earth, of humanity, and of other life. Species were once widely believed to be fixed products of divine creation in accordance with creationism, but since the mid-19th century evolution by natural selection has been established as an empirical scientific fact. The debate is religious, not scientific: in the scientific community, evolution is accepted as fact and efforts to sustain the traditional view are almost universally regarded as pseudoscience. While the controversy has a long history, today it has retreated to be mainly over what constitutes good science education, with the politics of creationism primarily focusing on the teaching of creationism in public education. Among majority-Christian countries, the debate is most prominent in the United States, where it may be portrayed as part of a culture war. Parallel controversies also exist in some other religious communities, such as the more fundamentalist branches of Judaism and Islam. In Europe and elsewhere, creationism is less widespread (notably, the Catholic Church and Anglican Communion both accept evolution), and there is much less pressure to teach it as fact. Christian fundamentalists repudiate the evidence of common descent of humans and other animals as demonstrated in modern paleontology, genetics, histology and cladistics and those other sub-disciplines which are based upon the conclusions of modern evolutionary biology, geology, cosmology, and other related fields. They argue for the Abrahamic accounts of creation, and, in order to attempt to gain a place alongside evolutionary biology in the science classroom, have developed a rhetorical framework of "creation science". In the landmark Kitzmiller v. Dover, the purported basis of scientific creationism was exposed as a wholly religious construct without formal scientific merit. The Catholic Church now recognizes the existence of evolution (see Catholic Church and evolution). Pope Francis has stated: "God is not a demiurge or a magician, but the Creator who brought everything to life...Evolution in nature is not inconsistent with the notion of creation, because evolution requires the creation of beings that evolve." The rules of genetic evolutionary inheritance were first discovered by a Catholic priest, the Augustinian monk Gregor Mendel, who is known today as the founder of modern genetics. According to a 2014 Gallup survey, "More than four in 10 Americans continue to believe that God created humans in their present form 10,000 years ago, a view that has changed little over the past three decades. Half of Americans believe humans evolved, with the majority of these saying God guided the evolutionary process. However, the percentage who say God was not involved is rising." A 2015 Pew Research Center survey found "that while 37% of those older than 65 thought that God created humans in their present form within the last 10,000 years, only 21% of respondents between the ages of 18 and 29 agreed." The debate is sometimes portrayed as being between science and religion, and the United States National Academy of Sciences states:
  • 4.7K
  • 10 Nov 2022
Topic Review
Hybrid Circuit Breaker
One of the hurdles in the LVDC distribution system is arc flash at the contact points that occurs during the circuit is opening. Unlike alternating current, direct current has no zero points and sustains constantly.  Through 400V class LVDC cutoff test, the operation of the proposed hybrid circuit breaker is verified and the characteristics are analyzed. 
  • 4.7K
  • 24 Jun 2021
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