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Topic Review
NAFLD and Cardiovascular Comorbidities
Non-alcoholic fatty liver disease (NAFLD) is a liver disease that can progress from hepatic steatosis to steatohepatitis and even cirrhosis and hepatocellular carcinoma. From the histopathological point of view, it is characterized by excess storage of macrovesicular fat in hepatocytes. These macrovesicular storages are composed of triglycerides that accumulate in the liver. The process can lead in some individuals to an inflammatory response, which is responsible for steatohepatitis, that leads to fibrosis and, finally, cirrhosis.NAFLD has a growing prevalence in recent years. Its association with cardiovascular disease has been intensively studied, and certain correlations have been identified. The connection between these two entities has lately aroused interest regarding therapeutic management. 
  • 4.7K
  • 07 May 2021
Topic Review Peer Reviewed
John II Komnenos (1118–1143)
John II Komnenos was the son of Emperor Alexios I Komnenos and Eirene Doukaina, and brother of Princess Anna Komnene, the author of the Alexiad. Born in 1087, he was crowned soon after his fifth birthday as co-emperor with his father, and in 1105, he was married to Piroska Árpád, daughter of King Ladislaus I of Hungary and Adelaide of Rheinfelden. He is principally known for continuing his father’s work of stabilising Byzantium after the crises of the eleventh century. This included major wars of defence and conquest in both the Balkans and Anatolia, and especially a major eastern expedition in 1137–1139. During this campaign, he conquered Cilicia, but he was recalled to defend his borders against the Turks before he could make further conquests in Syria and bring the crusader states under his aegis. He died in a hunting accident just before he returned to Syria, with intentions to go to Jerusalem as well. His best-known iconographic representation is a mosaic of him and his wife in the Great Church of Sophia. Whilst there is also an image of him in a contemporary ornate gospel book, his most common representations are found on his many coin issues and seals. 
  • 4.7K
  • 13 Apr 2022
Topic Review
List of Aircraft (H)
This is a list of aircraft in alphabetical order beginning with 'H'.
  • 4.7K
  • 08 Nov 2022
Topic Review
Jungle Warfare
Jungle warfare is a term used to cover the special techniques needed for military units to survive and fight in jungle terrain. It has been the topic of extensive study by military strategists, and was an important part of the planning for both sides in many conflicts, including World War II and the Vietnam War. The jungle has a variety of effects on military operations. Dense vegetation can limit lines of sight and arcs of fire, but can also provide ample opportunity for camouflage and plenty of material with which to build fortifications. Jungle terrain, often without good roads, can be inaccessible to vehicles and so makes logistical supply and transport difficult, which in turn places a premium on air mobility. The problems of transport make engineering resources important as they are needed to improve roads, build bridges and airfields, and improve water supplies. Jungle environments can also be inherently unhealthy, with various tropical diseases that have to be prevented or treated by medical services. Likewise the terrain can make it difficult to deploy armoured forces, or any other kind of forces on any large scale. Successful jungle fighting emphasises effective small unit tactics and leadership.
  • 4.7K
  • 09 Nov 2022
Topic Review
Hybrid Circuit Breaker
One of the hurdles in the LVDC distribution system is arc flash at the contact points that occurs during the circuit is opening. Unlike alternating current, direct current has no zero points and sustains constantly.  Through 400V class LVDC cutoff test, the operation of the proposed hybrid circuit breaker is verified and the characteristics are analyzed. 
  • 4.7K
  • 24 Jun 2021
Topic Review
SpaceX Dragon
Dragon, also known as Dragon 1 or Cargo Dragon, was a class of partially reusable cargo spacecraft developed by SpaceX, an American private space transportation company. Dragon was launched into orbit by the company's Falcon 9 launch vehicle to resupply the International Space Station (ISS). During its maiden flight in December 2010, Dragon became the first commercially built and operated spacecraft to be recovered successfully from orbit. On 25 May 2012, a cargo variant of Dragon became the first commercial spacecraft to successfully rendezvous with and attach to the ISS. SpaceX is contracted to deliver cargo to the ISS under NASA's Commercial Resupply Services program, and Dragon began regular cargo flights in October 2012. With the Dragon spacecraft and the Orbital ATK Cygnus, NASA seeks to increase its partnerships with domestic commercial aviation and aeronautics industry. On 3 June 2017, the C106 capsule, largely assembled from previously flown components from the CRS-4 mission in September 2014, was launched again for the first time on CRS-11, with the hull, structural elements, thrusters, harnesses, propellant tanks, plumbing and many of the avionics reused, while the heat shield, batteries and components exposed to sea water upon splashdown for recovery were replaced. SpaceX developed a second version called Dragon 2, which is capable of transporting humans. Flight testing was completed in 2019, after a delay caused by a test pad anomaly in April 2019, which resulted in the loss of a Dragon 2 capsule. The first flight of astronauts on Dragon 2 occurred on the Crew Dragon Demo-2 mission in May 2020. The last flight of the first version of the Dragon spacecraft (Dragon 1) launched 7 March 2020 (UTC); it was a cargo resupply mission (CRS-20) to International Space Station (ISS). This mission was the last mission of SpaceX of the first Commercial Resupply Services (CRS-1) program, and marked the retirement of the Dragon 1 fleet. Further SpaceX commercial resupply flights to ISS under the second Commercial Resupply Services (CRS-2) program use the cargo-carrying variant of the SpaceX Dragon 2 spacecraft.
  • 4.7K
  • 12 Oct 2022
Topic Review
Challenges to Renewable Energy Transition in China
Climate change and energy issues have become the prominent global challenge and a major concern of China. China’s energy sector, which heavily relies on fossil energy, especially coal, is the largest contributor to China’s carbon emissions. According to the International Energy Agency (IEA), China’s energy consumption accounts for nearly 90% of China’s total CO2 emissions in 2020. The carbon neutrality target poses a huge challenge to China’s energy system, causing energy transition to be the key to the overall decarbonization of China’s economy and society.
  • 4.7K
  • 07 Dec 2022
Topic Review
Types of Steel Liners
There are significant levels of concern about both the safety assessment and financial evaluation of the whole hydropower system, especially at early project stages. In addition, there is a variety of reliable and accurate methods for analysis, design, and optimization of steel pressure liners in hydropower plants. Several countries have developed specific regulations and codes for the design, installation, and safety evaluation of under-pressure piping, as well as estimates of the potential risks associated with failure. This article reviews the current methodologies and codes available for design and safety assessment of either unstiffened or stiffened pressure steel liners in hydropower plants.
  • 4.7K
  • 28 Mar 2022
Topic Review
Bio-Signals in Medical Applications
Artificial Intelligence (AI) has broadly connected the medical field at various levels of diagnosis based on the congruous data generated. Different types of bio-signal can be used to monitor a patient’s condition and in decision making. Medical equipment uses signals to communicate information to care staff. AI algorithms and approaches will help to predict health problems and check the health status of organs, while AI prediction, classification, and regression algorithms are helping the medical industry to protect from health hazards. The early prediction and detection of health conditions will guide people to stay healthy.
  • 4.7K
  • 03 Mar 2022
Topic Review
Telugu Script
Telugu script (Telugu: తెలుగు లిపి, romanized: Telugu lipi), an abugida from the Brahmic family of scripts, is used to write the Telugu language, a Dravidian language spoken in the India n states of Andhra Pradesh and Telangana as well as several other neighbouring states. The Telugu script is also widely used for writing Sanskrit texts and to some extent the Gondi language. It gained prominence during the Eastern Chalukyas also known as Vengi Chalukya era. It shares extensive similarities with the Kannada script, as it has evolved from Kadamba and Bhattiprolu scripts of the Brahmi family. In 2008, Telugu language was given the status of Classical Languages of India, this status owes to its rich history and heritage.
  • 4.7K
  • 14 Oct 2022
Topic Review
FIB-SEM Tomography: Fundamentals and Applications in Materials Sciences
Focused ion beam (FIB)-scanning electron microscopy (SEM) tomography is an extremely important and reliable technique for the three-dimensional reconstruction of microscopic structures with nanometric resolution, with great potential to be integrated with other analytical techniques. FIB-SEM tomography plays a crucial role in the development of innovative multiscale and multimodal correlative microscopy workflows because it can be seamlessly integrated with other imaging modalities, as the reconstruction range bridges the gap between the non-destructive X-ray families of tomographic techniques, which provide sub-micron resolution, and the nano- to atomic-scale resolution achieved by transmission electron microscopy (TEM) tomography.
  • 4.7K
  • 26 Oct 2023
Topic Review
IB and ND in Poultry
Infectious bronchitis (IB) and Newcastle disease (ND) are among the most important viral diseases of poultry with substantial global economic impact . Infectious bronchitis is caused by the IB virus (IBV), a member of the Gammacoronavirus genus, family Coronaviridae, and subfamily Orthocoronavirinae. IBV is commonly referred to as avian coronavirus and it belongs in the same family and subfamily as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is currently ravaging the world, although the latter is in a different genus—Betacoronavirus. Newcastle disease (ND) is caused by ND virus (NDV), which belongs to the genus Avulavirus in the family Paramyxoviridae. Both viruses have genomes made up of single stranded RNA (ssRNA). 
  • 4.7K
  • 21 Jan 2021
Topic Review
Muscle Tone Physiology
The simple definition of tone as the resistance to passive stretch is physiologically a complex interlaced network encompassing neural circuits in the brain, spinal cord, and muscle spindle. Disorders of muscle tone can arise from dysfunction in these pathways and manifest as hypertonia or hypotonia. The loss of supraspinal control mechanisms gives rise to hypertonia, resulting in spasticity or rigidity. On the other hand, dystonia and paratonia also manifest as abnormalities of muscle tone, but arise more due to the network dysfunction between the basal ganglia and the thalamo-cerebello-cortical connections. 
  • 4.7K
  • 19 May 2021
Topic Review
Hotels' Services and Amenities for Family Tourism
Travelling families are interested in urban tourism due to its cognitive and entertainment aspects. Some expectations of parents travelling with children are the same independent of the accommodation location. It can be stated that the most important factor regarding family tourism, which should make the services and amenities offered by hotels diverse, is the age of children. It is their age that determines childrens’ needs and interests from the earliest period of infancy to early school age. The biggest challenge for the hoteliers is to prepare an offer that meets the expectations of families with children of different ages (the greater the age difference is, the more difficult it becomes to meet parents’ requirements regarding amenities and hotel facilities).
  • 4.7K
  • 04 Aug 2022
Topic Review
Start School Later Movement
The movement to start school later consists of efforts by health care professionals, sleep scientists, educators, economists, legislators, parents, students, and other concerned citizens to restore a later start to the school day. Based on a growing body of evidence that starting middle and high schools too early in the morning is unhealthy, counterproductive, and incompatible with adolescent sleep needs and patterns. During the second half of the 20th century, many public schools in the United States began shifting instructional time earlier than the more conventional bell time, thought to be about 9 a.m. Today it is common for American schools to begin the instructional day in the 7 a.m. hour and end about seven hours later, around 2 p.m. Most sleep research suggests that morning classes should begin no earlier than 8:30 a.m. for middle and high school students. Advocates of a return to later school start times argue that sleep and school hours should be viewed as a public health issue, citing evidence linking early school start times to widespread sleep deprivation among teenagers as well as a wide array of acute and chronic physical, psychological, and educational problems. Not only do students consistently get significantly more sleep on school nights when their schools move to later start times, but later school hours have been consistently linked with improved school performance, reduced impulsiveness, and greater motivation, as well as with lower rates of depression, tardiness, truancy, and morning automobile accidents. Recent (2011) studies suggest that early school start times disproportionately hurt economically disadvantaged students and may even negatively impact future earning potential of students, offsetting any financial savings to the school system attributed to earlier hours.
  • 4.7K
  • 06 Oct 2022
Topic Review
Pluteus Larva
An echinoderm (/ɪˈkaɪnəˌdɜːrm, ˈɛkə-/) is any member of the phylum Echinodermata (/ɪˌkaɪnoʊˈdɜːrmətə/). The adults are recognisable by their (usually five-point) radial symmetry, and include starfish, brittle stars, sea urchins, sand dollars, and sea cucumbers, as well as the sea lilies or "stone lilies". Adult echinoderms are found on the sea bed at every ocean depth, from the intertidal zone to the abyssal zone. The phylum contains about 7,000 living species, making it the second-largest grouping of deuterostomes, after the chordates. Echinoderms are the largest entirely marine phylum. The first definitive echinoderms appeared near the start of the Cambrian. The echinoderms are important both ecologically and geologically. Ecologically, there are few other groupings so abundant in the biotic desert of the deep sea, as well as shallower oceans. Most echinoderms are able to reproduce asexually and regenerate tissue, organs, and limbs; in some cases, they can undergo complete regeneration from a single limb. Geologically, the value of echinoderms is in their ossified skeletons, which are major contributors to many limestone formations, and can provide valuable clues as to the geological environment. They were the most used species in regenerative research in the 19th and 20th centuries. Further, some scientists hold that the radiation of echinoderms was responsible for the Mesozoic Marine Revolution.
  • 4.7K
  • 28 Nov 2022
Topic Review
UV Radiation in DNA Damage and Repair
Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma).
  • 4.7K
  • 27 Dec 2021
Topic Review
Serotonin Pathway
Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine produced from the essential amino acid tryptophan. Serotonin’s role as a neurotransmitter in the central nervous system and a motility mediator in the gastrointestinal tract has been well defined, and its function in tumorigenesis in various cancers (gliomas, carcinoids, and carcinomas) is being studied. Many studies have shown a potential stimulatory effect of serotonin on cancer cell proliferation, invasion, dissemination, and tumor angiogenesis.
  • 4.7K
  • 22 Sep 2021
Topic Review
Human Factors and Road Traffic Safety
Human factors play a huge role in road traffic safety. Research has found that a huge proportion of traffic crashes occur due to some form of human error. Improving road user behavior has been the major strategy that has been emphasized for improving road traffic safety. Meanwhile, despite the training efforts, and testing for drivers, the global status of road traffic safety is alarming.
  • 4.7K
  • 02 Feb 2024
Topic Review
GeForce 700 Series
The GeForce 700 series (stylized as GEFORCE GTX 700 SERIES) is a series of graphics processing units developed by Nvidia. While mainly a refresh of the Kepler microarchitecture (GK-codenamed chips), some cards use Fermi (GF) and later cards use Maxwell (GM). GeForce 700 series cards were first released in 2013, starting with the release of the GeForce GTX Titan on February 19, 2013, followed by the GeForce GTX 780 on May 23, 2013. The first mobile GeForce 700 series chips were released in April 2013.
  • 4.7K
  • 17 Oct 2022
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