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Topic Review
MET in Non-Small-Cell Lung Cancer
Non-Small-Cell Lung Cancer (NSCLC) can harbour different MET alterations, such as MET overexpression (MET OE), MET gene amplification (MET AMP), or MET gene mutations. Retrospective studies of surgical series of patients with MET-dysregulated NSCLC have shown worse clinical outcomes irrespective of the type of specific MET gene alteration. On the other hand, earlier attempts failed to identify the ‘druggable’ molecular gene driver until the discovery of MET exon 14 skipping mutations (METex14). METex14 are rare and amount to around 3% of all NSCLCs. Patients with METex14 NSCLC attain modest results when they are treated with immune checkpoint inhibitors (ICIs). New selective MET inhibitors (MET-Is) showed a long-lasting clinical benefit in patients with METex14 NSCLC and modest activity in patients with MET AMP NSCLC. 
  • 1.2K
  • 19 Oct 2023
Topic Review
Regional-to-Local Point-Voxel Transformer
Semantic segmentation of large-scale indoor 3D point cloud scenes is crucial for scene understanding but faces challenges in effectively modeling long-range dependencies and multi-scale features. Researchers present RegionPVT, a novel Regional-to-Local Point-Voxel Transformer that synergistically integrates voxel-based regional self-attention and window-based point-voxel self-attention for concurrent coarse-grained and fine-grained feature learning. The voxel-based regional branch focuses on capturing regional context and facilitating inter-window communication. The window-based point-voxel branch concentrates on local feature learning while integrating voxel-level information within each window.
  • 1.2K
  • 20 Oct 2023
Topic Review
CLN3 Gene
CLN3, battenin
  • 1.2K
  • 24 Dec 2020
Topic Review
Sedentary Behavior in Aging Populations
Sedentary behavior poses a significant health risk to older adults. Sedentary behavior (SB) is known to be an essential part of the daily routine of older adults, exceeding eight hours per day. The concept is defined as any waking behavior that involves minimal energy expenditure (less than 1.5 metabolic equivalents) while sitting, leaning, or lying down. Higher levels of daily SB have been associated with significant health outcomes for adults, particularly older adults.
  • 1.2K
  • 08 Aug 2023
Topic Review
Sensor Technologies for Human Motion Monitoring
Apart from the early video-based motion capture, the most widely used sensors for human motion capture include the traditional silicon-based sensors and the emerging flexible sensors. The former includes an accelerometer, gyroscope, magnetometer, inertial sensors, and tilt sensors; the latter involves soft strain and pressure sensors based on textile or polymer materials.
  • 1.2K
  • 17 Nov 2023
Topic Review
Open Innovation in the transition to Agriculture 4.0
Industry 4.0 digital technologies in agribusiness will enable traditional farming systems to migrate to Agriculture 4.0. Open innovation emerges as an enabler for implementing these technologies and increased sector competitiveness.
  • 1.2K
  • 05 Jun 2023
Topic Review
RIF1 Links Replication Timing
Replication timing (RT) is a cellular program to coordinate initiation of DNA replication in all origins within the genome. RIF1 (replication timing regulatory factor 1) is a master regulator of RT in human cells. This role of RIF1 is associated with binding G4-quadruplexes and changes in 3D chromatin that may suppress origin activation over a long distance. 
  • 1.2K
  • 01 Nov 2021
Topic Review
Carbapenem-Resistant Enterobacterales
Improper use of antimicrobials has resulted in the emergence of antimicrobial resistance (AMR), including multi-drug resistance (MDR) among bacteria. Recently, a sudden increase in Carbapenem-resistant Enterobacterales (CRE) has been observed. This presents a substantial challenge in the treatment of CRE-infected individuals. Bacterial plasmids include the genes for carbapenem resistance, which can also spread to other bacteria to make them resistant. The incidence of CRE is rising significantly despite the efforts of health authorities, clinicians, and scientists. Many genotypic and phenotypic techniques are available to identify CRE. However, effective identification requires the integration of two or more methods. Whole genome sequencing (WGS), an advanced molecular approach, helps identify new strains of CRE and screening of the patient population; however, WGS is challenging to apply in clinical settings due to the complexity and high expense involved with this technique.
  • 1.2K
  • 29 Nov 2022
Topic Review
Web-Based Serious Games and Accessibility
The entries consolidate the main concepts about serious web-based games; the characterization of serious games, accessibility, accessibility guidelines and types of disabilities, and the findings found after reviewing the literature.
  • 1.2K
  • 18 Nov 2020
Topic Review
Hypophosphatasia
Hypophosphatasia is an inherited disorder that affects the development of bones and teeth.
  • 1.2K
  • 23 Dec 2020
Topic Review
Hazelnut Allergy
Hazelnuts are frequently involved in IgE-mediated reactions and represent the main culprit of nut allergy in Europe. 
  • 1.2K
  • 24 Feb 2021
Topic Review
Protein-Bound Uremic Toxins
Protein-bound uremic toxins constitute approximately 25% of all currently identified uremic toxins. As a consequence of being highly bound to plasma proteins, protein-bound uremic toxins are poorly cleared by dialysis.
  • 1.2K
  • 18 Mar 2021
Topic Review
Chitosan and Fibroin
For the creation of tissue-engineered structures based on natural biopolymers with the necessary chemical, physical, adhesive, morphological, and regenerative properties, biocompatible materials based on polysaccharides and proteins are used.  This entry is devoted to a problem of the technology of polymeric materials for biomedical purposes: the creation of biopolymer tissue engineering matrix and the development of a methodology for studying morphology and functional properties of their surface to establish the prospects for using the material for contact with living objects.
  • 1.2K
  • 12 Apr 2021
Topic Review
Inorganic Nanoparticles in BC Therapy
Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This light activates the photosensitizer in the presence of molecular oxygen to produce phototoxic species, which in turn obliterate cancer cells. The incidence rate of breast cancer (BC) is regularly growing among women, which are currently being treated with methods, such as chemotherapy, radiotherapy, and surgery. These conventional treatment methods are invasive and often produce unwanted side effects, whereas PDT is more specific and localized method of cancer treatment. The utilization of nanoparticles in PDT has shown great advantages compared to free photosensitizers in terms of solubility, early degradation, and bio-distribution, as well as far more effective intercellular penetration and uptake in targeted cancer cells. 
  • 1.2K
  • 13 Apr 2021
Topic Review
The Viral Agents of BRDC
Bovine respiratory disease complex (BRDC) is a multifactorial disease of cattle which presents as bacterial and viral pneumonia. The causative agents of BRDC work in synergy to suppress the host immune response and increase the colonisation of the lower respiratory tracts by pathogenic bacteria. Environmental stress and/or viral infection predispose cattle to secondary bacterial infections via suppression of key innate and adaptive immune mechanisms. This allows bacteria to descend the respiratory tract unchallenged. BRDC is the costliest disease among feedlot cattle, and whilst vaccines exist for individual pathogens, there is still a lack of evidence for the efficacy of these vaccines and uncertainty surrounding the optimum timing of delivery. 
  • 1.2K
  • 14 Apr 2021
Topic Review
Pancreatic Ductal Adenocarcinoma Therapy
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in the US, and it is expected to be the second leading cause of cancer deaths by 2030. The lack of effective early screening tests and alarming symptoms with early undetectable micro-metastasis at the time of presentation play a vital role in the high death rate from pancreatic cancer. In addition to this, the low mutation burden in pancreatic cancer, low immunological profile, dense tumorigenesis stroma, and decreased tumor sensitivity to cytotoxic drugs contribute to the low survival rates in PDAC patients. Despite breakthroughs in chemotherapeutic and immunotherapeutic drugs, pancreatic cancer remains one of the solid tumors that exhibit meager curative rates.
  • 1.2K
  • 23 Jun 2021
Topic Review
Cancer Vaccines
Therapeutic cancer vaccines target TAAs alongside adjuvant molecules that can elicit specific antibodies or cytotoxic immune responses against cancer cells. There are different ways to present TAAs to the immune system. DNA and RNA encoding TAAs or whole peptides can be recognized and processed by the APCs; tumor cell lines express TAAs and can chemotactically attract APCs; viral vectors transfect APCs after being loaded with prespecified antigens; finally, DCs act as APCs and can be loaded with TAAs.
  • 1.2K
  • 29 Mar 2022
Topic Review
Plant Microbiomes
While plant microbiomes may include bacteria, fungi, oomycetes and archaea, the majority of the studies published on this topic deal with bacteria (bacteriome), and to a lesser extent, fungi (mycobiome). Consequently, this review is directed toward developing an understanding of the functioning of bacteria within plant microbiomes. Although the microbiome of the phyllosphere impact plant health and, often, food production, only a limited number of studies have been aimed at discovering these particular communities, well adapted to the hostile leaf environment and mainly dominated by Alphaproteobacteria and by the generaMethylobacteriumandSphingomonas.
  • 1.2K
  • 30 Jul 2021
Topic Review
Poult Enteritis and Mortality Syndrome
The poult enteritis complex (PEC) is common in turkeys and characterized by depression, enteritis, diarrhea, low feed conversion ratio and poor weight gain. It is a general term denoting all infectious intestinal diseases of young poults with uncertain etiology. The PEC is caused by a group of multifactorial infectious and non-infectious agents with significant effect on turkeys less than six weeks old.
  • 1.2K
  • 02 Aug 2021
Topic Review
Pulmonary Sarcoidosis
Sarcoidosis is a multisystem disorder of unknown origin and poorly understood pathogenesis that predominantly affects lungs and intrathoracic lymph nodes and is characterized by the presence of noncaseating granulomatous inflammation in involved organs. The disease is highly heterogeneous and can mimic a plethora of other disorders, making diagnosis a challenge even for experienced physicians. The evolution and severity of sarcoidosis are highly variable: many patients are asymptomatic and their disease course is generally benign with spontaneous resolution. However, up to one-third of patients develop chronic or progressive disease mainly due to pulmonary or cardiovascular complications that require long-term therapy. The diagnosis of sarcoidosis requires histopathological evidence of noncaseating granulomatous inflammation in one or more organs coupled with compatible clinical and radiological features and the exclusion of other causes of granulomatous inflammation; however, in the presence of typical disease manifestations such as Löfgren’s syndrome, Heerfordt’s syndrome, lupus pernio and asymptomatic bilateral and symmetrical hilar lymphadenopathy, the diagnosis can be established with high level of certainty on clinical grounds alone.
  • 1.2K
  • 23 Sep 2021
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