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Topic Review
Villa Tunari Massacre
The Villa Tunari Massacre was a 27 June 1988 mass murder committed by UMOPAR (Rural Patrol Mobile Unit) troops in response to a protest by coca-growing peasants (cocaleros) in the town of Villa Tunari in Chapare Province, Bolivia. The cocalero movement had mobilized since late May 1988 in opposition to coca eradication under Law 1008, then on the verge of becoming law. According to video evidence and a joint church-labor investigative commission, UMOPAR opened fired on unarmed protesters, at least two of whom were fatally shot, and many of whom fled to their deaths over a steep drop into the San Mateo River. The police violence caused the deaths of 9 to 12 civilian protesters, including three whose bodies were never found, and injured over a hundred. The killings were followed by further state violence in Villa Tunari, Sinahota, Ivirgarzama, and elsewhere in the region, including machine gun fire, beatings, and arrests. The massacre helped bring about the consolidation of Chapare coca growers' unions into the Coordinadora of the Six Federations of the Tropic of Cochabamba. Representatives of the National Congress, Catholic Church, Permanent Assembly for Human Rights, and the Central Obrera Boliviana labor federation formed a joint "multisectoral commission" to investigate the repression in the Chapare, which traveled to the region on 30 June 1988.
  • 1.2K
  • 04 Nov 2022
Topic Review
Chumash Traditional Medicine
Chumash traditional medicine is a type of traditional medicine practiced by the Chumash people of the southern coastal regions of California . Chumash medicine focused on treating mind, spirit, and body alike to promote the wellness of both the individual and the larger community. Healing practices included a knowledge of local plants, as well as a mix of spiritual practices including prayer, singing, and dancing. Post-European contact, Chumash healers adapted these methods to treat changes in environment and the introduction of deadly diseases. Prevention was key in promoting health, and healers took responsibility for ensuring all people worked and felt valued in the community. In the modern day, certain medicinal practices are viewed as controversial, including the treatment of menstruating women, the use of sacred datura, and the consumption of dangerous polycyclic aromatic hydrocarbons.
  • 1.2K
  • 23 Nov 2022
Topic Review
Biological Age Predictors
Age is a major risk factor for chronic noncommunicable diseases. It is a recognized contributor to severe COVID-19 and associated complications. However, many studies have suggested that it is biological rather than chronological age that underlies the development of numerous diseases. People age at a different pace, which is determined not only by genetic predisposition but also by external factors, such as socioeconomic factors and lifestyle. The likelihood of aging-associated diseases and mortality varies even among people of the same age. Certain combinations of biomarkers are more reliable predictors of biological age or mortality
  • 1.2K
  • 12 Dec 2022
Topic Review
The Application of Artificial Intelligence in Magnetic Hyperthermia
Magnetic hyperthermia (MHT) is more commonly used in various biomedical applications. Magnetic hyperthermia (MH), a clinical alternative to tumor treatments, also became a powerful tool for cancer treatment by exposing tumor tissue to elevated temperatures to achieve a therapeutic effect. It has been successfully applied to the treatment of different types of cancer including the brain, spine, lung, prostate, breast, and pancreas. It is also a promising alternative to traditional cancer therapies, particularly in the case of aggressive brain cancer like glioblastoma. MHT’s huge advantages are connected with biosafety, deep tissue penetration, and a focused place of action. The development of nanomedicine involves complex nanomaterial research involving magnetic nanomaterials and their use in magnetic hyperthermia. The selection of the optimal treatment strategies is time-consuming, expensive, unpredictable, and not consistently effective. Delivering personalized therapy that obtains maximal efficiency and minimal side effects is highly important. Thus, Artificial Intelligence (AI) based algorithms provide the opportunity to overcome these crucial issues.
  • 1.2K
  • 15 Dec 2022
Topic Review
Land Use and Global Environmental Change
Global environmental changes are multifactorial and affected by multiple forms of land use. Land use is closely linked to the global dynamics of the urbanization process, especially in recent decades in which the world has gone through intense migratory processes moving from rural to the urban setting. The dynamics that involve the urbanization process have multiple aspects and presuppose multiple ways of using the land and their linking to the economic aspect.
  • 1.2K
  • 05 Jan 2023
Topic Review
Graphene Applications in Microbial Fuel Cells
Microbial fuel cells are increasingly an object of interest due to the possibility of simultaneous electrical energy production and wastewater treatment, and connecting them with other technologies. In addition, this technology is used to recover different resources such as nutrients, e.g., nitrogen and phosphorus or critical metals, and for desalination and biodetection. One of the essential aspects on which intensive works are in progress is the material used to build electrodes. There has been considerable development in materials for electrodes used in microbial fuel cells. More and more often, scientists reach for materials based on the most recent achievements of technology, and one of them is graphene. This material is increasingly used in industry and science, including microbial fuel cells. Graphene is connected with other materials and modified in numerous ways, and it seems to be a perfect alternative for standard carbon or stainless steel electrodes.
  • 1.2K
  • 20 Jan 2023
Topic Review
E3s That Target Wild-Type p53
p53 plays a role in different biological processes such as proliferation, invasion, pluripotency, metabolism, cell cycle control, ROS (reactive oxygen species) production, apoptosis, inflammation and autophagy. In the nucleus, p53 functions as a bona-fide transcription factor which activates and represses transcription of a number of target genes. In the cytoplasm, p53 can interact with proteins of the apoptotic machinery and by this also induces cell death. Despite being so important for the fate of the cell, expression levels of p53 are kept low in unstressed cells and the protein is largely inactive. 
  • 1.2K
  • 27 Feb 2023
Topic Review
The Virtuous Galleria mellonella as Scientific Model
The first research on the insect Galleria mellonella was published 85 years ago, and the larva is now widely used as a model to study infections caused by bacterial and fungal pathogens, for screening new antimicrobials, to study the adjacent immune response in co-infections or in host-pathogen interaction, as well as in a toxicity model. The immune system of the G. mellonella model shows remarkable similarities with mammals. Furthermore, results from G. mellonella correlate positively with mammalian models and with other invertebrate models. Unlike other invertebrate models, G. mellonella can withstand temperatures of 37 °C, and its handling and experimental procedures are simpler. Despite having some disadvantages, G. mellonella is a virtuous in vivo model to be used in preclinical studies, as an intermediate model between in vitro and mammalian in vivo studies, and is a great example on how to apply the bioethics principle of the 3Rs (Replacement, Reduction, and Refinement) in animal experimentation. 
  • 1.2K
  • 13 Mar 2023
Topic Review
Collagen Antimicrobial Biomaterials for Tissue Engineering Applications
A fibrous, non-soluble protein, collagen, is one of the most studied biopolymers for the development of antimicrobial biomaterials owing to its superior physicochemical, biomechanical, and biological properties. 
  • 1.2K
  • 16 May 2023
Topic Review
History of Pleating
Pleating is basically the process of compressing high-quality hardwood along the grain after plasticization by supporting the sides of the wood to avoid buckling. Many treatment variations can be used with a wide range of parameters. Pleated wood can be bent into small curves in any direction. Industrial pleating is still done today in some parts of the world and its success is influenced by many factors, such as wood species, wood quality, moisture content, compression ratio, fixation time, etc. The treatment significantly changes the physical, mechanical and anatomical parameters of the wood. The first written record of the procedure dates back to 1917, and since then many patents, articles, and books on this subject have been published.
  • 1.2K
  • 25 May 2023
Topic Review
Self-Polymerization Mechanisms and Catalytic Reactions of PDA
Polydopamine (PDA), inspired by the adhesive mussel foot proteins, is widely applied in chemical, biological, medical, and material science due to its unique surface coating capability and abundant active sites.  Recently, PDA was introduced into Energetic Materials for the modification of crystal phase stability and the interfacial bonding effect, and, as a result, to enhance the mechanical, thermal, and safety performances.
  • 1.2K
  • 05 Jul 2023
Topic Review
Swarm Robotics for Area Coverage Problem
The area coverage problem solution is one of the vital research areas which can benefit from swarm robotics. The greatest challenge to the swarm robotics system is to complete the task of covering an area effectively. Many domains where area coverage is essential include exploration, surveillance, mapping, foraging, and several other applications.
  • 1.2K
  • 19 Jan 2024
Topic Review
Cardioprotective Activity of Polyphenols
Polyphenols have recently gained popularity among the general public as products and diets classified as healthy and containing naturally occurring phenols. Many polyphenolic extracts are available on the market as dietary supplements, functional foods, or cosmetics, taking advantage of clients' desire to live a healthier and longer life.   
  • 1.2K
  • 29 Dec 2020
Topic Review
Sustainable Fire-Resistant Polysaccharide-Based Composite Aerogels
Fire safety is a critical concern in various industries necessitating the development of sustainable and effective fire-resistant materials. Sustainable fire-resistant polysaccharide-based composite aerogels are regarded as an innovative solution in fire safety applications.
  • 1.2K
  • 16 Aug 2023
Topic Review
Tirzepatide in Type 2 Diabetes Mellitus
Tirzepatide is a novel once-a-week dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, currently under trial to assess glycemic efficacy and safety in people with type 2 diabetes.
  • 1.2K
  • 11 Nov 2021
Topic Review
3D Food Printing Applications and Dysphagia
Dysphagia is a condition in which the swallowing mechanism is impaired. It is most often a result of a stroke. Dysphagia has serious consequences, including choking and aspiration pneumonia, which can both be fatal. The population that is most affected by it is the elderly. Texture-modified diets are part of the treatment plan for dysphagia. This bland, restrictive diet often contributes to malnutrition in patients with dysphagia. Both energy and protein intake are of concern, which is especially worrying, as it affects the elderly. Making texture-modified diets more appealing is one method to increase food intake. As a recent technology, 3D food printing has great potential to increase the appeal of textured foods. With extrusion-based printing, both protein and vegetable products have already been 3D printed that fit into the texture categories provided by the International Dysphagia Diet Standardization Initiative. Another exciting advancement is 4D food printing which could make foods even more appealing by incorporating color change and aroma release following a stimulus. The ultra-processed nature of 3D-printed foods is of nutritional concern since this affects the digestion of the food and negatively affects the gut microbiome.
  • 1.2K
  • 23 Jun 2022
Topic Review
Green Assets of Equines
Equines have a peculiar place in our society. From livestock to sport, through to landscape managers and leisure partners, equines show a wide range of little-known environmental advantages and assets. Today’s wake-up calls about the environment are progressively putting pressure on stakeholders of the agricultural sector, including the equine industry. This study focusses on the main environmental consequences of equine use and possession in Europe based on scientific and technical sources under the lens of five leading sectors where equines show unique impacts as green assets. Now, more than ever before, it is important to highlight the role of equines as a green alternative in political debates and management practices to give them the place equines deserve in the ecological transition of agriculture.
  • 1.2K
  • 07 Jan 2022
Topic Review
Megalencephaly-Capillary Malformation Syndrome
Megalencephaly-capillary malformation syndrome (MCAP) is a disorder characterized by overgrowth of several tissues in the body. Its primary features are a large brain (megalencephaly) and abnormalities of small blood vessels in the skin called capillaries (capillary malformations).
  • 1.2K
  • 23 Dec 2020
Topic Review
Distal 18q Deletion Syndrome
Distal 18q deletion syndrome is a chromosomal condition that occurs when a piece of the long (q) arm of chromosome 18 is missing. The term "distal" means that the missing piece occurs near one end of the chromosome. Distal 18q deletion syndrome can lead to a wide variety of signs and symptoms among affected individuals.
  • 1.2K
  • 24 Dec 2020
Topic Review
Lipid Metabolism
  Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic reprogramming plays a critical role in the activation of these bone cells and skeletal metabolism, which fulfills the energy demand for bone remodeling. Among various metabolic pathways, the importance of lipid metabolism in bone cells has long been appreciated. More recent studies also establish the link between bone loss and lipid-altering conditions—such as atherosclerotic vascular disease, hyperlipidemia, and obesity—and uncover the detrimental effect of fat accumulation on skeletal homeostasis and increased risk of fracture. Targeting lipid metabolism with statin, a lipid-lowering drug, has been shown to improve bone density and quality in metabolic bone diseases. However, the molecular mechanisms of lipid-mediated regulation in osteoclasts are not completely understood. Thus, a better understanding of lipid metabolism in osteoclasts can be used to harness bone cell activity to treat pathological bone disorders.
  • 1.2K
  • 14 Jan 2021
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