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Topic Review
Natural and Synthetic Hydrogels in Wound Healing
The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be treated with a variety of approaches, which include surgery, negative pressure wound therapy, wound dressings, and hyperbaric oxygen therapy. However, each of these strategies has an array of limitations. The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Their unique composition enables them to absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds such as growth factors and antibacterial compounds. 
  • 1.3K
  • 08 Jan 2024
Topic Review
Monoclonal Antibodies Production Processes
Monoclonal Abs detect only one epitope, because they are produced from a family of genetically stable cells (cloned hybridoma); consequently, they have high specificity to the Ag than the polyclonal Abs that are less specific, because they are produced by different cell clones.
  • 1.3K
  • 27 Mar 2021
Topic Review
Collagen Type I Biomaterials
Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. 
  • 1.3K
  • 20 Apr 2021
Topic Review
Fungi and Climate Change
With the over 2000 marine fungi and fungal-like organisms documented so far, some have adapted fully to life in the sea, while some have the ability to tolerate environmental conditions in the marine milieu. These organisms have evolved various mechanisms for growth in the marine environment, especially against salinity gradients. Marine, freshwater and terrestrial fungi and fungal-like organisms vary greatly in their response to salinity. Generally, terrestrial and freshwater fungi grow, germinate and sporulate better at lower salinities, while marine fungi do so over a wide range of salinities. Zoosporic fungal-like organisms are more sensitive to salinity than true fungi, especially Ascomycota and Basidiomycota. Labyrinthulomycota and marine Oomycota are more salinity tolerant than saprolegniaceous organisms in terms of growth and reproduction. Wide adaptability to saline conditions in marine or marine-related habitats requires mechanisms for maintaining accumulation of ions in the vacuoles, the exclusion of high levels of sodium chloride, the maintenance of turgor in the mycelium, optimal growth at alkaline pH, a broad temperature growth range from polar to tropical waters, and growth at depths and often under anoxic conditions, and these properties may allow marine fungi to positively respond to the challenges that climate change will bring.
  • 1.3K
  • 21 Apr 2022
Topic Review
MafA Regulation in β-Cells
β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin secretion. One of the key factors in this regulation is MAF bZIP transcription factor A (MafA). MafA expression is decreased in type 2 diabetes, contributing to β-cell dysfunction and disease progression. The molecular biology underlying MafA is complex, with numerous transcriptional and post-translational regulatory nodes. 
  • 1.3K
  • 21 Apr 2022
Topic Review
Formaldehyde Measurement in Biological Samples
Formaldehyde (FA) is the simplest aldehyde present both in the environment and in living organisms. FA is an extremely reactive compound capable of protein crosslinking and DNA damage. However, FA is a product of normal cellular metabolism, and it plays an important role in many biochemical processes. Different methods initially used for non-biological objects have been adapted for biological samples. In addition, numerous approaches, including chemically-synthesized probes and genetically encoded FA-sensors for in cellulo and in vivo FA monitoring, were developed. 
  • 1.3K
  • 05 Jul 2022
Topic Review
Valorization of Agro-Food Industrial Residues by Solid-State Fermentation
Agro-food industrial residues (AFIRs) are generated in large quantities all over the world. The vast majority of these wastes are lignocellulosic wastes that are a source of value-added products. Technologies such as solid-state fermentation (SSF) for bioconversion of lignocellulosic waste, based on the production of a wide range of bioproducts, offer both economic and environmental benefits. The versatility of application and interest in applying the principles of the circular bioeconomy make SSF one of the valorization strategies for AFIRs that can have a significant impact on the environment of the wider community.
  • 1.3K
  • 07 Nov 2022
Topic Review
Blockchain-Enabled Cross-Border E-Commerce Supply Chain Management
Driven by the internet-based advanced information technologies and logistics channel improvement, the cross-border e-commerce industry keeps an increasing trend in Chinese industrial market. Blockchain, as an empowered technology, contributes to the management innovations for industrial sectors. The blockchain technology, due to its transparency, visibility, and dis-intermediation characteristics, helps to improve operations management of cross-border e-commerce supply chain by innovative industrial applications.
  • 1.3K
  • 11 Jan 2023
Topic Review
Nitrogen Removal in Bioretention System
Bioretention is considered one of the best management practices (BMPS) for managing stormwater quality and quantity. The bioretention system has proven good performance in removing total suspended solids, oil, and heavy metals. The nitrogen (N) removal efficiency of the bioretention system is insufficient, however, due to the complex forms of nitrogen. 
  • 1.3K
  • 06 Sep 2021
Topic Review
Targeting Chemosensitive Channels for Dysphagia
Swallowing is a physiological process that transports ingested foods, liquids, and saliva from the oral cavity into the stomach. Difficulty in the oropharyngeal swallowing process or oropharyngeal dysphagia is a major health problem. There is no established pharmacological therapy for the management of oropharyngeal dysphagia. Studies have suggested that the current clinical management of oropharyngeal dysphagia has limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia.
  • 1.3K
  • 27 Oct 2020
Topic Review
Sugar Reduction in Dairy Food
1. The World Health Organization (WHO) and Public Health England (PHE) recommend cutting down added sugar in processed foods 2. Flavoured milk is one the sources of sugar and calorie intake in all age groups 3. Sugar reduction by partial substitution with natural non-nutritive sweeteners like stevia and monk fruit is one of the most suitable options for food industries 4. Sugar reduction will help manage the chronic diseases like obesity, cardiovascular diseases and diabetes
  • 1.3K
  • 14 Oct 2020
Topic Review
Mitochondrial Ribosomal Proteins
Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes, all of which play roles in the mitochondrial respiratory chain. After a long period of reconstruction, mitochondrial ribosomes are the most protein-rich ribosomes. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes, synthesized in the cytoplasm and then, transported to the mitochondria to be assembled into mitochondrial ribosomes. MRPs not only play a role in mitochondrial oxidative phosphorylation (OXPHOS). Moreover, they participate in the regulation of cell state as apoptosis inducing factors. Abnormal expressions of MRPs will lead to mitochondrial metabolism disorder, cell dysfunction, etc. Many researches have demonstrated the abnormal expression of MRPs in various tumors.
  • 1.3K
  • 16 Dec 2020
Topic Review
Iterared Skew Polynomial Rings
Skew polynomial rings used to be, especially during the 1970’s and 1980’s, a popular topic of the modern abstract Algebra with great theoretical interest. The researchers’ attention about them has renewed recently, due to the important applications that they have found to the study of Quantum Groups and to Cryptography. The present work studies a special class of iterated skew polynomial rings over a ring R, defined with respect to a finite set of pairwise commuting derivations of R.
  • 1.3K
  • 17 Dec 2020
Topic Review
Freeman-Sheldon Syndrome
Freeman-Sheldon syndrome is a condition that primarily affects the face, hands, and feet. People with this disorder have a distinctive facial appearance including a small mouth (microstomia) with pursed lips, giving the appearance of a "whistling face." For this reason, the condition is sometimes called "whistling face syndrome."
  • 1.3K
  • 25 Dec 2020
Topic Review
MSTN Gene
Myostatin
  • 1.3K
  • 04 Jan 2021
Topic Review
Physical Activity in Older Adults
Healthy aging makes the practice of physical activity (PA) a necessity. However, PA guidelines achievement in older adults is scarce. The use of behavioral theories such as Transtheoretical Model (TTM), helps in older adults PA promotion. The aim of this review was to identify the use of TTM for PA in older adults (>60 years). PubMed, SPORTdiscus, and Medline databases were used to conduct the search. All steps of the process followed the recommendations of the PRISMA flow-diagram. We identified eight studies: Six were descriptive cross-sectional studies, one prospective-cohort study and one with a quasi-experimental design. Only two papers evaluated the four behavior change dimensions within the same study, three evaluated the processes of change and the decisional balance, four evaluated the exercise self-efficacy and all assessed the stages of change for PA behavior. 
  • 1.3K
  • 24 Apr 2021
Topic Review
Perovskite Solar Cells
Charge transporting materials (CTMs) in perovskite solar cells (PSCs) have played an important role in improving the stability by replacing the liquid electrolyte with solid state electron or hole conductors and enhancing the photovoltaic efficiency by the efficient electron collection. Many organic and inorganic materials for charge transporting in PSCs have been studied and applied to increase the charge extraction, transport and collection, such as Spiro-OMeTAD for hole transporting material (HTM), TiO2 for electron transporting material (ETM) and MoOX for HTM etc. However, recently inorganic CTMs are used to replace the disadvantages of organic materials in PSCs such as, the long-term operational instability, low charge mobility. Especially, atomic layer deposition (ALD) has many advantages in obtaining the conformal, dense and virtually pinhole-free layers. 
  • 1.3K
  • 10 Mar 2021
Topic Review
Hodgkin Lymphoma
Hodgkin lymphoma (HL) is a rare neoplasm of the lymphatic system representing one of the most common cancers in young adults. The disease is characterized by a low number of malignant cells (Hodgkin- and  Reed-Sternberg cells) deriving from B-lymphocytes and an extensive inflammatory microenvironment This unique histopathological picture and its pathogenesis are still only partially understood. 
  • 1.3K
  • 08 Jul 2021
Topic Review
Endoscopic Photoacoustic Imaging
Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong light scattering and attenuation. Endoscopic PA technology enables direct delivery of excitation light into the interior of a hollow organ or cavity of the body for functional and molecular PA imaging of target tissue.
  • 1.3K
  • 16 Aug 2021
Topic Review
Sea Urchin-like Si@MnO2@rGO
An unique structure which can effectively reduce the volume change of Si, extend the cycle life and increase the lithium-ion battery capacity.
  • 1.3K
  • 24 Feb 2022
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