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Topic Review
Pathomechanisms for GABRG2 and GABRB3 Mutations in DEEs
GABAA receptor genes (GABR) are a group of genes associated with DEE, although previous studies have been focused on relatively mild epileptic syndromes, such as childhood absence epilepsy (CAE), febrile seizures (FS), and generalized tonic-clonic seizures with febrile seizure plus (GEFS+). Mutations in GABAA receptor subunit genes (GABRs) are a major etiology for developmental and epileptic encephalopathies (DEEs).
  • 1.3K
  • 15 Sep 2022
Topic Review
Immunological Methods of Common Intestinal Protozoa
Intestinal protozoan infection is a persistent public health problem affecting the populations of developing countries in tropical and subtropical regions. The diagnosis of intestinal protozoa remains a challenge especially in developing countries due to a shortage of laboratory facilities, limited health funding, and the remoteness of communities. Despite still being widely used, conventional diagnoses using microscopy and staining methods pose important limitations, particularly due to their low sensitivities and specificities. The selection of diagnostic methods needs to be carefully considered based on the objective of examination, availability of resources, and the expected parasite to be found. Immunodiagnostic tests are generally inexpensive, user-friendly, and enable fast-obtained results. Antibody and antigen detection tests, such as indirect hemagglutination (IHA), indirect immunofluorescence (IIF), enzyme-linked immunosorbent assay (ELISA), direct fluorescent antibody (DFA), rapid enzyme immune assay (EIA), immunochromatographic test (ICT), or latex agglutination, are commercially available via several different platforms. The combination of antibody and fecal antigen detection assays is more sensitive and specific than microscopy for the diagnosis of several intestinal protozoan infections.
  • 1.3K
  • 11 Oct 2022
Topic Review
Muklishgarh
Muklishgarh is a rang mahal fort in the foothills of the Himalayas in the Yamunanagar district of Haryana in India .
  • 1.3K
  • 22 Nov 2022
Topic Review
Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies
Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate and adaptive immune systems and subsequently lead to chronic neuroinflammation that drives the onset and progression of neurodegenerative diseases. Since there is still no effective disease-modifying treatment, new therapeutic targets for neurodegenerative proteinopathies have been sought. The endocannabinoid system, and in particular the cannabinoid CB2 receptors, have been extensively studied, due to their important role in neuroinflammation, especially in microglial cells.
  • 1.3K
  • 08 Dec 2022
Topic Review
The Molecular Mechanisms of 4-N-[2-(4-Phenoxyphenyl)Ethyl]Quinazoline-4,6-Diamine Activity
Quinazoline derivatives are a large pool of natural and synthetic compounds. The first derivatives of quinazoline were synthesized at the end of the 19th century. one quinazoline derivative (4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine)—EVP4593 (also marked as QNZ) was originally synthesized in 2003 as a modulator of the nuclear factor kappa B (NF-κB) signal transduction pathway. Since that time, EVP4593 has been widely used as a blocker of NF-κB signaling (Sigma-Aldrich, cat #481417). Further it has been reported the ability of EVP4593 to affect store-operated calcium channels.
  • 1.3K
  • 21 Dec 2022
Topic Review
Solubility of Organic Compounds in Subcritical Water
Data on the solubility and decomposition of organic compounds in subcritical water, a green solvent, are needed in environmental remediation, chemistry, chemical engineering, medicine, polymer, food, agriculture, and many other fields. The solubility of organics is significantly enhanced with increasing water temperature. Likewise, the percentage of organic decomposition also increases with higher temperature.
  • 1.3K
  • 09 Mar 2023
Topic Review
Synthesis of the 1,2,3-Dithiazole Scaffold
The 1,2,3-dithiazole is an underappreciated scaffold in medicinal chemistry despite possessing a wide variety of nascent pharmacological activities. The scaffold has a potential wealth of opportunities within these activities and further afield. The synthesis of Appel salt 1 acted as a catalyst to the field and granted access to many 1,2,3-dithiazole derivatives, and to other heterocycles incorporating sulfur and nitrogen atoms.
  • 1.3K
  • 12 Apr 2023
Topic Review
Probiotics Influence the Gut–Brain Link
The effect of the intestinal microbiome on the gut–brain axis has received considerable attention, strengthening the evidence that intestinal bacteria influence emotions and behavior. The colonic microbiome is important to health and the pattern of composition and concentration varies extensively in complexity from birth to adulthood. That is, host genetics and environmental factors are complicit in shaping the development of the intestinal microbiome to achieve immunological tolerance and metabolic homeostasis from birth. Given that the intestinal microbiome perseveres to maintain gut homeostasis throughout the life cycle, epigenetic actions may determine the effect on the gut–brain axis and the beneficial outcomes on mood.
  • 1.3K
  • 02 Jun 2023
Topic Review
Reinforcement Materials
The role of the reinforcement in a composite material is mainly one of increasing the mechanical and anti-corrosion properties of the system, but the intrinsic properties of nanofillers, as well as their size, morphology, chemical functional groups, and their amounts, influence significantly many more properties of nanocomposites.
  • 1.3K
  • 27 Jul 2023
Topic Review
Steppe Polecat
The Steppe Polecat, scientifically known as Mustela eversmannii, is a small carnivorous mammal native to the steppes and semi-deserts of Central Asia. With a sleek body and distinctive facial markings, this elusive predator is well-adapted to its arid habitat, where it preys on rodents, birds, and insects. Despite its relatively small size, the Steppe Polecat plays a crucial role in controlling rodent populations and maintaining the balance of its ecosystem.
  • 1.3K
  • 15 Mar 2024
Topic Review
Cytokine-Induced Killer Cells
Cytokine-induced killer (CIK) cells are a cluster of heterogeneous cells uniting a T cell and natural killer cell‐like phenotype in their terminally differentiated CD3+CD56+ subset, and exert anti-tumor activity in a non-MHC restricted manner. CIK cells are expanded ex vivo with the sequential addition of multiple cytokines, including interferon‐γ, monoclonal antibodies against CD3 and interleukin‐2.
  • 1.3K
  • 29 Sep 2020
Topic Review
Genesis of Endotheliopathy
Endotheliopathy, according to the “two-activation theory of the endothelium”, is triggered by the activated complement system in critical illnesses, such as sepsis, diabetes and polytrauma, leading to two distinctly different molecular dysfunctions: (1) the activation of the inflammatory pathway due to the release of inflammatory cytokines, such as interleukins, interferons and tumor necrosis factors, and (2) the activation of the microthrombotic pathway due to the exocytosis of hemostatic factors, including ultra-large von Willebrand factor (ULVWF) multimers and FVIII. These lead to inflammation and microthrombogenesis. The former produces inflammatory diseases, and the latter produces endotheliopathy-associated vascular microthrombotic disease (EA-VMTD), which orchestrates not only TTP-like syndrome characterized by the triad of consumptive thrombocytopenia, microangiopathic hemolytic anemia and multiorgan dysfunction syndrome, but also many other endotheliopathic syndromes. The diagnostic features of EA-VMTD are well established now and therapeutic strategies are being formulated. 
  • 1.3K
  • 11 Oct 2022
Topic Review
Pathophysiology of Vasoplegic Syndrome after Cardiopulmonary Bypass
Vasoplegic syndrome (VS) is a common complication following cardiovascular surgery with cardiopulmonary bypass (CPB), and its incidence varies from 5 to 44%. It is defined as a distributive form of shock due to a significant drop in vascular resistance after CPB. 
  • 1.3K
  • 28 Nov 2022
Topic Review
Ig Nobel Prize
The Ig Nobel Prize is a satirical yet legitimate annual award presented by the Annals of Improbable Research to honor scientific achievements that are unusual, imaginative, and thought-provoking. Established in 1991, the prize celebrates research that "first makes people laugh, and then makes them think," highlighting the intersection of humor and scientific inquiry. While often humorous in subject matter, winning studies are typically grounded in peer-reviewed research and aim to promote public engagement with science through curiosity, creativity, and accessibility.
  • 1.3K
  • 20 May 2025
Topic Review
Fungi Affecting Wall Paintings of Historical Value
Wall paintings have been a cultural expression of human creativity throughout history. Their degradation or destruction represents a loss to the world’s cultural heritage, and fungi have been identified as a major contributor to their decay. For this reason, is of utmost importance to know the species involved, their distribution, the method used for their identification, and the possible relation with the environment.
  • 1.3K
  • 06 Apr 2022
Topic Review
1q21.1 Microdeletion
1q21.1 microdeletion is a chromosomal change in which a small piece of chromosome 1 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome in a region designated q21.1. This chromosomal change increases the risk of delayed development, intellectual disability, physical abnormalities, and neurological and psychiatric problems. However, some people with a 1q21.1 microdeletion do not appear to have any associated features.
  • 1.3K
  • 23 Dec 2020
Topic Review
Filled Polymers and DMA
Dynamic mechanical analysis (DMA) provides reliable information about the viscoelastic behavior of neat and filled polymers. The properties of filled polymers are relevant to different industries as protective organic coatings, composites etc. Interfacial interactions in filled polymers play an important role in determining their bulk properties and performance during service life. In this entry, studies which used DMA to characterize the interfacial interactions in filled polymers have been reviewed.
  • 1.3K
  • 26 Apr 2021
Topic Review
Plant Ribonuclease J
RNA quality control is an indispensable but poorly understood process that enables organisms to distinguish functional RNAs from nonfunctional or inhibitory ones. In chloroplasts, whose gene expression activities are required for photosynthesis, retrograde signaling and plant development, RNA quality control is of paramount importance as transcription is relatively unregulated. The functional RNA population is distilled from this initial transcriptome by a combination of RNA-binding proteins and ribonucleases. One of the key enzymes is RNase J, a 5’ - 3’ exoribonuclease, and endoribonuclease, that has been shown to trim 5’ and 3’ RNA termini, and eliminate deleterious antisense RNA. In the absence of RNase J, embryo development cannot be completed. Land plant RNase J contains a highly conserved C-terminal domain that is found in GT-1 DNA-binding transcription factors and is not present in its bacterial, archaeal and algal counterparts. The GT-1 domain may confer specificity through DNA and/or RNA binding and/or protein-protein interactions, and thus be an element in the mechanisms that identify target transcripts among diverse RNA populations. Further understanding of chloroplast RNA quality control relies on discovering how RNase J is regulated, and how its specificity is imparted.
  • 1.3K
  • 28 Oct 2020
Topic Review
Resveratrol and Cancer Evidence
Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmatic and nuclear proteins in human cells, resveratrol was studied in these years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy, heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.
  • 1.3K
  • 29 Oct 2020
Topic Review
ECM1 Gene
Extracellular matrix protein 1
  • 1.3K
  • 24 Dec 2020
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