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Topic Review
Chronic Renal Failure and Cardiovascular Disease
Coronary artery disease (CAD) is highly prevalent in patients with chronic kidney disease (CKD), with a linear increase in the risk of cardiovascular mortality with decreasing eGFR. The concomitant renal disease often poses a major challenge in decision making as symptoms, cardiac biomarkers, and noninvasive studies for evaluation of myocardial ischemia have different sensitivity and specificity thresholds in this specific population.
  • 1.4K
  • 11 Mar 2022
Topic Review
The Macro-Physics of the Quark-Nova
A quark-nova is a hypothetical stellar evolution branch where a neutron star converts explosively into a quark star. Due to the high peak neutrino luminosities, neutrino pair annihilation can deposit as much as 1052 ergs in kinetic energy in the matter overlaying the neutrinosphere, yielding relativistic quark-nova ejecta. 
  • 1.4K
  • 28 Jun 2022
Topic Review
The Importance of Organoids for One Health
One Health describes the importance of considering humans, animals, and the environment in health research. One Health and the 3R concept, i.e., the replacement, reduction, and refinement of animal experimentation, shape today’s research more and more. The development of organoids from many different organs and animals led to the development of highly sophisticated model systems trying to replace animal experiments. Organoids may be used for disease modelling in various ways elucidating the manifold host–pathogen interactions. 
  • 1.4K
  • 28 Sep 2022
Topic Review
Geological Structure and Tectonic Complexity of Northern Thessaly
Knowing the rich presence of active faults in northern Thessaly and the lack of any significant seismic activity since at least the mid-1940s, the 2021 seismic sequence did not surprise people. What did surprise people was the fact that (i) despite the great knowledge of the neotectonic faults in the area, the causative faults were unknown, or almost unknown; (ii) the direction of the 2021 faulting was different than the expected, and given that the focal mechanisms showed almost pure normal dip-slip motion, the extensional main axis was also different than the one known for this area; and (iii) besides the co-seismic ruptures that occurred within the Domeniko-Amouri basin and along the Titarissios River valley, there is evidence of rupturing in the alpine basement of Zarkos mountains. 
  • 1.4K
  • 15 Nov 2022
Topic Review
Large Strategic Science Missions
NASA's Large Strategic Science Missions, formerly known as Flagship missions or Flagship-class missions, are the costliest and most capable NASA science spacecraft. Flagship missions exist within all four divisions of NASA's Science Mission Directorate: the astrophysics, Earth science, heliophysics and planetary science divisions. "Large" refers to the budget of each mission, typically the most expensive mission in the scientific discipline. Within the Astrophysics Division and the Planetary Science Division, the large strategic missions are usually in excess of $1 billion. Within Earth Science Division and Heliophysics Division, the large strategic missions are usually in excess of $500 million. "Strategic" refers to their role advancing multiple strategic priorities set forth in plans such as the Decadal Surveys. "Science" marks these missions as primarily scientific in nature, under the Science Mission Directorate (SMD), as opposed to, e.g., human exploration missions under the Human Exploration and Operations Mission Directorate (HEOMD). The lines can be blurred, as when the Lunar Reconnaissance Orbiter began as a directed mission from the HEOMD, and was later transferred to the SMD. Flagship missions are not under the purview of any larger "Flagship Program", unlike, e.g., Discovery-class missions that are under the purview of the Discovery Program. Unlike these competed classes that tender proposals through a competitive selection process, the development of Flagship missions is directed to a specific institution — usually a NASA center or the Jet Propulsion Laboratory — by the Science Mission Directorate. Flagship missions are developed ad-hoc, with no predetermined launch cadence or uniform budget size. Flagship missions are always Class A missions: high priority, very low risk.
  • 1.4K
  • 17 Nov 2022
Topic Review
Narcissistic Triangulation
Triangulation is a term most closely associated with the work of Murray Bowen called Family Theory. Bowen theorized that a two-person emotional system is unstable, in that under stress it forms itself into a three-person system or triangle.
  • 1.4K
  • 17 Nov 2022
Topic Review
Aviptadil
Aviptadil is an injectable synthetic formulation of human vasoactive intestinal peptide (VIP). VIP was discovered in 1970, and has been used to treat various inflammatory conditions, such as acute respiratory distress syndrome (ARDS), asthma and chronic obstructive pulmonary disease (COPD).
  • 1.4K
  • 17 Nov 2022
Topic Review
Shark Net
A shark net is a submerged net placed around beaches to reduce shark attacks on swimmers. The majority of Shark nets used are Gillnets which is a wall of netting that hangs in the water and captures the targeted sharks by entanglement. The nets in Queensland, Australia, are typically 186m long, set at a depth of 6 m, have a mesh size of 500 mm and are designed to catch sharks longer than 2m in length. Shark nets are not to be confused with shark barriers. Shark nets do not offer complete protection but work on the principle of "fewer sharks, fewer attacks". They reduce occurrence via shark mortality. Shark nets such as those in New South Wales are designed to entangle and kill sharks and other animals that pass near them. Reducing the local shark populations is believed to reduce the chance of an attack. Historical shark attack figures suggest that the use of shark nets and drumlines does markedly reduce the incidence of shark attack when implemented on a regular and consistent basis. The large mesh size of the nets is designed specifically to capture sharks and prevent their escape until eventually, they drown. Due to boating activity, the nets also float 4 metres or more below the surface and do not connect with the shoreline (excluding Hong Kong's shark barrier nets) thus allowing sharks the opportunity to swim over and around nets. Shark nets can cost A$1 million or A$20,000 per beach per year. Shark nets have been criticized by environmentalists, conservationists and animal rights activists — they say shark nets are unethical and harm the marine ecosystem. They also say there is no science showing that nets make the ocean safer for people. Christopher Neff, a Ph.D. scholar at the University of Sydney notes, "Internationally, shark nets have been labeled a 'key threatening process' for killing endangered species." He adds: " ... killing endangered species to boost public confidence or to show government action is not workable. It is a disservice to the public." Jessica Morris of Humane Society International calls shark nets a "knee-jerk reaction" and says, "sharks are top order predators that play an important role in the functioning of marine ecosystems. We need them for healthy oceans."
  • 1.4K
  • 05 Dec 2022
Topic Review
Metallic and Metal Oxide Nanoparticles
Diseases caused by infections are becoming harder to treat as the antibiotics used become less effective. A combination of strategies to develop active biomaterials that enhance antibacterial effects are desirable, especially ones that cause fewer side effects and promote healing properties. The development of new antimicrobial products is necessary to avoid the transmission of infection in healthcare environments. In this sense, metallic and metal oxide nanoparticles (NPs) have been gaining attention due to their unique size-dependent physical and chemical properties. The best known examples of this category are the NPs of elements such as silver, copper, gold, palladium, and platinum, which are used in varied areas of application (catalytic, biomedical, and electronic) as their properties are distinguished from those presented by the bulk. NPs are especially effective against Gram-negative and Gram-positive bacteria, such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. 
  • 1.4K
  • 18 Apr 2023
Topic Review
Genetics of Female Pattern Hair Loss
Pattern hair loss can occur in both men and women, and the underlying molecular mechanisms have been continuously studied in recent years. Male androgenetic alopecia (M-AGA), also termed male pattern hair loss, is the most common type of hair loss in men. M-AGA is considered an androgen-dependent trait with a background of genetic predisposition.
  • 1.4K
  • 04 Jul 2023
Topic Review Video
Cryogenic Treatments in Energy Sector
Cryogenic treatment (CT) is one of the possible solutions for an environmentally friendly, sustainable, and cost-effective technology for tailoring the properties of different metallic materials.
  • 1.4K
  • 01 Nov 2023
Topic Review
The Making of Surgical Guide for TADs
A temporary anchorage devices (TADs)  surgical guide is a guide that allows a dental surgeon to place TAD in a precise, pre-planned location to give the ideal depth, angulation, and screw size to fit the area for anchorage purposes. The purpose of anchorage in orthodontics is to move a tooth or teeth for dental and alveolar orthopedic purposes. The TAD number of the screw that can be placed using the surgical guide may range from one to multiple, depending on the purpose of the anchorage needed. The surgical guide is made from hard materials like acrylic or metal. The TAD surgical guide is positioned over the adjacent teeth to maintain stability during the maneuver. The surgical guide is created using CAD/CAM technology and a 3D printer.
  • 1.4K
  • 01 Dec 2023
Topic Review
Antimicrobial Properties of Ocimum basilicum, Lamiaceae
Since ancient times, various scientists and doctors have utilized different herbs to heal diseases. Due to the rise in drug resistance and the negative effects of chemosynthetic drugs, researchers and the general public around the world have become more interested in medicinal herbs and plant metabolites/extracts. This is due to its non-toxicity and its several health benefits when used to treat diseases in clinical and medical settings. Ocimum basilicum is one such plant, possessing a wide range of bioactive phytochemicals including alkaloids, phenolics, flavonoids, tannins, saponins, reducing sugars, cardiac glycosides, steroids and glycosides, as well as complex pharmacological activities, including anti-inflammatory, antifungal, antibacterial, antioxidant, wound healing and antiviral properties.
  • 1.4K
  • 07 Feb 2024
Topic Review
HIV-1 Gag Mutations in Protease Inhibitors Resistance
HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this drug resistance and inhibit viral maturation, targeting Gag alongside protease rather than targeting protease alone may be more efficient. 
  • 1.4K
  • 29 Mar 2022
Topic Review
Methods for Chemico-Physical Characterization of Refineries Solid Wastes
In the delayed coker the residues of the vacuum distillation units are cracked into lighter hydrocarbons, producing coker gas oil, but also a solid carbonaceous byproduct which is called “pet-coke”. This is a highly viscous, black, sticky material, it remains liquid as long as it is transported hot, but solidifies otherwise. Its insoluble fraction in n-heptane is called asphaltene, which thus represents the heaviest fraction of crude oil.  The detailed and complete analysis of heavy petroleum fractions requires the use of many different analytical tools because of their chemical complexity and low volatility. However, the molecular weight (MW), the aromaticity and, in general, the chemical functionalities, are the key properties to determine for guiding their processing technology development. In particular, size exclusion chromatography (SEC) and mass spectrometry (MS) are the most eligible techniques for MW determination, while Raman and Fourier Transform Infrared (FTIR) spectroscopy can provide information on aromaticity and chemical functionalities, respectively.
  • 1.4K
  • 09 Jun 2022
Topic Review
Roger A. Pielke Jr.
Roger A. Pielke Jr. (born November 2, 1968) is an American political scientist and professor, and was the director of the Sports Governance Center within the Department of Athletics at the Center for Science and Technology Policy Research at the University of Colorado Boulder. He previously served in the Environmental Studies Program and was a Fellow of the Cooperative Institute for Research in Environmental Sciences (CIRES) where he served as Director of the Center for Science and Technology Policy Research at the University of Colorado Boulder from 2001 to 2007. Pielke was a visiting scholar at Oxford University's Saïd Business School in the 2007-2008 academic year. A prolific writer, his interests include understanding the politicization of science; decision making under uncertainty; policy education for scientists in areas such as climate change, disaster mitigation, and world trade; and research on the governance of sports organizations, including FIFA and the NCAA.
  • 1.4K
  • 20 Oct 2022
Topic Review
Electrification of Offshore Oil and Gas Production
Subsea oil and gas (O&G) exploration demands significantly high power to supply the electrical loads for extraction and pumping of the oil and gas. The energy demand is usually met by fossil fuel combustion-based platform generation, which releases a substantial volume of greenhouse gases including carbon dioxide (CO2) and methane into the atmosphere.
  • 1.4K
  • 14 Aug 2023
Topic Review
Non-Invasive Indoor Thermal Discomfort Detection
Since 1997, scientists have been trying to utilize new non-invasive approaches for thermal discomfort detection, which promise to be more effective for comparing frameworks that need direct responses from users. Due to rapid technological development in the bio-metrical field, a systematic literature review to investigate the possibility of thermal discomfort detection at the work place by non-invasive means using bio-sensing technology was performed. Firstly, the problem intervention comparison outcome context (PICOC) framework was introduced in the study to identify the main points for meta-analysis and, in turn, to provide relevant keywords for the literature search. In total, 2776 studies were found and processed using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) methodology. After filtering by defined criterion, 35 articles were obtained for detailed investigation with respect to facility types used in the experiment, amount of people for data collection and algorithms used for prediction of the thermal discomfort event. The given study concludes that there is potential for the creation of non-invasive thermal discomfort detection models via utilization of bio-sensing technologies, which will provide a better user interaction with the built environment, potentially decrease energy use and enable better productivity. There is definitely room for improvement within the field of non-invasive thermal discomfort detection, especially with respect to data collection, algorithm implementation and sample size, in order to have opportunities for the deployment of developed solutions in real life. Based on the literature review, the potential of novel technology is seen to utilize a more intelligent approach for performing non-invasive thermal discomfort prediction. The architecture of deep neural networks should be studied more due to the specifics of its hidden layers and its ability of hierarchical data extraction. This machine learning algorithm can provide a better model for thermal discomfort detection based on a data set with different types of bio-metrical variables.
  • 1.4K
  • 11 Feb 2021
Topic Review
Diabetic Kidney Disease Protein Restriction
Low-protein diets have been recommended as diet therapy for the management of chronic kidney disease. Several studies have reported significantly more favorable results with low-protein diet than with normal-protein diet, the renal protective effects of low-protein diets are still unclear in diabetic patients with chronic kidney disease. Moreover, some studies have reported that extremely low-protein diets may increase the risk of mortality.
  • 1.4K
  • 03 May 2021
Topic Review
Annona cherimola Mill.
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds.
  • 1.4K
  • 18 Jun 2021
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