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Topic Review Peer Reviewed
Generational Effects of Opioid Exposure
The inheritance of substance abuse, including opioid abuse, may be influenced by genetic and non-genetic factors related to the environment, such as stress and socioeconomic status. These non-genetic influences on the heritability of a trait can be attributed to epigenetics. Epigenetic inheritance can result from modifications passed down from the mother, father, or both, resulting in either maternal, paternal, or parental epigenetic inheritance, respectively. These epigenetic modifications can be passed to the offspring to result in multigenerational, intergenerational, or transgenerational inheritance. Human and animal models of opioid exposure have shown generational effects that result in molecular, developmental, and behavioral alterations in future generations. 
  • 1.4K
  • 13 Apr 2022
Topic Review
Mechanochemistry in Portugal
In Portugal, publications with mechanochemical methods date back to 2009, with the report on mechanochemical strategies for the synthesis of metallopharmaceuticals. Since then, mechanochemical applications have grown in Portugal, spanning several fields, mainly crystal engineering and supramolecular chemistry, catalysis, and organic and inorganic chemistry.
  • 1.4K
  • 24 Jan 2022
Topic Review
Acrylic Carrier
Wood used outdoor is subjected to different sources of degradation and should be protected properly. In this study, acrylic resins were added to a wood impregnation system using amine oxides and propiconazole, an organic fungicide, to create a two-part wood protection preservation treatment. Since amine oxides can diffuse readily into wood, this treatment protected both the surface and inner structure of the treated wood following a simple dipping. Many aspects of the treatment were studied: the adhesion of the acrylic coatings, their permeability to water, and the impregnation depth of the propiconazole. In each case, a particular attention was accorded to the interactions between the resins and the impregnation system. Adhesion and permeability tests were coupled with an artificial aging process simulating severely wet conditions. Amine oxides reduced the adhesion of the coatings, but did not impair their aging properties. Because of their hydrophilic nature, they also increased the permeability to liquid water, although they did not affect the air moisture permeability. The penetration of the propiconazole, estimated with a dye, decreased with the resin. Overall, the two parts of the treatment lightly impaired each other, but the practical aspect of this treatment may overcome these disadvantages.
  • 1.4K
  • 30 Oct 2020
Topic Review
Dicer-Type Ribonucleases
Ribonuclease Dicer belongs to the family of RNase III endoribonucleases, the enzymes that specifically hydrolyze phosphodiester bonds found in double-stranded regions of RNAs. Dicer enzymes are mostly known for their essential role in the biogenesis of small regulatory RNAs. A typical Dicer-type RNase consists of a helicase domain, a domain of unknown function (DUF283), a PAZ (Piwi-Argonaute-Zwille) domain, two RNase III domains, and a double-stranded RNA binding domain; however, the domain composition of Dicers varies among species. Dicer and its homologues developed only in eukaryotes; nevertheless, the two enzymatic domains of Dicer, helicase and RNase III, display high sequence similarity to their prokaryotic orthologs. Evolutionary studies indicate that a combination of the helicase and RNase III domains in a single protein is a eukaryotic signature and is supposed to be one of the critical events that triggered the consolidation of the eukaryotic RNA interference.
  • 1.4K
  • 22 Feb 2021
Topic Review
Bile Acids in Metabolic Disease
Bile acids are cholesterol-derived metabolites with a well-established role in the digestion and absorption of dietary fat. More recently, the discovery of bile acids as natural ligands for the nuclear farnesoid X receptor (FXR) and membrane Takeda G-protein-coupled receptor 5 (TGR5), and the recognition of the effects of FXR and TGR5 signaling have led to a paradigm shift in knowledge regarding bile acid physiology and metabolic health. Bile acids are now recognized as signaling molecules that orchestrate blood glucose, lipid and energy metabolism. Changes in FXR and/or TGR5 signaling modulates the secretion of gastrointestinal hormones including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), hepatic gluconeogenesis, glycogen synthesis, energy expenditure, and the composition of the gut microbiome.
  • 1.4K
  • 28 Sep 2021
Topic Review
Contact Dermatitis of the Vulva
The vulvar area is a common site of contact dermatitis due to the thin skin, easily traversable by irritant and allergic substances. The nonkeratinized vulvar vestibule is likely to be more permeable than the keratinized portions of the vulva and thus more susceptible to exogenous topical agents. The vulva is an area of occlusion due to both its intrinsic anatomical structure and the frequent use of occlusive napkins or underwear, which increase penetration or absorption of both irritants and allergens. Furthermore, women at different ages, due to urine and feces as children and to vaginal mucosal atrophy and the increase in the vulvar pH in menopause, may have an altered barrier function and, in incontinent elderly subjects, the use of diapers may contribute to increased susceptibility to irritants and allergens.
  • 1.4K
  • 16 Nov 2021
Topic Review
Glutamate Protects against Catecholamine Oxidation
Catecholamines, such as dopamine and norepinephrine, take part in regulating a variety of mental processes, including cognitive ability, attention, memory, mood, and reward. Glutamate, as a neurotransmitter, plays an important role in learning, memory, neuronal plasticity, and brain development. The excessive stimulation of glutamate receptors causes the excitatory toxicity of neuron cells; thus, neurons are endowed with high-affinity glutamate transporters to enrich glutamate.
  • 1.4K
  • 16 Nov 2021
Topic Review
INOS in Ovarian Cancer
Inducible nitric oxide synthase (iNOS), the enzyme responsible for nitric oxide (NO) production, is not present in most cells under normal conditions. The expression of its mRNA, as well as its protein synthesis and full enzymatic activity, undergoes multilevel regulation including transcriptional and posttranscriptional mechanisms, the availability of iNOS substrate and cofactors and oxygen tension.
  • 1.4K
  • 22 Dec 2021
Topic Review
Soil Nanoremediation and Mushrooms
Soil pollution is a serious challenge facing the global community. This pollution is a direct and/or indirect harmful deterioration, which penetrates all aspects of our life, especially human health. Therefore, there is an urgent need to repair, remove, or decompose these pollutants according to various approaches. Concerning the relationship between soil nanoremediation and its mushrooms, this process can be called nano myco-remediation. The mechanism of this kind of remediation depends mainly on the enzymatic system of mushroom species and is involved in the bioremediation of organic environmental pollutants.
  • 1.4K
  • 06 Dec 2022
Topic Review
Thermocatalytic Conversion of Plastics into Liquid Fuels
The problem of recycling polymer waste remains the main one in the context of the growth in the use of plastics. Given the non-renewability of fossil fuels, the task of processing plastic waste into liquid fuels seems to be a promising one. Thermocatalytic conversion is one of the methods that allows obtaining liquid products of the required hydrocarbon range. Clays and clay minerals can be distinguished among possible environmental-friendly, cheap and common catalysts.
  • 1.4K
  • 08 Jun 2022
Topic Review Video
Interdisciplinary Management of Lung Cancer in European Community
Lung cancer continues to be the largest cause of cancer-related mortality among men and women globally, accounting for around 27% of all cancer-related deaths. Recent advances in lung cancer medicines, particularly for non-small-cell lung cancer (NSCLC), have increased the need for multidisciplinary disease care, thereby enhancing patient outcomes and quality of life. Different studies in the European community have evaluated the impact of multidisciplinary care on outcomes for lung cancer patients, including its impact on survival, adherence to guideline treatment, utilization of all treatment modalities, timeliness of treatment, patient satisfaction, quality of life, and referral to palliative care.
  • 1.4K
  • 02 Aug 2022
Topic Review
Diploid Wheats and Non Celiac Wheat Sensitivity
Non-celiac wheat sensitivity (NCWS) is a clinical entity induced by the ingestion of gluten that leads to intestinal and/or extraintestinal symptoms, and is diagnosed when celiac disease and wheat allergy have been ruled out. In addition to gluten, other grains’ components, including amylase trypsin inhibitors (ATIs) and fermentable short-chain carbohydrates (FODMAPs), may trigger symptoms in NCWS subjects. Several studies suggest that, compared with tetraploid and hexaploid modern wheats, ancient diploid wheats species could possess a lower immunogenicity for subjects suffering from NCWS. 
  • 1.4K
  • 02 Sep 2022
Topic Review
The Reconstruction of Diet in the Past
The retrospective reconstruction of our ancestors’ diet is far more difficult than it is for recent populations, offers numerous options and usually depends on a successful transdisciplinary cooperation at the interface between prehistory (archaeology), anthropology (bioarchaeology), chemistry, biochemistry, geology, and evolutionary medicine.
  • 1.4K
  • 29 Sep 2022
Topic Review
Spinning Dancer
The Spinning Dancer, also known as the Silhouette Illusion, is a kinetic, bistable, animated optical illusion GIF image showing a silhouette of a pirouetting female dancer. The illusion, created in 2003 by Japanese web designer Nobuyuki Kayahara, involves the apparent direction of motion of the figure. Some observers initially see the figure as spinning clockwise (viewed from above) and some counterclockwise. Additionally, some may see the figure suddenly spin in the opposite direction. The illusion derives from the lack of visual cues for depth. For instance, as the dancer's arms move from viewer's left to right, it is possible to view her arms passing between her body and the viewer (that is, in the foreground of the picture, in which case she would be circling counterclockwise on her right foot) and it is also possible to view her arms as passing behind the dancer's body (that is, in the background of the picture, in which case she is seen circling clockwise on her left foot). When she is facing to the left or to the right, her breasts and ponytail clearly define the direction she is facing, although there is ambiguity in which leg is which. However, as she moves away from facing to the left (or from facing to the right), the dancer can be seen facing in either of two directions. At first, these two directions are fairly close to each other (both left, say, but one facing slightly forward, the other facing slightly backward) but they become further away from each other until we reach a position where her ponytail and breasts are in line with the viewer (so that neither her breasts nor her ponytail are seen so readily). In this position, she could be facing either away from the viewer or towards the viewer, so that the two possible positions are 180 degrees apart. Another interesting aspect of this illusion can be triggered by placing a mirror vertically, besides the image. The natural expectation would be for the normal image and its reflection to spin in opposite directions. This does not necessarily happen, and provides a paradoxical situation where both mirrored dancers spin in the same direction.
  • 1.4K
  • 23 Nov 2022
Topic Review
Rapid DNA Systems
The generation of STR profiles currently requires highly skilled geneticists and dedicated laboratories. Therefore, there is an urgent need for fast and reliable DNA devices for analysis directly at the crime scene. A few systems became commercially available for integrated forensic DNA analysis to be used in the field, which are fully integrated platforms that can generate STR profiles from (reference) samples within 2 hours. In the following a distinction is made between 'rapid DNA analysis' - defined as using a rapid DNA instrument without human intervention - and 'modified rapid DNA analysis'' which is defined as using a rapid DNA instrument in combination with human interpretation of the DNA analyses results.
  • 1.4K
  • 10 Feb 2023
Topic Review
Actual Application of Propolis
Propolis is a natural hive product collected by honeybees from different plants and trees. The collected resins are then mixed with bee wax and secretions. Propolis has a long history of use in traditional and alternative medicine. Propolis possesses recognized antimicrobial and antioxidant properties. Both properties are characteristics of food preservatives. The antimicrobial and antioxidant properties of propolis were extensively studied. In addition, propolis is recognized as safe (GRAS) and can be considered as an alternative to chemical preservatives. Before its use in food products, propolis was in most cases extracted using different solvents such as ethanol, water, and glycerol. Each solvent offers advantages and disadvantages. Ethanol extracts (PEE) are reported to be the richest extracts in bioactive components. While water extracts (WPE) are the lowest extract on phenolic content. In contrast, the two extracts exhibited a strong flavor and aroma. 
  • 1.4K
  • 06 May 2023
Topic Review
Nanomaterial-Modified Electrodes for Electrochemical Biosensors
Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. 
  • 1.4K
  • 16 Jun 2023
Topic Review
Corporate Responsibility in the Digital Era
As the digital era advances, many industries continue to expand their use of digital technologies to support company operations, notably at the customer interface, bringing new commercial opportunities and increased efficiencies. New sets of responsibilities associated with the deployment of these technologies are emerging, encompassed within the concept of corporate digital responsibility (CDR). The scope of CDR is wide-ranging and overlaps with the other dimensions of corporate social responsibility (CSR), having social, economic, ethical, and environmental—as well as technological components.
  • 1.4K
  • 31 Jul 2023
Topic Review
HTT Gene
Huntingtin
  • 1.4K
  • 23 Dec 2020
Topic Review
Rural Housing Rental Rates in China
Through recognition and mastery of the regional differences and influencing factors of China’s rural housing rental rates, we can better understand changes in the functional attributes of homesteads and deepen the reform of “separating rural land ownership rights, contract rights, and management rights” of homesteads. Accordingly, it can use village residence data from the China Labor-force Dynamics Survey to measure the degree of regional differences in rural housing rental rates at the province level and empirically analyze the influencing factors with villages (residences) as measuring unit. The study yields four main findings. First, rural housing rental behavior exists to varying degrees in the vast majority of provinces nationwide. Second, according to the spatial distribution pattern, rural housing rental rates are generally high in the eastern coastal region and low in the central, western, and northeastern regions, mainly reflecting unique characteristics of the eastern region. Third, although the level of economic development is important, it is not the only factor explaining regional differences in rural housing rental rates. Fourth, rural housing rental rates are mainly influenced by a combination of three types of factors: physiographic, socioeconomic, and village governance factors. Among them, factors such as proximity to suburban areas, the proportion of non-local permanent residents, annual per capita income, and village infrastructure conditions have significant positive effects, whereas factors such as distance from administrative centers, reliance on funding from the higher-level authority of the village committee, and the degree of harmony between villages and cadres have significant negative effects. 
  • 1.4K
  • 26 Aug 2022
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